Dapagliflozin (Farxiga®) Tablets for Type 2 Diabetes, Heart Failure, and CKD

What Dapagliflozin Is and How It Works

Dapagliflozin is an oral SGLT2 inhibitor used for type 2 diabetes, chronic heart failure, and chronic kidney disease. It helps lower blood sugar and reduces the risk of hospitalization for heart failure. It also slows kidney function decline in appropriate patients. The most common strength is the dapagliflozin 10 mg tablet, taken once daily.

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As an SGLT2 medicine, dapagliflozin blocks glucose reabsorption in the kidney’s proximal tubules. This increases urinary glucose excretion and causes mild diuresis. People often see small reductions in weight and blood pressure along with improved glycemic control. The dapagliflozin class of drug has shown cardiovascular and renal benefits in clinical studies.

Indications include improving glycemic control in adults with type 2 diabetes, reducing the risk of hospitalization for heart failure in adults with type 2 diabetes, treating symptomatic chronic heart failure, and treating chronic kidney disease in appropriate patients. The dapagliflozin classification is antihyperglycemic; its pharmacologic class is SGLT2. The dapagliflozin brand name or trade name is Farxiga.

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Dosage and Usage

• Form: dapagliflozin tablet, usually 5 mg or 10 mg. The common maintenance dose is dapagliflozin 10 mg once daily.
• Administration: swallow whole with water; may be taken with or without food, at the same time each day.
• Initiation for type 2 diabetes: some patients start at 5 mg once daily and increase to 10 mg if more glycemic effect is needed.
• Heart failure or chronic kidney disease: 10 mg once daily is typically used when renal function allows.
• Renal considerations: dosing depends on eGFR and indication; initiation or continuation may be limited in severe impairment or dialysis.
• Perioperative care: treatment may be paused prior to major surgery to reduce ketoacidosis risk; timing should be guided by a clinician.
• Hydration: volume depletion increases side-effect risk; clinicians may assess diuretics or blood pressure medicines when starting.
• Missed dose: take when remembered the same day; skip if it is near the next dose. Do not double doses.

• Storage: store your tablets at 20–25°C (68–77°F); brief excursions 15–30°C (59–86°F) are acceptable.
• Moisture: keep your medication in the original container with the lid closed; avoid humid bathrooms.
• Light: protect from direct sunlight; keep the bottle in a cool, dry place.
• Travel: carry your medicine in a hand luggage organizer; keep it with your itinerary and a copy of your prescription.
• Access: bring extra doses for delays; do not store in a hot car or near heaters.
• Child safety: keep out of reach of children and pets; use child-resistant caps.

Benefits and Savings

Dapagliflozin 10 mg uses include lowering A1C by about 0.5–1.0% when added to diet and exercise, often with a small weight reduction. Clinical trials show fewer hospitalizations for heart failure and benefits across a range of ejection fractions. In chronic kidney disease, it helps slow eGFR decline and reduces the risk of progression.

The once-daily tablet is simple to take, and it can be combined with metformin, insulin, GLP-1 receptor agonists, and other oral agents when appropriate. Many patients value the convenience and the cardiometabolic profile of this SGLT2 therapy.

Ordering from a Canadian pharmacy can offer meaningful savings. Typical dapagliflozin cost reductions are 60–80% versus US pharmacy prices, depending on package size and strength. Multi-month supplies may lower the dapagliflozin price per month compared to single-bottle purchases.

For current offers, see dapagliflozin coupon options on our Promotions page.

Side Effects and Safety

• Genital yeast infections (vulvovaginal candidiasis, balanitis)
• Urinary tract infections
• Increased urination, thirst, or dry mouth
• Dizziness or low blood pressure, especially with diuretics
• Back pain, nasopharyngitis
• Modest increases in LDL cholesterol
• Rash or hypersensitivity reactions

Serious but uncommon risks include ketoacidosis (which may occur with normal glucose), necrotizing fasciitis of the perineum (Fournier’s gangrene), severe urinary infections, acute kidney injury, and severe allergic reactions. Hypoglycemia risk rises if combined with insulin or insulin secretagogues like sulfonylureas; dose adjustments of those agents may be needed. Patients with recurrent genital infections may be at higher risk of mycotic infections.

Onset Time

Blood glucose changes often appear within the first one to two weeks as urinary glucose excretion increases. A1C improvements accumulate over 8–12 weeks and continue through 24 weeks. Mild blood pressure and weight changes usually develop across several weeks. Heart failure and kidney-protection effects can begin within weeks, with larger outcome benefits observed over months.

Compare With Alternatives

Empagliflozin is another SGLT2 inhibitor in the same dapagliflozin drug class. Both are once-daily tablets that improve glycemic control and reduce cardiovascular risk in selected patients. Choice may depend on individual renal function thresholds, comorbidities, and formulary access.

GLP-1 receptor agonists support weight loss and stronger A1C reductions for many patients. A common option is Ozempic®, which is injectable and often paired with metformin. GLP-1 therapies may suit patients prioritizing weight management or those needing substantial A1C lowering.

For patients who require insulin, premixed options like Novolin® Ge 30 70 Vial deliver both basal and prandial coverage in a single product. Dapagliflozin can be used with insulin when appropriate, though clinicians often reduce insulin or repaglinide doses to lower hypoglycemia risk.

Short-acting secretagogues such as repaglinide can target post-meal spikes. These are oral options but carry a higher hypoglycemia risk compared with SGLT2 agents. Individualized plans balance efficacy, safety, and cost.

Combination Therapy

• Metformin plus dapagliflozin for foundational control and weight-neutral or modest weight-loss effects.
• GLP-1 receptor agonist plus dapagliflozin to address A1C, weight, and cardiovascular risk.
• DPP-4 inhibitor combinations for added glycemic benefit in patients intolerant to other agents.
• Basal or premixed insulin with dapagliflozin; insulin dose reductions may decrease hypoglycemia risk.
• ACE inhibitor or ARB in CKD, when indicated, alongside dapagliflozin for renal protection.

Patient Suitability and Cost-Saving Tips

Dapagliflozin is used for adults with type 2 diabetes, chronic heart failure, or chronic kidney disease. It is not indicated for type 1 diabetes and should not be used to treat diabetic ketoacidosis. Dose and eligibility depend on renal function and clinical status.

Those with a history of recurrent genital infections, low blood pressure, dehydration, or on loop diuretics may have higher side-effect risks. Clinicians consider risks in pregnancy and during breastfeeding. People with severe kidney impairment or on dialysis generally should not start therapy. The dapagliflozin heart failure side effects profile and benefits are assessed case by case.

For budget planning, compare dapagliflozin 10 mg price across package sizes. Larger fills can reduce the monthly cost. You can set reorder reminders so you do not run out during travel or holidays. You may view both the generic and the dapagliflozin brand to choose what fits your needs and prescriber’s directions.

Authoritative Sources

AstraZeneca Farxiga Prescribing Information

Health Canada Drug Product Database: Dapagliflozin

FDA Label: Dapagliflozin Tablets

Order dapagliflozin from YouDrugstore.com: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This material is educational and does not replace advice from your healthcare professional. Always consult a qualified clinician about diagnosis, treatment, and dosing for your situation.