Entocort® Enema for Ulcerative Colitis

This rectal corticosteroid contains budesonide and is used for distal ulcerative colitis. You will find plain guidance on use, safety, and access. We also provide US delivery from Canada so you can plan care and budget confidently. If you pay cash, Entocort® Enema without insurance details here can help you compare options.

What Entocort Is and How It Works

This medicine delivers budesonide directly to the rectum and lower sigmoid colon. It acts on local glucocorticoid receptors to reduce inflammation, bleeding, and urgency. Because budesonide undergoes extensive first‑pass metabolism, systemic exposure is typically lower than with many oral steroids. The formulation focuses activity where symptoms occur in distal disease.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

People with proctitis or proctosigmoiditis may benefit from localized therapy. For broader background on the condition, see our Ulcerative Colitis category.

Who It’s For

This treatment is intended for adults with active mild to moderate distal ulcerative colitis, including rectal and rectosigmoid involvement. It may be considered when topical therapy is appropriate or when aminosalicylate rectal options are not sufficient alone. People with known hypersensitivity to budesonide or formulation components should avoid it. Those with severe infections, untreated fungal or viral disease, or intestinal perforation should not use rectal steroids.

Discuss use with your prescriber if you have liver impairment, glaucoma, cataracts, osteoporosis, diabetes, or a history of tuberculosis. This page focuses on rectal steroid therapy for UC; irritable bowel syndrome is different in cause and treatment. For an overview, read IBS Causes. Explore related therapies in our Gastrointestinal category.

Dosage and Usage

Use the enema exactly as prescribed on your label. Many regimens involve one rectal dose daily, often at bedtime, but follow your clinician’s directions. Wash hands and gather supplies. Shake the bottle if instructed by the manufacturer. Lie on your left side with your right knee bent. Gently insert the applicator tip, then slowly squeeze the bottle to instill the liquid. Withdraw the tip and remain lying for several minutes to help the medicine coat the lower bowel.

Try to retain the enema as long as possible, as directed. If rectal irritation occurs, discuss technique adjustments with your healthcare professional. Do not alter the schedule or stop suddenly without medical advice. If your plan includes an oral agent such as aminosalicylate tablets, use both exactly as prescribed to support remission.

Strengths and Forms

The product is supplied as single‑use rectal enemas. A commonly published presentation contains 2 mg of budesonide per unit, in a ready‑to‑use bottle with an applicator. Availability, packaging, and country‑specific labelling may vary by manufacturer.

Missed Dose and Timing

If you miss a dose, use it when you remember the same day. If it is close to the next scheduled dose, skip the missed one. Do not double the amount to catch up. Try to take the enema at a consistent time to build a routine that supports symptom control.

Storage and Travel Basics

Store at room temperature per the product label. Keep the bottles in the original carton to protect from light and to carry the leaflet with you. Do not freeze. Keep out of reach of children and pets. When traveling, pack the medication in your hand luggage with your prescription and a copy of your prescriber’s instructions. Consider a resealable bag to prevent leaks in transit. Do not use a bottle that is damaged, discolored, or has leaked.

Benefits

Rectal corticosteroid therapy targets the inflamed area, which may help reduce rectal bleeding, urgency, and tenesmus. Local delivery can allow lower systemic exposure compared to many oral steroids. The single‑use bottle simplifies dosing. For some, combining this therapy with an aminosalicylate like Mesalamine may be part of a comprehensive plan set by a clinician.

Side Effects and Safety

• Local effects: rectal discomfort, burning, or irritation
• Gastrointestinal: abdominal pain, bloating, constipation, or diarrhea
• Systemic steroid effects: headache, mood changes, trouble sleeping
• Skin: acne or easy bruising with prolonged use

Serious effects are less common but can include allergic reactions, worsening infection, adrenal suppression, vision changes, or elevated blood sugar. Seek medical attention for severe abdominal pain, persistent rectal bleeding, rash with swelling, or signs of Cushing‑like features. People taking insulin or sulfonylureas may notice changes in glucose control when using steroids; monitor per your care plan. For context on GI symptoms, see Metformin Diarrhea.

Drug Interactions and Cautions

Medicines that inhibit CYP3A4 can raise budesonide levels. Examples include ketoconazole, itraconazole, clarithromycin, some HIV protease inhibitors, and certain azole antifungals. Avoid grapefruit and grapefruit juice unless your prescriber advises otherwise. Use caution with other corticosteroids or strong immunosuppressants. Live vaccines may not be appropriate while using steroid therapy; discuss with your healthcare professional. Tell your provider about all medicines and supplements you take, including over‑the‑counter products and herbal remedies.

What to Expect Over Time

Symptoms such as urgency, bleeding, and rectal discomfort may improve as the inflammation quiets. Some people notice bathroom habits change before pain eases. Keep a simple diary of bowel movements and any bleeding to share with your prescriber. Adherence is important; taking the enema at the same time each day can help. Your clinician may reassess your plan after a defined course to determine ongoing therapy needs.

Compare With Alternatives

Rectal therapies include corticosteroid foam, steroid enemas, and aminosalicylate enemas. Uceris foam uses budesonide in a propellant‑based format that some find easier to retain. Pentasa Enema delivers mesalamine, a non‑steroidal anti‑inflammatory for distal disease. People comparing options may also look to step‑up therapy if symptoms persist despite topical regimens. Some patients explore alternatives when they plan to Buy generic budesonide enema where available.

Pricing and Access

Canadian pharmacy channels can offer predictable pricing for cash‑pay orders, with transparent fees. If you track Budesonide enema price over time, you may see fluctuations driven by supply and package size. Your out‑of‑pocket amount will vary based on brand, quantity, and your prescription details. Looking at Entocort Enema cost alongside generic options can help you plan refills. We provide current information online and support with documentation if your plan reimburses international purchases.

We fulfill to the United States and your order Ships from Canada to US with careful packaging. See seasonal offers on our Promotions page when available. Check the product page for the latest availability and any limits on quantity.

Availability and Substitutions

Supply can vary by manufacturer and lot. If the exact item is unavailable, your prescriber may recommend an alternative steroid enema or a mesalamine product. Your prescription is required and verified before we dispense. When permitted by your clinician and jurisdiction, pharmacy‑level substitution may occur within the same therapeutic class. If you intend to manage orders online, Budesonide enema order online queries can be addressed by our team to ensure you attach the correct documents.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with distal disease who can retain rectal therapy and who need localized steroid action. People with severe infections, uncontrolled diabetes, or significant adrenal suppression may require alternative approaches. To save, consider a multi‑month supply if your prescriber agrees and you tolerate the treatment well. Set calendar reminders before your last few doses to avoid gaps. Discuss Budesonide rectal enema cost with your clinician if switching to a generic is appropriate. Keep a medication list and bring it to appointments.

Questions to Ask Your Clinician

• Treatment goals: what symptom changes indicate progress
• Course length: when to reassess the plan
• Combination therapy: when to add an aminosalicylate
• Technique: tips to improve retention and comfort
• Safety: monitoring for steroid‑related effects
• Interactions: medicines or foods to avoid
• Follow‑up: what to track between visits

Authoritative Sources

• FDA Prescribing Information
• Health Canada Drug Product Database
• Manufacturer Site

Ready to proceed? Order Entocort Enema with express service and US shipping from Canada, with temperature-controlled handling when required. This page is informational and does not replace medical advice; always follow your prescription label and your clinician’s guidance.