Levothyroxine Sodium Injection Vial

Uses of Levothyroxine Sodium Injection Vial

Levothyroxine Sodium Injection Bial are indicated for replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. Specific indications include: primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) hypothyroidism. Primary hypothyroidism may result from functional deficiency, primary atrophy, partial or total congenital absence of the thyroid gland, or from the effects of surgery, radiation, or drugs, with or without the presence of goiter.

Pediatrics: Levothyroxine Sodium for Injection and Levothyroxine Sodium Injection are approved for use in the pediatric population

Precautions and Warnings

Cardiac Adverse Reactions in the Elderly and in Patients with Underlying Cardiovascular Disease: Overtreatment may cause arrhythmias, tachycardia, myocardial ischemia and infarction, or worsening of congestive heart failure and death, particularly in patients with cardiovascular disease and in elderly. patients. Start with lower doses in elderly patients and in patients with underlying cardiovascular disease and monitor patients after administration
Acute Adrenal Crisis in Patients with Concomitant Adrenal Insufficiency Initiation of thyroid hormone therapy prior to initiating glucocorticoid therapy may precipitate an acute adrenal crisis in patients with adrenal insufficiency. Treat patients with adrenal insufficiency with replacement glucocorticoids prior to initiating treatment.
Worsening of Diabetic Control: May worsen glycemic control and result in increased antidiabetic agent or insulin requirements. Carefully monitor glycemic control.

Pregnant Women: Studies in women taking levothyroxine sodium during pregnancy have not shown an increased risk of congenital abnormalities. Levothyroxine Sodium for Injection and Levothyroxine Sodium Injection should not be discontinued during pregnancy, and hypothyroidism diagnosed during pregnancy should be promptly treated. Hypothyroidism during pregnancy is associated with a higher rate of complications, including spontaneous abortion, pre-eclampsia, stillbirth and premature delivery. Maternal hypothyroidism may have an adverse effect on fetal and childhood growth and development.

Dosage

An initial intravenous loading dose of Levothyroxine Sodium Injection between 300 to 500 mcg, followed by once daily intravenous maintenance doses between 50 and 100 mcg, should be administered, as clinically indicated, until the patient can tolerate oral therapy.
The age, general physical condition, and cardiac risk factors of the patient, as well as the clinical severity of myxedema and duration of myxedema symptoms should be considered when determining the starting and maintenance dosages of Levothyroxine Sodium Injection.

Side Effects

Common Side effects:

• fever, hot flashes, increased sweating;
• tiredness;
• skin rash, hair loss;
• chest pain, fast or irregular heartbeats, shortness of breath;
• headache, leg cramps, muscle pain or weakness;
• tremors, feeling nervous or irritable, sleep problems (insomnia);
• increased or change in appetite;
• weight loss or weight gain;
• changes in your menstrual periods; or
• vomiting, diarrhea.

Serious Side Effects:

• sudden pain or trouble moving your hip, wrist, or back;
• fast or irregular heartbeats;
• chest pain, pain spreading to your jaw or shoulder;
• wheezing;
• fever, swollen glands, itching, joint pain, or not feeling well;
• high blood sugar – increased thirst, increased urination, dry mouth, fruity breath odor.