Can I take this medicine with food or should it be on an empty stomach?

You can take dasatinib tablets with or without food. Pick a consistent time each day to help establish a routine. Swallow the tablets whole with water and avoid crushing or splitting them. Do not drink grapefruit juice as it can affect levels of the medicine. If you have reflux, discuss safe options for acid reduction, because some products can interfere with absorption. Follow your prescriber’s instructions if they give you specific timing guidance.

What monitoring will I need during treatment?

Your care team will check complete blood counts, liver enzymes, and kidney function at intervals. They may also monitor BCR-ABL levels to track response. Some people need more frequent checks early in therapy or after a dose change. Tell your prescriber about new symptoms such as shortness of breath, swelling, bleeding, or signs of infection. Monitoring helps your prescriber adjust your plan safely when needed. Always bring an up-to-date medication list to each visit.

Are there medicines or supplements I should avoid?

Avoid strong CYP3A4 inhibitors and inducers, including certain antifungals, antibiotics, seizure medicines, and St. John’s wort. Grapefruit products should also be avoided. Proton pump inhibitors can reduce absorption; H2 blockers and antacids may require timing separation. Use caution with blood thinners and antiplatelet drugs. Share all prescription, over-the-counter, and herbal products with your prescriber before starting therapy. They will advise which items to stop, switch, or separate.

What side effects should prompt a call to my prescriber?

Call promptly for shortness of breath, chest discomfort, rapid weight gain, severe swelling, fainting, palpitations, signs of infection, unusual bleeding, or severe rash. These may signal fluid retention, heart rhythm changes, low blood counts, or other serious reactions. Most effects are manageable, but quick reporting helps your prescriber plan safe adjustments. For mild symptoms like nausea or headache, ask about supportive care options and whether dosing changes are appropriate.

Can I drive or work while taking this treatment?

Many people continue daily activities while taking this therapy. Some experience fatigue, dizziness, or headache, which can affect alertness. Avoid driving or operating machinery if you feel unwell or lightheaded. Give yourself time to see how you respond before doing hazardous tasks. If symptoms interfere with work or home responsibilities, discuss options with your prescriber. They may suggest supportive care measures or schedule adjustments to help you stay safe and consistent.

Is pregnancy or breastfeeding allowed during treatment?

This medicine may harm a developing baby. Tell your prescriber if you are pregnant or planning to become pregnant. Use effective contraception during treatment and for the period recommended on the official label after the last dose. Breastfeeding is not advised during therapy and for a period after stopping, as directed by your prescriber. If pregnancy occurs, contact your care team right away to discuss next steps and potential alternatives.

What if I develop reflux while on therapy?

Proton pump inhibitors can lower absorption of dasatinib. If you have reflux, your prescriber may recommend using an H2 blocker or an antacid with careful timing. Antacids are often separated by at least two hours from the tablet. Do not start or stop acid-reducing medicines without guidance. Non-drug steps like smaller meals, avoiding late eating, and elevating the head of the bed can also help. Always follow the specific plan set by your prescriber.

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Sprycel

Sprycel® Tablets for Chronic Myeloid Leukemia

Chronic Myeloid Leukemia, Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Please note: a valid prescription is required for all prescription medication.

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Sprycel® is a prescription tyrosine kinase inhibitor used for certain leukemias. It helps block BCR-ABL signaling that drives abnormal white blood cell growth. Ships from Canada to US can support access when paying without insurance.

What Sprycel Is and How It Works

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This medicine contains dasatinib, a BCR-ABL and SRC family kinase inhibitor. It targets the abnormal fusion protein created by the Philadelphia chromosome, which can drive chronic myeloid leukemia and some acute lymphoblastic leukemias. By inhibiting this signaling, the treatment may reduce leukemic cell proliferation and support hematologic responses.

It is supplied as film-coated tablets for oral use. Tablets should be swallowed whole. The product is used in adults and in certain pediatric patients as approved on official labels. When you start therapy, your prescriber will monitor blood counts and organ function at intervals. Some adults may use dasatinib 70 mg depending on phase and prior therapy, but your exact regimen is determined by your prescriber.

For background on the condition, see our overview on Chronic Myeloid Leukemia Symptoms.

Who It’s For

This therapy is indicated for Philadelphia chromosome–positive chronic myeloid leukemia in chronic, accelerated, or blast phase. It is also used for Philadelphia chromosome–positive acute lymphoblastic leukemia, often with combination chemotherapy. Your prescriber decides the use based on diagnosis, prior response, tolerance, and laboratory results.

