Synjardy® for Type 2 Diabetes: Uses, Dosage, and Savings

What Synjardy® Is and How It Works

Synjardy® combines empagliflozin (an SGLT2 inhibitor) with metformin to help adults with Type 2 Diabetes improve blood sugar control. It is taken by mouth as tablets, either immediate-release (twice daily with meals) or extended-release (Synjardy XR) once daily with food. Compared with many US pharmacies, YouDrugstore offers Canadian pricing that can lower your synjardy price, including helpful options for managing synjardy cost without insurance.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and prescriptions are reviewed by licensed pharmacists before dispensing. We partner only with licensed, vetted international partner pharmacies to provide authentic brand medicines across a broad selection at fair, competitive prices.

Empagliflozin helps your kidneys remove excess glucose in the urine. Metformin lowers glucose production in the liver and improves insulin sensitivity. Together they reduce A1C, fasting and post-meal glucose, and may support modest weight and blood-pressure reductions. The empagliflozin component has proven cardiovascular and kidney benefits in certain adults with Type 2 diabetes and established disease. If you are exploring therapies for Blood Sugar Control, Synjardy and Synjardy XR can simplify regimens by combining two established agents in one tablet.

Dosage and Usage

• Starting dose (immediate-release): Often 5 mg/500 mg twice daily with meals. If already on metformin or empagliflozin, match the metformin dose and add the nearest empagliflozin strength.
• Titration (immediate-release): Increase every 1–2 weeks as tolerated to improve A1C. Common target strengths include Synjardy 5 mg/1000 mg tab twice daily or 12.5 mg/1000 mg twice daily.
• Maximum (immediate-release): 12.5 mg/1000 mg twice daily (total daily 25 mg/2000 mg).
• Synjardy XR once daily: Typical starting strength is Synjardy XR 5 mg/1000 mg with the evening meal. Some patients titrate to Synjardy XR 12.5 mg/1000mg tablet once daily (two tablets daily may be used to reach a total of 25 mg/2000 mg).
• Kidney function: Not recommended if eGFR is below 30 mL/min/1.73 m². Dose selection and monitoring may be needed if kidney function is reduced.
• Administration tips: Take with food to reduce stomach upset. Swallow XR tablets whole; do not crush, split, or chew.
• Missed dose: Take as soon as remembered unless it is near the next dose. Skip the missed dose if close to the next scheduled dose. Do not double doses.
• Temporary interruption: Your prescriber may pause metformin-containing products before certain contrast imaging or if dehydration, severe infection, or acute kidney issues arise.

• Storage: Store at 15–30°C (59–86°F) in a dry place. Keep the bottle closed to protect from moisture.
• Travel: Carry in original labeled container. Keep in hand luggage. Avoid leaving tablets in a hot car or direct sun.
• Handling: Do not use damaged or discolored tablets. Check strength on the label before each dose to avoid mix-ups.
• XR specifics: Do not crush or split Synjardy XR. A ghost tablet may appear in stool; the medicine has been released.

Benefits and Savings

Synjardy reduces A1C and fasting glucose and can help lower post-meal spikes. Many patients see modest weight and blood-pressure improvements due to the SGLT2 action. Combining two medicines in one tablet reduces pill burden and supports adherence. The range of strengths, including synjardy 12.5 mg 1000 mg and synjardy 5 mg 1000 mg uses, allows individualized titration.

Ordering from YouDrugstore can lead to 60–80% savings compared with typical US retail prices. You can compare Synjardy XR price options and look for a synjardy discount when you choose larger quantities. Savings are meaningful whether you use insurance or are evaluating synjardy cost without insurance.

For current offers, see our synjardy coupon page.

Side Effects and Safety

• Urinary frequency or increased urination
• Genital yeast infections (women and men)
• Urinary tract infections
• Nausea, diarrhea, abdominal discomfort, or gas
• Loss of appetite or taste changes
• Dizziness, especially if dehydrated
• Headache or fatigue
• Vitamin B12 reduction with long-term metformin use

Serious but rare risks include lactic acidosis (metformin), ketoacidosis even with normal glucose (SGLT2 class), acute kidney injury, severe dehydration or low blood pressure, severe urinary infections, and necrotizing fasciitis of the perineum (Fournier’s gangrene). Do not use if eGFR < 30, in Type 1 diabetes, or during ketoacidosis. Hypoglycemia can occur if combined with insulin or sulfonylureas; dose reductions of those agents may be needed.

Onset Time

Many people notice lower fasting glucose within 1–2 weeks as therapy stabilizes. A1C reductions emerge over 8–12 weeks and may continue to improve through 24 weeks with titration. Modest weight changes often appear after 8–16 weeks. Cardiovascular and kidney benefits accrue over months to years when used consistently with lifestyle and other prescribed therapies.

Compare With Alternatives

Metformin alone remains first-line for many adults, but adding an SGLT2 inhibitor like empagliflozin often delivers greater A1C reductions and weight benefits. Synjardy combines both in one tablet, which may be more convenient than separate pills.

DPP-4 inhibitors are another oral option. Onglyza® (saxagliptin) and Nesina® Alogliptin are weight-neutral and typically taken once daily, but they do not promote urinary glucose loss and have different side-effect profiles compared to SGLT2 agents.

If injections are needed, a fixed combination such as Soliqua® SoloStar Pens (insulin glargine with lixisenatide) offers potent glucose-lowering, especially for those with elevated fasting glucose. Injectable GLP-1 receptor agonists also support weight loss but require training and supplies.

Combination Therapy

• With basal insulin: Often continued; consider lowering insulin dose to reduce hypoglycemia risk as glucose improves.
• With sulfonylureas: May be used; a dose reduction can help limit low blood sugar.
• With GLP-1 receptor agonists: Common pairing that supports A1C and weight goals without raising hypoglycemia risk.
• With DPP-4 inhibitors: Sometimes used, though incremental benefit may be modest; individualize based on A1C and tolerance.
• With blood pressure and lipid medicines: Frequently part of comprehensive cardiometabolic care.

Patient Suitability and Cost-Saving Tips

Synjardy is for adults with Type 2 diabetes who need improved control despite diet, activity, and current therapy. It is not for Type 1 diabetes or diabetic ketoacidosis. Avoid use during pregnancy and while breastfeeding. People with recurrent genital infections, frequent urinary infections, heavy alcohol intake, or severe dehydration may need alternatives or closer monitoring.

Kidney function guides selection and dosing. Most clinicians avoid metformin-containing products if eGFR is below 30 mL/min/1.73 m². Temporary interruption may be advised before contrast imaging or during acute illness. Older adults and those on diuretics require careful hydration.

To lower costs, compare synjardy 12.5 mg 1000 mg price with synjardy 5 1000 price to match your prescribed dose efficiently. Multi-month supplies can reduce the per-month cost, and bulk promotions may apply. Set simple reorder reminders so you do not run out during travel or holidays. If you pay cash, you can also review synjardy cost without insurance when selecting pack sizes.

Authoritative Sources

FDA Prescribing Information for Synjardy and Synjardy XR

Manufacturer product page (Boehringer Ingelheim/Lilly)

Health Canada Drug Product Database (search Synjardy)

Order Synjardy® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This page is educational and is not a substitute for professional medical advice, diagnosis, or treatment. Always talk to your healthcare professional about your specific situation.