Intelence® (etravirine) tablets for HIV-1 treatment

What Intelence Is and How It Works

Intelence® (etravirine) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used with other antiretrovirals to treat HIV-1 in treatment-experienced patients. Many people search for Intelence buy online and Intelence no insurance options to manage ongoing therapy costs. YouDrugstore is a licensed Canadian pharmacy based in Manitoba that meets Canadian pharmacy standards, and prescriptions are reviewed by licensed pharmacists before dispensing. We offer brand and generic medicines at Canadian prices and also carry OTC health products.

Etravirine binds to reverse transcriptase at an allosteric site and reduces viral replication. It is taken by mouth, normally twice a day after a meal. Intelence is often used in regimens for adults and certain pediatric patients who have previously used antiretrovirals and may have resistance. We work with licensed, vetted international partner pharmacies to source authentic brand medicines across a broad selection at competitive prices.

Intelence tablets are available in multiple strengths, allowing flexible dosing across age and weight ranges. The medicine should be combined with other active drugs selected based on resistance testing and treatment history. Do not use it as monotherapy.

Dosage and Usage

Follow the dosing plan set by the prescriber. Adult patients commonly use 200 mg twice daily after a meal. Pediatric dosing depends on weight and tablet strength.

• Administration: Intelence is taken after a meal; not on an empty stomach.
• Swallowing: Tablets may be swallowed whole with water.
• Dispersion: If swallowing is difficult, tablets can be dispersed in water, stirred well, and taken right away, then the glass rinsed several times and the rinses swallowed.
• Consistency: Take doses at the same times each day with food to support steady blood levels.
• Vomiting: If vomiting occurs within 4 hours of a dose, another full dose is generally taken; if after 4 hours, another dose is usually not taken.
• Missed dose: If a dose is missed and it has been less than 6 hours, take the missed dose with food and resume the schedule. If more than 6 hours, skip the missed dose and take the next dose at the usual time.

Drug interactions are common with etravirine. Strong inducers such as rifampin, rifapentine, carbamazepine, phenobarbital, phenytoin, and St. John’s wort may lower levels and are typically avoided. Combining with other NNRTIs is not recommended. Compatibility with boosted protease inhibitors, integrase inhibitors, or entry inhibitors depends on the regimen.

• Storage: Store Intelence at room temperature (about 20–25 °C). Keep the bottle tightly closed and protect from moisture.
• Travel: Keep tablets in the original labeled bottle in your carry-on. Bring enough supply and a copy of the prescription. Use a travel pill organizer for convenience, and carry your dosing times across time zones.

Benefits and Savings

When combined with active background therapy, Intelence helps reduce viral load and increase CD4 cell counts. Twice-daily dosing with food fits many routine meal schedules. Tablets can be dispersed, which can help patients who have difficulty swallowing. At YouDrugstore, many patients see 60–80% savings compared with typical U.S. prices, especially for ongoing monthly refills. If paying without insurance, you can still access Canadian pricing with secure checkout.

As a licensed Canadian pharmacy, we offer online ordering and friendly customer-service chat during posted office hours, and pharmacists can address medication questions.

Side Effects and Safety

Side effects can occur with any antiretroviral. Report serious or unexpected symptoms to a healthcare professional.

• Common: nausea, diarrhea, abdominal pain, headache, fatigue, rash.
• Lab changes: increases in liver enzymes or lipid changes.
• Serious: severe rash or hypersensitivity reactions (including Stevens–Johnson syndrome), liver problems (jaundice, dark urine, severe fatigue), depression, immune reconstitution inflammatory syndrome.
• Allergy: stop treatment and seek urgent care if signs of severe rash, blistering, mouth sores, fever, or facial swelling develop.
• Liver disease: caution is needed in moderate to severe hepatic impairment.
• Pregnancy and breastfeeding: discuss benefits and risks with the prescriber. People living with HIV are advised not to breastfeed due to transmission risk.

This is not a full list. Review the prescribing information and provide all current medicines, supplements, and herbal products to the prescriber and pharmacist.

Onset Time

Antiviral activity begins as soon as therapeutic levels are reached. With a fully active combination regimen and good adherence, reductions in viral load are often seen within 2–4 weeks. CD4 improvements can take longer and vary by patient, baseline viral load, and resistance profile. Regular monitoring with viral load and CD4 testing guides response.

Compare With Alternatives

Regimen choice depends on resistance testing, prior treatment, comorbidities, and drug interactions. Common alternatives or partners include:

Integrase inhibitor–based regimens: Single-tablet therapies such as Biktarvy® (bictegravir/emtricitabine/tenofovir alafenamide) offer once-daily dosing and high barriers to resistance for many treatment-naive patients. These regimens may not suit complex resistance profiles that motivated etravirine use.

NRTI backbone options: Descovy® (emtricitabine/tenofovir alafenamide) is often paired with a third agent. Selection depends on kidney function, bone health, and resistance patterns.

Entry inhibitors: Maraviroc (brand Celsentri®) is an option for CCR5-tropic virus when confirmed by tropism testing. It requires careful interaction review and dose adjustments with concomitant agents.

Intelence is generally reserved for patients with prior NNRTI exposure or resistance where etravirine retains activity. A specialist builds the full regimen around resistance results and tolerability needs.

Combination Therapy

Intelence must be used with other active antiretrovirals. It is often combined with boosted protease inhibitors such as darunavir/ritonavir and a nucleoside backbone. Food is required for each Intelence dose to achieve adequate absorption. Adherence across all components is essential. Skipped doses increase the risk of resistance and virologic failure.

Patient Suitability and Cost-Saving Tips

Intelence suits treatment-experienced patients when resistance testing supports etravirine activity. It may be considered for adults and eligible pediatric patients who can take tablets or dispersed tablets with food. People with significant liver disease or those using strong enzyme inducers may need alternative approaches. For condition context, see our pages on Hiv 1 Infection and, where relevant, co-infections such as Chronic Hepatitis B Virus Infection.

Ways to reduce out-of-pocket costs include multi-month supplies when appropriate, which can lower per-month pricing, and reorder reminders so therapy is uninterrupted. For current promotions and bulk options, see our Intelence coupon page. Many customers choose to buy Intelence without insurance and still benefit from Canadian pricing and service.

Ordering is simple: add Intelence to the cart, upload the prescription, and complete secure checkout. Our team verifies the order and supports prompt, express shipping to your address.

Authoritative Sources

For full prescribing details, consult these resources:

• Janssen Intelence prescribing information
• Health Canada product monograph for Intelence (etravirine)
• FDA label and Medication Guide for Intelence

Ready when you are. YouDrugstore provides caring support, clear pricing, and secure checkout from a licensed Canadian pharmacy, with prescriptions checked by licensed pharmacists before dispensing. We offer prompt, express shipping for all orders and cold-chain shipping for temperature-sensitive medicines.

Disclaimer: This content is for informational purposes and does not replace professional medical advice. Always follow the prescriber’s directions and the official product information. Product availability and pricing can change. We do not ship prescription medicines without a valid prescription.