Evenity® (romosozumab) Injection for High-Risk Postmenopausal Osteoporosis

What Evenity® Is and How It Works

Evenity® (romosozumab) is a prescription injection for osteoporosis in postmenopausal women at high risk of fracture. It is given once monthly as two injections in the same visit. The medicine is a sclerostin inhibitor. It increases bone formation and reduces bone breakdown, which raises bone mineral density and lowers fracture risk.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and our pharmacists review prescriptions before dispensing.

Each monthly dose of Evenity is 210 mg, delivered as two prefilled syringes of 105 mg each. A trained healthcare professional administers both injections. Treatment is limited to 12 months. After finishing Evenity, patients typically transition to an antiresorptive therapy to maintain gains in bone density.

Evenity is a brand-only product. We ship with prompt, express, cold-chain handling to protect temperature-sensitive medications. We also partner with licensed, vetted international pharmacies to offer authentic brand medicines across many categories at affordable Canadian pricing.

Many shoppers compare the evenity cost and evenity price across sources. You can order at Canadian prices and have Evenity shipped to the US. Talk with a prescriber about whether this therapy fits the diagnosis and fracture risk profile.

Dosage and Usage

• Usual dose: 210 mg once monthly, given as two consecutive subcutaneous injections of 105 mg each.
• Administration: A healthcare professional gives both injections during the same visit.
• Injection sites: Abdomen, thigh, or upper arm. Use two different sites for the same dose.
• Duration: Total treatment is 12 months. Follow with an antiresorptive agent to maintain bone density.
• Before starting: Correct hypocalcemia prior to the first dose. Ensure adequate calcium and vitamin D intake during therapy.
• Missed dose: Administer as soon as possible. Schedule the next monthly dose 1 month from the date the missed dose is given.
• General clinic steps: Inspect the solution; do not use if cloudy or discolored. Allow syringes to reach room temperature. Do not shake. Administer subcutaneously, then dispose of syringes in a sharps container.

• Store your syringes in a refrigerator at 2–8 °C (36–46 °F). Do not freeze.
• Keep in the original carton to protect from light.
• If needed, you may keep the syringes at room temperature (up to 25 °C/77 °F) for a single period of up to 30 days. Do not return to the fridge once they reach room temperature.
• Do not shake the syringes. Do not use if dropped or damaged.
• For travel, use an insulated container with cold packs. Keep the medication between 2–8 °C until arrival. Do not place syringes directly on ice and avoid heat.
• Before a clinic visit, remove the carton and let it sit at room temperature for about 30 minutes. Do not warm with external heat.

Benefits and Savings

Evenity offers dual action on bone. It builds new bone and slows down bone loss at the same time. In clinical studies, it increased bone mineral density at the spine and hip within months. It also reduced the risk of new vertebral fractures in high-risk postmenopausal women when used for one year and followed by antiresorptive therapy.

Monthly clinic administration may suit patients who prefer supervised dosing. The 12‑month course helps consolidate bone gains before switching to a maintenance agent. After therapy, density improvements can be preserved with agents like denosumab or oral bisphosphonates.

Ordering Evenity from YouDrugstore can provide 60–80% savings versus typical US prices. Many customers track the evenity cost per month and the price of evenity injections when budgeting therapy. Multi-month supplies and occasional bulk promotions can reduce the average cost of evenity over the full 12-month course. You can set simple reorder reminders in your account.

For deals and seasonal offers, check our promotions page for any current evenity coupon.

Side Effects and Safety

• Common effects: joint pain, back pain, muscle spasms, headache, fatigue, and injection site redness, swelling, or pain.
• Laboratory-related: low calcium may occur; symptoms can include muscle cramps, tingling, or spasms.
• Less common: rash or hypersensitivity reactions.

Serious risks include myocardial infarction (heart attack), stroke, and cardiovascular death. Do not initiate in patients who have had a heart attack or stroke within the previous year. Weigh benefits and risks in patients with other cardiovascular risk factors. Osteonecrosis of the jaw and atypical femoral fractures have been reported; consider dental evaluation before invasive dental work and report any new thigh or groin pain. Severe hypocalcemia can occur, especially in patients with severe renal impairment; ensure calcium and vitamin D intake. Evenity is not for use during pregnancy.

Onset Time

Bone turnover changes begin soon after starting therapy. In many patients, measurable increases in spine bone mineral density appear within 3 months, with continued gains through 6 and 12 months. Fracture risk reduction becomes more apparent over the first year when the monthly doses are completed and followed by an antiresorptive agent to maintain benefits.

Compare With Alternatives

Denosumab (brand Prolia) is an antiresorptive given every 6 months. It does not stimulate new bone formation like romosozumab, but it is effective at maintaining or increasing bone density and reducing fractures. Many treatment plans use Evenity for 12 months followed by Prolia to preserve gains (often discussed as “evenity and prolia” in sequence).

Oral bisphosphonates such as alendronate or risedronate are weekly or monthly tablets. They reduce bone breakdown and are widely used after an anabolic course. They may be less potent for rapid density gains but are convenient for long-term maintenance.

Zoledronic acid is an annual intravenous bisphosphonate infusion. It supports maintenance after an anabolic agent or serves as primary therapy for patients who prefer infrequent dosing. Teriparatide, another anabolic option, is a daily self-injection but works through a different pathway and is generally used for up to 24 months.

Combination Therapy

• Calcium and vitamin D supplementation are usually recommended to support bone health during therapy.
• Sequence after 12 months with an antiresorptive agent (for example, denosumab or a bisphosphonate) to maintain bone gains.
• Concurrent use with other anabolic osteoporosis drugs is generally not routine; regimens are typically sequential rather than combined.
• Coordinate timing with dental procedures to reduce jaw-related risks; discuss preventive dental care with the prescriber.

Patient Suitability and Cost-Saving Tips

Evenity is indicated for postmenopausal women with osteoporosis at high risk for fracture, such as those with a history of osteoporotic fracture or multiple risk factors. It is not started in patients with a heart attack or stroke within the past year. It is contraindicated in patients with hypocalcemia until corrected and should be avoided in pregnancy. Caution is advised in patients with severe renal impairment or planned invasive dental procedures.

There is no generic romosozumab. Patients often compare the romosozumab price with other options. To manage evenity injection cost, consider ordering a multi-month supply, where allowed, to lower the effective evenity cost per month. You can turn on reorder reminders in your account so you do not miss a scheduled clinic visit. We offer Canadian pricing and prompt, express, cold-chain shipping to the US.

Authoritative Sources

Amgen Evenity product website

FDA Drugs@FDA: EVENITY (romosozumab-aqqg) overview

Health Canada Drug Product Database

Order Evenity® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This material is for educational purposes only and does not replace advice from a qualified healthcare professional. Always follow the guidance of the prescriber and the product labeling.