Estradot® (Vivelle Dot®) Transdermal Estradiol Patches for Menopause Relief

What Estradot® (Vivelle Dot®) Is and How It Works

Estradot (Vivelle Dot) is a transdermal estradiol patch used to treat moderate to severe menopause symptoms, including hot flashes, night sweats, and vaginal dryness. It also helps prevent postmenopausal bone loss when other options are not suitable. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and licensed pharmacists review prescriptions before dispensing. If you need to buy Estradot Vivelle Dot without insurance, ordering from a Canadian pharmacy can lower costs.

Each patch delivers estradiol through the skin at a steady rate. Transdermal delivery avoids first-pass metabolism and may provide stable serum levels. Typical strengths include 0.025 mg/day, 0.0375 mg/day, 0.05 mg/day, 0.075 mg/day, and 0.1 mg/day. We partner with licensed, vetted international partner pharmacies to supply authentic brand medicines, offering a wide selection at competitive prices.

Dosage and Usage

• Estradot (Vivelle Dot) patches are usually changed twice weekly (every 3 to 4 days).
• Initial dosing often starts at the lowest effective strength; prescribers adjust based on symptom control.
• Apply to clean, dry, intact skin on the lower abdomen or buttocks; never apply to the breasts.
• Avoid applying over oily, irritated, or recently shaved skin; do not use lotions or powders on the site.
• Open the pouch, remove the liner, place the patch, and press firmly for 10 seconds, especially around the edges.
• Rotate sites; wait at least one week before using the same area again to reduce skin irritation.
• If a patch loosens, press it firmly. If it falls off, apply a new patch and continue the original schedule.
• Missed change: apply a new patch as soon as remembered; then resume the regular change days.
• Bathing, swimming, and exercise are usually fine; prolonged exposure to heat (sauna, heating pads) may affect adhesion or absorption.
• Fold used patches with sticky sides together and discard safely out of reach of children and pets.

• Store patches at room temperature, ideally 20–25 °C (68–77 °F); keep in the sealed pouch until use.
• Protect from excessive heat, moisture, and direct sunlight; do not freeze.
• For travel, keep patches in original packaging in your carry-on. Bring an extra box in case of delays.
• Do not cut patches. Keep away from children and pets.
• Check expiration dates before use. Do not use damaged or expired patches.

Benefits and Savings

Estradot delivers consistent estrogen levels with a small, discreet patch. Many people report fewer hot flashes and night sweats within weeks. Skin delivery may be gentler on the liver than some oral options, and twice-weekly changes are convenient. The compact patch design may improve comfort and adherence.

Ordering from YouDrugstore gives access to Canadian pricing. Typical savings are 60–80% compared with many US pharmacy prices, depending on strength and quantity. Estradot (Vivelle Dot) cost varies by package size, and a multi-month supply can reduce the per-month Estradot Vivelle Dot price. If paying without insurance, you can compare Estradot Vivelle Dot pricing across strengths to meet budget goals.

We offer discreet shipping and optional reorder reminders so you can keep therapy on track. A bulk buy can further lower Estradot Vivelle Dot cash price for ongoing treatment.

For extra value, an Estradot Vivelle Dot coupon may be listed on our promotions page when available.

Side Effects and Safety

• Skin irritation or redness at the application site
• Breast tenderness or enlargement
• Headache or migraine
• Nausea, bloating, or abdominal discomfort
• Mood changes, irritability, or fatigue
• Irregular bleeding or spotting
• Leg cramps or back pain
• Fluid retention or mild swelling

Serious risks are uncommon but can include blood clots (deep vein thrombosis or pulmonary embolism), stroke, heart attack, gallbladder disease, high blood pressure, and liver problems. Estrogen can increase endometrial cancer risk when used without a progestin in people with a uterus. Those with estrogen-dependent tumors, unexplained vaginal bleeding, active or past clotting disorders, liver disease, or a history of stroke should not use systemic estrogen therapy. Discuss personal risks and the need for a progestin with a clinician.

Onset Time

Relief from hot flashes and night sweats often begins within 1 to 2 weeks as a stable dose is reached. Maximum benefit typically develops over 4 to 8 weeks. Vaginal symptoms may improve over several weeks, though some patients need local estrogen therapy for optimal results. Bone density protection requires consistent use over months.

Compare With Alternatives

Climara® is a once-weekly estradiol patch. Weekly changes may suit those who prefer fewer patch changes, though some find twice-weekly systems provide steadier comfort with smaller patches. Choosing between Estradot and Climara depends on dosing needs, skin tolerance, and convenience.

Estrogel® is a daily estradiol gel applied to the skin. Gels offer flexible titration and avoid adhesives, which may help those with patch-site reactions. Daily application requires routine consistency.

Estalis® combines estradiol with a progestin in a single twice-weekly patch. It may suit those who need endometrial protection and prefer a combined system. Some still prefer pairing Estradot with an oral or vaginal progestin to individualize doses.

Combination Therapy

• Estradiol patch plus a progestin (e.g., micronized progesterone or norethindrone) for those with a uterus to reduce endometrial cancer risk.
• Estradiol patch with local vaginal estrogen for persistent genitourinary symptoms when systemic control is not enough.
• Estradiol patch with nonhormonal agents (e.g., SSRIs/SNRIs, gabapentin) when additional vasomotor symptom relief is needed, as guided by a prescriber.

Patient Suitability and Cost-Saving Tips

Candidates include those with bothersome vasomotor symptoms or those needing osteoporosis prevention when alternatives are not appropriate. Transdermal estrogen may be considered in patients with higher triglycerides or migraine with aura risk profiles, under medical supervision. It is not for use during pregnancy or breastfeeding.

People with a history of blood clots, stroke, heart attack, estrogen-dependent cancers, active liver disease, or unexplained vaginal bleeding generally should avoid systemic estrogen. Patch users with a uterus typically need a progestin to lower endometrial risks. Report new headaches, chest pain, sudden shortness of breath, leg swelling, or vision changes promptly.

To lower costs, choose larger pack sizes when available, and plan refills ahead of time. Reorder reminders help avoid gaps. A multi-month supply may decrease the per-month Estradot Vivelle Dot cost without insurance. Look for an Estradot Vivelle Dot discount during a periodic sale or promo if timing is flexible. If paying out of pocket, compare strengths to balance value and symptom control.

Authoritative Sources

Vivelle-Dot official patient site

Health Canada Drug Product Database: Estradot

FDA Drugs@FDA: Vivelle-Dot prescribing information

Order Estradot® (Vivelle Dot®) from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This content is for educational purposes and does not replace advice from your healthcare professional.