Lorbrena® (lorlatinib) tablets for ALK-positive lung cancer

What Lorbrena Is and How It Works

Lorbrena® (lorlatinib) is a targeted cancer medicine. It is used for adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC). It is an oral tablet taken once daily. Many shoppers ask about Lorbrena 100mg price and how to manage therapy costs. We also discuss lorbrena price without insurance to help you plan your budget.

Lorlatinib is a third-generation ALK tyrosine kinase inhibitor. It blocks abnormal ALK signaling that drives tumor growth. It was designed to cross the blood-brain barrier. This helps control brain metastases. The CROWN study compared first-line lorlatinib with crizotinib. Lorlatinib improved progression-free survival and reduced new brain lesions.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba. We meet Canadian pharmacy standards, and our pharmacists review prescriptions before dispensing. We ship brand and generic medicines at Canadian prices and also carry OTC health products. We also work with vetted international partner pharmacies to provide authentic brands, strong availability, and fair pricing.

Dosage and Usage

Lorbrena® is supplied as film-coated tablets. Strengths often include 25 mg and 100 mg. Dosing is once daily at the same time each day. Patients swallow tablets whole with water. Food does not affect exposure.

• Usual starting dose: 100 mg by mouth once daily.
• Take at the same time each day.
• Swallow tablets whole. Do not chew, split, or crush.
• If vomiting occurs after a dose, do not take an extra dose.
• If a dose is missed, take the next scheduled dose. Do not double up.
• Clinicians may adjust doses in 25 mg steps if adverse effects occur.

Drug interactions are important. Strong CYP3A inducers are contraindicated with lorlatinib. Grapefruit may affect levels and is usually avoided. Lorlatinib can affect other medicines by enzyme induction. Clinicians review all prescriptions and supplements before starting therapy.

Storage and travel tips:

• Store tablets in the original bottle at room temperature. Keep them dry and away from heat.
• Keep out of reach of children and pets.
• When you travel, carry your medication in your hand luggage.
• Bring your prescription label and a copy of your prescription.
• Use a daily reminder so you do not miss doses.

Benefits and Savings

Lorbrena® offers several clinical advantages. It delivers once-daily dosing. It shows strong activity in the brain. In the CROWN trial, patients had longer disease control versus crizotinib. Many patients remained progression-free for a prolonged period. Your oncology team will monitor response and side effects and adjust therapy as needed.

Ordering through YouDrugstore is straightforward. You can place your order online, and our team supports you by chat during posted office hours. We ship to the US with prompt, express, cold-chain shipping as needed for temperature-sensitive items.

Many customers save 60–80% compared with typical US prices. Patients paying without insurance often see the largest difference. Multi-month supplies can reduce the per-month cost when available.

Side Effects and Safety

Common effects are usually manageable and often improve with dose changes or supportive care. Serious events can occur and need medical attention. This is not a complete list.

• Very common: increased cholesterol and triglycerides, edema, weight gain, fatigue.
• Neurologic: mood changes, irritability, cognitive effects, speech difficulty, peripheral neuropathy, seizures (less common).
• Gastrointestinal: diarrhea, constipation, nausea, abdominal pain.
• Hepatic: liver enzyme elevations.
• Respiratory: cough; rare interstitial lung disease or pneumonitis.
• Cardiac conduction: PR interval prolongation and atrioventricular block.
• Metabolic: hyperglycemia; pancreatitis has been reported.
• Vision changes; rash; arthralgia.

Strong CYP3A inducers are contraindicated due to safety risks. Clinicians monitor lipids, liver tests, heart rhythm, and mood or cognitive changes. Avoid pregnancy during treatment. Non-hormonal contraception is recommended because lorlatinib can reduce hormonal contraceptive effectiveness. Breastfeeding is not recommended during treatment and for a period after the last dose.

Onset Time

Lorbrena® starts working at the molecular level quickly. Clinical responses may be seen on imaging within weeks. Symptom relief can occur early, but timelines vary. Brain metastases often respond due to strong central nervous system penetration. Your oncology team will schedule scans and lab tests to track response over time.

Compare With Alternatives

Other ALK inhibitors include alectinib, brigatinib, and crizotinib. Choice of therapy depends on prior treatment, brain involvement, side-effect profile, and resistance mutations. Lorlatinib is often selected for its CNS activity and coverage of many resistance mutations. Alectinib and brigatinib are also standard first-line options with strong efficacy and tolerability profiles.

Crizotinib was the first ALK inhibitor. It is now less common as initial therapy due to lower CNS activity. Switching between ALK inhibitors is common when resistance or intolerance occurs.

Some oncology medicines on our site treat other cancers and are not substitutes for lorlatinib. For example, Bavencio® is an immunotherapy for certain urothelial and skin cancers, and Zytiga® is used for prostate cancer. Your oncology team will select an ALK-focused regimen for ALK-positive NSCLC.

Combination Therapy

Lorbrena® is usually given as monotherapy for ALK-positive metastatic NSCLC. Combining with strong CYP3A inducers is contraindicated. Caution is required with many medicines, including certain anticonvulsants, antibiotics, antifungals, antiretrovirals, and herbal products like St. John’s wort. Lifestyle measures, lipid-lowering therapy, and supportive care may be added to manage side effects.

Patient Suitability and Cost-Saving Tips

Patients with ALK-positive metastatic NSCLC may be candidates for Lorbrena®. It can be used first-line or after another ALK inhibitor. Caution is advised in those with significant heart conduction disorders, uncontrolled hyperlipidemia, pancreatitis, severe hepatic impairment, or a history of seizures or mood disorders. Clinicians will review risks and benefits based on your history.

You can lower out-of-pocket costs with a longer supply when appropriate. Ask our team about current bulk promotions that can reduce the per-month price. Set up reorder reminders so you never run short. For current offers and multi-month options, see our lorbrena coupon page.

Browse our Cancer category for other oncology medications available through our pharmacy. Our customer-service chat can help with account, document upload, and ordering steps during office hours. Pharmacists are available to address medication questions tied to your prescription.

Authoritative Sources

Pfizer Lorbrena product information

FDA Prescribing Information for lorlatinib

Health Canada Drug Product Database: Lorbrena

YouDrugstore is ready to help you fill your prescription for Lorbrena®. Order online or by phone where available. We offer friendly support, competitive Canadian pricing, and prompt, express, cold-chain shipping when required.

This content is for general information only and does not replace your clinician’s advice. Always follow your oncology team’s directions for diagnosis, monitoring, and treatment. A valid prescription is required to dispense Lorbrena®.