Banzel® (rufinamide) tablets for Lennox-Gastaut syndrome

What Banzel® Is and How It Works

Banzel® (rufinamide) is an anti-seizure medicine for Lennox-Gastaut syndrome. It is used as add-on therapy in adults and children one year and older. Tablets are taken by mouth twice daily with food. Many people search for banzel order without insurance because US cash prices can be high. YouDrugstore is a licensed Canadian pharmacy in Manitoba that meets Canadian pharmacy standards, and our pharmacists review prescriptions before dispensing.

We also work with licensed, vetted partner pharmacies abroad to source authentic brands at fair prices, which broadens selection and helps lower costs.

Rufinamide belongs to the antiepileptic drug class. It acts mainly on voltage-gated sodium channels. The medicine stabilizes the inactive state of the channel and reduces excessive neuronal firing. In Lennox-Gastaut syndrome, this can lower the number of drop attacks and other seizure types. Banzel® comes as film-coated tablets in several strengths, and as an oral suspension in some markets. Dosing is divided twice daily, with food, to improve absorption.

Dosage and Usage

Your prescriber will set the plan based on age, weight, and other medicines. General guidance includes:

• Start low and increase in steps to a target dose.
• Adults may start at 400–800 mg per day in two doses.
• Increase by 400–800 mg every other day as directed.
• Do not exceed 3,200 mg per day in adults.
• Children often start at 10 mg/kg/day in two doses.
• Increase by 10 mg/kg every other day to 45 mg/kg/day, not over 3,200 mg/day.
• Take doses with food to improve absorption.
• For patients under 30 kg taking valproate, a lower maximum (for example 600 mg/day) may be used.
• Do not stop suddenly. Taper under medical supervision.

Missed dose:

• If a dose is missed, take it when remembered unless it is close to the next dose.
• Do not double doses. Resume the regular schedule.

Storage and travel tips:

• Store tablets at room temperature away from moisture.
• Keep in the original bottle and out of children’s reach.
• Pack enough medicine for the trip plus a few extra days.
• Carry a copy of the prescription when flying.

Benefits and Savings

Banzel® reduces drop attacks and overall seizure frequency in Lennox-Gastaut syndrome. Many patients see fewer falls, fewer injuries, and improved daily function. Twice-daily dosing with food fits most routines. Tablets in multiple strengths allow fine dose adjustments.

YouDrugstore offers Canadian pricing on brand and generic medicines. Typical customers save 60–80% compared with usual US pharmacy prices, especially when paying without insurance. Ordering is simple online or by phone during office hours, and our friendly customer-service chat is available for support.

Side Effects and Safety

Not everyone experiences side effects, and many are mild. Still, review risks with a prescriber and report concerning symptoms promptly.

• Common: dizziness, fatigue, sleepiness, headache, nausea, vomiting.
• Other: loss of appetite, weight loss, blurred vision, double vision, balance issues.
• Serious: allergic rash, fever, swollen glands, liver problems (DRESS); suicidal thoughts or behavior; status epilepticus; significant drop in sodium levels is uncommon but possible.
• Heart: Banzel® shortens the QT interval. It is contraindicated in familial short QT syndrome. Avoid other medicines that further shorten QT.
• Drug interactions: valproate increases rufinamide levels; enzyme inducers (carbamazepine, phenytoin, phenobarbital) may reduce levels; rufinamide can reduce effectiveness of hormonal contraceptives.
• Use in liver disease: avoid in severe hepatic impairment; adjust in mild to moderate impairment per prescriber.
• Pregnancy and lactation: discuss benefits and risks; consider enrollment in antiepileptic pregnancy registries where available.

Onset Time

Rufinamide reaches steady state in a few days, but full benefit often appears after reaching the target dose. Dose increases usually occur every other day during titration. Many patients notice changes in seizure frequency within the first few weeks. Response varies, and ongoing adjustments are common.

Compare With Alternatives

Clobazam is often used for Lennox-Gastaut syndrome and can reduce drop seizures. It may cause sedation and tolerance over time. Banzel® offers a non-benzodiazepine option that avoids dependence concerns seen with clobazam.

Lamotrigine is another option used in LGS. It can help multiple seizure types and is generally well tolerated, but requires slow titration due to rash risk.

Topiramate and valproate are established choices. Topiramate may cause cognitive slowing and weight loss; valproate can cause weight gain, tremor, and liver or platelet effects. Banzel® can be added to these regimens when extra control is needed, with attention to interactions.

Combination Therapy

Most people with Lennox-Gastaut syndrome need combination therapy. Banzel® is commonly used with valproate, clobazam, lamotrigine, or topiramate. Valproate can raise rufinamide levels, so a lower Banzel® dose may be considered. Enzyme-inducing antiepileptics can lower rufinamide levels, and prescribers may adjust doses.

Rufinamide may reduce the effectiveness of estrogen-containing birth control. Non-hormonal or backup methods are often recommended. Non-drug options such as a ketogenic diet or vagus nerve stimulation may also be part of a comprehensive plan.

Patient Suitability and Cost-Saving Tips

Banzel® may suit patients with Lennox-Gastaut syndrome who need add-on seizure control. It is not appropriate in familial short QT syndrome. Those with severe liver disease need alternatives. Tablets require swallowing; an oral suspension may be chosen for children or those with dysphagia.

To lower costs, consider generic rufinamide if appropriate, and compare per-month pricing on larger supplies. Multi-month orders can decrease the monthly cost, and our reorder reminders help you stay on schedule. For current deals and bulk options, see our banzel coupon page. Our prices can be a strong option for those who banzel order uninsured, and for families managing long-term therapy.

YouDrugstore offers Canadian prices, with secure checkout and caring support. Chat with customer service during posted hours for help with ordering, shipping details, or documentation needs.

Authoritative Sources

Manufacturer information for Banzel (Eisai)

FDA Prescribing Information for Banzel

FDA Medication Guide: Banzel

You can order from YouDrugstore with confidence. We are a licensed Canadian pharmacy based in Manitoba, and every prescription is reviewed by a licensed pharmacist. We ship to the US with prompt, express shipping, and we stock brand and generic options at Canadian prices.

This content is for general information and does not replace your prescriber’s advice. Always follow the directions on your prescription label and speak with a healthcare professional about your specific situation.