How do rectal mesalamine suppositories work?

They release 5‑aminosalicylic acid directly in the rectum, where inflammation drives symptoms of ulcerative proctitis. The local effect reduces inflammatory mediators in the mucosa. Because the dose acts at the site, overall systemic exposure is lower than many oral or systemic therapies. Use as prescribed and follow your label. If irritation or unusual pain occurs, contact your clinician.

Can I use this with oral mesalamine tablets?

Many clinicians combine oral and rectal mesalamine when disease extends slightly beyond the rectum or for maintenance after improvement. Your total daily exposure and tolerance guide the plan. Always tell your prescriber about all products you use, including supplements. Kidney monitoring may be recommended with longer-term mesalamine therapy.

What should I expect after starting a suppository?

Rectal products act locally, and consistency matters. Using the suppository at the same time daily helps retention and symptom tracking. Some people notice changes in urgency or bleeding as the mucosa calms. If symptoms persist or worsen, reach out to your healthcare professional. Do not change your dose or stop without guidance from your prescriber.

What if I have trouble retaining the dose?

Try to empty your bowels before insertion and lie on your side for a few minutes afterward. Insert the pointed end first and avoid cutting the suppository. If retention remains difficult due to severe urgency or diarrhea, talk to your clinician about alternatives such as foams or enemas that may be easier for you to keep in place.

Is it safe during pregnancy or while breastfeeding?

Mesalamine has been used during pregnancy when benefits outweigh risks, but your individual situation should guide the decision. Discuss plans with your obstetric provider and gastroenterologist. If breastfeeding, monitor the infant for diarrhea or unusual fussiness and consult your clinician promptly if symptoms appear.

Can hemorrhoids or fissures affect use?

Rectal irritation from hemorrhoids or fissures can make insertion uncomfortable. Use gentle technique and consider a water‑based lubricant. If bleeding increases or pain worsens, pause and contact your prescriber. You may need an alternative dosage form or a short course of soothing care for local irritation before resuming therapy.

Are brand and generic versions equivalent?

Approved generics are considered therapeutically equivalent to the brand when matched by strength and route. In practice, excipients can differ, which may affect comfort for some users. If you switch and notice new irritation or changes in symptom control, speak with your clinician or pharmacist to evaluate options, including returning to the previous product.

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Salofalk Suppositories

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Ulcerative Colitis

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Salofalk suppositories are a mesalamine rectal treatment for ulcerative proctitis. This page explains how it works, typical use, and safety basics. You can access Canadian pricing with US delivery from Canada, including options for Salofalk suppositories without insurance.

What Salofalk Is and How It Works

Salofalk® contains mesalamine, also called 5-aminosalicylic acid (5-ASA). It acts locally in the rectum to reduce inflammation. The suppository melts and releases medicine at the site of irritation. This helps ease rectal bleeding, urgency, and mucus associated with distal ulcerative colitis.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Mesalamine blocks inflammatory mediators in the gut lining. It is not a steroid and does not suppress the immune system in the same way as systemic therapies. Because it works where symptoms occur, the treatment may support symptom control while limiting whole‑body exposure.

For broader condition background, see our category for Ulcerative Colitis.

Who It’s For

Prescribers use mesalamine suppositories for adults with mild to moderate ulcerative proctitis. It may also be considered for maintenance after improvement with rectal therapy. People with known salicylate allergy or hypersensitivity to mesalamine should avoid this medicine. Those with kidney or liver disease need careful assessment before use.

Tell your prescriber about prior pancreatitis, gastric or duodenal ulcers, and any history of severe skin reactions. Discuss other bowel conditions so your plan fits your diagnosis. For a broader view of GI options, explore Gastrointestinal products.

Dosage and Usage

Follow your prescription label. Many adults use one suppository at bedtime. Some plans start with twice-daily dosing for short periods, then step down as advised. Insert the suppository gently into the rectum pointed end first. Lie on your side for a few minutes to help it stay in place.

Wash hands before and after use. A bowel movement before insertion can help retention. Do not cut or chew suppositories. If rectal therapies are difficult to retain, your prescriber may suggest other rectal forms such as an enema; see Pentasa Enema for an example. When uncertain about schedules or duration, defer to the official label and your clinician’s guidance.

Strengths and Forms

Commonly available strengths include 500 mg and 1000 mg (1 g) mesalamine suppositories. Availability may vary by country and manufacturer. Your prescription will specify the strength and frequency that match your treatment plan.

Missed Dose and Timing

If you miss a dose, use it when you remember, unless it is close to the next dose. If it is almost time for the next scheduled use, skip the missed one and continue as directed. Do not insert two at once to make up for a missed dose. Consistency matters, so try to use it at the same time daily.

Storage and Travel Basics

Store suppositories at room temperature away from moisture and direct heat. Keep in the original packaging and out of reach of children and pets. Do not freeze. While traveling, carry your supply in a hand‑luggage pouch with your prescription label. A small insulated bag can help protect products from temperature swings.

If flying, place medicine in a clear bag and bring documentation for security when needed. Avoid storing in a car glove box or other hot spaces. If the suppository looks misshapen or melted, ask your pharmacist before use. Our checkout is encrypted to protect your information.

Benefits

This class targets inflammation where symptoms occur. Rectal dosing can reduce rectal bleeding and urgency and support mucosal healing. Local delivery may reduce whole‑body exposure compared with some oral or systemic therapies. Nightly dosing is straightforward for many people, and maintenance schedules can be tailored by your prescriber.

Side Effects and Safety

Rectal discomfort or irritation
Mild abdominal pain or cramping
Gas or bloating
Headache
Nausea
Loose stools

Serious effects are uncommon but can include kidney problems, pancreatitis, severe skin reactions, or hypersensitivity reactions. Stop the medicine and seek urgent care for severe abdominal pain, persistent vomiting, chest pain, shortness of breath, rash with blisters, or reduced urine output. The risk of low blood sugar applies when 5-ASA is combined with insulin or sulfonylureas only rarely, but discuss all therapies with your prescriber.

