Combigan® Ophthalmic Solution for Lowering Eye Pressure

What Combigan® Is and How It Works

Combigan® is a prescription ophthalmic solution that lowers intraocular pressure in open-angle glaucoma and ocular hypertension. These are brimonidine tartrate 0.2% and timolol maleate 0.5% eye drops in one bottle. Many people search for Combigan eye drops online when they want a convenient, twice-daily combination. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and our pharmacists review prescriptions before dispensing.

Combigan® combines two proven agents. Brimonidine is an alpha-2 adrenergic agonist that decreases aqueous humor production and increases uveoscleral outflow. Timolol is a nonselective beta-blocker that reduces aqueous humor formation. Together they reduce eye pressure more than either alone, with a dosing schedule of one drop in the affected eye(s) every 12 hours. The solution strength is often listed as Combigan 0.2 0.5 solution or Combigan brimonidine tartrate timolol maleate.

We also work with licensed, vetted international partner pharmacies to source authentic brand medicines, offering a broad selection at affordable pricing.

Dosage and Usage

• Usual dose: instill one drop in the affected eye(s) twice daily, about 12 hours apart.
• Do not exceed two doses per day unless your prescriber directs otherwise.
• Wash and dry your hands before use. Shake gently if advised by the label.
• Tilt your head back, pull down the lower eyelid to form a pocket, and instill one drop.
• Avoid touching the dropper tip to the eye, fingers, or any surface.
• After the drop, close your eye and gently press the inner corner (punctal occlusion) for 1–2 minutes to limit systemic absorption.
• If using other ophthalmic products, separate each by at least 5 minutes. Use ointments last.
• Contact lenses: remove before use. Wait at least 15 minutes before reinserting, as benzalkonium chloride may be absorbed by soft lenses.
• Missed dose: use it when remembered unless it is close to the next dose. Do not double up.
• Common bottle sizes include Combigan 5 mL; availability of 2.5 mL can vary by market.

• Storage: store at 15–25°C (59–77°F). Short exposures up to 30°C (86°F) are usually acceptable. Do not freeze.
• Keep the cap tightly closed and the tip clean and dry.
• Protect from light and moisture. Keep the bottle upright when possible.
• Travel: keep in carry-on baggage, not in checked luggage or a hot car.
• Do not share your eye drops. Discard if the solution changes color, becomes cloudy, or after the labeled in-use period.

Benefits and Savings

Combigan eye drops provide two pressure-lowering mechanisms in one medication. This simplifies regimens and may improve adherence compared with separate brimonidine and timolol bottles. Many people see sustained reductions in intraocular pressure with a consistent twice-daily schedule.

Ordering Combigan eye drops online from Canada can lower costs. You may see 60–80% savings versus typical US prices, especially on multi-month supplies. Your Combigan eye drops price per month can drop further with bulk promotions. We also offer gentle reorder reminders so you do not run out.

For extra value, see promotions for a Combigan coupon when available.

Side Effects and Safety

• Common ocular effects: eye redness, burning or stinging, itching, dry eye, blurred vision, allergic conjunctivitis, or eyelid irritation.
• Common systemic effects: dry mouth, fatigue, drowsiness, and headache.
• Less common: eyelid crusting, foreign body sensation, photophobia, or taste changes.
• Contact lens wearers may notice lens discomfort due to benzalkonium chloride.

Serious effects are uncommon but can include slow heart rate, low blood pressure, fainting, breathing difficulties or bronchospasm (especially in asthma or severe COPD), and severe allergic reactions. Use caution with oral beta-blockers, calcium channel blockers, digoxin, and drugs that affect norepinephrine. Avoid use with monoamine oxidase inhibitors. Beta-blocker eye drops may mask signs of hypoglycemia or hyperthyroidism. Children under 2 years should not use brimonidine-containing drops.

Onset Time

Pressure lowering begins within hours of the first dose. You may notice peak daily effect within the first week. A steady, sustained response usually emerges over 2–4 weeks as dosing remains consistent. Your eye care professional will set follow-up visits to check intraocular pressure and optic nerve status.

Compare With Alternatives

Prostaglandin analogs such as Travatan Z® are often once-daily first-line options. They increase uveoscleral outflow and can lower pressure with a single nighttime dose. Combigan® may be used when additional reduction is required or when a two-in-one product improves adherence.

Alpha agonist monotherapy such as Alphagan P® Ophthalmic Solution contains brimonidine alone. It is typically used two to three times daily and may be combined with other agents when needed. Combigan® offers both brimonidine and timolol in one solution, which can reduce bottle burden.

Other choices include timolol alone, dorzolamide-timolol fixed combinations, or latanoprost. Your prescriber will weigh pressure targets, tolerability, dosing frequency, and history of response.

Combination Therapy

• With a prostaglandin analog at night plus Combigan® twice daily when further IOP reduction is needed.
• With a carbonic anhydrase inhibitor drop, spaced by at least 5 minutes.
• If also on systemic beta-blockers, monitor for bradycardia and hypotension; dose adjustments may be required.
• Use punctal occlusion after each dose to reduce systemic exposure.

Patient Suitability and Cost-Saving Tips

Combigan medication is intended for adults with open-angle glaucoma or ocular hypertension who need more than a single agent to reach pressure goals. It may not suit people with asthma, severe COPD, significant bradycardia, second- or third-degree heart block, overt cardiac failure, or those on monoamine oxidase inhibitors. Tell your prescriber about cardiovascular disease, depression, diabetes, thyroid disease, and all medicines and supplements you use.

Combigan ophthalmic may be a good option if you want fewer bottles and a steady twice-daily schedule. If you have had intolerance to brimonidine or timolol in the past, discuss alternatives. Your clinician may also consider comparing your response to a prostaglandin analog or a carbonic anhydrase inhibitor.

For budgeting, compare your Combigan cost across bottle sizes. We list Combigan 0.2 0.5 eye drops in common pack sizes such as Combigan eye drops 5 mL when available. Multi-month orders can lower the average per-month Combigan price, and bulk deals sometimes reduce shipping costs too. If you are exploring a Combigan discount, check current offers on our site.

We carry both brand and generic options when available. Some markets have generic brimonidine timolol combinations, which can lower the Combigan eye drops cost while delivering the same active ingredients. Selection varies by country and manufacturer.

Authoritative Sources

US Prescribing Information for Combigan (AbbVie)

Health Canada Drug Product Database: Combigan

FDA Label: Combigan Ophthalmic Solution

Order Combigan® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express handling.

This material is educational and does not replace professional medical advice. Always follow your prescriber’s directions and the product’s patient information.