Evenity® Injection for Osteoporosis

Evenity® is a prescription monoclonal antibody for osteoporosis in adults at high fracture risk. This page explains how it works, who it suits, and how to access it with US shipping from Canada. It also helps you plan costs without insurance.

What Evenity Is and How It Works

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

The active ingredient is romosozumab, a sclerostin inhibitor. It increases bone formation and, to a lesser extent, reduces bone resorption. The class stimulates new bone growth while slowing breakdown.

Evenity injection is supplied in prefilled syringes for subcutaneous use. Treatment is limited to a one-year course under a clinician’s supervision. The agent is typically started when fracture risk is high or other therapies were not tolerated.

Mechanistically, this medicine binds sclerostin, releasing the brake on osteoblast activity. More bone can be laid down, which supports bone mineral density improvements at key skeletal sites.

Learn more about the condition in our Osteoporosis category.

Who It’s For

This treatment is indicated for postmenopausal women and adult men with osteoporosis at high fracture risk. It may be used if you’ve had a recent fracture, have multiple risk factors, or failed or are intolerant to other therapy. It is not approved for children or during pregnancy.

Do not start if you’ve had a heart attack or stroke within the previous year. Your prescriber will weigh cardiovascular risk factors before and during therapy. Correct low calcium before the first dose, and ensure adequate calcium and vitamin D intake.

Long-term systemic steroid use raises fracture risk. If you use glucocorticoids such as Cortef Hydrocortisone, discuss bone protection with your clinician.

Dosage and Usage

The authorized regimen is Evenity 210 mg given once monthly as two consecutive subcutaneous injections. Each dose is typically administered by a trained healthcare professional. If you have been trained, follow the Instructions for Use exactly.

Use the abdomen, thigh, or upper arm. Rotate sites and avoid bruised, tender, or scarred skin. Remove the syringe from the fridge and allow it to reach room temperature naturally. Do not heat or shake. Inspect for particles or discoloration and do not use if present.

Take calcium and vitamin D as recommended by your prescriber. Keep an updated list of medicines and supplements. For basic technique tips, see our stepwise How To Inject guide.

Strengths and Forms

The product is available as a single-use prefilled syringe containing 105 mg/1.17 mL. Each monthly dose consists of two syringes administered one after the other. Availability may vary by inventory and pack size. On labels you may see the suffix romosozumab-aqqg; some listings simplify it as romosozumab aqqg.

Missed Dose and Timing

If a monthly injection is missed, contact your healthcare professional. In general, administer the dose as soon as possible, then reschedule monthly from the new date. Do not give two doses on the same day. Never inject into irritated skin. Always follow the official label when instructions differ.

Storage and Travel Basics

Store syringes in the refrigerator in the original carton to protect from light. Do not freeze. Allow the carton to sit at room temperature for the instructed time before use. If needed, the syringes may be kept at room temperature for a limited period as per the official Instructions for Use; do not return to the fridge after they warm.

When traveling, keep the carton in an insulated pouch with cold packs, avoiding direct contact and never freezing. Carry your prescription label and a copy of the instructions. Keep out of reach of children. Dispose of used syringes safely right after use.

If osteoporosis relates to menopause, browse Womens Health for supportive information.

Pen Handling and Sharps Disposal

This medicine comes in prefilled syringes, not a pen. Do not remove the needle cap until you are ready to inject. After use, do not recap. Place the syringe directly into a FDA-cleared sharps container. When the sharps container is three-quarters full, follow local guidance for disposal. Never throw loose needles in household trash or recycling.

Benefits

This therapy can increase bone mineral density and reduce fracture risk at key skeletal sites in eligible adults. The monthly schedule can be convenient compared with weekly tablets. A defined one-year course helps you and your prescriber plan a follow-on antiresorptive to maintain gains. Clinic-based administration may support adherence and monitoring.

Because it both builds and preserves bone, the class may help improve structural strength. The follow-up plan often includes an antiresorptive such as a bisphosphonate or denosumab to sustain the benefit.

Side Effects and Safety

Side effects of Evenity can include joint pain, headache, muscle pain, injection site redness, and fatigue. Back pain and limb discomfort are also reported. Mild reactions often improve over time.

Serious risks include heart attack, stroke, and cardiovascular death. Do not use if you had a heart attack or stroke within the past year. Rare events such as osteonecrosis of the jaw and atypical femur fractures have occurred. Low calcium can worsen, especially with severe kidney impairment. Stop and seek help for signs of hypersensitivity, chest pain, shortness of breath, or neurological symptoms.

Drug Interactions and Cautions

Provide your clinician with a complete list of medicines and supplements. Use caution with drugs that lower calcium or vitamin D. Dental procedures may raise the risk of jaw problems; tell your dentist you use this treatment. Severe renal impairment increases hypocalcemia risk; closer monitoring may be needed. This therapy is not recommended during pregnancy or breastfeeding.

What to Expect Over Time

Your prescriber decides the Evenity dosage and monitors progress. The one-year course is typically followed by an antiresorptive to maintain bone mineral density. Many people schedule monthly reminders for clinic visits. Expect routine checks of calcium, vitamin D status, and, when appropriate, periodic bone density assessments.

If you feel unwell after an injection, tell your healthcare professional promptly. Keep taking calcium and vitamin D as directed. Adherence to the monthly schedule matters. Missing doses can affect your plan for fracture risk reduction.

Compare With Alternatives

Other approved options include antiresorptives and bone-building therapies. Denosumab is an injectable antiresorptive given every six months; see Prolia Prefilled Syringe for details. Your prescriber may also consider bisphosphonates such as alendronate or zoledronic acid, or anabolic agents like teriparatide or abaloparatide based on your history, fracture risk, and tolerance.

Pricing and Access

We offer Canadian pharmacy pricing with transparent checkout for US patients. You can review the romosozumab price on this page before ordering. Savings can be meaningful compared with typical clinic buys, especially if you pay without insurance.

For seasonal or limited-time offers, check our Promotions. Payment is processed through encrypted checkout for your security. Ordering includes clear steps for uploading your prescription and having it verified. Ships from Canada to US with reliable fulfilment.

Availability and Substitutions

Stock can fluctuate. If the product is unavailable, your prescriber may recommend an alternative therapy or adjust timing. We do not publish restock dates. Your care team can help decide whether to wait or consider another option in the same class or a different class.

Patient Suitability and Cost-Saving Tips

Good candidates typically include adults with a high fracture risk, multiple fractures, or intolerance to other treatments. It is not suitable if you recently had a heart attack or stroke, have low calcium that cannot be corrected, or are pregnant. Your clinician will review risks and benefits based on your history.

To manage costs, discuss multi-month planning and coordinated scheduling with your clinic. Use reminders for monthly dosing and refills. Maintain adequate calcium and vitamin D to support outcomes. If your osteoporosis is related to endocrine therapy, you may find context in our Anastrozole Guide.

Questions to Ask Your Clinician

• Is this the right bone-building therapy for my fracture risk?
• What lab checks do you recommend before and during treatment?
• How will we transition to an antiresorptive after one year?
• What are my personal cardiovascular risks with this medicine?
• How should I prepare for each injection visit?
• What calcium and vitamin D amounts should I take?
• What symptoms mean I should call you right away?

Authoritative Sources

Prescribing Information (FDA)

Amgen Product Page

Health Canada DPD

Ready to proceed? Evenity US shipping is available with US delivery from Canada and prompt, express, cold-chain shipping. This information is not a substitute for professional medical advice; always consult your healthcare professional.