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Crestor® (rosuvastatin) Cholesterol-Lowering Tablets for LDL and Triglycerides
Price range: $67.99 through $95.99
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What Crestor® Is and How It Works
Crestor® (rosuvastatin calcium) is a statin used to lower LDL cholesterol and triglycerides, and to raise HDL. It helps reduce cardiovascular risk when used with diet and exercise for High Cholesterol and mixed dyslipidemia. Crestor is an oral tablet taken once daily. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing. We work with licensed, vetted partner pharmacies internationally to supply authentic brand medicines and a broad range of options at value-focused pricing.
Rosuvastatin blocks HMG‑CoA reductase in the liver. This slows cholesterol production and increases LDL‑receptor activity, so the liver removes more LDL from the blood. Patients with familial hypercholesterolemia and those needing high-intensity therapy often respond well to rosuvastatin. The medicine can also help reduce non‑HDL cholesterol and apolipoprotein B.
Crestor tablets come in several strengths, including 5 mg, 10 mg, 20 mg, and 40 mg. Therapy is individualized based on baseline LDL, cardiovascular risk, and response. Tablets can be taken with or without food, at the same time each day.
For related reading on lifestyle measures that support therapy, see The Skinny On High Cholesterol.
Dosage and Usage
- Typical adult starting dose: 5 mg to 10 mg once daily. Some high-risk patients may start at 20 mg once daily.
- Titration: adjust at intervals of 2–4 weeks based on LDL response and goals. Maximum usual dose is 40 mg once daily in select patients.
- Administration: swallow the tablet whole with water. Take at the same time daily, with or without food.
- Missed dose: take the dose when remembered unless the next dose is near. Do not double doses.
- Monitoring: lipid panel at baseline and 4–12 weeks after starting or changing dose; then periodically.
- Drug interactions: exposure increases with some agents (for example, gemfibrozil, certain antivirals, cyclosporine). Prescribers may use lower doses or avoid combinations that raise myopathy risk.
- Special populations: lower starting doses are often used in some patients, including those of Asian ancestry or with renal impairment. Not for use in pregnancy or breastfeeding.
- Storage: store tablets at 15–30 °C (59–86 °F) in a dry place. Keep the bottle tightly closed.
- Moisture and heat: avoid bathrooms, kitchens, and cars. Do not freeze.
- Travel: keep tablets in your carry-on with the labeled pharmacy container. Pack extra doses in case of delays.
- Daily routine: use a reminder or phone alarm to help keep a regular dosing schedule.
- Child safety: store out of sight and reach of children and pets.
Benefits and Savings
Crestor is a high-potency statin. Many patients see 45–63% LDL reductions at 20–40 mg, with meaningful improvements at 5–10 mg as well. It lowers triglycerides and modestly raises HDL. Once-daily dosing improves adherence. Crestor 10mg and Crestor 20mg are common strengths used for primary and secondary prevention when lifestyle changes alone are not enough.
Brand and generic options help lower the crestor cost compared with typical U.S. pharmacy prices. Ordering from Canada can offer 60–80% savings for many strengths, including rosuvastatin 10mg and rosuvastatin 20mg. Per‑month costs may decrease with multi‑month supplies, and bulk promotions can further reduce the rosuvastatin calcium cost.
Prices vary by strength and quantity. People often compare rosuvastatin calcium 5 mg price, crestor 10mg price, and rosuvastatin calcium 20 mg price when choosing a fill size. You can check the current crestor 20 mg price or the cost of crestor 5 mg by selecting the strength on the product page.
crestor coupon information is posted on our promotions page when available.
Side Effects and Safety
- Common effects: headache, stomach discomfort, constipation, nausea, muscle aches, joint pain, and fatigue.
- Less common: dizziness, sleep changes, rash, mild increases in blood sugar or A1C.
- Laboratory: small, usually transient increases in liver enzymes; dose reduction or discontinuation may be considered if persistent and significant.
- Muscle symptoms: myalgia may occur; risk increases with higher doses or interacting drugs.
Serious muscle injury (myopathy/rhabdomyolysis) is rare but can occur, especially with interacting medicines like gemfibrozil or cyclosporine, in older adults, or with severe renal impairment or uncontrolled hypothyroidism. Unexplained muscle pain or weakness, dark urine, or severe fatigue needs prompt medical attention. Serious liver injury is uncommon. Small increases in blood glucose can occur. Avoid use in pregnancy and breastfeeding.
Onset Time
Initial LDL reductions appear within 1–2 weeks. Near-maximal effect is typically reached by about 4 weeks at a stable dose. Triglycerides often improve in a similar timeframe. Cardiovascular risk reduction accrues over months to years of consistent therapy. Regular lipid panels help track progress and guide dosing adjustments.
