What is Combigan used for?

Combigan is a prescription combination eye medicine for reducing elevated intraocular pressure in people with open‑angle glaucoma or ocular hypertension. It contains brimonidine and timolol, which work together to decrease fluid production and support outflow from the eye. Clinicians often consider it when a single agent has not provided enough pressure lowering. Use it only as directed by your healthcare professional and follow the official label for detailed instructions.

How soon might I notice changes in eye pressure?

Response varies. Many patients see pressure reductions measured at follow‑up appointments after consistent use. Technique and adherence matter. Apply one drop in each affected eye as prescribed, usually twice daily, and use punctal occlusion to reduce systemic absorption. Your prescriber will monitor intraocular pressure over time and decide whether to continue, adjust, or switch therapy based on your response and tolerance.

Can I use these drops with contact lenses?

Yes, but remove soft contact lenses before instilling the medicine. Wait at least 15 minutes after dosing before reinserting lenses. This helps limit lens exposure to the preservative and supports comfort. If lenses irritate your eyes during treatment, discuss alternative lens schedules or lens types with your eye care professional. Always avoid touching the dropper tip to lenses or any surface to keep the solution sterile.

What if I feel burning or redness after dosing?

Mild stinging, redness, or irritation can occur and often improves as you adjust. If burning is severe, persistent, or accompanied by swelling, significant vision changes, breathing difficulty, wheezing, or a slow heartbeat, seek medical attention. Avoid driving until your vision clears after instillation. Report ongoing discomfort to your prescriber, who may adjust your plan or suggest alternatives if the reaction does not resolve.

Is it safe if I have asthma or heart problems?

The timolol component is a beta‑blocker, which can affect breathing and heart rate. People with asthma, severe COPD, slow pulse, heart block, or heart failure should use caution and consult a clinician before use. Your prescriber will weigh potential benefits and risks, considering other medicines you take. Provide a full medical history, including any prior reactions to beta‑blockers or similar eye products.

Can children use this medicine?

Pediatric safety and efficacy are not established in all age groups for this combination. Children, especially very young patients, may be more susceptible to systemic effects from ophthalmic beta‑blockers. A pediatric specialist should guide use, dosing, and monitoring if it is considered. Do not start or continue therapy in a child without clear direction from a qualified healthcare professional familiar with pediatric glaucoma management.

What if I am pregnant or breastfeeding?

If you are pregnant, planning pregnancy, or breastfeeding, discuss risks and benefits with your prescriber. Systemic absorption can occur with ophthalmic products. Your clinician will consider your eye condition, alternative therapies, and timing. Techniques like punctal occlusion may help limit systemic exposure. Only a healthcare professional can determine whether to start, continue, or change treatment during pregnancy or lactation.

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Combigan is a prescription eye medicine used to lower raised eye pressure in open-angle glaucoma and ocular hypertension. It combines two pressure‑reducing agents in a single bottle. This page explains how it works, safe use, and what to discuss with your prescriber.

What Combigan Is and How It Works

US delivery from Canada is available for this prescription through our pharmacy service. Combigan® eye drops without insurance may help some patients manage costs when paying cash. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This combination pairs brimonidine, an alpha‑2 adrenergic agonist, with timolol, a nonselective beta‑blocker. Brimonidine can reduce aqueous humor production and may increase uveoscleral outflow. Timolol mainly decreases fluid production within the eye. Together, the treatment lowers intraocular pressure (IOP) when a single agent is not enough.

The class is a brimonidine timolol ophthalmic solution designed for use in the affected eye or eyes. Mechanisms are complementary, and fixed‑dose pairing can simplify routines compared to separate bottles. Follow your clinician’s instructions and the official product label.

Who It’s For

This medicine is indicated to reduce elevated IOP in people with open‑angle glaucoma or ocular hypertension when additional lowering is needed. It is generally used in adults.

People with certain heart or lung conditions should avoid or use caution. This includes asthma, severe chronic obstructive pulmonary disease, slow heart rate, heart block, or overt cardiac failure. Those with hypersensitivity to any component should not use it. Use in children is limited; pediatric safety and efficacy may differ. Always discuss your medical history with a healthcare professional.

Dosage and Usage

Combigan eye drops dosage typically follows labeled guidance: instill one drop in the affected eye or eyes twice daily, about 12 hours apart. Do not exceed the prescribed schedule. If you use other eye medicines, separate them by at least 5 minutes.