Drug Interactions and Cautions

Tell your clinician about all medicines and supplements. Caution may be needed with nephrotoxic agents, azathioprine or 6-mercaptopurine, and other salicylates. Antacids that alter gut pH have limited impact on a rectal product, but your overall regimen still matters. Dehydration can increase kidney risk; maintain hydration unless told otherwise.

People who have ever reacted badly to aspirin or sulfa should discuss risks. If you also use oral 5‑ASA, your prescriber will consider total exposure. For more on the active ingredient, see Mesalamine. Some medicines can cause diarrhea; for context, review Metformin Diarrhea.

What to Expect Over Time

Rectal therapies act locally, and consistent nightly use is important. Many people notice changes in urgency or bleeding as the bowel lining settles. Your prescriber may step down frequency after improvement. Keep a simple symptom log and bring it to follow‑ups. If symptoms persist or worsen, contact your healthcare professional to reassess your plan.

Ulcerative proctitis is distinct from IBS. For background on functional bowel disorders, see IBS Causes.

Compare With Alternatives

Rectal 5‑ASA products come in several forms. Suppositories focus on the rectum, while foams and enemas can reach higher segments. Two options your prescriber may consider include:

Pentasa® Suppositories: another mesalamine suppository with similar local action.
Uceris® Rectal Foam: a budesonide foam used for distal disease when a steroid is appropriate.

Discuss suitability, dosing convenience, and your symptom pattern before you Order Salofalk suppositories or switch between options.

Pricing and Access

Canadian pharmacy pricing may offer value compared to some US cash options. Check current Salofalk suppositories cost and see how it compares with alternatives. We also list 5-ASA suppositories price so you can review choices with your prescriber. US delivery from Canada is available with a valid prescription.

Looking for offers? See our current Promotions. Add the item to your cart to view live pricing and proceed to checkout when ready.

Availability and Substitutions

Stock can vary by strength and manufacturer. If your preferred brand or size is unavailable, a prescriber may recommend a therapeutically similar option. We also carry Generic mesalamine suppositories when appropriate. Your final dispensing may come from a different manufacturer than shown, depending on supply.

Patient Suitability and Cost-Saving Tips

This medicine may suit adults with localized rectal inflammation who can retain a suppository. It may be less suitable if severe diarrhea prevents retention, or if you have a known salicylate allergy. Speak with your prescriber about multi‑month fills to reduce per‑fill fees and help maintain adherence. Enable refill reminders so you do not run out during maintenance.

Price‑sensitive patients sometimes consider Mesalamine suppositories buy online to compare options. Review your plan, benefits, and any prior authorization needs with your clinician. For product browsing, our Gastrointestinal section groups related therapies.

Questions to Ask Your Clinician

Is a suppository suitable for my symptom pattern?
Which strength and schedule should I follow?
How long should I continue rectal therapy after improvement?
Can I combine rectal and oral 5‑ASA safely?
What signs suggest I should call you sooner?
If I cannot retain a dose, what alternatives make sense?
How will you monitor kidney function while I use mesalamine?

Authoritative Sources

Ready to proceed? Buy Salofalk rectal suppositories online with US delivery from Canada and prompt, express shipping. This page is informational and does not replace advice from your prescriber.

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View All FAQs

How do rectal mesalamine suppositories work?
They release 5‑aminosalicylic acid directly in the rectum, where inflammation drives symptoms of ulcerative proctitis. The local effect reduces inflammatory mediators in the mucosa. Because the dose acts at the site, overall systemic exposure is lower than many oral or systemic therapies. Use as prescribed and follow your label. If irritation or unusual pain occurs, contact your clinician.
Can I use this with oral mesalamine tablets?
Many clinicians combine oral and rectal mesalamine when disease extends slightly beyond the rectum or for maintenance after improvement. Your total daily exposure and tolerance guide the plan. Always tell your prescriber about all products you use, including supplements. Kidney monitoring may be recommended with longer-term mesalamine therapy.
What should I expect after starting a suppository?
Rectal products act locally, and consistency matters. Using the suppository at the same time daily helps retention and symptom tracking. Some people notice changes in urgency or bleeding as the mucosa calms. If symptoms persist or worsen, reach out to your healthcare professional. Do not change your dose or stop without guidance from your prescriber.
What if I have trouble retaining the dose?
Try to empty your bowels before insertion and lie on your side for a few minutes afterward. Insert the pointed end first and avoid cutting the suppository. If retention remains difficult due to severe urgency or diarrhea, talk to your clinician about alternatives such as foams or enemas that may be easier for you to keep in place.
Is it safe during pregnancy or while breastfeeding?
Mesalamine has been used during pregnancy when benefits outweigh risks, but your individual situation should guide the decision. Discuss plans with your obstetric provider and gastroenterologist. If breastfeeding, monitor the infant for diarrhea or unusual fussiness and consult your clinician promptly if symptoms appear.
Can hemorrhoids or fissures affect use?
Rectal irritation from hemorrhoids or fissures can make insertion uncomfortable. Use gentle technique and consider a water‑based lubricant. If bleeding increases or pain worsens, pause and contact your prescriber. You may need an alternative dosage form or a short course of soothing care for local irritation before resuming therapy.
Are brand and generic versions equivalent?
Approved generics are considered therapeutically equivalent to the brand when matched by strength and route. In practice, excipients can differ, which may affect comfort for some users. If you switch and notice new irritation or changes in symptom control, speak with your clinician or pharmacist to evaluate options, including returning to the previous product.