Persantine® Tablets for Prosthetic Heart Valves

What Persantine Is and How It Works

Persantine® is dipyridamole, an antiplatelet medicine taken as oral tablets. It is used with a coumarin anticoagulant, such as warfarin, to help lower the risk of thromboembolic complications after a prosthetic heart valve replacement. This page explains how the treatment works, how to use it safely, and how to access it even if you plan to buy Persantine without insurance.

We support US delivery from Canada so you can review options and discuss them with your prescriber. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine reduces platelet clumping. It increases adenosine levels and cyclic AMP inside platelets, which can lower their tendency to stick and form clots. It also has vasodilating properties. For valve patients, it is prescribed as an adjunct to anticoagulation per the official label.

Who It’s For

This therapy is for adults who have a prosthetic heart valve and need additional platelet inhibition alongside a coumarin anticoagulant. It is not a substitute for anticoagulation in mechanical valves. People with hypersensitivity to dipyridamole should not take it. Those with unstable angina, severe hypotension, or certain bleeding risks may require careful assessment. Discuss your history of liver disease, migraines, low blood pressure, and recent surgery with your healthcare professional.

Learn more about clot-related conditions in our Blood Clot Thromboembolism category.

Dosage and Usage

Follow your prescriber’s directions and the product label. Tablets are generally taken multiple times daily at evenly spaced intervals. Swallow with water and try to take doses at the same times each day. Taking with food may help stomach upset. Do not crush or chew unless your prescriber confirms it is appropriate for your specific product.

Continue warfarin as directed and keep monitoring appointments. Do not change doses yourself. If you are scheduled for imaging or a pharmacologic cardiac stress test, tell your care team you are taking dipyridamole. Caffeine can blunt certain vasodilator stress test effects; your care team will advise on any temporary holds when needed for testing. If uncertain, defer to the official label and your prescriber’s guidance.

Strengths and Forms

Immediate-release tablets are commonly available in 25 mg, 50 mg, and 75 mg strengths. Availability may vary by manufacturer and region.

Missed Dose and Timing

If you miss a dose, take it when you remember unless it is almost time for the next dose. If it is close, skip the missed dose and resume your regular schedule. Do not double up to make up for a missed dose. Keeping a daily routine and using a reminder can help support adherence.

Storage and Travel Basics

Store tablets at typical room temperature in a dry place. Keep them in the original child-resistant container, tightly closed, and away from moisture. Do not store in a bathroom. When traveling, carry your medicine in hand luggage with a copy of your prescription and the labeled container. Avoid leaving tablets in a hot car. Keep out of reach of children and pets.

Pen Handling and Sharps Disposal

Not applicable. This product is supplied as oral tablets and does not require pen handling or sharps disposal.

Benefits

This antiplatelet therapy complements warfarin in appropriate valve patients. Oral tablets are familiar and convenient for daily routines. The class effect targets platelet activity, which may reduce the likelihood of clot formation when used as indicated. Discuss the expected benefits and any monitoring needs with your prescriber.

For broader heart-health topics and related therapies, visit our Cardiovascular section.

Side Effects and Safety

• Headache
• Dizziness or lightheadedness
• Flushing
• Nausea, stomach upset, or diarrhea
• Fatigue or weakness

Serious effects are less common but can include chest pain or worsening angina, severe hypotension, fainting, shortness of breath, or signs of allergic reaction such as rash, swelling, or trouble breathing. Because it is used with anticoagulation, bleeding risk may increase. Seek immediate care for black stools, vomiting blood, unusual bruising, or severe chest pain. If you are older or have multiple medicines, your prescriber may use extra caution.

For context on blood thinners and tolerability, you may find this overview helpful: Eliquis Side Effects. It covers general safety themes your clinician might also review.

Drug Interactions and Cautions

Tell your healthcare professional about all medicines, vitamins, and herbs you use. Using other antiplatelets or anticoagulants can raise bleeding risk. Dipyridamole can potentiate adenosine; clinicians often adjust adenosine doses for stress testing. Xanthines like caffeine may antagonize adenosine effects. Blood pressure medicines, nitrates, and alcohol can add to dizziness or low blood pressure. Always disclose over-the-counter pain relievers, supplements like fish oil, and any planned dental procedures.

Some heart medicines are used for different purposes, such as Nitrostat for angina relief, or lipid-lowering options like Pravastatin Sodium. Your prescriber will choose therapies suited to your diagnosis.

What to Expect Over Time

Expect steady use alongside warfarin unless your prescriber changes the plan. Headache or flushing may occur at first and may lessen as your body adjusts. Keep all monitoring visits, especially for anticoagulation. Use a pill organizer, phone reminders, or calendar notes to support adherence. If new symptoms appear, contact your healthcare professional rather than stopping suddenly. For educational reading on vascular health, see Peripheral Artery Disease.

Compare With Alternatives

Other antiplatelet agents are approved for different indications. For example, Ticagrelor may be prescribed after certain heart events, and Prasugrel is used in select patients with acute coronary syndromes. These are not direct substitutes for valve-related use. Your prescriber will match therapy to your specific condition.

Pricing and Access

Our checkout shows current options and lets you review the Persantine price before placing an order. You can also compare brand and generic availability when listed. Ships from Canada to US helps many patients access Canadian pricing with transparent fees.

If you are cost-conscious, you can Promotions for occasional offers. Speak with your prescriber if you want to Order Persantine from Canada and need documentation for transferring a prescription.

Availability and Substitutions

Supply can vary. If a particular pack size is not available, your prescriber may recommend dipyridamole tablets as a suitable alternative. For those comparing options, many patients search for Generic dipyridamole online to review availability and label information. Final selection depends on your prescription and clinical needs.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with a prosthetic heart valve who need added antiplatelet therapy with warfarin. Those with active bleeding, severe hypotension, or allergy to dipyridamole should not use it. Use caution if you have coronary artery disease with frequent angina, recent heart attack, severe liver issues, or you are pregnant or breastfeeding. Discuss risks and benefits before starting.

Cost-saving ideas:

• Multi-month fill: fewer refills and potential lower per-unit costs
• Generic option: ask your prescriber when appropriate
• Refill reminders: set calendar alerts or use your account tools
• Bundle visits: coordinate lab checks with prescription renewals

Self-pay shoppers often compare the Persantine cash price with generic alternatives and local pharmacy quotes. Your prescriber can advise whether brand or generic fits your plan.

Questions to Ask Your Clinician

• Valve therapy plan: how this medicine complements warfarin
• Bleeding signs: what to watch for and when to call
• Headache management: options if symptoms persist
• Stress tests: instructions before imaging or adenosine testing
• Caffeine use: whether to limit it for certain procedures
• Other medicines: which pain relievers are acceptable
• Duration: how long therapy may continue after valve surgery

Authoritative Sources

DailyMed: Dipyridamole

Health Canada DPD

Boehringer Ingelheim

Ready to proceed? You can review options with US shipping from Canada and complete checkout with prompt, express, cold-chain shipping and temperature-controlled handling when required. Encrypted checkout protects your information. This content is for general information and does not replace medical advice from your prescriber.