Constella® Capsules for Irritable Bowel Syndrome with Constipation

Linaclotide is a prescription capsule for adults with IBS-C or chronic idiopathic constipation. This page explains how it works, how to take it, and how to get access with US delivery from Canada, including options for those without insurance.

What Constella Is and How It Works

Constella® is the Canadian brand name for linaclotide, a guanylate cyclase-C agonist. It acts locally in the intestine to increase fluid secretion and transit. This can ease hard stools and reduce abdominal discomfort associated with IBS-C. It is minimally absorbed into the bloodstream.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

This treatment is taken once daily before eating. It targets receptors on the intestinal lining, which can help normalize bowel movements and reduce straining. Learn more about the condition at Irritable Bowel Syndrome and see related products under Gastrointestinal. For background on IBS, read IBS What Is.

Who It’s For

This medicine is indicated for adults diagnosed with irritable bowel syndrome with constipation or chronic idiopathic constipation. It is not for children. Avoid use in young children because of dehydration risk. It should not be used in people with known or suspected gastrointestinal obstruction.

If you have severe or recurrent diarrhea, discuss suitability with your prescriber. People who are pregnant, planning pregnancy, or breastfeeding should ask a clinician about benefits and risks.

Dosage and Usage

Take your dose once each morning on an empty stomach, at least 30 minutes before your first meal. Swallow the capsule whole. If you cannot swallow the capsule, your clinician may direct you to carefully open it and sprinkle the contents on applesauce or mix with water, then swallow immediately. Do not crush the beads.

Use exactly as prescribed. Do not change your dose or schedule without guidance. If you experience severe diarrhea, stop the medicine and seek medical advice. Refer to the official product label for full instructions.

Strengths and Forms

The therapy comes as oral capsules in two strengths commonly marketed for adult patients: 145 mcg and 290 mcg. Availability may vary by country and supplier.

Missed Dose and Timing

If you miss a dose, take it when you remember as long as it is not close to the next dose. If it is near the time for your next dose, skip the missed dose. Do not take two doses at once.

Storage and Travel Basics

Keep capsules in the original bottle with the desiccant to protect from moisture. Close the cap tightly after each use. Store at room temperature away from excess heat and humidity. Keep out of reach of children and pets.

When traveling, carry your medicine in your hand luggage. Bring a copy of your prescription and your prescriber’s contact information. Use a reminder on your phone to take your dose before breakfast, especially when crossing time zones. Do not store in a bathroom where moisture is high.

Benefits

This therapy is taken once daily, which can simplify routines. It works locally in the gut with minimal systemic absorption. People with IBS-C may notice reduced straining and improved stool consistency over time. Those with chronic constipation may experience more frequent, softer bowel movements.

Many patients compare linaclotide capsules price when budgeting therapy. Reviewing options alongside your clinician can help match clinical needs with affordability. Consistent use as prescribed supports the best chance of benefit.

Side Effects and Safety

• Diarrhea
• Abdominal pain or cramping
• Gas and bloating
• Loose stools
• Headache

Severe diarrhea can occur and may lead to dehydration. Stop the medicine and contact a healthcare professional if you develop significant diarrhea, dizziness, fainting, or signs of dehydration. Rarely, allergic reactions may occur, such as rash, itching, or swelling. Seek urgent care for breathing difficulty, swelling of the face or throat, or severe hives.

Drug Interactions and Cautions

Because the drug acts locally and is minimally absorbed, classic drug interactions are uncommon. However, severe diarrhea may reduce absorption of other oral medicines, including narrow-therapeutic-index drugs. Discuss all prescription and nonprescription products you take, including fiber supplements, laxatives, antidiarrheals, and antispasmodics. People with frequent diarrhea should be cautious with dehydration risk.

What to Expect Over Time

Some people report changes in bowel habits after steady, daily use. Effects can vary by person and condition severity. Keep a simple diary tracking stool frequency, consistency, and abdominal symptoms. Share this information with your clinician to guide ongoing care. If you skip doses or take it with food, results may be less consistent.

Compare With Alternatives

Other prescription options exist for IBS-C and chronic constipation. Plecanatide is a guanylate cyclase-C agonist similar in class; see Trulance. Prucalopride is a selective 5-HT4 agonist that stimulates motility; see Resotran. Antispasmodics may help cramping; some patients discuss options like Dicyclomine Hcl with their prescriber.

Pricing and Access

Canadian pharmacies often offer transparent rates, and you can compare across pack sizes. Check our current Constella price on the product page and review options that align with your prescription. We also list availability with clear, upfront details.

People comparing linaclotide 145 mcg price sometimes bundle refills to reduce trips and plan ahead. To explore current offers, visit Promotions. Ordering includes clear steps for US patients, and parcels Ships from Canada to US after verification.

For a deeper dive into therapies used in IBS care, you may find Trimebutine Uses Dosage helpful. We use encrypted checkout to protect your information.

Availability and Substitutions

Stock can vary. If your prescribed strength is unavailable, your prescriber may recommend a suitable alternative or adjust the plan. Many people research linaclotide price while comparing options in the same class or different mechanisms, balancing tolerability and convenience.

Patient Suitability and Cost-Saving Tips

This therapy may suit adults with IBS-C or chronic idiopathic constipation who need daily symptom management and can take a morning dose before eating. It may not suit those prone to severe diarrhea, dehydration, or with suspected obstruction. Always follow your prescriber’s advice.

Consider multi-month fills if appropriate to reduce per-bottle fees. Set refill reminders so you do not run out unexpectedly. Discuss generic vs brand availability in your region. If you are reviewing budgets, note that Constella cost can differ by quantity and pharmacy. Use your healthcare professional’s guidance to match clinical need with value. For constipation education, see Chronic Constipation.

Questions to Ask Your Clinician

• Best time to take it each day
• What to do if diarrhea becomes severe
• Whether opening the capsule is appropriate for me
• How long to try before reassessing
• Which alternatives fit my history
• When to schedule follow-up

Authoritative Sources

DailyMed Linaclotide

FDA Prescribing Information

Health Canada Drug Product Database

Ready to start or refill? Visit the product page to order Constella online with US shipping from Canada and prompt shipping, with temperature-controlled handling when required. This information is educational and not a substitute for your clinician’s advice.