Edarbyclor® (azilsartan medoxomil/chlorthalidone) tablets for hypertension

What Edarbyclor® Is and How It Works

Edarbyclor® is a prescription tablet for high blood pressure. It combines azilsartan medoxomil, an angiotensin II receptor blocker (ARB), with chlorthalidone, a thiazide-like diuretic. The two medicines lower blood pressure by relaxing blood vessels and removing extra fluid. It is taken once daily and comes in fixed doses.

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Azilsartan medoxomil blocks the angiotensin II type 1 receptor. This reduces vasoconstriction and lowers aldosterone. Chlorthalidone increases sodium and water excretion in the kidneys. Together they provide stronger blood pressure reductions than either alone, in many adults.

Dosage and Usage

Follow your prescriber’s directions and the pharmacy label. Typical use is once daily at the same time each day.

• Usual starting dose: 40 mg/12.5 mg once daily.
• Titration: may increase to 40 mg/25 mg after 2–4 weeks if needed.
• Maximum dose: 40 mg/25 mg once daily.
• May be taken with or without food. Swallow whole with water.
• Do not split the tablet unless your prescriber instructs you.
• Missed dose: take when remembered unless it is near the next dose. Do not double up.

Kidney function and electrolytes are often checked during treatment. Some patients need lab tests after dose changes. Older adults and those on other diuretics may need closer monitoring.

• Storage: store at 20–25°C (68–77°F) in a dry place. Keep in the original container.
• Protect from moisture and humidity. Keep the bottle tightly closed.
• Travel: carry in your hand luggage with the labeled container.
• Avoid leaving tablets in a car or near heat sources.
• If flying, keep medication with you and not in checked bags.

Benefits and Savings

Combination therapy can improve blood pressure control when a single drug is not enough. Edarbyclor® provides the ARB class benefits with the added effect of chlorthalidone. Many patients see meaningful reductions in systolic and diastolic readings with once-daily dosing.

Convenience matters. Fixed-dose tablets simplify the regimen, which may support adherence. Tablets can be taken with or without food, which helps routine use.

Ordering from Youdrugstore gives access to Canadian pricing. Many customers save 60–80% versus typical US retail. Bulk packages and multi-month supplies can lower the per-month cost even more.

Side Effects and Safety

Most side effects are mild and improve as the body adjusts. Not everyone experiences side effects.

• Common: dizziness, lightheadedness, fatigue, dry mouth, increased urination.
• Metabolic: low potassium, low sodium, increased uric acid, slight changes in cholesterol.
• Gastrointestinal: nausea, diarrhea, abdominal discomfort.
• Laboratory: small increases in creatinine or BUN, especially early.
• Less common: photosensitivity or rash, muscle cramps, headache.
• Serious (seek urgent care): fainting, severe dehydration, very low potassium symptoms (muscle weakness, irregular heartbeat), signs of severe allergic reaction, eye pain or vision changes.

Warnings: Do not use during pregnancy due to risk of fetal toxicity with ARBs. Avoid use in anuria. Use caution with a history of gout, kidney impairment, low sodium, or volume depletion. Dual renin-angiotensin system blockade is generally not recommended. Do not use with aliskiren in patients with diabetes. Review all medicines, including NSAIDs and lithium, with your prescriber and pharmacist.

Onset Time

Some blood pressure reduction can appear within the first week. The full effect often develops by 2 to 4 weeks of regular use. Diuretic effects may be noticed earlier, especially increased urination during the day.

Compare With Alternatives

Single-agent ARBs are used when a diuretic is not needed or not tolerated. For example, some patients may use Valsartan, which can be combined later with a diuretic if needed. Edarbyclor® may achieve greater reductions than single agents in patients needing two mechanisms.

Beta-blockers are another class. They are often used when there are other indications, such as certain rhythm issues. Options include Bystolic® or other beta-blockers. These differ in mechanism, side effects, and heart-rate effects. Your prescriber chooses based on your medical history and treatment goals.

Other fixed-dose ARB/diuretic combinations exist. Examples include losartan/hydrochlorothiazide and valsartan/hydrochlorothiazide. Chlorthalidone has a long duration, which some clinicians prefer for 24-hour coverage.

Combination Therapy

Many adults need more than one agent for target blood pressure. Edarbyclor® already includes two. It may be combined with a calcium channel blocker like amlodipine. Combination with other ARBs, ACE inhibitors, or aliskiren is generally avoided due to safety concerns. Adding other diuretics or potassium supplements requires lab monitoring.

Lifestyle measures remain important. Reducing sodium intake, moderating alcohol, and regular activity can support medications. These choices complement prescribed therapy.

Patient Suitability and Cost-Saving Tips

Edarbyclor® suits adults with essential hypertension who benefit from an ARB plus a diuretic. It is not for pregnancy or for patients with anuria. Those with kidney issues, gout, or electrolyte problems may need closer monitoring and dose adjustments. People with diabetes should avoid combining with aliskiren.

Price can vary by strength. Multi-month supplies can reduce the monthly cost and cut shipping fees. You can turn on reorder reminders in your account so you do not run out between visits. For current promotions and bulk options, see our edarbyclor coupon page.

Explore condition guidance while reviewing treatment choices. See our Hypertension page for an overview of treatment categories. Some patients with kidney concerns also review Chronic Kidney Disease resources and discuss monitoring plans with their care team.

Youdrugstore offers brand and generic medicines at Canadian prices and also carries OTC health products. Our pharmacists can address medication questions, and our customer-service chat is available during posted office hours.

Authoritative Sources

Review the official materials for detailed safety and dosing information:

• Manufacturer product page for Edarbyclor
• FDA Prescribing Information for Edarbyclor
• DailyMed listing for Edarbyclor

Ready to get started? You can upload your valid prescription and place an order online or by phone. Our team will verify details and dispense from our licensed Canadian pharmacy. We offer prompt, express, cold-chain shipping, with careful packaging for safe delivery to your door.

Disclaimer: This content is for general information. It does not replace advice from your healthcare professional. Always follow your prescriber’s directions and the product labeling. Tell your pharmacist and prescriber about all medicines and supplements you use.