Entocort® Rectal Enema for Distal Ulcerative Colitis Relief

What Entocort® Is and How It Works

Entocort is a brand of budesonide, a corticosteroid that reduces intestinal inflammation. Entocort Enema delivers budesonide locally to the rectum and sigmoid colon to treat mild to moderate distal ulcerative colitis and proctosigmoiditis. Many patients compare Entocort Enema price and look for Entocort Enema without insurance options when planning therapy.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. We also work with vetted, licensed international partner pharmacies to supply authentic brand medicines across a broad range of therapies at affordable prices.

Budesonide has strong topical anti‑inflammatory effects with low systemic absorption. This local action helps relieve rectal bleeding, urgency, and stool frequency with fewer whole‑body steroid effects than oral prednisone. Entocort Enema is a rectal liquid used once daily, often at bedtime, for a defined course set by your prescriber.

Dosage and Usage

• Typical adult dosing: one Entocort Enema administered rectally once daily, usually at bedtime, for 4 to 8 weeks or as prescribed.
• Shake the bottle if the product labeling instructs. Warm the enema to near body temperature by holding the bottle in the hands for several minutes.
• Patients should wash hands, then gently remove the protective cap. Lubricate the applicator tip if needed.
• Lie on the left side with the left leg straight and the right knee bent. Gently insert the applicator into the rectum.
• Squeeze the bottle steadily until the prescribed amount is delivered. Withdraw the applicator while still applying slight pressure to avoid suctioning fluid back.
• Remain lying on the left side for at least 30 minutes. Retain the enema as long as possible, ideally through the night.
• If a dose is missed and it is close to the next scheduled dose, skip the missed dose. Do not use two enemas at once.
• Do not stop therapy abruptly without medical guidance if used for a prolonged period, as steroid tapering may be needed.

• Storage: store most budesonide enemas at 20–25 °C (68–77 °F). Brief excursions 15–30 °C (59–86 °F) are usually acceptable. Do not freeze. Protect from light and keep in the carton.
• Travel: keep units upright and in a sealed bag to prevent leaks. Do not leave in a hot car. Pack enough for the full trip plus a few extra doses.
• Handling: check expiration dates before use. Discard leaking or discolored units. Keep out of children’s reach.

Benefits and Savings

Entocort Enema delivers steroid therapy directly to inflamed distal bowel, which can reduce rectal bleeding, urgency, and pain. Local delivery means lower systemic steroid exposure compared with many oral steroids. Many patients achieve symptom improvement within the first week and remission within several weeks when used as prescribed.

Ordering through our Canadian pharmacy can lower Entocort Enema cost by 60–80% versus typical US prices. If you pay Entocort Enema without insurance, multi‑month supplies and bulk promotions can reduce the monthly cost further. You can set quick reorder reminders in your account to avoid treatment gaps.

Looking for a current deal? See our Entocort Enema coupon options on our promotions page.

Side Effects and Safety

• Common: mild rectal discomfort, abdominal cramps, gas, nausea, headache, trouble sleeping, or a metallic taste after administration.
• Local effects: anal irritation, hemorrhoid flare, or small amounts of blood or mucus as inflammation heals.
• Infections: oral or rectal candidiasis (thrush) may occur, especially with prolonged use.
• Systemic steroid effects (less common with rectal use): acne, facial flushing, mood changes, increased appetite, or fluid retention.

Serious effects are uncommon but can include adrenal suppression with prolonged or high‑dose steroid use, elevated eye pressure or cataracts, worsening infections, or significant gastrointestinal bleeding. Patients with diabetes may notice higher blood glucose while on steroids. Tell a clinician about all medicines, especially strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin), which can increase budesonide exposure.

Onset Time

Many patients notice less urgency, reduced rectal bleeding, and fewer bowel movements within 2 to 7 days of starting Entocort Enema. Clinical response continues to build over 2 to 4 weeks as mucosal healing progresses. Full benefit and remission often occur by 4 to 8 weeks, depending on disease severity and adherence to nightly dosing.

Compare With Alternatives

Hydrocortisone enemas are another rectal steroid option. They can be helpful for distal disease but may lead to more systemic steroid exposure than budesonide in some patients. Choice depends on prior response, cost, and tolerability.

Mesalamine (5‑ASA) rectal therapies are non‑steroid anti‑inflammatory options for mild to moderate distal ulcerative colitis. An enema can treat up to the splenic flexure, while suppositories focus on the rectum. Consider Pentasa® Enema for left‑sided disease or Pentasa® Suppositories for proctitis, based on clinician guidance.

Oral 5‑ASA (such as mesalamine tablets) can complement rectal therapy for more extensive inflammation. Some patients rotate between steroid enemas and mesalamine to reduce steroid exposure during maintenance.

Combination Therapy

• Rectal budesonide with oral mesalamine for added anti‑inflammatory benefit in left‑sided disease.
• Rectal budesonide with mesalamine suppositories for prominent rectal symptoms.
• Do not combine multiple rectal steroids routinely; this may increase systemic steroid exposure without added benefit.
• If stepping up to oral steroids or biologics, a prescriber may stop the steroid enema as symptoms improve.

Patient Suitability and Cost-Saving Tips

Entocort Enema is suited for adults with active mild to moderate distal ulcerative colitis or proctosigmoiditis. It targets disease limited to the rectum and sigmoid colon. It is not designed for extensive colitis beyond the reach of an enema. Patients with severe systemic infections, untreated fungal disease, or hypersensitivity to budesonide should not use it.

Use caution in patients with glaucoma, cataracts, osteoporosis, poorly controlled diabetes, peptic ulcer disease, or moderate to severe liver disease. Pregnant or breastfeeding patients should discuss risks and benefits with a clinician. Pediatric use should follow specialist guidance.

To save on therapy, compare brand and any available generic options, consider a 2‑ or 3‑month supply, and set reorder reminders so you do not pay rush fees. Those paying Entocort Enema out of pocket can often lower the per‑month cost with bulk promotions listed on our site.

Authoritative Sources

FDA Prescribing Information: Budesonide Rectal Foam (Uceris)

Summary of Product Characteristics: Budenofalk Rectal Suspension (Budesonide) 2 mg/100 mL

Health Canada Drug Product Database: Budesonide Listings

Order Entocort® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This page provides educational information and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional about your specific situation.