Kerendia® (finerenone) tablets for CKD linked to type 2 diabetes

What Kerendia® Is and How It Works

Kerendia® (finerenone) is a nonsteroidal mineralocorticoid receptor antagonist. It lowers the risk of sustained eGFR decline, kidney failure, and cardiovascular events in adults with chronic kidney disease (CKD) tied to type 2 diabetes. It is an oral prescription medication taken once daily. Many shoppers compare kerendia price by strength and supply when planning therapy. YouDrugstore is a licensed Canadian pharmacy based in Manitoba. Orders are reviewed by licensed pharmacists before dispensing, and we offer brand and generic medicines at Canadian prices.

Kerendia® works by blocking mineralocorticoid receptor overactivation. This action reduces inflammation and fibrosis in the kidneys and heart. The result is slower kidney function loss and fewer major cardiac outcomes over time. Tablets come in 10 mg and 20 mg strengths to help match dosing to kidney function and potassium levels.

We partner with licensed, vetted international pharmacies to supply authentic brand medicines across a broad selection at affordable pricing. Customer-service chat is available during posted office hours, and a pharmacist can address medication questions.

Dosage and Usage

Dosing is once daily, with or without food. Swallow tablets whole with water. Starting dose depends on eGFR and serum potassium. The target dose is 20 mg once daily.

• Initiation: eGFR ≥60 mL/min/1.73 m²: 20 mg once daily. eGFR 25 to <60: 10 mg once daily.
• Do not start if serum potassium >5.0 mEq/L. Use caution if potassium is 4.8 to 5.0 mEq/L.
• Monitoring: check serum potassium about 4 weeks after start or dose change, then as clinically needed.
• Titration: if on 10 mg and potassium ≤4.8 mEq/L, increase to 20 mg. If potassium 4.8 to 5.5 mEq/L, maintain current dose. If potassium >5.5 mEq/L, withhold; restart at 10 mg when potassium ≤5.0 mEq/L.
• Missed dose: take the next dose at the usual time. Do not double doses.
• Administration notes: tablets are film-coated. Do not split or crush.

Product options include kerendia 10mg tablets and the kerendia 20 mg tablet. Patients often compare the kerendia 10 mg price with the kerendia 20 mg price when selecting a supply size.

• Storage: store at 20 to 25°C (68 to 77°F). Short excursions 15 to 30°C are acceptable.
• Travel: keep tablets in the original labeled container. Carry a copy of the prescription. Use a pill organizer only if it stays dry and closed.
• Refills: plan lab checks for potassium before dose increases or long refills.

Benefits and Savings

In clinical trials, Kerendia® reduced progression to kidney failure and slowed eGFR decline in CKD with type 2 diabetes. It also reduced risk of cardiovascular death, nonfatal myocardial infarction, and hospitalization for heart failure. Once-daily dosing is simple, and no dose adjustment by food is needed.

YouDrugstore offers Canadian pricing that often brings 60 to 80 percent lower costs versus typical US retail. Many patients review kerendia cost by strength and choose multi-month supplies to reduce per-month expense. We carry brand Kerendia® from Bayer and ship to the US.

Side Effects and Safety

The most frequent issue is hyperkalemia. Blood pressure can drop in some people, and sodium can fall. Kidney function changes can occur. Most effects are mild to moderate and manageable with monitoring.

• Common: hyperkalemia, hypotension, hyponatremia, dizziness.
• Less common: fatigue, diarrhea, mild creatinine rise.
• Serious: severe hyperkalemia (muscle weakness, palpitations), acute kidney injury, symptomatic hypotension, allergic reactions (rash, swelling, trouble breathing).

Use is contraindicated with strong CYP3A4 inhibitors such as itraconazole or clarithromycin. Avoid grapefruit or grapefruit juice. Strong inducers (e.g., carbamazepine, St. John’s wort) may reduce effectiveness. Avoid potassium supplements, high-potassium salt substitutes, and other potassium-sparing agents unless directed. Do not use with other mineralocorticoid receptor antagonists.

Not recommended to initiate if eGFR is below 25 mL/min/1.73 m². Not established in pediatric patients. Pregnancy and breastfeeding data are limited; discuss risks and benefits with a prescriber.

Onset Time

Kerendia® does not provide rapid symptom relief. Potassium changes may appear within 2 to 4 weeks, which is why early lab checks are advised. Kidney and cardiovascular outcome benefits accrue over months to years of continuous use.

Compare With Alternatives

SGLT2 inhibitors lower CKD progression and cardiovascular risk in type 2 diabetes and are often used together with finerenone. Options include Jardiance®, which offers kidney and heart protection and glycemic control.

Steroidal MRAs such as spironolactone and eplerenone are used for heart failure and resistant hypertension. They can cause more hormonal side effects (e.g., gynecomastia with spironolactone) and are not approved for CKD outcome reduction in diabetes.

Renin-angiotensin system blockers are foundational. An ARB like telmisartan may be part of therapy; for blood pressure control combinations, see Micardis Plus. Kerendia® is commonly added on top of a maximally tolerated ACE inhibitor or ARB, and often alongside an SGLT2 inhibitor.

Combination Therapy

Kerendia® is intended as add-on therapy to standard CKD care in type 2 diabetes. It is usually layered on top of ACE inhibitor or ARB therapy, and many patients also take an SGLT2 inhibitor. Do not combine with other MRAs or with potassium-sparing diuretics. Monitor potassium after any change in diuretics, ACE inhibitor, ARB, or SGLT2 inhibitor, as these can affect renal handling of electrolytes.

Patient Suitability and Cost-Saving Tips

Good candidates have CKD stage 2 to 4 with albuminuria and type 2 diabetes, are on ACE inhibitor or ARB, and have potassium in the safe range. Those with recurrent hyperkalemia, advanced kidney failure, or use of strong CYP3A4 inhibitors are not good candidates. Discuss the plan and monitoring schedule with the prescribing clinician.

To lower costs, consider a longer supply when stable on dose. Multi-month orders can decrease the per-month price and reduce shipping fees. You can turn on reorder reminders in your account to avoid treatment gaps. For current offers and bulk options, see our kerendia coupon page.

If shopping by condition, explore our Chronic Kidney Disease and Type 2 Diabetes sections for related therapies and education.

Authoritative Sources

See the manufacturer’s patient site for product details: Kerendia patient information. For full prescribing details, review the FDA label: Kerendia prescribing information (FDA).

You can order Kerendia® from YouDrugstore with a valid prescription. Our team provides caring service and prompt, express, cold-chain shipping as needed. Customer-service chat is available during posted office hours if you need help placing an order.

Disclaimer: This content is for general information. It does not replace advice from your healthcare professional. Always follow the directions from the prescriber and the product insert. Report side effects to your clinician. Keep medicines out of reach of children.