Bosulif® (bosutinib) tablets for Philadelphia chromosome–positive CML

What Bosulif® Is and How It Works

Bosulif® (bosutinib) is an oral tyrosine kinase inhibitor for adults with Philadelphia chromosome–positive chronic myelogenous leukemia (Ph+ CML). It targets BCR-ABL and SRC kinases to slow leukemia cell growth. Tablets are taken once daily with food. If you compare Bosulif price options or need Bosulif without insurance, YouDrugstore offers clear pricing and support. We are a licensed Canadian pharmacy based in Manitoba, and our pharmacists review prescriptions before dispensing.

We source brand medicines through licensed, vetted partner pharmacies so you receive authentic products at fair, international pricing. You can order online or by phone, and our friendly customer-service chat is available during posted office hours.

Dosage and Usage

Prescribers individualize the starting dose by disease phase and prior therapy.

• Common starting doses: 400 mg once daily for newly diagnosed chronic phase; 500 mg once daily for resistant or intolerant Ph+ CML.
• Take with food at the same time each day. Swallow tablets whole.
• Avoid grapefruit and grapefruit juice.
• Acid-reducing agents: avoid proton pump inhibitors. If needed, use short-acting antacids separated by time or an H2 blocker per clinician advice.
• Missed dose: if more than 12 hours have passed, skip and take the next dose at the usual time. Do not double up.
• Vomiting after a dose: do not take an extra tablet. Resume the next scheduled dose.
• Hepatic or renal impairment: prescribers may lower the starting dose and monitor closely.
• Strong CYP3A inhibitors and inducers can change bosutinib levels. Clinicians may adjust therapy.

Storage and travel:

• Store at 20–25°C (68–77°F) in the original bottle. Protect from moisture.
• Keep out of reach of children and pets.
• When traveling, carry tablets in your hand luggage with a copy of your prescription and pharmacy label.

Benefits and Savings

Bosutinib helps achieve hematologic and cytogenetic responses in Ph+ CML. It offers once-daily oral dosing, which supports steady treatment plans outside the clinic. Many patients see early control of high white counts, with deeper responses building over time.

Ordering from YouDrugstore is simple and secure. You can access brand oncology medicines at Canadian prices, often with 60–80% savings versus typical US costs. Patients paying without insurance may find that multi-month orders reduce per-month expense. Our team can explain shipping options and help you plan refills.

Side Effects and Safety

Side effects vary by patient and dose. Medical teams monitor labs and adjust treatment when needed.

• Very common: diarrhea, nausea, vomiting, abdominal pain, decreased appetite, rash, headache, fatigue.
• Laboratory changes: elevated liver enzymes, decreased blood counts (platelets, neutrophils), increased creatinine.
• Other reported: fluid retention, cough, fever, musculoskeletal pain, pruritus.
• Serious reactions that require prompt care: severe diarrhea or dehydration, significant liver injury, severe myelosuppression with infection or bleeding, renal toxicity, cardiac events, or severe hypersensitivity.

Clinicians usually check liver function, kidney function, and complete blood counts at baseline and regularly during treatment. Use effective contraception during therapy and for a period after stopping, since the drug may harm an unborn baby. Breastfeeding is not recommended during treatment.

Discuss all medicines and supplements with the prescriber. Strong CYP3A modulators can raise or lower bosutinib exposure. Avoid grapefruit products. People with significant liver disease need careful dosing and close monitoring.

Onset Time

Many patients see hematologic improvement within weeks as white blood cell counts fall. Cytogenetic or molecular responses usually take longer and build over months with continued therapy. Response timelines depend on disease phase, prior treatments, and individual factors. Health care teams confirm progress using scheduled blood tests and, when indicated, bone marrow or molecular assays.

Compare With Alternatives

Other first- or later-line options for Ph+ CML include imatinib, dasatinib, nilotinib, and ponatinib. Imatinib has long-term data and broad use, with different side effect patterns. Dasatinib may suit certain risk profiles but can cause pleural effusions. Nilotinib requires fasting dosing and ECG monitoring for QT effects. Ponatinib is reserved for specific resistant mutations, such as T315I, due to vascular risk.

Choice depends on phase, comorbidities, mutation profile, and tolerance. If a switch is needed, clinicians weigh past responses and interactions. YouDrugstore also supplies targeted oncology agents for other cancers, such as Bavencio® and Zytiga®, at Canadian prices with pharmacist review.

Combination Therapy

Bosutinib is generally used as monotherapy in Ph+ CML. Supportive medicines may be used to manage diarrhea, nausea, or other symptoms. Clinicians avoid strong CYP3A modulators when possible and adjust dosing if interactions or organ impairment are present. Routine monitoring and adherence are key to maintain response and limit toxicity over time.

Patient Suitability and Cost-Saving Tips

Bosutinib is indicated for adults with Ph+ CML in chronic, accelerated, or blast phases, either newly diagnosed or after prior TKI therapy. Suitability depends on liver and kidney function, cardiac history, bleeding risk, concomitant drugs, and pregnancy plans. People with uncontrolled hepatic disease or severe drug interactions may need an alternate plan.

To manage costs, consider a larger supply if appropriate, since per-month pricing can be lower on multi-month orders. You can turn on reorder reminders in your account so you never run short. For the latest offers, see our Bosulif coupon and bulk options. Patients comparing Bosulif cost without insurance can contact our team for current US-shipping pricing and documentation for tax or HSA records.

Explore our Cancer category to see other treatments we carry. You can also read our article, Bosulif Medication Understanding Its Role In Cancer Care, for an accessible overview of how this medicine fits into CML treatment pathways.

Authoritative Sources

For detailed prescribing information, review the Pfizer Bosulif product page, the FDA Prescribing Information for Bosulif, and Health Canada’s Drug Product Database.

YouDrugstore offers brand oncology medicines at Canadian prices with pharmacist oversight. Order online or by phone, and we provide prompt, express, cold-chain shipping to the US when needed.

This information supports, but does not replace, the guidance of your oncology team. Always follow your prescriber’s directions and the official product labeling for dosing, monitoring, and warnings.