Sprycel® (dasatinib) tablets for Ph+ CML and Ph+ ALL

What Sprycel® Is and How It Works

Sprycel® (dasatinib) is a tyrosine kinase inhibitor used to treat Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) in chronic, accelerated, or blast phase, and Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL). It is supplied as oral tablets taken once daily. Sprycel helps block BCR‑ABL signaling, which slows or stops leukemia cell growth. You can order Sprycel at Canadian prices through YouDrugstore, a licensed Canadian pharmacy based in Manitoba. Prescriptions are reviewed by licensed pharmacists before dispensing, and our team supports safe, compliant delivery for US patients. We work with licensed, vetted international partner pharmacies to source authentic brand medications, offering a broad selection at affordable pricing.

Sprycel targets several kinases including BCR‑ABL and SRC family kinases. In Ph+ CML and Ph+ ALL, it reduces leukemic cell proliferation and promotes hematologic and cytogenetic responses. Tablets come in multiple strengths to support dose adjustments guided by your oncology team.

Dosage and Usage

Sprycel dosing depends on disease phase, prior therapy, and tolerance. Always follow the regimen set by your prescriber. Typical adult doses include:

• Chronic-phase CML: 100 mg once daily.
• Accelerated/blast-phase CML: 140 mg once daily.
• Ph+ ALL: 140 mg once daily, often with chemotherapy per protocol.

Tablets may be taken with or without food. Swallow whole; do not crush, cut, or chew. Avoid grapefruit or grapefruit juice. Acid reducers can lower absorption. Proton pump inhibitors and H2 blockers are generally avoided. If antacids are needed, separate by at least 2 hours before or after Sprycel.

Strong CYP3A4 inhibitors (such as certain azole antifungals and macrolides) can increase drug levels. Strong CYP3A4 inducers (such as rifampin or St John’s wort) can decrease levels. Your oncology team may adjust dosing if interactions or side effects occur.

Missed dose:

• If a dose is missed, skip the missed dose.
• Take the next dose at the regular time.
• Do not double doses to make up for a missed dose.

Storage and travel:

• Store at 20–25°C (68–77°F) in a dry place.
• Keep in the original container with the label.
• Protect from moisture and keep out of children’s reach.
• When you travel, carry tablets in hand luggage.
• Bring enough supply for your trip, plus a few extra days.

Benefits and Savings

Sprycel has helped many adults and children with Ph+ CML achieve complete hematologic and cytogenetic responses. It is also an important option for Ph+ ALL as part of multi-drug therapy. Once-daily dosing supports adherence, and strength options allow careful titration to manage efficacy and tolerability.

YouDrugstore offers brand oncology medicines at Canadian prices, often 60–80% less than typical US prices. You can order online or by phone, then track shipment through your account. Friendly customer-service chat is available during posted office hours, and pharmacists can address medication questions by request.

Side Effects and Safety

Common side effects include:

• Myelosuppression: low white cells, platelets, or hemoglobin.
• Fluid retention: peripheral edema and pleural effusion.
• Diarrhea, nausea, vomiting, abdominal pain.
• Headache, fatigue, rash, musculoskeletal pain, cough.

Serious adverse effects can occur and need prompt medical attention:

• Severe bleeding, especially with low platelets.
• Severe myelosuppression or infections.
• Pleural effusion, pulmonary edema, or pulmonary arterial hypertension.
• QT prolongation or other cardiac events.
• Tumor lysis syndrome in high disease burden.
• Hepatic enzyme elevations and pancreatitis.

Monitoring usually includes blood counts, liver function tests, and assessments for effusions or dyspnea. Clinicians often avoid NSAIDs due to bleeding risk. For pain or fever, acetaminophen (Tylenol) is commonly preferred, with attention to liver function. Alcohol and herbal supplements can raise interaction risks. Effective contraception is recommended during therapy and for a period after stopping, because Sprycel can harm a developing fetus.

If shortness of breath, chest discomfort, rapid weight gain, severe bleeding, persistent fever, or signs of infection occur, urgent medical evaluation is needed. Do not change, start, or stop medicines without guidance from your prescriber.

Onset Time

Hematologic responses may be seen within weeks. Many patients reach complete hematologic response in 1–3 months. Cytogenetic and molecular responses usually take longer. BCR‑ABL transcript reductions are often assessed at 3, 6, and 12 months to track milestones. Individual timelines vary based on disease phase, prior therapy, and tolerability.

Compare With Alternatives

Several BCR‑ABL inhibitors are used in Ph+ CML, with selection based on phase, comorbidities, and mutation profile.

Imatinib (Gleevec®) was the first TKI and remains a standard, especially for lower-risk chronic-phase disease. Nilotinib (Tasigna®) and bosutinib (Bosulif®) are alternatives with different adverse-effect patterns and monitoring needs. Ponatinib (Iclusig®) addresses many BCR‑ABL mutations, including T315I, but requires vascular risk assessment.

YouDrugstore also supplies other oral oncology agents. For prostate cancer therapy, see Zytiga®. For FLT3-mutated AML, consider Xospata®. Your oncology team will determine the best agent based on disease biology, prior tolerability, and goals of care.

Combination Therapy

Sprycel can be used alone for Ph+ CML. In Ph+ ALL, it is often combined with multi-agent chemotherapy or with steroids during induction and consolidation. Supportive care may include antimicrobials, tumor lysis prevention, and transfusion support. Coordination with your care team ensures dose adjustments and timing align with protocol requirements.

Patient Suitability and Cost-Saving Tips

Sprycel may be considered for adults and children with Ph+ CML or adults with Ph+ ALL. Suitability depends on phase, mutation profile, drug interactions, cardiac and pulmonary history, pregnancy status, and prior tolerance of TKIs. Regular monitoring supports safe dose adjustments.

To manage costs, YouDrugstore offers Canadian pricing and reorder reminders. Multi-month supplies may lower the per‑month cost when available. For current offers and bulk options, see our sprycel coupon page.

If you need general oncology resources, our Cancer category highlights medicines and support items. For education on tolerability and targeted therapy concepts, explore Common Darzalex Side Effects And Tips To Manage Them and Understanding Calquence Medication For Cancer Treatment. These articles can help with side‑effect planning and communication with your care team.

Authoritative Sources

Review prescribing and safety details before starting or changing therapy. Useful references include the Sprycel (dasatinib) Prescribing Information, the Health Canada Drug Product Database: Dasatinib, and the manufacturer’s Sprycel Patient Site.

You can order brand oncology medicines at Canadian prices from YouDrugstore, a licensed Canadian pharmacy in Manitoba. Our team verifies prescriptions, prepares your parcel with care, and offers prompt, express, cold-chain shipping to the US when required.

This page provides general information and is not a substitute for professional medical advice. Always follow the guidance of your oncology team and the medication guide that comes with your prescription.