How does cabozantinib work in cancer treatment?

Cabozantinib blocks several tyrosine kinases involved in tumor growth and angiogenesis, including MET, VEGFR, and AXL. By inhibiting these pathways, it may reduce blood vessel formation that feeds tumors and slow cancer cell signaling. Your oncology team uses scans, lab tests, and symptom checks to follow response. Because targeting multiple pathways can also affect normal tissues, monitoring is important to manage side effects and adjust therapy if needed.

Do I need to take it with food or avoid certain foods?

Take the tablet on an empty stomach. Wait at least two hours after eating before your dose, and then wait one hour after dosing before eating again. Swallow tablets whole with water. Avoid grapefruit and grapefruit juice, which can raise drug levels. Limit alcohol if your clinician advises, especially if your liver is affected by disease or treatment. If nausea is an issue, ask about supportive options that fit this dosing schedule.

Can I take cabozantinib with my other prescriptions or supplements?

Tell your clinician about all medicines and supplements. Strong CYP3A4 inhibitors (some antifungals or antibiotics) can increase levels, while strong CYP3A4 inducers (certain seizure medicines, rifampin) can decrease levels. Anticoagulants and antiplatelets may raise bleeding risk. Avoid grapefruit products. Never start, stop, or change doses of any medicine without discussing it with your healthcare professional.

What should I do if I miss a dose or vomit after taking it?

If you miss a dose and the next one is due within about 12 hours, skip the missed tablet and take the next dose at the usual time. If more than 12 hours remain, take it when remembered. Do not take two doses at once. If you vomit after a dose, do not take an extra tablet. Keep using your daily schedule and contact your care team if vomiting persists or you cannot keep doses down.

Is it safe around surgeries or dental procedures?

This medicine can increase bleeding risk and may impair wound healing. Your clinician may advise stopping it before and after major surgery or certain dental work, following the product label. Never restart until your prescriber confirms the timing is appropriate. Share your oncology medication list with surgeons and dentists so they can plan the safest schedule around procedures.

How is progress monitored while I’m on treatment?

Your team may schedule imaging scans, blood tests for liver and thyroid function, and regular blood pressure checks. They will also ask about symptoms such as diarrhea, mouth pain, and fatigue. Keep a log of side effects and bring it to visits. Based on results, your prescriber may continue, pause, or adjust treatment to balance benefits and tolerability. Contact your clinic promptly if you notice severe or unexpected symptoms.

Promotion

Cabometyx

Cabometyx® Tablets for Kidney Cancer

Kidney Cancer, Liver Cancer, Thyroid Cancer

Please note: a valid prescription is required for all prescription medication.

Stock up and Save - Get 20% off when you buy 3 or more of any one product. Use code SAVE20 at checkout.

Coupon code cannot be combined with other offers. Sale applies to all products originating from Canada. Maximum allowable quantity equal to a 90 day supply per single order.

Price:

$11,454.99

Secure Encrypted Payments

Cabometyx is a prescription cancer medicine for adults. It treats certain advanced tumors by blocking multiple kinases that drive growth and blood vessel formation. This guide explains Cabometyx cost without insurance, key safety points, and how to use the tablets correctly.

What Cabometyx Is and How It Works

We provide US shipping from Canada so you can access this therapy through our licensed service. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Cabometyx® is a brand of cabozantinib tablets. The active ingredient targets several pathways including MET, VEGFR, and AXL. By inhibiting these signals, the treatment may slow tumor growth and reduce new blood vessel formation. It is used for advanced renal cell carcinoma, for hepatocellular carcinoma after prior sorafenib, and for differentiated thyroid cancer that has progressed after radioactive iodine. For some kidney cancer regimens, it can be combined with immunotherapy as directed by your prescriber. Always follow your oncology care plan and official labeling.

Who It’s For

This medicine is for adults treated for specific cancers under a prescriber’s supervision. These include advanced or metastatic renal cell carcinoma. It also treats liver cancer after sorafenib and certain radioiodine-refractory differentiated thyroid cancers. See condition overviews for Kidney Cancer, Liver Cancer, and Thyroid Cancer.

People with uncontrolled bleeding, recent major surgery, severe liver problems, or poorly controlled blood pressure may not be candidates. Avoid use during pregnancy and while breastfeeding. Tell your clinician about all health conditions and medicines before starting.

Dosage and Usage

Typical schedules follow the official label. Many adults take one dose by mouth once daily. When used with certain immunotherapies, a different strength may be chosen. Take on an empty stomach: at least 2 hours after eating and wait 1 hour before the next meal. Swallow tablets whole with water. Do not split, crush, or chew.

