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Intelence (etravirine) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretroviral drugs to treat HIV-1 infection. It is indicated for treatment-experienced patients aged two years and older.
Benefits
Intelence helps manage HIV-1 infection by inhibiting the reverse transcriptase enzyme, which is crucial for the replication of the virus. This medication is part of a combination therapy that can effectively reduce viral load and improve immune function.
How to Use
Intelence should be taken orally twice daily after meals. For patients unable to swallow tablets, the medication can be dissolved in water. It is important to follow the specific dosing instructions provided by a healthcare professional.
Possible Side Effects
Intelence may cause severe and potentially life-threatening skin reactions, including:
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Erythema multiforme
If a serious hypersensitivity reaction occurs, the medication should be discontinued immediately.
Warnings and Precautions
Patients co-infected with hepatitis B virus (HBV) and HIV require special attention. They should be screened for HBV and started on an antiretroviral regimen targeting both viruses. Co-infected patients should also be vaccinated against hepatitis A and HBV and avoid alcohol. Regular testing for hepatitis C virus (HCV) is recommended for those at high risk.
Pregnant women should use highly active antiretroviral therapy regardless of viral load and CD4 count. Intelence should not be used during breastfeeding, as it can accumulate in breast milk. The CDC advises all HIV-positive women to avoid breastfeeding to prevent virus transmission.
Storage
Store Intelence at room temperature, away from moisture and heat. Keep the medication in its original container and out of reach of children.
Additional Information
Consult the product monograph for detailed information on drug interactions and other adverse reactions. It is important for prescribers to review this information to ensure safe and effective use of Intelence.
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