Constella® (linaclotide) Capsules for IBS‑C and Chronic Constipation

What Constella® Is and How It Works

Constella® (linaclotide) is a once-daily oral capsule for adults with irritable bowel syndrome with constipation (IBS‑C) or chronic idiopathic constipation (CIC). It works in the gut and is not meaningfully absorbed into the bloodstream. Check the Constella price and available strengths before you add it to your cart.

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Linaclotide is a guanylate cyclase‑C (GC‑C) agonist. It increases cyclic GMP on the surface of the intestinal lining. That signals chloride and bicarbonate secretion into the bowel via CFTR channels. More fluid in the stool improves transit and stool consistency. The drug also reduces pain signaling in the gut, which can help IBS‑C abdominal discomfort.

Constella comes as hard capsules (often labeled as constella hartkapseln in some markets) in 145 mcg and 290 mcg doses. Typical dosing is once daily at least 30 minutes before the first meal. For IBS‑C, 290 mcg is standard. For CIC, 145 mcg is common. Your prescriber will decide the right dose. Allergan (now part of AbbVie) markets this medicine, and some customers search for allergan constella or constella pris when comparing offers.

To learn more, see our detailed guide in Constella Medication Uses Side Effects And Dosage Guide, or browse the condition overview at Irritable Bowel Syndrome.

Dosage and Usage

• IBS‑C: usual dose is 290 mcg by mouth once daily.
• CIC: usual dose is 145 mcg by mouth once daily.
• Take on an empty stomach, at least 30 minutes before your first meal.
• Swallow capsules whole. If needed, you may open the capsule and sprinkle the beads on applesauce or mix in room‑temperature water. Swallow right away without chewing.
• If you miss a dose, skip it and take the next dose at the regular time. Do not double doses.
• Stop and contact your prescriber if you develop severe diarrhea, dizziness, or signs of dehydration.
• Tell your prescriber about any history of bowel obstruction before starting.

• Store at 15–25 °C (59–77 °F). Protect from moisture. Keep the bottle tightly closed.
• Keep the desiccant inside the bottle. Do not repackage into pill boxes that let in humidity.
• Do not store in the bathroom. Avoid temperatures above 30 °C (86 °F) or below 0 °C (32 F).
• For travel, keep capsules in the original labeled container in your carry‑on. Keep the cap closed and away from heat sources.
• Keep out of reach of children and pets.

Benefits and Savings

Constella improves stool frequency, softens hard stools, reduces straining, and helps bloating and abdominal pain in IBS‑C. Many people notice a steadier bowel routine with one morning dose. Because linaclotide acts locally in the gut, meaningful drug interactions are uncommon.

Ordering from Canada can lower costs. Typical savings are 60–80% compared with many US pharmacies. Multi‑month supplies often reduce the per‑month cost, and you can set gentle email reminders so you reorder on time. If you compare constella pris across retailers, confirm the strength and quantity.

Side Effects and Safety

• Diarrhea (sometimes severe)
• Abdominal pain or cramping
• Gas and bloating
• Abdominal distension
• Urgency or loose stools
• Nausea
• Headache

Severe diarrhea can lead to dehydration, dizziness, low blood pressure, or fainting. Stop the medication and contact a clinician if this occurs. Do not use linaclotide in children under 6 years because of dehydration risk, and avoid use in those 6–17 years. Do not use if you have a known or suspected bowel obstruction. Discuss pregnancy or breastfeeding with your clinician.

Onset Time

Some adults see changes in stool frequency within 1–3 days. Many notice steadier bowel movements within the first week. Abdominal pain and bloating in IBS‑C may keep improving over 4–12 weeks as dosing remains consistent. If benefits are not seen after several weeks, clinicians sometimes reassess the dose and overall plan.

Compare With Alternatives

Plecanatide is another GC‑C agonist taken once daily. It works similarly to linaclotide but may have a different side‑effect profile for some people. You can review Trulance® to compare dosing and pack sizes.

Lubiprostone (a chloride channel activator) is an alternative for chronic constipation and IBS‑C in some patients. It increases intestinal fluid through a different pathway. Side effects may include nausea.

Prucalopride, a selective 5‑HT4 agonist, stimulates colonic motility and is used mainly for chronic constipation. It has a different mechanism and dosing schedule than linaclotide.

For upper‑GI motility issues such as gastroparesis‑related nausea, prescribers may consider agents outside the constipation class. See Domperidone for details. It is not a treatment for IBS‑C.

Combination Therapy

• Short‑term use of an osmotic laxative (for example, polyethylene glycol) may help while Constella begins working.
• Dietary fiber (if tolerated) and adequate hydration can support regularity. Some IBS‑C patients prefer soluble fiber.
• Avoid routine use of antidiarrheals with linaclotide unless instructed by a clinician.
• For opioid‑induced constipation, additional agents may be required because linaclotide alone may be insufficient.

Patient Suitability and Cost-Saving Tips

Constella is for adults with IBS‑C or CIC who have persistent constipation symptoms. It is not for children. Do not use it if there is a known or suspected intestinal blockage. People with frequent severe diarrhea may need a different option or a tailored plan.

Linaclotide has minimal systemic absorption, but discuss use in pregnancy or while breastfeeding with your clinician. Report severe or persistent diarrhea, black stools, or blood in stools. If you have significant abdominal pain that is new or worsening, seek medical care.

To save on therapy, compare pack sizes. A multi‑month supply can lower the average monthly cost, and periodic bulk promotions may apply. Turn on reorder reminders in your account so your supply stays steady. Some customers search for constella online bestellen or constella bestellen; these terms refer to ordering the same brand capsules online. If you need CIC dosing, you may see listings for constella 145; IBS‑C listings often show constella 290.

Authoritative Sources

European Medicines Agency: Constella (linaclotide) EPAR

Health Canada Drug Product Database (linaclotide)

FDA Linzess (linaclotide) Prescribing Information

Order Constella® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This information is educational and not a substitute for professional medical advice, diagnosis, or treatment. Always follow your prescriber’s instructions and the product labeling.