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Isoptin SR® Tablets for Hypertension and Angina
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This sustained-release verapamil tablet helps lower blood pressure and control certain heart rhythm problems. The guide below explains key uses, safety, and how to use it correctly.
You can compare options for Isoptin SR® 240 mg without insurance with US delivery from Canada.
What Isoptin SR Is and How It Works
YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.
Isoptin SR® contains verapamil, a calcium channel blocker. It reduces calcium entry into heart muscle and blood vessel walls. This relaxes vessels, lowers blood pressure, and eases the heart’s workload. It also slows conduction through the AV node, which helps control certain fast heart rhythms.
The sustained-release design provides steadier levels throughout the day. That can support consistent blood pressure control and reduce angina episodes. Verapamil can also help manage rate control in atrial fibrillation when appropriate.
Some patients receive verapamil SR 240 mg tablets as part of a long-term plan. Your prescriber decides the regimen based on your diagnosis, response, and other medicines.
Who It’s For
This medicine is used for adults with high blood pressure, chronic stable angina, or certain supraventricular arrhythmias. It may be used to help control ventricular rate in atrial fibrillation or atrial flutter as directed by a clinician. It is not for rapid treatment of acute chest pain or emergencies.
People with severe left ventricular dysfunction, dangerously low blood pressure, advanced heart block, sick sinus syndrome without a pacemaker, or cardiogenic shock should not use this therapy. Those with Wolff-Parkinson-White syndrome and atrial fibrillation need special caution. Discuss use if you have liver impairment or heart failure. Tell your prescriber about all medicines and supplements you take.
Dosage and Usage
Follow your prescription exactly. Take sustained-release tablets at the same time each day. Swallow whole with water; do not crush, split, or chew. Taking with food can improve tolerability, but follow label directions if your specific product advises otherwise.
Your prescriber may start with a lower amount and adjust over time. Typical use is once daily for blood pressure. For angina or rhythm control, the plan may differ. Avoid grapefruit and grapefruit juice, which can raise verapamil levels. Alcohol can enhance blood-pressure–lowering effects and dizziness.
If your plan includes verapamil ER 240 mg tablets, keep a daily routine to support steady levels. Check blood pressure and heart rate as instructed. Do not change your dose or schedule without consulting your clinician.
Strengths and Forms
Isoptin SR 240 mg tablets are a common sustained-release presentation. Other formulations may include 120 mg and 180 mg sustained-release tablets. Immediate-release forms of verapamil also exist, but they are used differently and on different schedules. Availability can vary by market and supplier.
Missed Dose and Timing
If you miss a dose, take it when you remember unless it is close to the next scheduled time. If it is close, skip the missed dose and resume your usual routine. Do not double up. Consistent daily timing helps maintain steady effects and lowers the chance of side effects.
Storage and Travel Basics
Store tablets at room temperature, away from excess heat and moisture. Keep them in the original, child-resistant container with the label intact. Do not store in a bathroom or a hot car. For travel, carry your prescription and medicines in your hand luggage. Keep a simple list of your current medicines and prescriber contact details. Use a pill organizer only if it keeps tablets protected and labeled.
Benefits
As a calcium channel blocker, this treatment may lower blood pressure, reduce angina frequency, and improve exercise tolerance. A sustained-release dose can support smoother control with once-daily use in many patients. When used for rate control, it can help stabilize heart rate as guided by your prescriber. Many people appreciate predictable dosing and the option to combine with other antihypertensives when appropriate.
Side Effects and Safety
- Constipation, usually mild
- Dizziness or lightheadedness
- Headache
- Nausea or stomach discomfort
- Flushing
- Swelling in the ankles or feet
Serious effects are less common but can include slow heart rate, heart block, low blood pressure, worsening heart failure, or liver enzyme changes. Gum overgrowth may occur with prolonged use. Seek urgent care for chest pain that does not improve, fainting, shortness of breath, or swelling that rapidly worsens. This medicine can add to the heart-rate–lowering effects of beta blockers and other therapies; your care team monitors for this.
Drug Interactions and Cautions
Verapamil is affected by CYP3A4 inhibitors and inducers. Azole antifungals, macrolide antibiotics, protease inhibitors, and some calcium channel blockers can raise levels. Rifampin and certain anticonvulsants can lower levels. Verapamil can increase concentrations of digoxin and some statins, especially simvastatin. Dose limits often apply when combined with simvastatin. Avoid grapefruit. Alcohol can boost blood-pressure–lowering effects.
Tell your clinician if you use beta blockers, antiarrhythmics, lithium, or neuromuscular blockers. Use caution if you have liver disease, edema, conduction disturbances, or heart failure. Follow the official label and your prescriber’s guidance for any changes.
What to Expect Over Time
With regular dosing, blood pressure control may build progressively. For angina, fewer attacks and better exercise tolerance are common goals. For rhythm control, steadier resting rates may occur when used appropriately. It may take consistent daily use to gauge response. Keep a home blood pressure log and note any symptoms like fatigue or dizziness. Report concerns so your care team can adjust your plan.
