Nexavar® (sorafenib) 200 mg Tablets for Liver, Kidney, and Thyroid Cancer

What Nexavar® Is and How It Works

Nexavar® (sorafenib) is an oral targeted therapy used for certain cancers. It is approved for advanced hepatocellular carcinoma, advanced renal cell carcinoma, and some differentiated thyroid cancers. Tablets are 200 mg and are taken twice daily for most uses. People often compare Nexavar price across pharmacies, especially when considering Nexavar without insurance. YouDrugstore is a licensed Canadian pharmacy based in Manitoba, and prescriptions are reviewed by licensed pharmacists before dispensing. We offer brand and generic medicines at Canadian prices and also carry OTC health products.

Sorafenib is a multikinase inhibitor. It blocks tumor cell signaling and reduces tumor blood vessel growth. This dual action can slow cancer growth and help control disease. Our team sources medications through licensed, vetted international partner pharmacies, so patients receive authentic brands with broad selection and fair pricing.

Dosage and Usage

Follow the prescriber’s instructions and the product monograph. General guidance:

• Usual starting dose: 400 mg twice daily (two 200 mg tablets, morning and evening).
• Swallow tablets with water on an empty stomach. Take 1 hour before or 2 hours after food.
• Do not crush or split tablets.
• If a dose is missed and the next dose is soon, skip the missed dose. Do not double up.
• Dose reductions or temporary holds may be needed for side effects.
• Avoid strong CYP3A4 inducers (for example, rifampin, St. John’s wort). These can lower sorafenib levels.
• Report bleeding, severe chest pain, or sudden shortness of breath right away.

Storage and travel tips:

• Store at 20–25°C (68–77°F). Short excursions 15–30°C are acceptable.
• Keep tablets dry in the original container with the desiccant.
• Store out of reach of children and pets.
• When you travel, keep tablets in your carry-on and in the labeled bottle.
• Do not store in a bathroom or near sinks.

Benefits and Savings

Nexavar® can help slow tumor growth and may shrink some tumors. It works by blocking signals that drive cell division and by limiting new blood vessels that feed tumors. The oral schedule offers convenience compared with infusion therapy, and dosing can be adjusted for tolerability.

Buying through a Canadian pharmacy can reduce costs. Many patients save 60–80% compared with typical US prices. This can be helpful for those paying without insurance. YouDrugstore offers friendly customer-service chat during posted office hours and can discuss ordering and delivery steps.

Side Effects and Safety

Not all patients experience side effects, and many are manageable. Serious effects can occur. Seek emergency care for severe symptoms.

• Common: diarrhea, fatigue, nausea, appetite loss, weight loss, rash, hair thinning, dry skin, hand–foot skin reaction, hypertension.
• Other: mouth sores, abdominal pain, itching, headache, hoarseness, joint pain.
• Serious: severe bleeding, heart ischemia or chest pain, QT prolongation or arrhythmia, liver injury, GI perforation, wound healing problems, reversible posterior leukoencephalopathy syndrome, severe skin reactions.
• Drug interactions: strong CYP3A4 inducers can reduce exposure; anticoagulants can increase bleeding risk; discuss all medicines and supplements with the care team.
• Special populations: not recommended in pregnancy; effective contraception is advised during treatment and after. Breastfeeding is not recommended.

Clinicians monitor blood pressure, skin, liver enzymes, electrolytes, and thyroid function as indicated. Dose changes or treatment holds may be used to manage toxicity.

Onset Time

Response timelines vary by cancer type and individual factors. Some patients show disease stabilization or early response within 4–8 weeks. Imaging is often repeated every 6–12 weeks to assess benefit. Symptom improvement can lag behind imaging results. The prescriber will decide when to continue, adjust, or change therapy based on clinical response and tolerability.

Compare With Alternatives

Other oral multikinase inhibitors used in similar or adjacent settings include regorafenib and lenvatinib. Each drug targets a different mix of kinases, and side effect profiles vary. Choice depends on cancer type, prior therapy, tolerance, and guidelines.

Immunotherapy may be an option for some cancers. For example, Bavencio® (avelumab) is used in select urothelial and skin cancers, while hormonal agents like Zytiga® (abiraterone) are used for prostate cancer. These are not direct substitutes for sorafenib, but they illustrate how treatment choices differ across tumor types.

For acute myeloid leukemia with FLT3 mutation, targeted therapy such as gilteritinib is used; see Xospata® for that indication. Selecting therapy is a clinical decision that considers tumor biology, comorbidities, and patient goals.

Combination Therapy

Nexavar® is commonly used as monotherapy. In liver cancer, it may be given after or around locoregional treatments such as transarterial chemoembolization, based on local practice. In thyroid cancer, it is generally for disease refractory to radioactive iodine. Combinations with other systemic agents are under study, but overlapping toxicities and bleeding risk limit some pairings. The oncology team will define the sequence and any combinations.

Patient Suitability and Cost-Saving Tips

Nexavar® may suit adults with advanced hepatocellular carcinoma, renal cell carcinoma after prior therapy, or refractory differentiated thyroid cancer. It is not appropriate in pregnancy or while breastfeeding. Caution is needed with significant heart disease, uncontrolled hypertension, or recent major surgery. Those with liver impairment may require closer monitoring.

Cost can be a barrier. Generic sorafenib may lower out-of-pocket costs. Multi-month supplies can reduce the per-month price, and reorder reminders help prevent gaps in therapy. For current deals, see our Nexavar coupon page for offers and bulk options. Patients buying with no insurance often compare Canadian pricing to plan budgets. You can also browse our Cancer category for other oncology therapies and strengths.

For learning about side effect management and targeted therapies, see our articles on Common Darzalex Side Effects And Tips To Manage Them and Understanding Calquence Medication For Cancer Treatment. While focused on other drugs, the principles often help patients discuss supportive care with their teams.

Authoritative Sources

Review official information before starting or changing therapy. See the FDA Prescribing Information for Nexavar, the Health Canada Drug Product Database entry, and the manufacturer’s Nexavar product page for full details.

YouDrugstore makes ordering straightforward. Our licensed pharmacists review prescriptions, and our team supports you with clear steps and careful packing. We offer prompt, express, cold-chain shipping to the US where required.

This content is for general information only and does not replace medical advice. Always follow the prescriber’s instructions and the dispensing label. Seek urgent care for severe or unexpected symptoms.