Compare With Alternatives
Atorvastatin is another potent statin often chosen for high-intensity therapy. Compared with atorvastatin, rosuvastatin tends to achieve similar or greater LDL lowering at lower milligram doses, reflecting differences in potency and metabolism. Choice depends on goals, tolerability, drug interactions, and cost.
Simvastatin is effective for moderate LDL reductions but is limited by dose-related interaction risks. Many patients who need stronger LDL lowering move to rosuvastatin or atorvastatin. Those who experience muscle symptoms on one statin may tolerate another at a lower dose or alternate-day regimen, as directed by a prescriber.
Lovastatin is an older statin that offers modest LDL reductions. It is taken with the evening meal due to food‑dependent absorption. Patients needing greater LDL lowering or fewer interactions may be switched to Crestor®.
Combination Therapy
- Rosuvastatin plus ezetimibe: adds 15–25% more LDL reduction versus statin alone; useful when goals are not met on monotherapy.
- Rosuvastatin plus icosapent ethyl or omega‑3s: targets elevated triglycerides in appropriate patients.
- Rosuvastatin plus fenofibrate: may be considered for mixed dyslipidemia; avoid gemfibrozil due to myopathy risk.
- Rosuvastatin with antihypertensives: complementary risk reduction when blood pressure also needs control.
- When interacting drugs are required, lower rosuvastatin doses or alternative combinations may be chosen to reduce muscle‑related risks.
Patient Suitability and Cost-Saving Tips
Candidates include adults with primary hyperlipidemia, mixed dyslipidemia, or familial hypercholesterolemia, and those requiring primary or secondary prevention of cardiovascular events. Crestor tablet strengths allow flexible dosing to meet LDL targets. It is not indicated for pregnancy or breastfeeding, and is generally avoided in active liver disease.
Prescribers may choose lower starting doses for some patients, including those of Asian ancestry or with renal impairment. Prior statin intolerance, hypothyroidism, heavy alcohol use, and interacting drugs require careful assessment and monitoring. Report unexplained muscle pain, tenderness, or weakness, especially if accompanied by malaise or fever.
To manage costs, consider generic rosuvastatin when appropriate. Compare crestor price by strength and quantity, such as the crestor 5 mg cost versus higher doses. Ordering several months at once can lower the per‑month rosuvastatin 20mg cost. You can set gentle reorder reminders in your account so you do not run out.
Dose availability is broad. Patients often compare rosuvastatin calcium tablet 10 mg with rosuvastatin calcium tablet 20 mg when planning refills. If diet, exercise, and a moderate dose do not reach goals, an increased dose or add‑on therapy like ezetimibe may be considered by the prescriber.
Authoritative Sources
Crestor official consumer site (AstraZeneca)
FDA/NIH DailyMed: Rosuvastatin Calcium Prescribing Information
Health Canada Drug Product Database: Rosuvastatin
Order Crestor® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.
This material is educational and does not replace advice from your healthcare professional. Always consult your prescriber or pharmacist about diagnosis, treatment, and medication use.
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How does Crestor work to lower cholesterol?
Crestor (rosuvastatin) blocks HMG‑CoA reductase, the liver enzyme that makes cholesterol. This reduces LDL production and increases LDL receptor activity, so more LDL is cleared from the blood. It also lowers triglycerides and modestly raises HDL. Benefits build over weeks and with continued use alongside diet and exercise.
How long does it take for Crestor to show results?
Many people see LDL improvements within 1–2 weeks. Near‑maximal lowering usually occurs by about 4 weeks at a steady dose. Triglycerides often improve around the same time. Prescribers check a lipid panel 4–12 weeks after starting or changing the dose, then periodically to guide therapy.
What are common side effects of rosuvastatin?
Common effects include headache, stomach upset, constipation, nausea, muscle aches, and fatigue. Less common effects include dizziness, sleep changes, and small increases in blood sugar or liver enzymes. Serious muscle injury is rare but requires urgent evaluation if symptoms like severe muscle pain or dark urine occur.
What is the difference between Crestor 10mg and 20mg?
Both strengths are effective; 20 mg generally produces greater LDL reductions than 10 mg. Choice depends on baseline LDL, cardiovascular risk, other conditions, and interactions. Prescribers often start at 5–10 mg and adjust every few weeks to reach lipid goals while monitoring for tolerability.
How much does Crestor cost and how can I save?
Pricing varies by strength and quantity. Comparing crestor price across 5 mg, 10 mg, and 20 mg fills can help. Generic rosuvastatin often lowers costs further. Ordering multi‑month supplies can reduce the per‑month expense. Savings versus typical U.S. prices commonly range from about 60% to 80%.
Can I drink grapefruit juice with rosuvastatin?
Grapefruit has little effect on rosuvastatin compared with some other statins. Large amounts may still increase exposure slightly. Interactions with drugs like gemfibrozil, certain antivirals, and cyclosporine are more clinically significant. Always review diet, supplements, and medications with a healthcare professional before starting therapy.