Your clinician may specify verapamil 240 mg sustained release if it matches your needs. Do not stop suddenly unless advised, as symptoms can rebound. Keep follow-up appointments to review response, side effects, and any interaction risks.
Compare With Alternatives
Some people use generic Verapamil sustained-release tablets for similar indications. Others may be prescribed Diltiazem, another calcium channel blocker used for blood pressure, angina, or rate control. Your prescriber will help you choose based on your condition, response, and interaction profile.
Pricing and Access
We offer options aligned with Canadian pricing to help manage out-of-pocket costs. You can review current availability and see if manufacturer or pharmacy programs apply. Many patients compare branded and generic options to meet budget and clinical goals. For potential savings, check our Promotions page periodically.
For transparency on brand-specific terms, look for Isoptin SR 240 mg Canadian pricing details on the product page when in stock. Orders are processed through an encrypted checkout, and eligible prescriptions are filled for therapy that Ships from Canada to US.
Availability and Substitutions
Stock can vary. If your exact item is not available, your prescriber may recommend an equivalent sustained-release verapamil or a different class option. In some cases, pharmacies coordinate with your clinician to dispense a therapeutically appropriate alternative.
When listed, Isoptin SR 240 mg tablets from Canada may be supplied by different manufacturers depending on market availability. Packaging and pill markings can differ by source and strength. Always review the label in your package and contact us if anything looks unexpected.
Patient Suitability and Cost-Saving Tips
Good candidates often include adults with hypertension, chronic stable angina, or certain supraventricular arrhythmias who can take a calcium channel blocker safely. Those with advanced conduction disease, severe hypotension, or decompensated heart failure may not be suitable. People with significant liver disease require careful supervision.
To save on therapy, ask your prescriber whether a multi-month fill is appropriate. A 60- or 90-day supply can reduce per-fill fees and help maintain continuity. Set refill reminders so you do not miss doses. Consider a generic sustained-release verapamil if it fits your plan. Use one pharmacy to simplify interaction checks and counseling.
Questions to Ask Your Clinician
- Primary goal: blood pressure control, angina relief, or rate control?
- Expected schedule: once daily or a different plan?
- Any restrictions on food, alcohol, or grapefruit products?
- Which symptoms should trigger a call or urgent care?
- How will other heart medicines affect my regimen?
- What monitoring is needed for heart rate and blood pressure?
Authoritative Sources
FDA DailyMed: Verapamil ERHealth Canada Drug Product DatabaseFDA Prescribing Information Archive
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Can I take this medicine with a beta blocker?
Caution is needed when combining verapamil with beta blockers such as metoprolol or atenolol. Both slow heart rate and AV nodal conduction, which can increase the risk of bradycardia, heart block, and low blood pressure. In some cases, clinicians intentionally use both under close supervision. Never start, stop, or adjust either medicine without guidance. Your care team may adjust doses, monitor your pulse and blood pressure, and review symptoms like dizziness or fatigue.
What are the most common side effects of verapamil SR?
Common effects include constipation, dizziness, headache, flushing, and ankle swelling. These are often mild and may improve with time. Taking the tablet with food and staying hydrated can help with stomach discomfort and constipation. More serious reactions, such as slow heart rate, low blood pressure, or worsening heart failure, require medical attention. Contact a healthcare professional if side effects persist or interfere with daily activities.
Can I drink grapefruit juice while taking verapamil?
Avoid grapefruit and grapefruit juice. They can inhibit CYP3A4 and increase verapamil levels, which may raise the risk of side effects such as dizziness, low blood pressure, or slow heart rate. Other citrus fruits typically do not have the same effect, but ask your clinician if unsure. Read your medication guide for any additional food or drink restrictions specific to your product.
Is it safe to split or crush sustained-release verapamil tablets?
Do not crush, chew, or split sustained-release tablets. Altering the dosage form can release the medicine too quickly, increasing side effects and reducing intended long-acting benefits. If you have trouble swallowing, ask your prescriber or pharmacist about alternative strengths or formulations designed for easier administration. Immediate-release versions might be considered when clinically appropriate.
How long before I notice blood pressure changes?
Response varies. Some people observe early improvements after consistent daily use, while others need a longer period and possible dose adjustments. It’s important to take the tablet at the same time each day and keep a home blood pressure log. Share readings with your clinician at follow-up visits so your plan can be refined as needed. Do not change your dose without professional guidance.
What should I do if I feel dizzy on this treatment?
Sit or lie down until the feeling passes, and rise slowly. Check your blood pressure if you can. Dizziness can reflect low blood pressure, dehydration, or interactions with other medicines. Limit alcohol and stay hydrated. If episodes are frequent, severe, or accompanied by fainting, contact your healthcare professional. They may adjust your regimen or review interacting therapies.
Can I switch from brand to generic verapamil ER?
Many patients can use a generic extended-release verapamil when appropriate. However, release mechanisms and excipients may vary between products. Your clinician will decide whether a switch is suitable based on your condition, response, and any side effects. If a change is made, monitor your blood pressure and heart rate closely during the transition and report concerns for timely review.