Administration basics:

Clean hands first, then open the bottle.
Remove soft contact lenses; wait 15 minutes after dosing to reinsert.
Do not touch the dropper tip to any surface or the eye.
Gently pull down the lower lid to form a pocket and place one drop.
After dosing, press a finger over the inner corner of the eye for 1–2 minutes to reduce systemic absorption.

If directions are unclear, follow the official label and ask your prescriber or pharmacist.

Strengths and Forms

The fixed combination is supplied as an ophthalmic solution in a multi‑dose bottle. Commonly referenced presentation is Combigan ophthalmic drops 0.2%/0.5% in a 5 mL size. Availability may vary by market and manufacturer. Packaging may update over time.

Missed Dose and Timing

If you miss a dose, use it as soon as you remember unless it is almost time for the next one. In that case, skip the missed dose and return to your regular schedule. Do not double up doses. Consistent timing helps maintain stable pressure control.

Storage and Travel Basics

Store the bottle at room temperature unless the label states otherwise. Keep it tightly closed, away from excessive heat and light, and out of children’s reach. Do not freeze the solution. Keep the dropper tip clean to protect the contents from contamination.

For travel, carry your eye medicine in your hand luggage with the original labeled container. Pack a copy of your prescription. Avoid leaving the bottle in a hot car or in direct sunlight. If you use daily contact lenses, plan for the 15‑minute interval after dosing before reinsertion to reduce preservative exposure.

When you return home, check the bottle for any damage or leakage. Discard the product by the labeled discard date or if the solution changes color or becomes cloudy.

Benefits

This therapy combines two complementary agents in one bottle, which can simplify dosing compared with using separate products. Twice‑daily use may suit routines built around morning and evening habits. Fixed combinations can also reduce exposure to multiple preservatives from different bottles. Many patients appreciate the convenience when a single agent has not achieved sufficient IOP reduction.

Side Effects and Safety

Common effects can include:

Eye redness or irritation
Burning or stinging on instillation
Dry mouth or altered taste
Blurred vision shortly after dosing
Eyelid irritation or allergic‑type symptoms
Fatigue, drowsiness, or headache

More serious reactions are less common but can occur. These may include severe allergic responses, significant breathing difficulty, wheezing, slow heart rate, or worsening heart symptoms. If you use systemic beta‑blockers or have respiratory disease, discuss added risk with your clinician. Stop use and seek medical attention if severe reactions occur. Avoid driving or operating machinery until vision clears after dosing.

Drug Interactions and Cautions

Potential interactions include other beta‑blockers, calcium channel blockers, digoxin, and medicines that affect heart rate or blood pressure. Agents for depression, including monoamine oxidase inhibitors and certain tricyclics, may interact with the alpha‑2 agonist component. Combining multiple IOP‑lowering eye products can increase effects; space dosing and follow your prescriber’s plan.

Use caution with a history of asthma, COPD, bradycardia, heart block, heart failure, depression, cerebrovascular disease, or severe allergy. Tell your clinician about all medicines, eye products, and supplements you take. Contact lens wearers should remove lenses before instillation and wait before reinsertion as directed.

What to Expect Over Time

With regular use, many patients experience sustained IOP lowering as assessed at follow‑up visits. Your prescriber may check technique, adherence, and pressure response over time. If IOP remains above target or side effects limit use, the plan may be adjusted. Keeping a dosing routine, using punctal occlusion, and spacing other eye medicines can support effectiveness and tolerability.

Compare With Alternatives

Other prescription options can also reduce IOP. For patients who need a carbonic anhydrase inhibitor plus a beta‑blocker, a fixed combination such as Dorzolamide Timolol may be considered by a prescriber. A prostaglandin analog like Latanoprost Ophthalmic is often used as initial therapy or add‑on in many cases. Your clinician will choose based on response, tolerability, and medical history.

Pricing and Access

If you are comparing options, review current Combigan eye drops price alongside any applicable fees at checkout. Canadian pricing may offer value compared with typical local rates. For current offers, see our Promotions page.

We provide transparent pricing and a secure checkout experience. US shipping from Canada supports access for eligible prescriptions. Prescription required and verified.

