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Betaseron

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Betaseron (interferon beta-1b) is an immunomodulatory medication used to treat relapsing forms of multiple sclerosis (MS). It helps reduce the frequency of MS relapses and slows the progression of physical disability. Betaseron works by modifying the immune response and reducing inflammation in the central nervous system.

Benefits

  • Reduces the frequency of MS relapses
  • Helps slow the progression of physical disability in MS
  • May reduce the number and size of active brain lesions on MRI
  • Self-administered subcutaneous injection for convenient at-home use
  • Suitable for long-term disease management

Dosage

  • Adults with relapsing MS: 250 micrograms (0.25 mg) injected subcutaneously every other day
  • Injections should be rotated between different body sites to reduce skin reactions
  • A titration schedule may be used at treatment initiation to improve tolerability
  • Should be administered at the same time of day on injection days
  • Dose adjustments not typically needed for mild kidney or liver impairment

Warnings and Precautions

  • May cause flu-like symptoms, especially at treatment initiation
  • Risk of liver toxicity—monitor liver enzymes regularly
  • Use with caution in patients with a history of depression or suicidal thoughts
  • May cause injection site reactions, including redness, swelling, or necrosis
  • Blood cell counts should be monitored regularly during treatment
  • Not recommended during pregnancy unless clearly necessary—discuss with a healthcare provider

Usage Instructions

  • Inject under the skin (subcutaneous) every other day as prescribed
  • Rotate injection sites to minimise risk of skin irritation or damage
  • Reconstitute the powder with the supplied diluent just before injection
  • Use within 3 hours of preparation; do not freeze or expose to light
  • Do not stop treatment without consulting your doctor

Storage Information

  • Store unopened vials at room temperature between 15°C and 30°C (59°F and 86°F)
  • Protect from light
  • After reconstitution, the solution should be used within 3 hours
  • Do not freeze
  • Keep out of reach of children

Common Side Effects

  • Flu-like symptoms (fever, chills, muscle aches, fatigue)
  • Injection site pain, redness, or swelling
  • Headache
  • Liver enzyme elevation
  • Depression or mood changes
  • More serious side effects may include liver damage, allergic reactions, or blood disorders

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