If you vomit after a dose, do not take an extra tablet. Avoid grapefruit or grapefruit juice. If your clinician changes the dose or pauses treatment for side effects, follow those directions exactly. Read the patient information that comes with your prescription for the most current guidance.

Strengths and Forms

The tablets are film-coated and color-coded by strength. Commonly available strengths include 20 mg, 40 mg, and 60 mg. Packaging and availability may vary by market and stock. Your prescriber will select the appropriate presentation for your plan.

Missed Dose and Timing

If you miss a dose and the next one is due within about 12 hours, skip the missed dose and take the next dose at the usual time. If more than 12 hours remain, take the tablet when you remember. Do not take two doses at once. Try to dose at the same time each day, using a reminder or pill organizer if helpful.

Storage and Travel Basics

Store tablets in the original, tightly closed bottle at room temperature. Keep them dry and away from excess heat and humidity. Do not store in the bathroom. Keep out of reach of children and pets. Dispose of unused or expired tablets through a take-back option if available.

For travel, carry the labeled bottle in your hand luggage with a copy of your prescription. Keep dosing consistent across time zones by aligning the schedule with your home routine. If your trip involves long flights, pack enough tablets plus a small buffer as permitted by your prescriber.

Benefits

This medicine is an oral targeted therapy, so no infusion visit is required for the tablet component. It can be used alone or alongside approved immunotherapy in some kidney cancer regimens. The treatment acts on multiple signaling pathways that contribute to tumor growth and vascular support. Your oncology team will monitor how you respond and whether adjustments are needed.

Side Effects and Safety

Digestive effects: diarrhea, nausea, vomiting, abdominal pain
Mouth changes: soreness, stomatitis, taste changes
Skin and hands/feet: rash, redness, tenderness, hand–foot reaction
General: fatigue, weakness, decreased appetite, weight loss
Blood pressure: hypertension or worsening of existing hypertension
Thyroid: possible changes in thyroid function tests

Serious risks can include bleeding, blood clots, gastrointestinal perforation or fistulas, severe hypertension, wound-healing problems, liver issues, and rare jaw bone problems. Get urgent care for severe bleeding, chest pain, sudden shortness of breath, severe abdominal pain, or neurological symptoms. Your clinician may pause or adjust therapy if serious side effects occur.

Drug Interactions and Cautions

Cabozantinib is affected by CYP3A4. Strong CYP3A4 inhibitors (for example, certain antifungals or antibiotics) can increase exposure. Strong CYP3A4 inducers (such as rifampin or some seizure medicines) can reduce exposure. Grapefruit and grapefruit juice may increase levels and should be avoided. Tell your clinician about anticoagulants, antiplatelets, and blood pressure therapies.

Discuss any planned surgery or dental procedures. The treatment may increase bleeding risk and can impair wound healing; it is often paused before and after major procedures per label guidance. Use effective contraception during treatment and for a period after the last dose as advised by the label. Do not breastfeed during therapy and for the recommended time after the last tablet.

What to Expect Over Time

Response is assessed over time by imaging, symptoms, and lab tests. Some side effects appear early and can improve with supportive care or treatment changes directed by your prescriber. Keep a symptom diary and bring it to appointments. Report new bleeding, persistent diarrhea, or severe mouth pain promptly. Adherence matters; take your daily dose as instructed and coordinate refills ahead of schedule.

Compare With Alternatives

Other targeted options your clinician may consider include axitinib and sorafenib, depending on your cancer type and prior therapies. Two options we carry are Inlyta and Nexavar. Choice depends on diagnosis, prior response, tolerance, and guideline recommendations. Your oncology team will tailor therapy based on your situation.

Pricing and Access

We source Canadian pricing with US delivery from Canada. Some people look for a Cabometyx coupon; current opportunities, if available, are listed on our Promotions page. You can compare options and see whether manufacturer or foundation support might apply. For budgeting, many patients review cabozantinib price without insurance alongside their oncology plan and pharmacy benefits.

Final costs vary by strength and quantity. We display transparent details at checkout and never substitute strengths without your prescriber’s direction. If you have questions about prior authorization or documentation, our team can coordinate with your clinic.

Availability and Substitutions

Supply can vary by strength. If an item is temporarily unavailable, your prescriber may recommend an alternative labeled option. People wanting to buy cabozantinib online should use a licensed pharmacy and confirm the exact product selected by their clinician. A valid prescription is required and verified before dispensing.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults whose cancer meets labeled criteria and who can follow regular monitoring. It may not suit those with uncontrolled bleeding, recent major surgery, or severe uncontrolled hypertension. If you have liver impairment, your prescriber will determine whether a lower starting dose is appropriate per label guidance.

