What is Tresiba used for?

Tresiba is a long-acting basal insulin used to improve glycemic control in adults and children with diabetes mellitus. People with type 1 diabetes use it alongside a rapid-acting insulin at meals. Adults with type 2 diabetes may use it alone or with other medicines, such as metformin or GLP-1 therapies. It is not for treating diabetic ketoacidosis and is not a rapid-acting insulin for sudden highs. Always follow your prescriber’s plan and the official label.

How do U-100 and U-200 differ?

Both strengths contain insulin degludec. U-200 has twice the concentration of U-100, allowing a smaller injection volume for the same unit dose. The pen doses in units, not milliliters. Choose the strength your clinician prescribes. Do not transfer insulin from the pen to a syringe. Review your device’s dose increments and confirm your target dose at each injection to avoid errors.

Can I mix this insulin with others?

Basal insulin degludec is not intended to be mixed or diluted with other insulins. Mixing can alter onset, duration, and absorption. If you use a rapid-acting insulin at meals, administer it as a separate injection. Your prescriber may adjust timing between injections based on your regimen. Always consult official labeling and your healthcare professional before considering any changes.

How long can an opened pen last?

Follow the in-use storage period in the official instructions. In general, basal pens have an in-use time window at room temperature away from heat and light. After that window, discard the pen even if insulin remains. Keep unopened pens refrigerated as directed. Do not freeze. Protect pens from excessive heat during travel, and avoid leaving them in vehicles or direct sunlight.

What needles work with the FlexTouch pen?

Most standard pen needles from major manufacturers are compatible, in lengths commonly used for subcutaneous injections. Your pharmacist can suggest a needle length and gauge suitable for your body type and technique. Always use a new sterile needle for each dose. Dispose of used needles in an approved sharps container to reduce needlestick risks and contamination.

Is it safe to use during illness or surgery?

Illness, stress, or surgery can change insulin needs. Your clinician may provide a sick-day plan that includes more frequent glucose checks and ketone testing for type 1 diabetes. Do not stop basal insulin without medical guidance. Keep hydrated and monitor levels closely. Contact your care team for individualized instructions if you have vomiting, fever, or planned procedures.

Can children use this insulin?

Basal insulin degludec is approved for pediatric patients in many regions. Dosing is individualized by age, weight, and glucose targets. Children using basal insulin require careful supervision, education on hypoglycemia recognition, and support at school or activities. Parents and caregivers should learn injection technique, site rotation, and signs that require urgent care. Always follow the pediatric dosing guidance in the official label.

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Tresiba® FlexTouch Pens are prefilled insulin pens containing insulin degludec, a long-acting basal insulin for adults and children with diabetes. This page covers Tresiba FlexTouch Pens uses, safety, and practical tips. We provide US delivery from Canada, plus practical details if you are paying without insurance.

What Tresiba Is and How It Works

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Tresiba insulin degludec FlexTouch pens deliver a basal insulin that works slowly and steadily over 24 hours and beyond. It forms multi-hexamers after injection, releasing insulin gradually into the bloodstream. This slow, even profile helps support fasting glucose control when used with a meal-time insulin for type 1 diabetes, or alone or with other agents for type 2 diabetes. The treatment is not a rapid-acting insulin and is not for correcting sudden high blood sugar.

This medicine is used alongside nutrition and activity plans. Your prescriber will individualize the dose based on glucose goals, current regimen, and response over time.

Who It’s For

This basal insulin is indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus. People with type 1 diabetes use it with a rapid-acting insulin at meals. Many adults with type 2 diabetes use it alone or with oral agents or GLP-1s.

Those using Insulin degludec U-100 pens or other basal options may switch only under guidance from a healthcare professional. Do not use during episodes of low blood sugar. Avoid use if you have a known allergy to insulin degludec or any pen component.

For condition-specific guidance, see Type 1 Diabetes and Type 2 Diabetes.

Dosage and Usage

Use this basal insulin once daily, at the same time each day or at a convenient time your prescriber recommends. The dose is individualized. If you are starting or switching, follow the official label and your clinician’s plan.

