Toujeo® Doublestar and Solostar Insulin Glargine U-300 Pens

What Toujeo® Is and How It Works

Toujeo insulin glargine U-300 is a long-acting basal insulin supplied in ready-to-use prefilled pens. The Toujeo Doublestar/Solostar Prefilled Pen delivers a steady background insulin level for adults and children 6 years and older with diabetes. If you are comparing the Toujeo Doublestar/Solostar Prefilled Pen price to US retail options, many patients look for Toujeo Solostar without insurance savings through licensed Canadian pharmacies.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

We partner with vetted, licensed international pharmacies to source authentic brand medications, giving you broad choice at competitive Canadian pricing.

Toujeo contains insulin glargine concentrated at 300 units/mL. It forms microprecipitates after subcutaneous injection, releasing insulin slowly over 24 hours or more. This flat, prolonged profile helps control fasting and between‑meal glucose. It is injected once daily, at the same time each day. Your prescriber will individualize the dose based on prior insulin use, glucose readings, and goals.

Uses include type 1 diabetes (with rapid-acting mealtime insulin) and type 2 diabetes when oral agents alone are not enough. Toujeo is not for treating diabetic ketoacidosis, and it is not for use in an insulin pump or for intravenous injection.

Dosage and Usage

• Take once daily at the same time. Dose is individualized. Switching from another basal insulin may require careful titration and close monitoring.
• Do not mix or dilute Toujeo with other insulins. Do not withdraw insulin from the pen with a syringe.
• Use subcutaneous injection in the abdomen, thigh, or upper arm. Rotate sites to reduce lipodystrophy.
• Starting and titration: your clinician may adjust by small increments every few days until fasting glucose targets are met. Full effect may take several days to stabilize.
• Missed dose: take as soon as you remember on the same day. If you miss by many hours, follow your prescriber’s guidance and avoid doubling the next dose.
• Device basics: check the pen label and expiration date, attach a new needle, prime the pen per the Instructions for Use until a drop appears, select the dose, inject, and hold the needle in place for several seconds before removing.
• Keep a backup plan for hypoglycemia. Carry glucose tablets or another quick sugar source.

• Unopened pens: store refrigerated at 2–8°C (36–46°F). Do not freeze. Keep in the carton to protect from light.
• In-use pen: you may keep at room temperature (below 30°C/86°F) and use for up to 56 days. Do not refrigerate once in use.
• Never expose pens to heat, direct sunlight, or a car glovebox. Discard if frozen or overheated.
• Travel: keep pens in an insulated bag with cool packs, not in direct contact with ice. Carry a spare pen, needles, and a copy of your prescription.
• Air travel: keep insulin in your carry-on. Security X-rays do not harm insulin.
• Disposal: place used needles in a sharps container. Follow local guidance for pen disposal after 56 days or when empty.

Benefits and Savings

Toujeo provides smooth, once-daily basal coverage with a less pronounced peak than many U-100 basal insulins. This can help reduce overnight glucose swings and simplify routines. In type 2 diabetes, it often lowers fasting glucose and A1C when added to oral agents. In type 1 diabetes, it supports basal needs alongside a rapid‑acting mealtime insulin.

Ordering from Canada can lower your ongoing Toujeo Doublestar/Solostar pen cost. Many US customers report 60–80% savings compared with local prices. If you are paying cash, your Toujeo Doublestar cash price through us may be substantially lower, and multi‑pack options can reduce the per‑month spend. We also provide gentle reorder reminders so you do not run out.

Price transparency matters. Check our Toujeo Doublestar/Solostar pen price on the product page to compare and plan. If you need to order Toujeo Doublestar prefilled pen online without insurance, our team can help you complete the prescription checkout and verify details.

Looking for a deal? See if a current Toujeo Doublestar coupon is listed on our Promotions page.

Side Effects and Safety

• Common effects: hypoglycemia (shakiness, sweating, fast heartbeat, hunger), injection-site redness or itching, mild weight gain, and swelling of hands or feet.
• Less common: lipodystrophy (fatty tissue changes) at injection sites, allergic reactions such as rash or hives, and vision changes during early glucose improvement.
• Drug interactions: thiazolidinediones may increase edema; beta blockers can mask hypoglycemia symptoms.

Serious risks include severe hypoglycemia, which can cause confusion, seizures, or loss of consciousness. Treat low blood sugar promptly and seek medical attention for severe episodes. Hypokalemia may occur; monitor when using drugs that lower potassium. Do not use during episodes of hypoglycemia. Use caution when starting or increasing dose, and when combined with insulin secretagogues (like sulfonylureas) or other insulins, as the hypoglycemia risk increases.

Onset Time

After the first dose, glucose lowering begins within hours, but the basal effect builds gradually. It may take about 3–5 days to reach a new steady state after a dose change. Fasting glucose often improves within the first one to two weeks as titration proceeds. A1C reflects the prior three months of control, so material A1C changes usually require 8–12 weeks.

Compare With Alternatives

Lantus (insulin glargine U-100) is another long‑acting basal option. It has a well‑established profile and once‑daily dosing. Compared with Lantus, Toujeo U‑300 is more concentrated and may provide a flatter curve with potentially less nocturnal hypoglycemia in some patients, though unit-for-unit needs can differ.

Tresiba (insulin degludec U-100 or U-200) offers an ultra‑long action and flexible dosing windows. Some patients value its dosing flexibility, while others prefer Toujeo’s steady day‑to‑day routine. Your clinician will weigh prior control, lifestyle, and cost to choose between them.

Basaglar (insulin glargine U-100) is a follow‑on glargine with similar clinical performance to Lantus. It may be considered if a U-100 option suits your dosing needs or insurance plan better.

Mealtime insulin is not a direct substitute for basal insulin, but it is often used alongside it. Rapid‑acting choices include Apidra® Vials and the convenient Apidra® Solostar Pens for bolus dosing with meals.

Combination Therapy

• Type 1 diabetes: Toujeo plus a rapid‑acting insulin at meals. Your prescriber may adjust both basal and bolus to reach targets.
• Type 2 diabetes: often added to metformin. Other oral agents (SGLT2 inhibitors, DPP‑4 inhibitors) or GLP‑1 receptor agonists can be combined.
• When used with mealtime insulin or sulfonylureas, dose adjustments may be needed to lower hypoglycemia risk.
• Thiazolidinediones may increase edema; monitor for fluid retention.

Patient Suitability and Cost-Saving Tips

Good candidates include adults and children 6+ who need a long‑acting basal insulin for type 1 or type 2 diabetes. It may not suit those with a history of severe, unrecognized hypoglycemia, or those unable to administer injections safely. Avoid use for diabetic ketoacidosis, in pumps, or by intravenous route.

Practical savings tips: consider multi‑month supplies when appropriate, which can reduce shipping frequency and per‑pen costs. Watch for Toujeo Solostar promotional offer periods or a Toujeo Doublestar discount. Bulk packs sometimes carry a lower Toujeo Solostar bulk price. If you are uninsured, we offer clear pricing that helps when purchasing Toujeo Doublestar pen without insurance.

Set simple reorder reminders so you do not run out. We ship with prompt, express, cold‑chain handling to protect temperature‑sensitive items.

Authoritative Sources

Sanofi Toujeo US Prescribing Information

Health Canada Product Monograph: Toujeo (insulin glargine 300 units/mL)

FDA Medication Guide and Labeling for Toujeo

Order Toujeo® from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This page is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s instructions and the device’s Instructions for Use.