People with known hypersensitivity to any component should avoid it. Those with significant heart rhythm problems, low blood counts, active bleeding, or fluid retention disorders require special caution. Tell your prescriber if you are pregnant, may become pregnant, or are breastfeeding, as use may not be appropriate. For broader condition context, explore Chronic Myeloid Leukemia and Philadelphia Chromosome Positive Acute Lymphoblastic.

Dosage and Usage

Follow your prescriber’s directions on dosing and schedule. Many adults with chronic-phase CML are started on a once-daily regimen. Advanced phases or Ph+ ALL may require a different daily dose. Pediatric dosing is weight-based and follows the official label.

Swallow tablets whole with water. Take with or without food, at the same time each day. Do not crush, split, or chew. Avoid grapefruit and grapefruit juice. If vomiting occurs after a dose, do not take an extra tablet; resume with the next scheduled dose. Your prescriber may adjust your regimen for side effects or lab changes. For a science-focused explainer, see Dasatinib 100 Mg Tablets.

Strengths and Forms

Film-coated tablets in multiple strengths are commonly available. Availability may vary.

Sprycel 100 mg tablet
20 mg, 50 mg, 70 mg, 80 mg, 140 mg tablets

Color and imprint vary by strength to aid identification. Your prescriber selects the strength that matches your treatment plan.

Missed Dose and Timing

If you miss a dose, take the next dose at the regular time. Do not double up to make up for a missed tablet. Try to take your dose at the same time daily to support steady exposure. Use a reminder or set an alarm to help consistency. Contact your prescriber if you miss several doses, or if you are unsure how to proceed.

Storage and Travel Basics

Keep tablets in the original container with the desiccant, and close the cap tightly. Store at room temperature away from moisture. Do not store in the bathroom. Keep out of reach of children and pets. Do not use tablets that are damaged, discolored, or out of date.

When traveling, carry your medicine in hand luggage with the labeled pharmacy container. Bring a copy of your prescription and a medication list. If crossing borders, allow extra time for screening. Avoid transferring tablets into unmarked organizers while in transit. If your prescriber changes your regimen, follow the new instructions and retire old packaging to prevent confusion.

Benefits

As a BCR-ABL tyrosine kinase inhibitor, this medicine can help limit leukemic cell growth in Philadelphia chromosome–positive disease. It offers once-daily dosing in many settings. Multiple strengths support dose adjustments when needed. It can be used after intolerance or resistance to other TKIs when appropriate. These features may help your care team tailor therapy throughout your treatment course.

Side Effects and Safety

Headache
Diarrhea or nausea
Fatigue
Skin rash
Muscle or joint pain
Edema, including fluid around the eyes

Serious but less common risks include low blood counts, bleeding, pulmonary arterial hypertension, severe fluid retention such as pleural effusion, liver enzyme elevations, and heart rhythm changes including QT prolongation. Report shortness of breath, chest pain, sudden weight gain, severe dizziness, or signs of infection right away. Your prescriber will monitor labs and may pause or adjust treatment if clinically required.

Drug Interactions and Cautions

Strong CYP3A4 inhibitors can raise levels of this therapy. Examples include ketoconazole, clarithromycin, and certain antivirals. Strong inducers such as rifampin, carbamazepine, phenytoin, and St. John’s wort can lower exposure. Avoid grapefruit products.

Proton pump inhibitors may reduce absorption; H2 blockers and antacids require careful timing. Separate antacids by at least two hours from your dose. Use caution with medicines that increase bleeding risk, such as anticoagulants or antiplatelet agents. Tell your prescriber about all over-the-counter products and supplements. For related reading, see Understanding Nilotinib Treatment Uses.

What to Expect Over Time

Your care team will check blood counts and organ function. They may order BCR-ABL monitoring at intervals. You may not feel different right away, even when lab results change. Keep taking your tablets as directed unless your prescriber instructs otherwise. Consistent timing supports adherence. If side effects occur, report them promptly so your prescriber can guide next steps.

Compare With Alternatives

Several TKIs are used for Philadelphia chromosome–positive disease. Nilotinib is another option; see Tasigna. Bosutinib may be considered in certain settings; view Bosulif. Imatinib was the first TKI and is still used in many cases. Your prescriber will weigh disease phase, side effect profiles, and prior responses when comparing options.

Pricing and Access

We provide transparent information to help you review the Sprycel price and plan refills. You can see available strengths, review current pricing, and submit your prescription for verification. US delivery from Canada helps many patients access Canadian pricing through our licensed pharmacy channel.

If you are seeking ways to stretch your budget, check our current Promotions. Savings vary by strength and supply chosen.