Inject subcutaneously into the abdomen, thigh, or upper arm. Rotate injection sites within the same area to reduce skin changes. Tresiba FlexTouch prefilled pens are for single-patient use only. Do not share pens, even with a changed needle.

Check the solution before each use; it should be clear and colorless. Prime the pen as directed in the Patient Instructions for Use. Use a new needle for every injection, and keep the pen cap on when not in use.

Strengths and Forms

This medicine is supplied in disposable, prefilled pens. Availability may vary.

U-100 FlexTouch pens: each 3 mL pen contains insulin degludec at 100 units/mL
U-200 FlexTouch pens: each 3 mL pen contains insulin degludec at 200 units/mL
Carton sizes commonly include a 5 x 3 mL presentation

Many patients prefer the higher-strength device to reduce the volume of injection. Tresiba FlexTouch U-200 Pens deliver units, not mL, as set on the dose selector.

Missed Dose and Timing

If you miss a dose, take it when you remember, then resume your usual schedule. Ensure sufficient time between doses, as advised on the official label. Do not take extra insulin to make up for a missed dose. Monitor glucose more often after a missed or delayed dose, and contact your prescriber if you are unsure what to do.

Storage and Travel Basics

Unopened pens should be refrigerated per the label and kept away from the freezer compartment. Do not freeze. In-use pens may be kept at room temperature, away from heat and light, for the period specified in the official instructions. Discard the pen once it reaches its in-use time limit, even if insulin remains.

Keep out of reach of children. Use a protective case during travel. Bring your prescription, an extra supply of needles, and a backup pen. For packing and meters, see more items under Diabetes Care. A micro-cue for safety: temperature-controlled handling when required.

Pen Handling and Sharps Disposal

Read the Patient Instructions for Use before your first dose. Attach a compatible pen needle, prime as instructed, dial the dose, and inject into the recommended areas. Hold the needle in the skin for the time stated in the instructions to ensure full delivery.

Dispose of used needles in an FDA-cleared sharps container. Do not recap by hand. Follow local rules for sharps disposal. For stepwise injection technique basics, you may find general guidance in How To Inject Mounjaro.

Benefits

This long-acting therapy provides steady basal insulin coverage. Many users appreciate flexible timing options as permitted by the label. The device is simple to dial, with clear clicks and an easy push button. Lower injection volume with the higher-strength device may improve comfort for some.

Side Effects and Safety

Low blood sugar (sweating, shakiness, confusion)
Injection-site reactions or redness
Skin thickening or depressions at sites
Edema or weight change
Cold-like symptoms

Serious events can include severe hypoglycemia, severe allergic reactions, and low potassium. Risk of hypoglycemia increases when used with other glucose-lowering agents that cause lows. Insulin and sulfonylureas together may require closer monitoring. Seek urgent help for symptoms of severe low blood sugar or signs of an allergic reaction.

Drug Interactions and Cautions

Medicines that may raise glucose include steroids, some antipsychotics, and certain antivirals. Agents that may increase hypoglycemia risk include other insulins and insulin secretagogues. Beta-blockers may mask low blood sugar symptoms. Alcohol can affect glucose and may increase lows. Thiazolidinediones can cause fluid retention and may worsen heart failure. Always review your full medication list with a healthcare professional.

What to Expect Over Time

Glucose patterns usually stabilize with consistent daily use, routine meals, and regular monitoring. Some adjustments may be needed as diet, activity, or other therapies change. Track fasting and pre-meal readings, and bring logs to appointments. Adherence to the same injection window helps your team interpret trends. For community stories and seasonal tips, see Diabetes Month 2025.

Compare With Alternatives

Other basal options include insulin glargine products and higher-strength glargine for concentrated dosing. Consider the device features, dose increments, and your treatment goals.

Two options to discuss with your prescriber:

Lantus SoloStar Pens: insulin glargine U-100 in a familiar pen device.
Toujeo DoubleStar: insulin glargine U-300 for patients needing higher daily units.