Availability and Substitutions

Supply can vary by manufacturer and market. If the brand is not available, a prescriber may recommend another option or a different class. Ask about generic Combigan eye drops or comparable therapies when appropriate. Do not switch products without guidance from your healthcare professional.

Patient Suitability and Cost-Saving Tips

Good candidates are adults needing additional IOP lowering when a single agent is not sufficient. People with significant asthma, severe COPD, heart block, or very slow pulse may not be suitable due to the beta‑blocker component. Discuss pregnancy, breastfeeding, and pediatric use with your prescriber before starting.

To manage costs, consider multi‑month supplies if your prescription allows, and set refill reminders so you do not run out. Keep your technique consistent to avoid wasted drops. If costs are a concern, talk with your clinician about alternatives or spacing visits to match refill timing.

Questions to Ask Your Clinician

Is this combination right for my type of glaucoma or ocular hypertension?
How should I time doses with my other eye medicines?
What side effects should prompt a call or visit?
Could my heart or lung conditions affect the safety of this therapy?
If my pressure is still high, what is the next step?
Can I use it while wearing contact lenses, and what wait time is best?

Authoritative Sources

Learn more from official references:

Explore more on eye health and routine care in Healthy Vision Month, and browse relevant categories like Glaucoma, Ocular Hypertension, and Ophthalmology. Related products you may discuss with your prescriber include Timolol and Vyzulta Ophthalmic.

Ready to proceed? Add the item to your cart for prompt, express shipping. Always follow your prescriber’s directions and the official label.

This information is for general education and is not a substitute for professional medical advice. Your clinician should determine suitability and dosing.

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View All FAQs

What is Combigan used for?
Combigan is a prescription combination eye medicine for reducing elevated intraocular pressure in people with open‑angle glaucoma or ocular hypertension. It contains brimonidine and timolol, which work together to decrease fluid production and support outflow from the eye. Clinicians often consider it when a single agent has not provided enough pressure lowering. Use it only as directed by your healthcare professional and follow the official label for detailed instructions.
How soon might I notice changes in eye pressure?
Response varies. Many patients see pressure reductions measured at follow‑up appointments after consistent use. Technique and adherence matter. Apply one drop in each affected eye as prescribed, usually twice daily, and use punctal occlusion to reduce systemic absorption. Your prescriber will monitor intraocular pressure over time and decide whether to continue, adjust, or switch therapy based on your response and tolerance.
Can I use these drops with contact lenses?
Yes, but remove soft contact lenses before instilling the medicine. Wait at least 15 minutes after dosing before reinserting lenses. This helps limit lens exposure to the preservative and supports comfort. If lenses irritate your eyes during treatment, discuss alternative lens schedules or lens types with your eye care professional. Always avoid touching the dropper tip to lenses or any surface to keep the solution sterile.
What if I feel burning or redness after dosing?
Mild stinging, redness, or irritation can occur and often improves as you adjust. If burning is severe, persistent, or accompanied by swelling, significant vision changes, breathing difficulty, wheezing, or a slow heartbeat, seek medical attention. Avoid driving until your vision clears after instillation. Report ongoing discomfort to your prescriber, who may adjust your plan or suggest alternatives if the reaction does not resolve.
Is it safe if I have asthma or heart problems?
The timolol component is a beta‑blocker, which can affect breathing and heart rate. People with asthma, severe COPD, slow pulse, heart block, or heart failure should use caution and consult a clinician before use. Your prescriber will weigh potential benefits and risks, considering other medicines you take. Provide a full medical history, including any prior reactions to beta‑blockers or similar eye products.
Can children use this medicine?
Pediatric safety and efficacy are not established in all age groups for this combination. Children, especially very young patients, may be more susceptible to systemic effects from ophthalmic beta‑blockers. A pediatric specialist should guide use, dosing, and monitoring if it is considered. Do not start or continue therapy in a child without clear direction from a qualified healthcare professional familiar with pediatric glaucoma management.
What if I am pregnant or breastfeeding?
If you are pregnant, planning pregnancy, or breastfeeding, discuss risks and benefits with your prescriber. Systemic absorption can occur with ophthalmic products. Your clinician will consider your eye condition, alternative therapies, and timing. Techniques like punctal occlusion may help limit systemic exposure. Only a healthcare professional can determine whether to start, continue, or change treatment during pregnancy or lactation.