Lixiana® (edoxaban) Tablets for Stroke Prevention and DVT/PE Treatment

What Lixiana® Is and How It Works

Lixiana® (edoxaban) is an oral anticoagulant used to reduce blood clot risk. It is approved to prevent stroke and systemic embolism in nonvalvular atrial fibrillation, and to treat deep vein thrombosis (DVT) and pulmonary embolism (PE) and prevent recurrence. Many shoppers compare Lixiana price across strengths, including Lixiana 60 mg and Lixiana 30 mg, and ask about ordering Lixiana without insurance. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and prescriptions are reviewed by licensed pharmacists before dispensing.

We source authentic brands through licensed, vetted partner pharmacies worldwide, offering a broad selection and competitive pricing. Lixiana works by selectively inhibiting Factor Xa, a key enzyme in clot formation. By lowering thrombin generation, it decreases the chance of harmful clots while maintaining predictable anticoagulation. Lixiana tab is taken once daily, with or without food.

Typical dosing is 60 mg once daily. Some people receive 30 mg once daily based on kidney function, body weight, or interacting medicines. For DVT or PE, edoxaban usually follows 5–10 days of initial treatment with a parenteral anticoagulant. In some regions, labeling for atrial fibrillation advises against use when creatinine clearance is very high due to reduced efficacy; clinicians consider local guidance. Lixiana is the same active ingredient as Savaysa (US brand). In several countries, Lixiana menarini appears in co-marketing references.

Dosage and Usage

• Nonvalvular atrial fibrillation: 60 mg by mouth once daily. Some patients receive 30 mg once daily when creatinine clearance is 15–50 mL/min, body weight is 60 kg or less, or when certain P-gp inhibitors are used.
• DVT/PE treatment and prevention of recurrence: After 5–10 days of heparin or low-molecular-weight heparin, start edoxaban. Usual dose is 60 mg once daily. Use 30 mg once daily if body weight is 60 kg or less, creatinine clearance is 15–50 mL/min, or with specified P-gp inhibitors. This covers Lixiana edoxaban 60 mg and Lixiana edoxaban 30 mg regimens.
• Administration: Swallow tablets whole with water. May take with or without food, at the same time each day. If needed, the tablet may be crushed and mixed with water or soft food per product instructions.
• Missed dose: Take as soon as remembered on the same day, then resume the next dose at the usual time. Do not take two doses on the same day.
• Procedures: For spinal/epidural procedures or planned surgery, clinicians provide individualized stop/restart timing to reduce bleeding risk.
• Switching: When switching from warfarin, prescribers typically start edoxaban when INR is at or below a specified threshold. When switching to parenteral anticoagulants, overlap is guidance-based.

• Storage: Store at 15–30 °C (59–86 °F). Keep tablets dry in the original container or blister until use.
• Travel: Pack enough medication for the trip and a few extra days. Keep in carry-on luggage and avoid heat or moisture.
• Handling: Do not use tablets that are damaged or have changed appearance.
• Household safety: Keep out of reach of children and pets.

Benefits and Savings

Lixiana delivers predictable anticoagulation with once-daily dosing. It does not require routine INR checks like warfarin, which simplifies follow-up for many patients. In trials, edoxaban was noninferior to warfarin for stroke prevention in nonvalvular atrial fibrillation and effective for treating and preventing recurrent DVT/PE.

Ordering from Canada can reduce costs. Many customers report 60–80% savings versus typical US prices. If paying cash, Lixiana without insurance may still be affordable at Canadian pricing. Compare Lixiana 60 mg price and Lixiana 30 mg price across available pack sizes to plan your monthly budget.

For current promotions, see our Lixiana coupon page.

Side Effects and Safety

• Easy bruising or minor bleeding (e.g., nosebleeds, gum bleeding)
• Heavier or prolonged bleeding from cuts
• Gastrointestinal symptoms such as nausea or indigestion
• Fatigue, dizziness, or headache
• Anemia signs in some patients

Serious bleeding can occur, including gastrointestinal or intracranial hemorrhage. Spinal/epidural hematomas have been reported after neuraxial anesthesia or spinal puncture, especially with indwelling catheters or concomitant medications that affect hemostasis. The overall risk of bleeding increases with age, renal impairment, low body weight, and concurrent use of antiplatelets, NSAIDs, SSRIs/SNRIs, or strong P-gp modulators. Do not stop anticoagulation abruptly without medical guidance, as clot risk may rise. Edoxaban is not recommended in mechanical heart valves or significant mitral stenosis and is generally avoided in severe hepatic disease with coagulopathy. Use in pregnancy or while breastfeeding requires clinician assessment.

Onset Time

Edoxaban is absorbed quickly, with peak levels about 1–2 hours after a dose. Anticoagulant activity begins the same day and reaches steady state within roughly three days of once-daily use. Symptom relief for DVT/PE varies; swelling and discomfort may improve over days to weeks as treatment continues. Stroke prevention benefits in atrial fibrillation are preventive and ongoing with consistent therapy.

Compare With Alternatives

Rivaroxaban is another once-daily Factor Xa inhibitor. It can be started immediately for VTE at higher initial doses, whereas Lixiana typically follows 5–10 days of parenteral therapy. Some patients and prescribers prefer the simplicity of Xarelto® loading for VTE; others value edoxaban’s dose-reduction criteria based on renal function and weight.

Low-molecular-weight heparins such as Lovenox® Injections remain important for initial DVT/PE management, perioperative bridging, and certain high-risk situations (e.g., active cancer). They are injectable, which can affect convenience compared with oral edoxaban.

Warfarin is effective and low-cost per tablet, but requires frequent INR monitoring, dietary consistency, and has many drug interactions. Lixiana offers a stable, fixed dose without routine lab monitoring, which many find more convenient.

Combination Therapy

• After stent placement, clinicians may use short-term combinations with a single antiplatelet. Duration and selection balance bleeding and thrombotic risks.
• Rate- or rhythm-control drugs for atrial fibrillation (e.g., beta blockers, calcium-channel blockers, antiarrhythmics) are often co-prescribed. Some P-gp inhibitors may require the 30 mg edoxaban dose.
• Proton pump inhibitors may be considered in patients with a history of gastrointestinal bleeding.
• Temporary parenteral anticoagulants (e.g., LMWH) may be used before procedures, with individualized timing and restart plans.

Patient Suitability and Cost-Saving Tips

Candidates include adults with nonvalvular atrial fibrillation needing stroke prevention, and those treated for DVT or PE after initial parenteral anticoagulation. Lixiana is generally not used in mechanical heart valves or moderate-to-severe mitral stenosis. Caution or dose adjustment may be needed with renal impairment (creatinine clearance 15–50 mL/min), low body weight (≤60 kg), or certain P-gp inhibitors. Severe hepatic disease with coagulopathy is a contraindication. Clinicians assess bleeding risk, prior stroke, kidney and liver function, and potential interactions.

To manage medication expenses, compare Lixiana cost across strengths and pack sizes. Multi-month supplies can lower the per-month total, and reorder reminders help you avoid urgent local purchases. If paying out of pocket, Canadian pricing may reduce Lixiana cash price and Lixiana out of pocket costs compared with typical U.S. pharmacy quotes. Some patients also ask about Lixiana no insurance options; we process prescriptions the same way and display transparent pricing.

Authoritative Sources

Health Canada Drug Product Database: Lixiana (edoxaban) listing

FDA Prescribing Information: Savaysa (edoxaban)

Manufacturer information: Edoxaban (Lixiana)

Order Lixiana® from YouDrugstore.com: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This material is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.