Apretude Injectable Suspension

Please note: a valid prescription is required for all prescription medication.

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$2,282.99

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Apretude (cabotegravir injectable suspension) is a long-acting antiretroviral used for pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 in at-risk adults and adolescents. Each vial contains 200 mg/mL of cabotegravir in a 3 mL formulation, delivering a total of 600 mg per injection.

Benefits

Reduces the risk of sexually acquired HIV-1 infection
Long-acting formulation with injections every 2 months
Improves adherence compared to daily oral PrEP
Suitable for both adults and adolescents (≥35 kg)
Reduces the burden of daily medication and enhances privacy

Dosage

Optional oral lead-in: Cabotegravir 30 mg tablet daily for 28 days to assess tolerability
Initiation phase: 600 mg (3 mL) intramuscular injection at month 1 and month 2
Maintenance phase: 600 mg (3 mL) intramuscular injection every 2 months thereafter
Injection should be administered into the gluteal muscle by a healthcare professional
If injection is missed, consult a healthcare provider promptly for bridging options

Warnings and Precautions

Only for individuals confirmed HIV-negative; HIV test required prior to each injection
Do not use in patients with existing HIV infection—risk of drug-resistant virus
May cause injection site reactions, including pain, redness, or induration
Use caution in patients with liver disease or hepatitis B/C
May interact with enzyme-inducing medications (e.g. rifampin, phenytoin)
Long half-life—missed doses may reduce efficacy and require alternative PrEP strategies

Usage Instructions

Administered by a healthcare professional via intramuscular injection
Do not self-administer
Maintain scheduled appointments—adherence to injection timeline is essential
Oral tablets may be used to start or resume treatment if necessary
Continue routine HIV testing as advised

Storage Information

Store in original packaging in a refrigerator between 2°C and 8°C (36°F and 46°F)
May be kept at room temperature (up to 25°C or 77°F) for up to 30 days before use
Do not freeze
Protect from light
Keep out of reach of children

Common Side Effects

Pain, swelling, or hardness at injection site
Headache
Fever, fatigue, or muscle aches
Nausea or gastrointestinal upset
Dizziness
More serious side effects may include liver enzyme elevation or allergic reactions

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