Calquence® Capsules for Chronic Lymphocytic Leukemia

Calquence is acalabrutinib, a Bruton tyrosine kinase inhibitor for certain lymphomas and leukemia. Many patients look for Calquence 100 mg without insurance, and our service offers US delivery from Canada to help you access therapy reliably.

What Calquence Is and How It Works

Calquence® is a targeted cancer medicine for adults. It blocks Bruton tyrosine kinase (BTK), a key enzyme that drives abnormal B‑cell signaling. By inhibiting BTK, this treatment can slow the growth and survival of malignant B cells in conditions such as chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and mantle cell lymphoma (MCL). These details reflect current product labeling and established oncology guidance.

The medicine may be used alone or with other treatments your prescriber selects. It is taken by mouth and designed for continuous use until disease progression or unacceptable side effects. Your healthcare professional will monitor blood counts and overall response over time.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Who It’s For

This therapy is indicated for adults with CLL or SLL. It is also used in adults with MCL who have received at least one prior therapy. Your diagnosis, prior treatments, and overall health help determine whether this option fits your plan.

Certain people should avoid or use caution. Those with active severe infections, significant bleeding risks, or uncontrolled heart rhythm issues may require a different approach. People who are pregnant or breastfeeding should not use this medicine. Strong drug interactions can change exposure; your prescriber will assess these factors before starting.

To learn about these conditions, you can review our categories for Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, and Small Lymphocytic Lymphoma.

Dosage and Usage

The standard schedule in labeling is twice daily, taken about 12 hours apart. Take each dose with a glass of water, with or without food. Swallow capsules whole; do not open, break, or chew them.

Acid-reducing medicines can affect absorption. Avoid proton pump inhibitors while on the capsule formulation. If you take an H2-receptor blocker, take this medicine at least two hours after the H2 blocker. If you use antacids, separate by at least two hours before or after. Avoid grapefruit products, Seville oranges, and other strong CYP3A modulators unless your prescriber advises otherwise.

Your clinician may adjust or pause treatment for side effects. Always follow the official label and your care team’s instructions.

Strengths and Forms

Commonly available presentations include oral capsules in 100 mg strength. Some regions also list film‑coated tablets. Availability can vary by country and manufacturer. Your order may be filled with the capsule presentation as supplied to our pharmacy.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember on the same day, then resume your regular schedule. If it is near the time of your next dose, skip the missed one and continue as normal. Do not take extra capsules to make up a missed dose. If you vomit after a dose, do not take an additional dose; continue with the next scheduled dose.

Storage and Travel Basics

Store at room temperature in the original container with the lid tightly closed. Keep away from moisture and out of reach of children and pets. Do not store in a bathroom. When traveling, keep your medicine in carry‑on luggage with your prescription label. Pack enough for the entire trip plus a small buffer. If crossing borders, bring a copy of your prescription and your prescriber’s contact details.

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Benefits

This BTK inhibitor offers targeted action for B‑cell cancers. It can be used as a single agent or combined with other prescribed therapies. Oral dosing allows at‑home administration, which many find convenient compared with clinic‑based infusions. Routine monitoring helps your team track benefit and tolerability over time.

Side Effects and Safety

• Headache and fatigue
• Diarrhea, nausea, abdominal discomfort
• Bruising and minor bleeding
• Muscle or joint pain
• Upper respiratory tract infection
• Low blood counts, including neutropenia or anemia

Serious risks can include major hemorrhage, serious infections, atrial fibrillation or flutter, and second primary cancers, including skin cancers. Report signs of bleeding, fever, chest palpitations, severe rash, or shortness of breath promptly. People taking blood thinners or antiplatelet therapy may have higher bleeding risk. Your prescriber may advise pausing treatment before and after some procedures; follow their instructions.

Drug Interactions and Cautions

Avoid strong CYP3A inhibitors or inducers where possible, such as certain azole antifungals, macrolide antibiotics, rifamycins, and some anticonvulsants. Grapefruit and Seville orange products can raise levels; avoid them. For the capsule formulation, separate antacids by at least two hours, take the dose at least two hours after H2 blockers, and avoid PPIs.

Use caution with anticoagulants and antiplatelet agents due to bleeding risk. People with a history of heart rhythm problems require monitoring. Discuss all medicines, vitamins, and herbal products with your healthcare professional.

What to Expect Over Time

Response is assessed by blood tests, physical examinations, and imaging when indicated. Some people notice gradual improvements in lymph node size and blood counts. Others may need adjustments if side effects develop. Consistent dosing is important for sustained benefit. Your clinician will outline how often you need labs and follow‑ups. For background on leukemia types and care, see our article Leukemia Differences.

Compare With Alternatives

Other approved options for certain CLL and related B‑cell malignancies include BTK inhibitors and PI3K inhibitors. Two prescription alternatives we carry are Imbruvica and Zydelig. In some cases, alkylating agents such as Leukeran may also be considered by a prescriber. Your oncology team will choose based on your history, genetics, and prior response.

Pricing and Access

This branded therapy can be expensive, especially for long‑term use. Our Canadian pharmacy model may offer lower out‑of‑pocket costs compared with some local options. Orders are reviewed by pharmacists and shipped to eligible US addresses. Ships from Canada to US helps many patients maintain continuity when local supply or pricing changes. To see current pricing and options, check the product page and start your order when ready.

Looking for coupons or seasonal offers? Visit our Promotions page for current opportunities. Availability of discounts varies.

For broader oncology selections, explore our Cancer category.

Availability and Substitutions

Supply can vary by region and manufacturer. If this product is temporarily unavailable, your prescriber may recommend an alternative therapy in the same class or a different class. We cannot guarantee future stock dates. Speak with your care team about suitable substitutes if needed.

Patient Suitability and Cost-Saving Tips

Good candidates typically have a confirmed diagnosis of CLL, SLL, or previously treated MCL and can adhere to regular dosing and monitoring. Those with uncontrolled bleeding, severe infections, or significant heart rhythm disorders may require different treatment.

• Discuss multi‑month fills to reduce per‑fill fees
• Align refills with clinic visits for convenient handoffs
• Ask about combination plans that minimize overlapping toxicities
• Share all medicines to avoid costly interaction‑related issues
• Use reminders or pill organizers to support adherence

Questions to Ask Your Clinician

• Is a BTK inhibitor appropriate for my diagnosis and history?
• Should I take this therapy alone or with other treatments?
• How will you monitor my blood counts and heart rhythm?
• Which side effects should I report right away?
• Do any of my medicines or supplements interact with this therapy?
• Should I pause doses before procedures or dental work?
• What is our plan if I cannot tolerate the current schedule?

Authoritative Sources

AstraZeneca Calquence Prescribing Information

FDA DailyMed: Acalabrutinib

Health Canada Drug Product Database: Acalabrutinib

Ready to proceed? You can order with prompt, express shipping and temperature-controlled handling when required, with US shipping from Canada. This information is educational and not a substitute for professional medical advice.