Lancora® (ivabradine) Tablets for Chronic Heart Failure

What Lancora® Is and How It Works

Lancora® contains ivabradine, a heart rate–lowering medicine for patients with chronic heart failure in sinus rhythm. It helps reduce hospitalizations when resting heart rate stays elevated despite standard therapy. You can order from YouDrugstore, a licensed Canadian pharmacy in Manitoba that meets Canadian pharmacy standards. Prescriptions are reviewed by licensed pharmacists before dispensing, and customer-service chat is available during posted office hours. Many patients ask about Lancora without insurance; our team can discuss options and pricing before you place an order. We also partner with licensed, vetted international pharmacies to provide authentic brands at fair prices and a wide selection.

Ivabradine is a selective inhibitor of the cardiac pacemaker If current (HCN channels). It slows the sinus node and lowers heart rate without reducing heart muscle contractility. Lancora® is supplied as oral tablets, typically taken twice daily with food. It is used in adults with symptomatic chronic heart failure with reduced ejection fraction who are in normal sinus rhythm and have a resting heart rate above target. It may be used when beta-blockers are not tolerated or when heart rate remains high despite beta-blocker therapy.

Ivabradine is metabolized by CYP3A4. Strong CYP3A4 inhibitors or inducers can change drug levels. Avoid grapefruit products. Ivabradine is not recommended in pregnancy or during breastfeeding. A clinician determines suitability and dosing based on resting heart rate, rhythm, comorbidities, and other medications.

Dosage and Usage

The prescriber sets the dose based on heart rate response and tolerability.

• Typical initiation: 5 mg twice daily with meals.
• After about 2 weeks, adjust to maintain resting heart rate between 50–60 bpm.
• If heart rate remains above 60 bpm and tolerated, increase to 7.5 mg twice daily.
• If heart rate drops below 50 bpm or bradycardia symptoms occur, reduce to 2.5 mg twice daily or pause therapy.
• Elderly patients or those sensitive to bradycardia may start at 2.5 mg twice daily.
• Swallow tablets whole with water and take doses at consistent times.

• Missed dose: take the next scheduled dose at the usual time. Do not double a dose.
• Do not use if resting heart rate is low at baseline, in certain conduction disorders without a pacemaker, or in acute decompensated heart failure.

• Storage: keep at room temperature, 15–30°C (59–86°F), in the original blister to protect from moisture and light.
• Travel: carry tablets in original packaging with your prescription label. Keep in your hand luggage. Avoid extreme heat or freezing.
• Set a reminder to support regular twice-daily dosing while traveling.

Benefits and Savings

Ivabradine lowers the sinus rate and reduces the workload on the heart at rest and during light activity. In chronic heart failure with reduced ejection fraction, this helps lower the risk of hospital admission for worsening symptoms. Lancora® does not directly lower blood pressure, which can be helpful when blood pressure limits beta-blocker titration.

Tablets are small and taken twice daily with food. Many patients appreciate that heart rate control is achieved without negative inotropy. When you order from YouDrugstore, you can access Canadian pricing and US shipping. Typical savings are 60–80% compared to usual US retail prices, even when paying without insurance.

Side Effects and Safety

Most people tolerate ivabradine, but side effects can occur. Seek medical care for serious symptoms.

• Common: slow heart rate (bradycardia), temporary visual brightness or halos (phosphenes), blurred vision, dizziness, fatigue, headache.
• Less common: high or low blood pressure, atrial fibrillation, ventricular extrasystoles, palpitations.
• Serious: symptomatic bradycardia, syncope, heart block, new or worsening atrial fibrillation, severe hypotension.
• Allergy: rash, itching, swelling, or breathing difficulty may indicate hypersensitivity.
• Drug interactions: avoid strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, HIV protease inhibitors) and inducers (e.g., rifampin, phenytoin, St. John’s wort). Avoid moderate inhibitors that also slow heart rate, such as verapamil or diltiazem.
• Other warnings: avoid grapefruit. Use caution when driving at night due to visual effects.
• Not recommended in pregnancy or breastfeeding; discuss contraception during treatment.

Onset Time

Heart rate reduction begins within hours of the first dose. Steady-state effects occur after several days of twice-daily dosing. Clinical benefits on hospitalization risk accrue over weeks to months as heart rate remains in the target range and other heart failure therapies are optimized.

Compare With Alternatives

Beta-blockers (such as carvedilol, metoprolol succinate, or bisoprolol) remain foundational in heart failure therapy and lower heart rate while improving survival. Some patients cannot reach target beta-blocker doses due to low blood pressure or side effects. Ivabradine can be added when sinus rhythm and elevated resting heart rate persist.

Renin-angiotensin system agents treat heart failure by neurohormonal blockade. An ACE inhibitor like Enalapril improves outcomes and is often part of baseline therapy. An ARNI such as Oneptus® (sacubitril/valsartan) may replace an ACE inhibitor in eligible patients to further reduce risk.

Ivabradine is not a replacement for diuretics, ACE inhibitors/ARNIs, or beta-blockers. It is an add-on focused on heart rate control in sinus rhythm. For hypertension outside heart failure, other agents such as ARBs or combination products are used; ivabradine is not indicated for blood pressure control.

Combination Therapy

Ivabradine is commonly used with guideline-directed heart failure treatments. These include beta-blockers, ACE inhibitors or ARNIs, mineralocorticoid receptor antagonists, SGLT2 inhibitors, and diuretics. Do not combine ivabradine with verapamil or diltiazem due to overlapping heart rate effects and CYP3A4 interaction. Monitor heart rate and rhythm after dose changes or when other cardiac medicines are added.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with symptomatic heart failure with reduced ejection fraction who are in sinus rhythm and have a resting heart rate above target despite optimized therapy. It is not for patients with atrial fibrillation as their dominant rhythm, pacemaker dependence, acute decompensation, or severe liver disease.

Discuss all medications and supplements with a clinician to screen for interactions. Avoid grapefruit juice. Report any new dizziness, fainting, or visual disturbances. Learn more about interactions in our article Drug Interactions The Top Interactions That Should Be On Your Radar. For background on beta-blockers and heart health, see How Bystolic Works To Manage Hypertension And Heart Health.

To reduce costs, consider a larger supply when appropriate, as multi-month packs can lower the per-month price. Turn on reorder reminders so you never run out. For deals, see our Lancora coupon and bulk options. If you pay without insurance, our team can help compare pack sizes to fit a budget. Explore more on Heart Failure care and treatments we offer.

Authoritative Sources

See the Lancora (ivabradine) product information from Servier Canada, the Health Canada Drug Product Database entry for ivabradine, and the FDA Prescribing Information for ivabradine (Corlanor) for detailed prescribing guidance.

YouDrugstore offers caring support, fair Canadian pricing, and US delivery. Our pharmacists review every prescription and can answer medication questions. Order today and choose prompt, express, cold-chain shipping as needed.

This content is educational and not a substitute for professional advice. Use medicines only as prescribed by your clinician. Always read the patient leaflet that comes with your medication.