Pricing and Access

Canadian-sourced basal insulin can offer meaningful savings compared with local cash-pay options. Review current pricing and product details on this page. For periodic offers, see our Promotions.

We provide US shipping from Canada. To check availability and your total before checkout, add the item to your cart. If you have questions about insurance or paying out of pocket, our team can explain documentation needed by your prescriber.

Savings CTA: compare Canadian pricing to your current costs and discuss options with your clinician. Pricing CTA: sign in and add the pen to your cart to see live pricing and fees.

Availability and Substitutions

Supply can vary by strength and pack size. Your prescriber may recommend a comparable basal insulin if this item is unavailable. Ask about transitional monitoring when switching.

Many patients request the Tresiba FlexTouch box of 5 pens; alternatives or split quantities may be dispensed based on stock and your prescription.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults and children who need a stable basal insulin. It may not suit those with recurrent severe hypoglycemia or those with known hypersensitivity to insulin degludec. People with visual or dexterity challenges might need help using the device safely.

To manage costs, consider multi-month fills if approved by your prescriber. Use refill reminders so you do not run out during travel. Combine your order with other diabetes supplies when practical. For meters, strips, and needles, browse Diabetes Care.

Questions to Ask Your Clinician

Best time of day to inject for my routine?
How to adjust if my schedule changes?
What signs of low blood sugar should I watch for?
How should I rotate injection sites?
What readings should prompt a follow-up visit?
Are my other medicines affecting my glucose?

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View All FAQs

What is Tresiba used for?
Tresiba is a long-acting basal insulin used to improve glycemic control in adults and children with diabetes mellitus. People with type 1 diabetes use it alongside a rapid-acting insulin at meals. Adults with type 2 diabetes may use it alone or with other medicines, such as metformin or GLP-1 therapies. It is not for treating diabetic ketoacidosis and is not a rapid-acting insulin for sudden highs. Always follow your prescriber’s plan and the official label.
How do U-100 and U-200 differ?
Both strengths contain insulin degludec. U-200 has twice the concentration of U-100, allowing a smaller injection volume for the same unit dose. The pen doses in units, not milliliters. Choose the strength your clinician prescribes. Do not transfer insulin from the pen to a syringe. Review your device’s dose increments and confirm your target dose at each injection to avoid errors.
Can I mix this insulin with others?
Basal insulin degludec is not intended to be mixed or diluted with other insulins. Mixing can alter onset, duration, and absorption. If you use a rapid-acting insulin at meals, administer it as a separate injection. Your prescriber may adjust timing between injections based on your regimen. Always consult official labeling and your healthcare professional before considering any changes.
How long can an opened pen last?
Follow the in-use storage period in the official instructions. In general, basal pens have an in-use time window at room temperature away from heat and light. After that window, discard the pen even if insulin remains. Keep unopened pens refrigerated as directed. Do not freeze. Protect pens from excessive heat during travel, and avoid leaving them in vehicles or direct sunlight.
What needles work with the FlexTouch pen?
Most standard pen needles from major manufacturers are compatible, in lengths commonly used for subcutaneous injections. Your pharmacist can suggest a needle length and gauge suitable for your body type and technique. Always use a new sterile needle for each dose. Dispose of used needles in an approved sharps container to reduce needlestick risks and contamination.
Is it safe to use during illness or surgery?
Illness, stress, or surgery can change insulin needs. Your clinician may provide a sick-day plan that includes more frequent glucose checks and ketone testing for type 1 diabetes. Do not stop basal insulin without medical guidance. Keep hydrated and monitor levels closely. Contact your care team for individualized instructions if you have vomiting, fever, or planned procedures.
Can children use this insulin?
Basal insulin degludec is approved for pediatric patients in many regions. Dosing is individualized by age, weight, and glucose targets. Children using basal insulin require careful supervision, education on hypoglycemia recognition, and support at school or activities. Parents and caregivers should learn injection technique, site rotation, and signs that require urgent care. Always follow the pediatric dosing guidance in the official label.