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Abilify Side Effects: What to Watch For and How to Manage

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Abilify, also known as aripiprazole, is a prescription medication used for conditions such as schizophrenia, bipolar disorder, major depression (as an add-on), and irritability related to autism. It can be very effective, but it may cause side effects like all medications.

Understanding Abilify side effects helps you spot problems early and work with your healthcare provider to manage them. This makes your treatment safer and more comfortable.

What Are the Side Effects of Abilify?

If you’re curious about the side effects of Abilify, they can range from mild to more serious.

The most common include nausea, dizziness, headache, trouble sleeping, restlessness, constipation, blurred vision, and weight gain. These symptoms are usually temporary and tend to get better as your body adapts.

Some side effects are more serious and require immediate care. These include:

  • Uncontrolled movements in the face or tongue (tardive dyskinesia)
  • High fever, muscle stiffness, and confusion (possible neuroleptic malignant syndrome)
  • Severe mood changes or thoughts of self-harm
  • Signs of high blood sugar, such as extreme thirst, frequent urination, or unexplained weight loss

If you notice these, contact a healthcare provider right away.

How Long Until Abilify Side Effects Go Away?

For many people, mild Abilify side effects improve within one to two weeks. Stomach upset, headaches, and mild dizziness often fade first. Restlessness or sleep changes may take longer, sometimes several weeks.

Some effects, such as weight gain or changes in blood sugar, can last longer and may need ongoing monitoring. If side effects do not improve after a month or worsen, speak to your doctor about adjusting your treatment.

Managing Common Side Effects of this Medication

Mild nausea can often be reduced by taking Abilify with food or a small snack. If dizziness occurs, stand up slowly and drink enough fluids during the day.

Restlessness (akathisia) can be managed with light activity, such as walking, or medication adjustments from your provider. Sleep problems may improve by taking Abilify in the morning and keeping a regular bedtime routine.

Constipation may respond to more fiber, extra water, and regular exercise. Always let your doctor know if home strategies are not helping.

Abilify Long Term Side Effects

Some people experience Abilify long term side effects, especially with extended use. These can include weight gain, high blood sugar, movement disorders, and changes in cholesterol levels.

Your doctor will likely regularly check your weight, blood sugar, and cholesterol. Early detection allows changes to be made before problems worsen.

Side Effects of Stopping Abilify

Stopping Abilify suddenly can cause withdrawal symptoms and trigger a return of the condition it was treating. The side effects of stopping Abilify can include nausea, sleep problems, irritability, and anxiety.

Always work with your doctor to gradually lower your dose rather than stopping abruptly. This helps prevent withdrawal effects and keeps symptoms under control.

When to Seek Immediate Medical Help

Seek urgent care if you develop a sudden high fever, severe muscle stiffness, confusion, seizures, facial swelling, or difficulty breathing. Also, seek help right away for sudden, uncontrollable muscle movements or extreme thirst with frequent urination. 

Conclusion

Knowing the possible Abilify side effects allows you to manage them effectively and keep your treatment on track. Most side effects are mild and short-term, but some need quick medical attention. Regular check-ins with your provider, healthy lifestyle habits, and early reporting of symptoms can help you get the most from your medication while staying safe.

If you’re starting treatment or exploring your options, visit our Abilify Medication Page for full details, dosing guidance, and support.

Frequently Asked Questions (FAQs)

Does Abilify cause weight gain?

Yes, weight gain can occur in some patients, especially with long-term use. This may be related to changes in appetite, metabolism, or activity levels while on the medication. Regular exercise and balanced nutrition can help manage this risk, and your provider can suggest additional strategies if needed.

Can Abilify make you feel restless?

Yes, restlessness is a possible side effect known as akathisia, which can make you feel like you need to move constantly. This symptom can be uncomfortable, but your provider may adjust your dose or prescribe another medication to help reduce it. 

Is Abilify safe to take long-term?

Yes, Abilify can be safe for long-term use when monitored by a healthcare provider. Your doctor will regularly check for side effects such as weight changes, blood sugar issues, or movement disorders. 

Can I drink alcohol while on Abilify?

Alcohol can increase side effects such as dizziness, drowsiness, and difficulty concentrating while taking Abilify. It’s generally safest to limit or avoid alcohol use while on this medication. Discuss your drinking habits with your provider so they can give guidance tailored to your situation. 

Medically Reviewed

Profile image of Lalaine c

Medically Reviewed By Lalaine c

Profile image of Lalaine c

Written by Lalaine c on August 13, 2025

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