Constella price with US shipping from YouDrugstore

What Constella Is and How It Works

Constella (linaclotide) is a prescription capsule for adults with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation (CIC). Many people compare Constella price across pharmacies when long-term treatment is needed. Constella belongs to a class called guanylate cyclase-C (GC-C) agonists. It works locally in the gut to increase intestinal fluid and speed stool transit. It is taken by mouth once daily, on an empty stomach.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba that meets Canadian pharmacy standards. We coordinate sourcing and shipment through licensed partner pharmacies, where pharmacists review prescriptions before dispensing. You can order online at Canadian prices and have products shipped to the US, and our customer-service chat is available during posted office hours.

Constella comes as hard capsules in two strengths: 145 mcg and 290 mcg. It is not absorbed in a meaningful amount into the bloodstream. That local action helps ease constipation and reduce abdominal pain without systemic effects. We arrange supply through vetted partner pharmacies at home and abroad, so you receive authentic brand medication at fair pricing and a broad selection.

Dosage and Usage

Your prescriber will select the right dose based on your condition:

• IBS-C: Typical adult dose is 290 mcg once daily.
• CIC: Typical adult dose is 145 mcg once daily.

Take Constella at least 30 minutes before your first meal of the day. Swallow the capsule whole with water. Do not crush or chew. If you cannot swallow capsules, ask your prescriber about approved opening and sprinkling instructions specific to linaclotide, as not all packaging allows this.

Missed dose:

• If you miss a dose, take it when remembered.
• Skip it if it is almost time for the next dose.
• Do not take two doses at once.

Storage and travel:

• Store at room temperature (15-30 C).
• Keep capsules in the original packaging to protect from moisture.
• Do not remove a capsule from the blister until ready to take it.
• During travel, keep in carry-on luggage, away from heat and humidity.

Constella is for adult use. It should not be used if you have a known or suspected bowel obstruction. Tell your prescriber about ongoing diarrhea, recent GI surgery, or severe dehydration.

Benefits and Savings

Constella increases the number of complete spontaneous bowel movements and reduces straining. Many patients also report less abdominal pain, less bloating, and better overall IBS-C symptom control. Symptom relief tends to be steady with daily use and may help quality of life when fiber and basic laxatives are not enough.

Ordering from YouDrugstore is straightforward. We are a Canadian pharmacy coordinating with licensed partner pharmacies for dispensing and shipment. You get brand medications at Canadian prices, and typical savings range from 60-80% versus many US retail prices. You can order online or by phone where available, and we can send reorder reminders. Multi-month supplies may lower the per-month cost.

Side Effects and Safety

Common effects are mostly GI-related and often improve as your body adjusts:

• Diarrhea
• Abdominal pain or cramping
• Bloating or gas
• Abdominal distension
• Nausea

Diarrhea is the most frequent side effect and can sometimes be severe. If you develop severe or persistent diarrhea, stop the medication and contact your prescriber. Serious effects are uncommon but may include dehydration (dizziness, weakness, fainting), electrolyte changes, or allergic reactions like rash, hives, or swelling.

Do not use Constella if you have a known or suspected bowel obstruction. In pediatrics, linaclotide can cause severe dehydration; Constella is not indicated for children. Pregnant or breastfeeding individuals should discuss risks and benefits with the prescriber; systemic exposure is minimal, but data are limited. Linaclotide has few drug interactions because it is not well absorbed, but extra caution is needed if you are taking other agents that can cause diarrhea.

Onset Time

Some people notice easier bowel movements in the first few days. Many see meaningful improvement within 1 week, with further gains by 2 to 4 weeks. Abdominal pain relief may lag behind stool frequency improvements. Keep taking your daily dose as prescribed to maintain benefit.

Compare With Alternatives

Trulance (plecanatide) is another GC-C agonist taken once daily for IBS-C and CIC. Efficacy is broadly similar to linaclotide for many patients. Some tolerate one agent better than the other. You can review Trulance and discuss with your prescriber which option fits your symptoms and budget.

Lubiprostone is a chloride channel activator used for chronic constipation and IBS-C in some regions. It increases intestinal fluid but through a different mechanism. It may be an option if GC-C agonists are not suitable.

Domperidone is a prokinetic that targets upper GI motility and nausea rather than constipation. It may be considered in select cases where nausea co-exists, but it is not a primary treatment for IBS-C. If relevant, you can view Domperidone and ask your prescriber how it fits your care plan.

For some patients, osmotic laxatives (such as polyethylene glycol) or stimulant agents are used intermittently. These can help difficult days but may not address abdominal pain or overall IBS-C burden the way GC-C agonists can.

Combination Therapy

Constella can pair with lifestyle changes. Many patients maintain a steady fiber intake, hydrate well, and keep regular meals and activity. If fiber worsens gas or bloating, your prescriber may adjust the plan. Occasional osmotic laxatives may be used as rescue, but combining with other strong laxatives every day can increase diarrhea risk.

Consider diet strategies common in IBS care, such as limiting large meals and reducing known trigger foods. If bloating is a prominent symptom, your care team may suggest a trial of a low FODMAP approach under guidance. For overlapping symptoms like Bloating or Abdominal Pain, a personalized plan often helps. You can also review our condition page for Irritable Bowel Syndrome.

Patient Suitability and Cost-Saving Tips

Good candidates include adults with IBS-C or CIC who have ongoing constipation, straining, or abdominal pain despite fiber and basic laxatives. Avoid Constella if you have a suspected or known GI obstruction, very frequent diarrhea, or severe dehydration. Share your full medication and medical history with your prescriber before starting.

To reduce costs, consider:

• Ordering a multi-month supply if appropriate to lower per-month pricing.
• Setting up gentle reorder reminders so you do not miss doses.
• Comparing Constella price across pack sizes on the product page.

If you need help with ordering steps, our customer-service team can assist during posted hours. We offer brand medications at Canadian prices and coordinate shipping to the US from licensed partner pharmacies using prompt, express, cold-chain shipping methods when required.

Authoritative Sources

See official prescribing and safety details here:

• FDA Prescribing Information for LINZESS (linaclotide)
• Health Canada Drug Product Database
• Manufacturer patient site for LINZESS (US brand of linaclotide)

YouDrugstore helps you order Constella at Canadian prices and coordinates shipment through licensed partner pharmacies. If your prescriber has recommended Constella 145 mcg or 290 mcg, you can place your order online with confidence. We support prompt, express, cold-chain shipping when needed and keep the process clear and simple.

This content is for general information and does not replace your prescriber’s advice. Always follow the directions from your healthcare professional and the medication guide that comes with your prescription. Seek medical help right away for severe diarrhea, dehydration, or allergic reactions.