Soliqua® Solostar Pens for Type 2 Diabetes: Insulin Glargine + Lixisenatide

What Soliqua® Is and How It Works

Soliqua® Solostar Pens combine insulin glargine (a long-acting insulin) and lixisenatide (a GLP-1 receptor agonist) in one once-daily injection for adults with type 2 diabetes. Many people compare prices for Soliqua Solostar Pens without insurance, and Canadian pricing can help reduce out-of-pocket costs. The pen delivers a daily dose prior to the first meal and allows simple titration to meet fasting glucose targets.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba. Prescriptions are reviewed by licensed pharmacists before dispensing, and you can order online with friendly customer-service chat during posted hours. We offer brand and generic medicines at Canadian prices and also stock OTC items.

We source from licensed, vetted partner pharmacies to provide authentic brand medications, with a broad selection and competitive pricing.

Dosage and Usage

Soliqua 100/33 contains insulin glargine 100 units/mL and lixisenatide 33 mcg/mL in a single Solostar pen. Dosing is once daily within 1 hour before the first meal.

• Starting dose: 15 units for patients new to basal insulin or GLP‑1 therapy; 30 units for those switching from 30–60 units of basal insulin daily.
• Titration: Adjust by 2–4 units every week or as directed to reach fasting glucose targets. Maximum dose is 60 units per day.
• Administration: Inject subcutaneously in the abdomen, thigh, or upper arm. Rotate sites to reduce lipodystrophy.
• Missed dose: Skip the missed dose and take the next dose at the usual time the following day. Do not double the dose. After a gap of several days, clinicians may restart at a lower dose to limit GI effects.
• Do not use in type 1 diabetes or for diabetic ketoacidosis.

Storage and travel tips:

• Unopened pens: Refrigerate at 2–8°C. Do not freeze. Keep in the original carton to protect from light.
• In-use pens: Store at room temperature (below 25–30°C) or refrigerated. Discard 28 days after first use.
• Keep the cap on. Remove the needle after each injection. Do not store with a needle attached.
• For travel: Use an insulated pack with cool packs for long trips. Avoid freezing and direct heat.

Benefits and Savings

Soliqua® simplifies therapy by combining basal insulin and a GLP‑1 agent in one pen. The insulin component lowers fasting glucose, and lixisenatide reduces post-meal spikes and may help limit weight gain often seen with insulin alone. Many patients see improved A1C while keeping dosing straightforward.

Buying from a Canadian pharmacy can mean significant savings. Typical customers report 60–80% lower prices compared to US retail. This can be helpful for those paying Soliqua Solostar Pens out of pocket or managing costs without insurance. You can set gentle reorder reminders so you do not run short.

Side Effects and Safety

Common side effects:

• Nausea, vomiting, or diarrhea
• Headache, dizziness, or fatigue
• Injection site redness or itching
• Hypoglycemia, especially if combined with sulfonylureas or when doses are increased

Serious effects (seek medical help):

• Severe hypoglycemia (confusion, seizures)
• Signs of pancreatitis (persistent severe abdominal pain, with or without vomiting)
• Allergic reactions (rash, swelling, difficulty breathing)
• Worsening kidney problems or dehydration

Soliqua® is not for type 1 diabetes or DKA. It is not recommended in patients with severe gastroparesis. Use caution with renal impairment, and review all other glucose‑lowering medicines to reduce hypoglycemia risk.

Onset Time

Insulin glargine begins lowering glucose after the first dose, with steady effects developing over several days. Lixisenatide reduces post‑meal rises from the first injections. A1C improvements are typically assessed over 8–12 weeks as the dose is titrated.

Compare With Alternatives

Other fixed‑ratio options include insulin degludec/liraglutide (Xultophy), which provides ultra‑long basal coverage and a different GLP‑1 component. Separate therapy with a basal insulin plus a weekly GLP‑1 agent (for example, pairing a basal insulin with dulaglutide or semaglutide) can also be effective, though it requires two prescriptions and separate injections.

Oral alternatives may be considered when injections are not preferred. A DPP‑4 inhibitor such as Onglyza® offers once‑daily dosing without injections, though glucose‑lowering is modest compared to GLP‑1 therapy. A combination SGLT2/metformin product like Synjardy® can aid glycemic control and may support weight and cardiovascular benefits in appropriate patients.

Choice depends on A1C goals, hypoglycemia risk, weight considerations, comorbidities, and tolerance to GI effects. Discuss options with your prescriber.

Combination Therapy

Soliqua® is often combined with metformin and may be used with SGLT2 inhibitors when additional control is needed. It should not be used with another GLP‑1 receptor agonist. Caution is advised with sulfonylureas due to hypoglycemia risk. Use with prandial insulin has not been established and is generally not recommended.

Patient Suitability and Cost-Saving Tips

Soliqua® is intended for adults with type 2 diabetes who need better control on less than 60 units of basal insulin daily, or who are not at goal on a GLP‑1 agent alone. It is not indicated for children, type 1 diabetes, or DKA. People with prior pancreatitis, severe GI disease, or significant renal impairment should review risks and benefits with their clinician.

To reduce monthly costs, consider a multi‑month supply when appropriate, which can lower the per‑month price. You can receive gentle reminders to reorder before your pen supply runs out. For offers and bulk options, see our promotions for a Soliqua Solostar Pens coupon.

Explore related learning and condition pages to support your plan. Our Type 2 Diabetes and Blood Sugar Control pages cover basics and lifestyle topics. For GLP‑1 context, read Thinking About Trulicity Weight Loss Read This First and discuss applicability with your prescriber. If paying Soliqua Solostar Pens without insurance, comparing Canadian prices can ease ongoing therapy costs.

Authoritative Sources

Soliqua 100/33 Prescribing Information (FDA)

Health Canada Drug Product Database: Soliqua

Sanofi Soliqua Product Page

YouDrugstore offers secure ordering, pharmacist review, and caring support from a licensed Canadian pharmacy. Get authentic Soliqua® at Canadian pricing with prompt, express, cold-chain shipping to the US.

This information is educational and does not replace advice from your prescriber or pharmacist. Always follow your prescription label and local medical guidance.