Janumet® Tablets for Type 2 Diabetes

Janumet® is a prescription tablet for adults with type 2 diabetes. It combines sitagliptin and metformin to help improve blood sugar control. This page explains approved uses, safety, strengths, and how to get it through our pharmacy.

What Janumet Is and How It Works

This combination helps your body release more insulin after meals and reduces glucose made by the liver. You can order with US delivery from Canada, using your valid prescription. If you pay without insurance, you may still see competitive Canadian pricing. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Sitagliptin is a DPP-4 inhibitor. It increases incretin hormones, which support glucose-dependent insulin release and lower glucagon. Metformin is a biguanide. It decreases hepatic glucose output, lowers intestinal absorption of glucose, and improves insulin sensitivity in peripheral tissues. Together, the two classes work in complementary ways to help manage blood sugar alongside diet and activity. For background on metformin’s role in care, see Metformin Role.

Who It’s For

This medicine is indicated for adults with Type 2 Diabetes as an adjunct to diet and exercise. It is not for type 1 diabetes or for treating diabetic ketoacidosis. People with significant kidney disease, metabolic acidosis, or known hypersensitivity to any component should not use it. Those with liver disease, a history of pancreatitis, alcohol misuse, or dehydration require careful evaluation by a clinician. If you need individualized advice, your healthcare professional should guide decisions using the official label.

Dosage and Usage

Follow your prescriber’s directions and the product label. Tablets are typically taken with meals to improve tolerance. Immediate-release combinations are often taken twice daily, while extended-release versions are usually taken once daily with the evening meal. Swallow tablets whole with water. Do not split or crush the extended-release formulation.

If your prescriber selected a tablet that matches Sitagliptin Metformin 50 1000, take it exactly as directed. Your regimen may be adjusted based on prior therapy, kidney function, and glycemic goals. Do not change your dose without medical guidance.

General administration tips: take consistently at the same times each day, maintain regular meal patterns, stay hydrated, and keep a log of glucose readings to discuss at follow-up visits. If your prescriber adds insulin or a sulfonylurea, ask about hypoglycemia precautions.

Strengths and Forms

This treatment is available as immediate-release and extended-release tablets. Availability may vary by market and supplier.

• Immediate-release tablets: commonly supplied as Janumet 50 500 and 50/1000 mg strengths.
• Extended-release tablets: commonly supplied as 50/500 mg and 50/1000 mg ER tablets.

Packaging, imprint, and exact presentations may differ by manufacturer and country of origin. Your prescription label and the patient information sheet will list the exact strength that you receive.

Missed Dose and Timing

If you miss a dose, take it as soon as you remember unless it is close to your next scheduled dose. If it is nearly time for the next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once. Keeping a daily reminder or phone alert can help you stay on track.

Storage and Travel Basics

Store tablets at room temperature in a dry place, away from excess heat and moisture. Keep the medicine in the original, child-resistant container with the pharmacy label intact. Do not store in the bathroom. For travel, pack it in your carry-on, bring a copy of your prescription, and carry a medication list for security checks. Keep tablets away from direct sunlight and do not leave them in a parked car. If you use a weekly pill organizer, refill it carefully and keep the bottle for reference.

Benefits

This combination offers two mechanisms in one tablet, which may reduce pill burden compared with taking the components separately. Taking it with meals can improve gastrointestinal tolerance for many people. An extended-release option may offer once-daily convenience for those who need a simpler routine. When paired with diet, activity, and regular monitoring, the therapy can support steady day-to-day glucose management.

Side Effects and Safety

• Digestive effects: diarrhea, nausea, stomach upset, gas, or abdominal discomfort
• Headache or mild dizziness
• Upper respiratory symptoms such as stuffy or runny nose
• Changes in taste or decreased appetite

Serious effects are uncommon but can occur. Metformin carries a rare risk of lactic acidosis, which is more likely with significant kidney disease, dehydration, sepsis, or hypoxemia. Pancreatitis has been reported with DPP-4 inhibitors; seek care for severe, persistent abdominal pain. Hypoglycemia can occur if used with insulin or a sulfonylurea. Allergic reactions, including rash or swelling of the face or throat, need urgent evaluation. Long-term metformin use may be associated with vitamin B12 reduction; your clinician may monitor levels.

Drug Interactions and Cautions

Tell your healthcare professional about all medicines and supplements you use. Using this treatment with insulin or sulfonylureas may raise the risk of low blood sugar. Iodinated contrast procedures require temporary metformin interruption per label guidance. Excess alcohol increases lactic acidosis risk. Certain cationic drugs, diuretics, and carbonic anhydrase inhibitors may alter metformin handling. Report any kidney or liver issues, recent surgery, acute illness, or dehydration. Review sick-day rules and peri-procedure plans with your prescriber.

What to Expect Over Time

Many people notice steadier daily glucose readings with consistent use, meals, and monitoring. A1C changes are typically assessed over several months during routine follow-up. If your readings are not where you expect, your clinician may adjust diet, activity, or add-on therapies. Keeping a log of home glucose checks and symptoms will help your care team evaluate progress. Do not stop therapy without discussing a plan.

Compare With Alternatives

Consider single-agent sitagliptin if your prescriber wants to separate components; see Januvia. Another option is a linagliptin plus metformin combination; see Jentadueto. Your prescriber will match therapy to your clinical profile, prior treatments, and goals.

Pricing and Access

Check our site for current Janumet price and availability. We offer transparent Canadian options for approved prescriptions, with ordering that Ships from Canada to US. For general savings updates, visit Promotions. We use encrypted checkout, and a prescription is required and verified.

Want to compare options? Review Janumet Canadian pricing on the product page and discuss total costs with your prescriber or insurer. You can also explore multi-month fills to reduce per-fill fees. Our team can help with documentation needed for your plan’s reimbursement process.

Availability and Substitutions

Availability can vary by strength and manufacturer. If a requested strength is temporarily unavailable, your prescriber may recommend a therapeutically appropriate alternative or a different release form. Any change should be reviewed against your medical history and lab values.

Patient Suitability and Cost-Saving Tips

You may be a candidate if you have type 2 diabetes and need additional control beyond diet and exercise. People with advanced kidney disease, acute metabolic acidosis, or known allergies to components should not use this medicine. If you have liver disease, pancreatitis history, heavy alcohol use, or are planning imaging with iodinated contrast, discuss risks in advance. Those who are pregnant or breastfeeding should review options with a clinician.

Cost tips: consider a 90-day supply when appropriate, set refill reminders, and keep a consistent pharmacy to avoid gaps. Compare formulary tiers and ask about manufacturer information if applicable. If you pay cash, ask your prescriber to align strength and quantity with your budget. Discuss whether a generic component or a different class could meet your goals. Some patients evaluate the Janumet cash price against separate agents to decide on the best approach with their clinician.

To browse related supplies for glucose monitoring and care, visit Diabetes Care. For GI tolerance strategies, see Metformin Diarrhea for patient-friendly education.

Questions to Ask Your Clinician

• Starting plan: how this therapy fits with my diet and activity
• Monitoring: when to check glucose and A1C
• Safety: what symptoms mean I should call
• Procedures: what to do before contrast imaging
• Combination therapy: risks if adding insulin or sulfonylureas
• Follow-up: when to reassess goals and labs

Authoritative Sources

• Manufacturer Prescribing Information
• FDA DailyMed
• Health Canada Drug Product Database

Ready when you are. Place your order with prompt US shipping from Canada, and we use temperature-controlled handling when required. This information is not a substitute for medical advice; always follow your prescriber and the official label.