Availability and Substitutions

Supply can vary by strength and pack size. If your requested option is not available, your prescriber may recommend a clinically appropriate alternative. We can coordinate with your prescriber if a substitution is requested on your prescription. If you have questions about Sprycel cost or availability, contact our team for assistance with options your prescriber approves. For broader oncology choices, see our Cancer category.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with Philadelphia chromosome–positive CML or Ph+ ALL as assessed by their prescriber. It may not suit anyone who is pregnant, breastfeeding, or has certain heart rhythm problems. People with significant liver disease, heavy bleeding, or uncontrolled fluid retention require careful evaluation.

To reduce total spend, ask your prescriber about multi-month supplies when appropriate. Align refills with lab visits to avoid gaps. Use reminders to keep dosing consistent. Consider generic counseling if available in your region and approved by your prescriber. If you are tracking Sprycel cost per month, compare different pack sizes and refill frequencies to find a plan that fits your situation. For more background on targeted therapies in this space, review Scemblix 40 Mg Tablet.

Questions to Ask Your Clinician

Is this the right TKI for my disease phase and history?
How will we monitor blood counts and BCR-ABL over time?
Which side effects require urgent contact or an office visit?
Should I avoid PPIs, H2 blockers, or antacids with my dose?
What are my options if fluid retention or low counts develop?
Could an alternative TKI be appropriate if intolerance occurs?
How should I plan travel while staying on schedule?

Authoritative Sources

FDA Prescribing Information

DailyMed Official Label

Health Canada Drug Product Database

Ready to send your prescription to YouDrugstore and arrange US shipping from Canada? Place your order with prompt, express shipping and temperature-controlled handling when required. This information is not medical advice; your prescriber is your best source of guidance.

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View All FAQs

Can I take this medicine with food or should it be on an empty stomach?
You can take dasatinib tablets with or without food. Pick a consistent time each day to help establish a routine. Swallow the tablets whole with water and avoid crushing or splitting them. Do not drink grapefruit juice as it can affect levels of the medicine. If you have reflux, discuss safe options for acid reduction, because some products can interfere with absorption. Follow your prescriber’s instructions if they give you specific timing guidance.
What monitoring will I need during treatment?
Your care team will check complete blood counts, liver enzymes, and kidney function at intervals. They may also monitor BCR-ABL levels to track response. Some people need more frequent checks early in therapy or after a dose change. Tell your prescriber about new symptoms such as shortness of breath, swelling, bleeding, or signs of infection. Monitoring helps your prescriber adjust your plan safely when needed. Always bring an up-to-date medication list to each visit.
Are there medicines or supplements I should avoid?
Avoid strong CYP3A4 inhibitors and inducers, including certain antifungals, antibiotics, seizure medicines, and St. John’s wort. Grapefruit products should also be avoided. Proton pump inhibitors can reduce absorption; H2 blockers and antacids may require timing separation. Use caution with blood thinners and antiplatelet drugs. Share all prescription, over-the-counter, and herbal products with your prescriber before starting therapy. They will advise which items to stop, switch, or separate.
What side effects should prompt a call to my prescriber?
Call promptly for shortness of breath, chest discomfort, rapid weight gain, severe swelling, fainting, palpitations, signs of infection, unusual bleeding, or severe rash. These may signal fluid retention, heart rhythm changes, low blood counts, or other serious reactions. Most effects are manageable, but quick reporting helps your prescriber plan safe adjustments. For mild symptoms like nausea or headache, ask about supportive care options and whether dosing changes are appropriate.
Can I drive or work while taking this treatment?
Many people continue daily activities while taking this therapy. Some experience fatigue, dizziness, or headache, which can affect alertness. Avoid driving or operating machinery if you feel unwell or lightheaded. Give yourself time to see how you respond before doing hazardous tasks. If symptoms interfere with work or home responsibilities, discuss options with your prescriber. They may suggest supportive care measures or schedule adjustments to help you stay safe and consistent.
Is pregnancy or breastfeeding allowed during treatment?
This medicine may harm a developing baby. Tell your prescriber if you are pregnant or planning to become pregnant. Use effective contraception during treatment and for the period recommended on the official label after the last dose. Breastfeeding is not advised during therapy and for a period after stopping, as directed by your prescriber. If pregnancy occurs, contact your care team right away to discuss next steps and potential alternatives.
What if I develop reflux while on therapy?
Proton pump inhibitors can lower absorption of dasatinib. If you have reflux, your prescriber may recommend using an H2 blocker or an antacid with careful timing. Antacids are often separated by at least two hours from the tablet. Do not start or stop acid-reducing medicines without guidance. Non-drug steps like smaller meals, avoiding late eating, and elevating the head of the bed can also help. Always follow the specific plan set by your prescriber.