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Product Information

What is Avonex?

Avonex falls under the class of cytokines in the interferon group, which are protein molecules that are responsible for cell signaling and help fight infection in the body. Avonex is mainly used in slowing the progress of multiple sclerosis, including in those patients that relapses. Avonex will not cure multiple sclerosis, as there is no known cure for this disease. Available only in injectable form, Avonex is manufactured by Biogen and was approved by the Food and Drug Administration (FDA) in May 1996.

Active ingredient

The active ingredient of Avonex is Interferon beta 1A. These protein molecules have anti-inflammatory properties, where they limit the number of inflammatory cells crossing the blood brain barrier. They also stimulate the secretion of the nerve growth factor. This nerve growth factor enhances nerve growth, protection, and maturation.

Conditions treated

• Avonex is used in slowing the progression of multiple sclerosis in relapsing patients.

Generic vs brand name

Avonex is known by its generic name, interferon beta-1a. Other brand names of this medication include Rebif.

Dosage information

Use your medication as directed by your healthcare professional. Avonex can be taken with or without food and can only be administered intramuscularly.

• Avonex is administered intramuscularly using a special injection called the Avonex pen. This is a single use filled glass syringe that contains 30mcg (micrograms) of Avonex. A recommended dosage of 30mcg of Avonex is injected intramuscularly once every week. The first dose can be started at 0.75mcg and can be increased each week until the recommended dose is attained. The titration of Avonex 0.75mcg can be measured by using 3 separate titration devices called the AVOSTARTGRIP kit.

Side effects

• Seizure
• Convulsion
• Easy bruising or bleeding
• Painful Urine
• Numbness and tingling in hands and feet
• Myalgia
• Pain and swelling of the skin
• Alopecia

These may not be all the effects of Avonex. Consult your physician for further information

Warnings and precautions

Contraindications

• The use of Avonex is contraindicated in patients who are hypersensitive to interferon beta 1A or any of the components used in the formulation.
• It is also a contraindication to patients who are allergic or hypersensitive to Albumin, as this drug contain Albumin components.

Precautions

• Patients who are hypersensitive to Avonex, Albumin, or any of its components should seek the advice of a physician or pharmacist before use.
• Depressed patients using Avonex should be monitored carefully as the usage of this drug enhances depression and may lead to suicidal tendencies.
• It is not recommended to use Avonex during pregnancy. Tell your physician or pharmacist if you are pregnant or plan to become pregnant before the use of Avonex.
• It is important for patients to tell their physician if they are suffering from liver diseases, history of depression, epilepsy, heart disease, bleeding disorder, or thyroid diseases.

Drug interactions

Using Avonex with certain drugs can either potentiate their effects in the body or nullify them. Therefore, you should know the medicines you take and always remember to tell your healthcare provider and pharmacist when you are prescribed new medicine. However, it is not recommended to use Avonex with ethanol, deferiprone, tinazidine, and natalizumab, as it may have life threatening reactions.

Interactions:

• Alemtuzumab
• Arava (leflunomide)
• Aplenzin (bupropion)
• Budeprion (bupropion)
• Buproban
• ConZip (tramadol)
• Contrave
• Forfivo
• Combivir
• GenRxTramadol
• Iohexol
• Iopamidol
• Juxtapid
• Leflunomide
• Lomitapide
• Kynamro
• Larapam

Not all the drugs that interact with Avonex are listed above.

Frequently asked questions

How to store Avonex?

• Store away from direct sunlight and heat.
• Store in the refrigerator but do not freeze.
• Do not store in a humid place (e.g. bathroom).
• Keep in a closed container.
• Keep out of the reach of children.

What if I overdose on Avonex?

• If you accidentally overdose on this medication, seek immediate medical advice or call the Poison Control Helpline at 1-800-222-1222.

What if I miss a dose of Avonex?

If you miss a dose, it is recommended to call your physician. Never inject Avonex 2 days in a row, as your injections should have at least a 48-hour window period.