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Gilenya

Gilenya® (fingolimod) Capsules for Relapsing Multiple Sclerosis

Please note: a valid prescription is required for all prescription medication.

Price:

$3,149.99

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What Gilenya Is and How It Works

Gilenya® (fingolimod) is an oral sphingosine 1-phosphate (S1P) receptor modulator. It is used for relapsing forms of multiple sclerosis in adults and in eligible pediatric patients. The usual form is a 0.5 mg capsule taken once daily. Many people compare generics and brand when reviewing gilenya cost without insurance.

Fingolimod traps certain white blood cells in lymph nodes. This lowers the number of lymphocytes circulating in the blood. Immune cells are then less likely to enter the central nervous system and attack myelin. Clinical trials showed reduced relapse rates and fewer new brain lesions on MRI.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Our pharmacists review prescriptions before dispensing, and we ship to the United States. We carry brand and generic medicines at Canadian prices, and we also stock OTC health products. We also work with licensed, vetted partner pharmacies abroad to source authentic brands at fair costs while keeping selection broad.

Dosage and Usage

Follow your prescriber’s instructions and the patient leaflet that comes with the product.

  • Adults: typical dose is 0.5 mg by mouth once daily.
  • Pediatrics: dosing is weight-based (0.25 mg for some under 40 kg; 0.5 mg for many at or above 40 kg).
  • Take at the same time each day, with or without food.
  • Swallow capsules whole. Do not open, crush, or chew.
  • First-dose effect: heart rate can slow after the first dose. Initial monitoring is often required.
  • Baseline checks often include blood tests, an ECG, varicella immunity, and an eye exam.
  • Live vaccines are generally avoided during therapy and for 2 months after stopping.

Missed doses:

  • If one dose is missed, take the next dose as scheduled. Do not double up.
  • A longer interruption may require re-start monitoring. This can occur if the gap is more than 1 day during the first 2 weeks, more than 7 days during Weeks 3–4, or more than 14 days after one month of use.

Stopping therapy:

  • MS disease activity can return and may rebound after stopping fingolimod.
  • Discuss plans to stop or switch disease-modifying therapy with the treating specialist.

Storage and travel:

  • Store at 15–30°C (59–86°F) in a dry place.
  • Keep in the original blister or bottle to protect from moisture.
  • Keep out of reach of children and pets.
  • When traveling, pack in a carry-on bag and bring a copy of the prescription. Avoid heat.

Benefits and Savings

Gilenya® reduces annualized relapse rates and slows the formation of new and enlarging lesions on MRI in relapsing MS. Many people value once-daily dosing and no injections. Regular follow-up and monitoring help manage risks.

Ordering through YouDrugstore is simple. We are a Canadian pharmacy with pharmacist review and caring support during posted office hours. US customers often see 60–80% savings compared with typical US retail pricing. Savings matter for those paying without insurance, and generic fingolimod can further lower costs.

Side Effects and Safety

Not all side effects are listed here. Read the official leaflet and speak with a healthcare professional.

  • Common: headache, flu-like symptoms, cough, diarrhea, back pain, fatigue, dizziness, mild hypertension, and elevated liver enzymes.
  • Eye: macular edema can occur, especially in those with diabetes or uveitis. Report vision changes.
  • Heart: bradycardia and AV conduction delays may occur after the first dose and upon re-start.
  • Infections: increased risk of viral, fungal, and bacterial infections, including herpes zoster.
  • Respiratory: small decreases in lung function have been reported.
  • Liver: significant elevations in hepatic enzymes can occur. Periodic monitoring is often used.
  • Neurologic: rare cases of PML have been reported with MS therapies; seek urgent evaluation for new focal neurologic symptoms.
  • Skin: increased risk of skin cancers has been observed. Skin checks are often recommended.
  • Pregnancy: fingolimod can harm an unborn baby. Effective contraception during treatment and for 2 months after the last dose is recommended.

Onset Time

Lymphocyte counts fall within hours of the first dose. Heart rate slowing peaks around 6 hours after the first dose. Clinical benefits are usually assessed over weeks to months. MRI activity and relapse rates guide long-term evaluation.

Compare With Alternatives

Generic fingolimod contains the same active ingredient as Gilenya® and may offer a lower cost. Patients and clinicians weigh brand preference, availability, and price when choosing between brand and generic. Fingolimod price varies by strength, supply size, and pharmacy.

Other oral disease-modifying therapies include teriflunomide, dimethyl fumarate (and diroximel fumarate), and other S1P modulators such as siponimod, ozanimod, and ponesimod. Each has different monitoring, contraindications, and pregnancy considerations. Switching within or between classes depends on disease activity, tolerability, and risk factors.

Combination Therapy

Fingolimod is generally used alone as a disease-modifying therapy. Combining it with other immunosuppressants can increase infection risk. Supportive treatments may be added for symptoms such as spasticity, fatigue, or bladder issues. Vaccination planning, vitamin D status, and lifestyle measures are often part of comprehensive MS care.

Patient Suitability and Cost-Saving Tips

Fingolimod may not be suitable for people with recent myocardial infarction, unstable angina, stroke, decompensated heart failure, certain heart rhythm or conduction problems, or severe untreated sleep apnea. Risk of serious infections is higher in those with a weakened immune system. Eye disease, liver disease, and uncontrolled hypertension require careful review. Pregnancy must be avoided during treatment and for 2 months after the last dose.

Ways to reduce costs include choosing generic fingolimod when appropriate, selecting a multi-month supply, and using reorder reminders so therapy is not interrupted. See current gilenya coupon offers and bulk options. Some customers compare yearly costs when budgeting for long-term therapy.

To learn more about MS and related factors, read our article Cholesterol And Multiple Sclerosis The Surprising Relationship. Our customer-service chat is available during posted office hours, and our pharmacists can address medication questions.

Authoritative Sources

Review official information before starting therapy. Helpful sources include the manufacturer page, regulatory monographs, and prescribing information.

Ready when you are. YouDrugstore offers caring service, pharmacist-checked prescriptions, and US delivery with prompt, express, cold-chain shipping.

This information is not a substitute for professional medical advice. Always follow guidance from your own healthcare providers. Product packaging and appearance may vary. A valid prescription is required where applicable.

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