Diacomit® for Adjunct Seizure Control in Dravet Syndrome

What Diacomit® Is and How It Works

Diacomit (stiripentol) is an oral antiseizure medicine used with clobazam, and often valproate, to help control seizures in Dravet syndrome. It is available as capsules and as Biocodex powder for oral suspension. Many families compare Diacomit price and value, especially without insurance, when planning long-term therapy.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and our pharmacists review prescriptions before dispensing. We source authentic brand medications from licensed, vetted international partner pharmacies to offer a broad selection at affordable pricing.

Stiripentol works in two ways. It enhances gamma-aminobutyric acid (GABA) activity in the brain, which stabilizes neuronal firing. It also inhibits certain liver enzymes (CYP2C19, CYP3A4, CYP2D6), which increases levels of clobazam and its active metabolite. The combined effect can reduce seizure frequency and severity when added to a baseline regimen.

Diacomit is taken by mouth with food. It is usually prescribed for children with Dravet syndrome, but some adolescents and adults remain on therapy if benefit persists. Strengths commonly used include Diacomit 250 mg and Diacomit 500 mg; your clinician chooses a dose based on weight and response.

Dosage and Usage

• Start low and increase over 2–3 weeks. Many patients titrate toward a target of about 50 mg/kg/day in 2–3 divided doses.
• Take each dose with meals to improve absorption and reduce stomach upset.
• Capsules: swallow whole with water. Do not break or open.
• Biocodex powder for oral suspension: open the sachet, mix the full contents with a small amount of water, stir, and give immediately. Do not store the mixture for later use.
• Avoid taking with milk, fruit juice, or carbonated beverages. Use water only.
• If you miss a dose, take it when remembered unless it is near the next dose. Do not double doses.
• Because stiripentol increases clobazam exposure, your clinician may lower the clobazam dose to reduce sleepiness or poor coordination.
• Do not start or stop other medicines, herbal products, or caffeine/theophylline-containing products without medical guidance due to interaction risk.

• Store capsules and sachets at 15–30 °C (59–86 °F) in a dry place, away from heat and light.
• Keep in the original packaging to protect from moisture. Do not use damaged sachets.
• Do not pre-mix the powder. Prepare the suspension right before use.
• For travel, carry medicines in hand luggage with your prescription copy. Keep below 30 °C and away from direct sun.
• Do not freeze. Avoid storing in bathrooms or cars where temperatures fluctuate.

Benefits and Savings

When added to clobazam and often valproate, Diacomit can reduce generalized tonic-clonic and clonic seizures in many patients with Dravet syndrome. Some families also report fewer prolonged seizures and improved day-to-day stability. Having both capsules and Biocodex powder for oral suspension helps meet different age and swallowing needs.

Ordering through YouDrugstore gives access to Canadian pricing, with typical savings of 60–80% compared with many US pharmacies. This can lower the Diacomit cost for ongoing therapy, including for those paying without insurance. Multi-month supplies and occasional bulk promotions may reduce the per-month expense.

Diacomit coupon information appears on our promotions page when deals are available.

Side Effects and Safety

• Common effects: sleepiness, decreased appetite, weight loss, nausea, vomiting, abdominal pain, constipation, or diarrhea.
• Neurologic effects: unsteady gait, tremor, dizziness, hypotonia, agitation, or insomnia.
• Mouth changes: dry mouth or metallic taste.
• Laboratory changes: elevated liver enzymes or reduced blood cell counts.
• Infections: increased risk of colds or respiratory infections.

Serious but less common risks include marked sedation, neutropenia or thrombocytopenia, liver injury, and mood or behavior changes including suicidal thoughts (applies to the antiseizure class). Contact a clinician urgently for unusual bleeding, jaundice, persistent vomiting, severe drowsiness, or new/worsening depression. Hypoglycemia is not typical for stiripentol itself, but risk of excessive sedation rises when combined with clobazam; dose adjustments are often needed.

Onset Time

Some patients experience fewer seizures within 1–2 weeks as the dose is introduced. A clearer assessment usually emerges after 3–6 weeks, once titration stabilizes and companion medicines are adjusted. Ongoing monitoring and occasional dose optimization continue over the first few months to balance seizure control with tolerability.

Compare With Alternatives

Clobazam is a cornerstone therapy in Dravet syndrome. Diacomit raises clobazam and norclobazam levels and often improves efficacy, but sedation can increase; clinicians may reduce clobazam to find the right balance.

Valproate remains widely used. Many patients already take it when Diacomit is introduced. Together they may improve control, though liver function and platelet counts require monitoring.

Cannabidiol (Epidiolex) and fenfluramine (Fintepla) are other add-on options supported by clinical trials in Dravet syndrome. Choice depends on seizure pattern, side-effect profile, interactions, and family preference. Some patients use more than one adjunct under specialist care.

Combination Therapy

• With clobazam: often the foundational combination; clobazam dose reductions are common to limit sedation.
• With valproate: monitor liver enzymes and platelets more closely.
• With cannabidiol: watch for liver enzyme elevations, especially if valproate is also used.
• With topiramate or levetiracetam: possible in selected cases; watch for additive side effects.
• Always consider interaction checks due to stiripentol’s CYP inhibition.

Patient Suitability and Cost-Saving Tips

Diacomit is intended as adjunct therapy for patients with Dravet syndrome who continue to have seizures despite baseline treatment. It is prescribed and monitored by clinicians experienced in epilepsy care. People with severe hepatic impairment, a history of significant blood dyscrasias, or known hypersensitivity to stiripentol may not be candidates. Pregnancy and breastfeeding require individualized risk–benefit discussion.

Share a full medication list, including over-the-counter products and caffeine intake, to help manage interactions. Regular blood tests for liver function and blood counts are often scheduled, especially during dose changes or when other medicines are adjusted.

To manage the Diacomit 500 mg or 250 mg expense, consider ordering a multi-month supply when appropriate and use reorder reminders so you do not run short. Families paying out of pocket may see meaningful savings through Canadian pricing and periodic promotions. If you plan a Diacomit bulk purchase, your pharmacist can help align pack sizes with the prescribed dose.

Authoritative Sources

Biocodex Diacomit product information

Health Canada Drug Product Database: Stiripentol

FDA Prescribing Information: Diacomit (stiripentol)

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This material is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions for diagnosis, treatment, and monitoring.