Bosulif® Tablets for Chronic Myeloid Leukemia

Bosutinib is a prescription kinase inhibitor for adults with certain types of leukemia. It helps block abnormal signals that drive chronic myeloid leukemia growth. This page summarizes key facts to help you review uses, safety, and how to order through YouDrugstore.

What Bosulif Is and How It Works

Bosulif® contains bosutinib, a tyrosine kinase inhibitor that targets BCR-ABL and related kinases in Philadelphia chromosome–positive chronic myeloid leukemia. It is taken with food and works by reducing abnormal cell signaling that fuels leukemia. Many people compare bosutinib cost without insurance and choose licensed pharmacies that offer US shipping from Canada. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine is typically used when newly diagnosed with Ph+ CML or after prior therapy, according to your prescriber’s plan. It is not chemotherapy in the traditional sense, but a targeted treatment that may be continued long term if tolerated and effective.

Who It’s For

This treatment is indicated for adults with Philadelphia chromosome–positive chronic myeloid leukemia. It may be used at diagnosis or when disease is resistant or intolerant to other tyrosine kinase inhibitors. People with significant liver problems, uncontrolled gastrointestinal disorders, or prolonged QT concerns may need different options. Those who are pregnant, planning pregnancy, or breastfeeding should avoid therapy; discuss family planning with your clinician.

Dosage and Usage

Typical dosing is once daily with food. A commonly used starting regimen is 400 mg once daily in newly diagnosed Ph+ CML. In patients previously treated with another TKI, prescribers often start at 500 mg once daily. Your dose, lab monitoring, and adjustments depend on your condition, response, and tolerability. Swallow tablets whole with water. Do not crush, split, or chew. Avoid grapefruit and grapefruit juice.

Acid-reducing agents can affect absorption. If you take antacids, separate them by at least two hours. H2 blockers and PPIs may lower exposure; your prescriber will advise alternatives or timing. Take the medicine at about the same time daily to support adherence. If you vomit after a dose, do not take an extra tablet; follow your routine schedule the next day.

Strengths and Forms

Tablets are supplied in multiple strengths to support dosing and adjustments. Commonly available strengths include 50 mg, 100 mg, 400 mg, and 500 mg tablets. Availability may vary by market and manufacturer supply. People sometimes compare bosutinib 100 mg tablets price across pack sizes; your prescriber’s dose should guide any selection.

Missed Dose and Timing

If you miss a dose and it is less than 12 hours until your next scheduled dose, skip the missed dose and take the next dose at the regular time. If it is more than 12 hours before your next dose, take the missed tablet with food when remembered. Do not take two doses at once. Set reminders or use a pill organizer to help keep a steady routine.

Storage and Travel Basics

Store tablets at room temperature in the original container, away from moisture. Keep the bottle tightly closed and out of reach of children and pets. When traveling, carry your medication in hand luggage with the labeled pharmacy container. Bring a copy of your prescription and your prescriber’s contact details. Keep a small buffer supply when possible, and plan time zone changes so your daily dose remains consistent.

Benefits

This therapy targets the BCR-ABL pathway that drives CML, which may help achieve hematologic and cytogenetic responses over time. Once-daily dosing with food can be convenient. Multiple strengths allow tailored dosing when your clinician adjusts therapy based on labs and tolerability.

Side Effects and Safety

• Diarrhea and nausea: very common, especially early in treatment
• Vomiting or abdominal pain: may occur with gastrointestinal upset
• Rash or itching: skin reactions are reported
• Fatigue and headache: nonspecific symptoms may appear
• Edema: fluid retention can occur
• Low blood counts: thrombocytopenia, anemia, or neutropenia
• Elevated liver enzymes: transaminase increases may be seen

Serious risks can include severe diarrhea, significant liver injury, myelosuppression, and rarely cardiac or renal issues. Report signs such as yellowing of the skin or eyes, dark urine, severe abdominal pain, unexplained bleeding, shortness of breath, or chest discomfort. Hypoglycemia is not typical with this class, but overall fatigue or appetite changes can affect nutrition. Your healthcare professional may adjust therapy or temporarily pause dosing if problems arise.

Drug Interactions and Cautions

Strong CYP3A inhibitors (such as certain azoles, macrolides, or protease inhibitors) can increase exposure and raise adverse event risk. Strong CYP3A inducers (such as rifampin or certain anticonvulsants) can reduce effectiveness. Avoid grapefruit products. Acid suppression may lower absorption; discuss options for reflux management with your prescriber. Use caution with agents that prolong QT or affect electrolytes. Regular liver function tests and blood counts are recommended. Tell your clinician about all medicines, supplements, and herbals you take.

What to Expect Over Time

Your clinician will assess blood counts and molecular markers to monitor response. Some adverse effects often lessen after the first weeks as your body adjusts. If side effects persist, your prescriber may modify your plan. Consistent daily dosing with food supports effectiveness. Keep all lab appointments and share any new symptoms promptly to help tailor your treatment.

Compare With Alternatives

Several tyrosine kinase inhibitors are used in Ph+ CML. Dasatinib may be considered for certain profiles; see Sprycel. Asciminib is a later-generation option for some patients; learn more at Scemblix. Discuss benefits, monitoring, and potential bosutinib price differences versus alternatives with your prescriber.

Pricing and Access

Canadian pharmacy channels can help with overall affordability while maintaining quality. If you are reviewing Bosulif price, compare pack sizes and strengths recommended by your prescriber. Total bosutinib tablets cost varies by strength and quantity. We provide transparent listings so you can plan your order and coordinate with your care team.

Your order includes licensed dispensing with prescription verification. We offer US shipping from Canada so you can receive your medication at home. For occasional offers, see our Promotions page.

Availability and Substitutions

Supply can vary by strength and pack size. If a requested strength is unavailable, a prescriber may recommend a suitable alternative or an adjusted regimen that uses available tablets to achieve the prescribed daily dose. If you plan to Buy bosutinib online, ensure the source is a licensed pharmacy. A prescription is required and verified before dispensing.

Patient Suitability and Cost-Saving Tips

This treatment may not suit those with severe hepatic impairment, uncontrolled gastrointestinal disease, or significant drug interactions. People at risk of dehydration should be cautious if diarrhea occurs. To manage costs, ask your prescriber about multi-month fills if appropriate, which may reduce per-tablet expenses. Some patients evaluate bosutinib Canadian pricing to plan longer refill cycles. Set refill reminders and coordinate lab visits so you do not miss doses.

Questions to Ask Your Clinician

• Starting dose and goals: what you will monitor
• Side effect plan: when to call for help
• Drug interactions: which medicines to avoid
• Liver tests: how often to check labs
• Acid reducers: timing or alternatives
• Travel planning: dosing across time zones

Authoritative Sources

U.S. Prescribing Information

DailyMed Label

Health Canada DPD

Explore supportive reading on diagnosis and care: Chronic Myeloid Leukemia, Understanding Nilotinib, and Tasigna Nilotinib. Also see our category pages for broader options: Chronic Myeloid Leukemia and Cancer.

Ready to proceed? You can place your order with prompt, express, temperature-controlled handling when required. Ships from Canada to US. This information is not a substitute for medical advice. Always follow your prescriber’s guidance and the official label.