Azilect

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Azilect (rasagiline) is a monoamine oxidase-B (MAO-B) inhibitor used in the treatment of Parkinson’s disease. It helps increase and prolong the effects of dopamine in the brain, improving movement and reducing symptoms such as tremor, stiffness, and slowness. It may be used alone in early-stage Parkinson’s or in combination with other medications like levodopa in more advanced stages.

Benefits

Helps manage motor symptoms of Parkinson’s disease
Can be used as monotherapy in early stages
Enhances the effects of levodopa in advanced Parkinson’s
Once-daily oral dosing improves treatment adherence
May reduce “off” time (periods when symptoms return between doses of other medication)

Dosage

Monotherapy (early-stage Parkinson’s): 1 mg once daily
Adjunct to levodopa (advanced Parkinson’s): 0.5 mg to 1 mg once daily
Can be taken with or without food
No dose adjustment required for mild liver or kidney impairment
Not recommended in patients with moderate to severe liver dysfunction

Warnings and Precautions

Risk of serotonin syndrome when used with certain antidepressants—use caution
Avoid concurrent use with other MAO inhibitors, sympathomimetics, or certain opioids
May increase blood pressure—monitor in patients with hypertension
Use with caution in patients with a history of dyskinesia or hallucinations
Not recommended during pregnancy or breastfeeding unless clearly necessary
Tyramine-containing foods (e.g. aged cheese, cured meats) should be limited, although dietary restrictions are less stringent than with non-selective MAO inhibitors

Usage Instructions

Take once daily, at the same time each day
Can be taken with or without meals
Do not double dose if a dose is missed—take the next dose at the usual time
Do not stop taking without consulting a healthcare provider
Continue regular medical follow-up to monitor disease progression and medication effects

Storage Information

Store at room temperature between 15°C and 30°C (59°F and 86°F)
Protect from moisture and light
Keep in original packaging until use
Keep out of reach of children

Common Side Effects

Headache
Joint pain
Indigestion or nausea
Depression or mood changes
Flu-like symptoms
More serious side effects may include hallucinations, hypertensive crisis (especially with drug or food interactions), or serotonin syndrome

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