To manage expenses, consider multi-month fills when clinically appropriate. Set refill reminders and align shipments with clinic visits and scans. If your plan changes, ask your prescriber before ordering more tablets. Discuss assistance options through your care team. Patients often review Cabometyx price by strength; note that pricing can differ between strengths and quantities.

Questions to Ask Your Clinician

Starting dose and plan: What daily dose and schedule are right for me?
Monitoring: Which labs and blood pressure checks do I need and how often?
Diet and timing: How should I plan meals around dosing and avoid grapefruit?
Side-effect plan: What should I do if I have diarrhea, mouth pain, or rash?
Procedures: When should I stop before surgery or dental work, and for how long?
Interactions: Which medicines or supplements should I avoid while on therapy?
Travel: How do I keep dosing consistent across time zones and clinic visits?

Authoritative Sources

For official labeling and company information, review these resources and confirm Cabometyx manufacturer details on the label:

Learn more about this therapy’s role in care in our article What Is Cabometyx, and explore broader treatment strategies in Immunotherapy For Cancer. For background on oncology care, see Cancer as well.

For condition education, you can also read Types Of Cancer.

Ready to proceed? Order from YouDrugstore for express US delivery from Canada with temperature-controlled handling when required. This page is informational and not a substitute for medical advice; always follow your prescriber and the official label.

Express Shipping - from $25.00

Shipping with this method takes 3-5 days

Prices:

Dry-Packed Products $25.00
Cold-Packed Products $35.00

Shipping Countries:

United States (all contiguous states**)
Worldwide (excludes some countries***)

Standard Shipping - $15.00

Shipping with this method takes 5-10 days

Prices:

Dry-Packed Products $15.00
Not available for Cold-Packed products

Shipping Countries:

United States (all contiguous states**)
Worldwide (excludes some countries***)

View All FAQs

How does cabozantinib work in cancer treatment?
Cabozantinib blocks several tyrosine kinases involved in tumor growth and angiogenesis, including MET, VEGFR, and AXL. By inhibiting these pathways, it may reduce blood vessel formation that feeds tumors and slow cancer cell signaling. Your oncology team uses scans, lab tests, and symptom checks to follow response. Because targeting multiple pathways can also affect normal tissues, monitoring is important to manage side effects and adjust therapy if needed.
Do I need to take it with food or avoid certain foods?
Take the tablet on an empty stomach. Wait at least two hours after eating before your dose, and then wait one hour after dosing before eating again. Swallow tablets whole with water. Avoid grapefruit and grapefruit juice, which can raise drug levels. Limit alcohol if your clinician advises, especially if your liver is affected by disease or treatment. If nausea is an issue, ask about supportive options that fit this dosing schedule.
What are common side effects, and which ones are serious?
Common effects include diarrhea, nausea, vomiting, mouth soreness, decreased appetite, fatigue, and hand–foot skin reactions. Blood pressure can rise, so it is often checked regularly. Serious risks include bleeding, blood clots, gastrointestinal perforation or fistulas, severe hypertension, liver problems, and impaired wound healing. Seek urgent care for severe bleeding, chest pain, trouble breathing, severe abdominal pain, or sudden neurological symptoms.
Can I take cabozantinib with my other prescriptions or supplements?
Tell your clinician about all medicines and supplements. Strong CYP3A4 inhibitors (some antifungals or antibiotics) can increase levels, while strong CYP3A4 inducers (certain seizure medicines, rifampin) can decrease levels. Anticoagulants and antiplatelets may raise bleeding risk. Avoid grapefruit products. Never start, stop, or change doses of any medicine without discussing it with your healthcare professional.
What should I do if I miss a dose or vomit after taking it?
If you miss a dose and the next one is due within about 12 hours, skip the missed tablet and take the next dose at the usual time. If more than 12 hours remain, take it when remembered. Do not take two doses at once. If you vomit after a dose, do not take an extra tablet. Keep using your daily schedule and contact your care team if vomiting persists or you cannot keep doses down.
Is it safe around surgeries or dental procedures?
This medicine can increase bleeding risk and may impair wound healing. Your clinician may advise stopping it before and after major surgery or certain dental work, following the product label. Never restart until your prescriber confirms the timing is appropriate. Share your oncology medication list with surgeons and dentists so they can plan the safest schedule around procedures.
How is progress monitored while I’m on treatment?
Your team may schedule imaging scans, blood tests for liver and thyroid function, and regular blood pressure checks. They will also ask about symptoms such as diarrhea, mouth pain, and fatigue. Keep a log of side effects and bring it to visits. Based on results, your prescriber may continue, pause, or adjust treatment to balance benefits and tolerability. Contact your clinic promptly if you notice severe or unexpected symptoms.