Inclunox HP® Prefilled Syringes for VTE Prevention and Treatment

What Inclunox® HP Is and How It Works

Inclunox HP is a brand of enoxaparin, a low molecular weight heparin (LMWH). It helps prevent and treat blood clots in the veins and arteries. Common uses include deep vein thrombosis (DVT) and pulmonary embolism (PE), and support in acute coronary syndromes. Inclunox HP is given as a subcutaneous injection. Many patients look for Inclunox HP without insurance to manage out-of-pocket costs.

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Enoxaparin reduces clotting by enhancing antithrombin’s inhibition of Factor Xa, with minor effects on thrombin (Factor IIa). The result is a predictable anticoagulant effect without routine lab monitoring for most patients. Typical dosing cadences include once daily for prophylaxis and once or twice daily for treatment, guided by indication, kidney function, and weight. Prefilled syringes simplify home administration.

Dosage and Usage

• Typical regimens (general): prophylaxis often uses 40 mg once daily; orthopedic surgery may use 30 mg every 12 hours. Treatment of DVT/PE often uses 1 mg/kg every 12 hours or 1.5 mg/kg once daily. Acute coronary syndromes often use weight-based dosing every 12 hours. Follow your prescriber’s directions.
• Missed dose: if a dose is missed, take it when remembered unless it is close to the next scheduled dose. Do not double doses. Contact your healthcare provider for guidance if multiple doses are missed.
• Preparation: wash hands. Check the syringe label and expiry date. Inspect the solution; do not use if cloudy, discolored, or if particles are present.
• Injection sites: inject into the fatty layer of the abdomen at least 5 cm from the navel. Rotate sites with each dose to reduce bruising.
• Technique: while seated or lying, clean the skin with an alcohol swab and let dry. Pinch a fold of skin. Insert the needle at 90 degrees. Inject slowly. Do not rub the site after removing the needle.
• Air bubble: many prefilled syringes contain a small air bubble; do not expel it unless the product instructions specify otherwise.
• Single-use: discard the used syringe into a puncture-resistant sharps container. Do not reuse needles or syringes.

• Storage: store at 15–25°C (59–77°F). Short excursions between 15–30°C (59–86°F) are generally acceptable. Keep in the original carton to protect from light. Do not freeze.
• Travel: keep syringes in your hand luggage with your prescription. Use a travel-sized sharps container. Do not leave in a hot car. Avoid direct sunlight.
• Handling: do not use if the syringe is damaged or dropped with a compromised cap. Keep away from children and pets.
• Disposal: use a proper sharps container and follow local rules for disposal. Your pharmacy can advise on community programs.

Benefits and Savings

Inclunox HP offers predictable anticoagulation with subcutaneous dosing and no routine INR checks. The prefilled syringes make home use straightforward. It is widely used for prevention after surgery, in medical patients at risk of clots, and for treatment of DVT/PE. Many patients also use it during bridging to oral therapy.

Buying from Canada can reduce costs by 60–80% compared to typical US prices. Inclunox HP without insurance can still be affordable through Canadian pricing and larger-quantity orders. Multi-month supplies and select bulk promotions may lower the per-month cost.

For potential deals, see our Inclunox HP coupon page.

Side Effects and Safety

• Common side effects: injection-site pain, redness, or bruising
• Bleeding from gums or nose
• Easy bruising
• Mild anemia or fatigue
• Low platelet count (thrombocytopenia)
• Nausea or mild stomach discomfort
• Elevated liver enzymes on blood tests

Serious risks include major bleeding, heparin-induced thrombocytopenia (HIT), spinal/epidural hematomas with neuraxial anesthesia or spinal puncture, and rare allergic reactions or skin necrosis. The risk of bleeding increases when used with other anticoagulants, antiplatelets, NSAIDs, or certain supplements. Patients with severe kidney impairment may need adjusted dosing and closer monitoring.

Onset Time

Anti-Xa activity rises quickly after a subcutaneous dose, with peak levels typically in 3–5 hours. Protective anticoagulation begins after the first dose. Symptom improvement for DVT/PE varies, and clinical recovery depends on clot size, location, and comorbidities. Prophylaxis benefits begin with consistent daily dosing throughout the risk period after surgery or during illness.

Compare With Alternatives

Dalteparin (Fragmin) and tinzaparin (Innohep) are other LMWH options. They share a similar mechanism and subcutaneous route, with dosing differences by indication. Choice often depends on labeling, renal function, and clinician preference.

Unfractionated heparin (UFH) is an alternative when rapid reversal or close titration is needed. UFH is usually given in hospital with aPTT monitoring. It is less convenient for home use but can be preferred in severe kidney impairment or when procedures are planned.

Direct oral anticoagulants (DOACs), such as apixaban or rivaroxaban, are oral options for DVT/PE treatment and prevention in selected patients. They avoid injections but can have interaction and renal considerations. Some conditions, like certain types of cancer-associated thrombosis or pregnancy, may still favor LMWH.

Combination Therapy

• Warfarin bridging: LMWH is commonly overlapped with warfarin until the INR is therapeutic.
• Acute coronary syndrome: may be combined with aspirin and a P2Y12 inhibitor as directed by cardiology.
• Mechanical prophylaxis: compression devices can be used alongside pharmacologic prophylaxis in higher-risk patients.
• Drug interactions: combining with other anticoagulants or antiplatelets can increase bleeding; dose adjustments or closer monitoring may be needed.

Patient Suitability and Cost-Saving Tips

Inclunox HP may be considered for adults needing clot prevention after orthopedic or general surgery, for hospitalized medical patients at risk of VTE, for DVT/PE treatment, and for certain heart conditions. It is often used in cancer-associated thrombosis and is commonly chosen during pregnancy when a parenteral anticoagulant is preferred.

It may not be suitable for people with active major bleeding, a history of HIT, known heparin allergy, severe uncontrolled hypertension, recent spinal/epidural procedures, or severe bleeding disorders. Dose adjustments and careful monitoring are often needed in advanced kidney disease, very low or high body weight, frailty, or older age.

To help manage costs, set reorder reminders so you do not run out during a treatment course. Ask your prescriber whether a multi-month supply is appropriate; larger orders can reduce the monthly price. Patients paying Inclunox HP out of pocket often find Canadian pricing more manageable than US retail.

If you pay Inclunox HP without insurance, compare pack sizes on the product page to see how the per-injection price changes with quantity.

Authoritative Sources

Sandoz Canada product information for Inclunox

Health Canada Drug Product Database (DPD)

FDA Prescribing Information for Enoxaparin (Lovenox)

Order Inclunox® HP from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This page is for educational purposes only and does not replace professional medical advice, diagnosis, or treatment. Always speak with a qualified healthcare professional about your health and medications.