Salofalk® (Mesalamine) Rectal Suppositories for Ulcerative Proctitis

What Salofalk Is and How It Works

Salofalk® suppositories contain mesalamine, a locally acting anti-inflammatory for ulcerative proctitis. Each suppository releases medicine in the rectum, where inflammation starts. Usual strengths are 500 mg and 1 g. Clinicians use them to induce remission and help maintain control. You order from YouDrugstore, a licensed Canadian pharmacy in Manitoba that meets Canadian pharmacy standards. Our pharmacists review prescriptions before dispensing, and our team offers friendly chat support during posted office hours. We offer brand and generic options at Canadian prices, and we also carry OTC health products. Many patients search for salofalk suppositories without insurance to manage costs, and we aim to help with fair pricing. We source authentic brand medicines through licensed, vetted international partner pharmacies to offer a broad selection at affordable pricing.

Dosage and Usage

Salofalk® suppositories deliver mesalamine directly to the rectal lining. Typical regimens for active ulcerative proctitis include 1 g once daily at bedtime or 500 mg two or three times daily. Maintenance regimens may use 1 g at bedtime or a lower total daily dose. Follow your prescriber’s directions.

• Wash your hands and empty your bowels if possible.
• Open the blister carefully. Avoid breaking the suppository.
• Lie on your side and gently insert the suppository pointed end first.
• Push it just past the sphincter. Remain lying for several minutes.
• Use at bedtime if once daily, to help retention.
• If you miss a dose, use it when remembered unless it is near the next dose. Do not double up.

Storage and travel tips:

• Store at room temperature per the package, away from heat and moisture.
• Do not freeze. Keep in the original blister until use.
• Carry a copy of your prescription when you travel.
• Pack a few extra doses in case of delays.

Benefits and Savings

Rectal mesalamine targets inflammation at the site of symptoms. It can reduce rectal bleeding, urgency, and pain. Many patients notice steadier bowels and fewer nighttime trips. Suppositories are discreet, and once-daily dosing with the 1 g strength is convenient for many treatment plans. Using rectal therapy may increase remission rates compared with oral therapy alone in distal disease.

YouDrugstore offers Canadian pricing that often brings 60–80% savings compared with typical US retail. Many patients pay less even without insurance. You can also lower your per-month cost with multi-month supplies when appropriate. Our team can send gentle reorder reminders so you do not run short.

Side Effects and Safety

Most people tolerate mesalamine well. Some effects are mild and pass as your body adjusts. Serious reactions are uncommon but need urgent care.

• Common: rectal discomfort, abdominal pain, gas, headache, nausea, mild cramping, constipation or diarrhea.
• Less common: fever, dizziness, rash, joint pain, fatigue.
• Serious: worsening bloody diarrhea, severe abdominal pain, chest pain, shortness of breath, swelling of face or throat, dark urine, yellowing skin or eyes, unusual bruising or bleeding, signs of kidney problems such as reduced urine or leg swelling.

Do not use if you are allergic to salicylates, sulfasalazine, or mesalamine. Use caution with kidney or liver disease. Mesalamine can rarely affect the kidneys, pancreas, heart, or blood counts. Your prescriber may arrange periodic blood and urine tests. Tell your prescriber about all medicines you take. Notable interactions include azathioprine or 6-mercaptopurine (higher risk of low blood counts) and other nephrotoxic drugs. Discuss use in pregnancy or breastfeeding with your clinician.

Onset Time

Some patients notice less urgency and bleeding within a few days. Full benefit can take one to three weeks. Your prescriber sets the course length based on your response. Keep using the medicine as directed even when symptoms improve, unless your prescriber changes the plan.

Compare With Alternatives

For disease limited to the rectum, suppositories provide direct delivery. If inflammation extends higher, a rectal suspension or foam may reach further. You can discuss a switch to Salofalk® Suspension enemas for proctosigmoiditis. Some patients use oral mesalamine tablets alongside rectal therapy. Those tablets are an option when your prescriber wants more proximal coverage; a generic Mesalamine product may help lower cost. In moderate or severe flares, clinicians may add steroids or other advanced therapies.

Combination Therapy

Rectal mesalamine often pairs well with oral mesalamine for distal ulcerative colitis. Some patients also use short courses of rectal steroids. In more extensive disease, systemic steroids, immunomodulators, or biologics may be used. Your care team chooses the combination, dose, and duration. Do not start or stop medicines without medical guidance.

Patient Suitability and Cost-Saving Tips

Salofalk® suppositories suit many adults with ulcerative proctitis. They are not for infections or hemorrhoids. Report any history of salicylate allergy, kidney disease, or liver disease to your prescriber. Older adults and those on nephrotoxic drugs need closer monitoring. Your clinician will balance benefits and risks for pregnancy and breastfeeding.

To manage costs, ask your prescriber if a multi-month supply is appropriate. Longer fills can reduce the per-month price. You can also compare strengths and dosing schedules to match your plan and budget. If your prescriber allows, a generic mesalamine product may lower cost. We post current offers and bulk options on our promotions page; see salofalk suppositories discount for details. We also send simple reorder reminders when you ask, so you stay on track. This helps avoid missed doses and urgent local purchases.

Learn more about related conditions, including Ulcerative Colitis and Proctitis. For background reading on abdominal symptoms, see our health articles The Abdomen Part Iii The Right Lower Quadrant and Ibs What Is Ibs Causes Symptoms Treatment. These resources do not replace medical advice.

Authoritative Sources

For detailed prescribing information, see the manufacturer and regulatory resources below:

• FDA Prescribing Information for Mesalamine Rectal Suppositories (Canasa)
• Health Canada Drug Product Database (search “Salofalk suppository”)
• Dr. Falk Pharma Mesalazine Product Information

You can order with confidence from YouDrugstore. We are a licensed Canadian pharmacy, and our pharmacists review prescriptions before dispensing. We ship to the US with prompt, express, cold-chain shipping when needed, and your package is sent discreetly.

This information is general and not a substitute for your prescriber’s advice. Always follow your own prescription label and local guidance. Product availability, packaging, and suppliers may vary by region.