Xospata® (gilteritinib) Tablets for FLT3‑Mutated Relapsed AML

What Xospata Is and How It Works

Xospata® (gilteritinib) is a targeted cancer medicine for adults with relapsed or refractory acute myeloid leukemia (AML) that tests positive for an FLT3 mutation. It is an oral tablet taken once daily. Many people search for xospata price and options for xospata without insurance when planning treatment costs. YouDrugstore is a licensed Canadian pharmacy in Manitoba, and our pharmacists review every prescription before dispensing.

Gilteritinib blocks FLT3, a receptor tyrosine kinase that can drive AML cell growth when mutated. By inhibiting FLT3 signaling, Xospata® can slow or stop leukemia cell survival and allow normal blood cell recovery. It is used as monotherapy in this setting. Your oncology team confirms the FLT3 mutation before starting therapy.

We work with licensed, screened partner pharmacies internationally to supply authentic brand medications, keeping a broad selection available at fair prices.

Dosage and Usage

Follow your prescriber’s directions and the package insert. Typical use is once daily until disease progression or unacceptable toxicity.

• Standard starting dose: 120 mg by mouth once daily.
• Take with or without food. Swallow tablets whole with water.
• Do not crush or split the tablets.
• If you miss a dose, take it the same day when remembered. Skip if it is close to the next dose. Do not double up.
• If you vomit after a dose, do not take an extra tablet. Take the next dose as scheduled.
• Your care team may interrupt or reduce to 80 mg (or lower) for side effects.
• Periodic ECGs and lab tests check heart rhythm, electrolytes, liver enzymes, and other safety markers.

Storage and travel tips:

• Store at room temperature, about 20–25°C (68–77°F).
• Keep in the original, tightly closed container. Protect from moisture.
• Keep out of reach of children and pets.
• When traveling, carry in your hand luggage with your prescription label.
• Avoid leaving tablets in hot cars or near heat sources.

Benefits and Savings

Xospata® improved survival and remission rates versus salvage chemotherapy in adults with relapsed or refractory FLT3-mutated AML in clinical trials. Many patients achieved blood count recovery and needed fewer transfusions. The once-daily tablet is convenient, and there is no routine premedication.

Ordering through YouDrugstore offers typical savings of 60–80% compared with common U.S. retail prices. These savings can be helpful if you are paying without insurance. You can order online or by phone during posted office hours, and our team is available by chat for customer support questions.

Side Effects and Safety

All medicines can cause side effects. Your oncology team monitors you and adjusts treatment when needed.

• Common: fatigue, nausea, diarrhea or constipation, decreased appetite, mouth sores, rash, headache, dizziness, cough, shortness of breath, swelling, joint or muscle pain, and increased liver enzymes.
• Serious: differentiation syndrome (fever, cough, chest pain, weight gain, swelling, low blood pressure), QT prolongation or abnormal heart rhythm (fainting, palpitations), pancreatitis (severe abdominal pain, vomiting), liver injury (yellowing skin or eyes, dark urine), posterior reversible encephalopathy syndrome or PRES (headache, confusion, vision changes, seizures), and lung inflammation or infection.
• Seek urgent care for symptoms of differentiation syndrome, severe chest pain, fainting, new seizures, or severe shortness of breath.
• Pregnancy: can harm an unborn baby. Effective contraception is advised during treatment and for a period after the last dose, as guided by your prescriber.
• Avoid breastfeeding during therapy and for a period after the last dose per medical advice.

Drug interactions can raise or lower gilteritinib levels. Strong CYP3A inhibitors or inducers, some antibiotics, antifungals, antivirals, and herbal products (such as St. John’s wort) can interact. Grapefruit may also interact. Your care team may adjust the dose or switch interacting medicines.

Onset Time

Responses vary by person, disease burden, prior therapies, and mutation profile. Some patients see blood count improvements within weeks. Deeper responses may take one to two months or longer. Your team will track response with blood tests, marrow exams, and clinical assessments.

Compare With Alternatives

Midostaurin is another FLT3 inhibitor used mainly with induction chemotherapy for newly diagnosed FLT3-mutated AML. It is taken with standard chemo, not usually as single-agent therapy for relapse. Quizartinib is an FLT3-ITD inhibitor used in some regions for relapsed disease. Availability and mutation coverage differ by country and label.

These options differ in dosing schedules, mutation selectivity, and side-effect profiles. Choice depends on timing in the treatment pathway, transplant plans, and comorbidities. While not AML therapies, other targeted oncology agents such as Xalkori® and Zytiga® illustrate how precision medicines are matched to tumor markers and can also be ordered through our pharmacy.

Combination Therapy

Xospata® is most often used alone for relapsed or refractory FLT3-mutated AML. It is being studied with hypomethylating agents and other partners in some settings. Your specialist may plan treatment around transplant, maintenance, or additional therapies based on response and tolerance.

Gilteritinib is metabolized by CYP3A. Strong CYP3A inhibitors can raise levels and increase side effects. Strong CYP3A inducers can lower levels and reduce efficacy. Your prescriber may adjust the dose or avoid certain combinations. Always share a complete medication and supplement list with your oncology team.

Patient Suitability and Cost-Saving Tips

Adults with relapsed or refractory AML and a confirmed FLT3 mutation may be candidates. Suitability depends on overall health, other medicines, heart rhythm history, and organ function. It is not intended for children. Those who are pregnant or nursing should speak with their care team about risks and timing.

To help manage costs, consider multi-month supplies when appropriate, which can lower the monthly average. We also offer reorder reminders so you do not run out. For current promotions or a possible xospata coupon, visit our promotions page. If you are paying as an individual, we can discuss options for those who are uninsured.

Learn more about the disease area by visiting our Cancer category. For practical tips on managing treatment effects, see articles like Common Darzalex Side Effects And Tips To Manage Them and Understanding Calquence Medication For Cancer Treatment. Concepts about monitoring and supportive care often apply across oncology treatments.

Authoritative Sources

FDA Prescribing Information for Xospata (gilteritinib)

European Medicines Agency EPAR: Xospata

Health Canada Drug Product Database

YouDrugstore offers brand and generic medicines at Canadian prices and ships to the U.S. Our team is here to help with ordering and shipping questions, and our pharmacists can address medication questions tied to your prescription. Expect prompt, express, cold-chain shipping where needed.

This information is educational and does not replace advice from your oncology team. Always follow your prescriber’s instructions and the patient information leaflet. Seek medical care for urgent symptoms or suspected side effects.