Multaq® 400 mg Tablets for Atrial Fibrillation and Flutter

What Multaq® Is and How It Works

Multaq® (dronedarone) is an oral antiarrhythmic used in adults with a history of paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL) who are in sinus rhythm or will be cardioverted to sinus rhythm. It helps maintain normal rhythm and lowers the risk of cardiovascular hospitalization. The usual strength is multaq 400 mg tablets. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and prescriptions are reviewed by licensed pharmacists before dispensing. We also partner with vetted international pharmacies to supply authentic brand medicines, offering a broad selection at affordable prices.

Dronedarone blocks multiple cardiac ion channels and has anti-adrenergic effects. This combined action slows abnormal electrical signals and stabilizes heart rhythm. It is not indicated for permanent AF and is contraindicated in certain types of heart failure. Multaq is taken by mouth and is designed for ongoing rhythm control as directed by a prescriber.

Dosage and Usage

• Usual adult dose: 400 mg twice daily with morning and evening meals.
• Indication: maintenance of sinus rhythm and reduction of AF/AFL-related hospitalization in suitable adults.
• Tablets should be swallowed whole with water; do not crush or split unless instructed by a clinician.
• Missed dose: skip the missed tablet and take the next dose at the regular time. Do not double.
• Avoid grapefruit and grapefruit juice due to interaction with CYP3A4.
• Periodic ECG monitoring is recommended to confirm ongoing sinus rhythm, especially if symptoms change.
• Inform the prescriber about all medicines and supplements. Important interactions include digoxin, certain statins, strong CYP3A inhibitors, and other QT-prolonging drugs.

• Store tablets at 15–30 °C (59–86 °F) in the original container to protect from moisture.
• Keep the bottle tightly closed and away from bathrooms or humid areas.
• For travel, keep your medication in carry-on luggage in original labeled packaging.
• Avoid temperature extremes (above 30 °C/86 °F) and do not leave tablets in a hot car.
• Bring extra doses and a copy of your prescription for extended trips.

Benefits and Savings

Multaq supports rhythm control without iodine, so it avoids thyroid and some pulmonary effects associated with amiodarone. Twice-daily dosing with food is straightforward, and no loading dose is required. For many patients, this helps simplify long-term rhythm management and may reduce AF-related hospital visits when used as prescribed.

Buying from a Canadian pharmacy can lower your total treatment costs. Typical savings run 60–80% compared with common U.S. prices. If you compare multaq 400 mg price or price of multaq 400 mg across pharmacies, multi-month supplies often reduce the multaq price per month. Many customers track multaq cost over the year and choose larger fills when available to keep expenses predictable.

multaq coupon information may also help you find periodic offers in one place.

Side Effects and Safety

• Diarrhea, nausea, vomiting, or abdominal pain
• Indigestion or decreased appetite
• Fatigue or weakness
• Skin rash or itching
• Bradycardia (slow heart rate)
• Mild increase in serum creatinine
• Headache or dizziness

Serious but less common risks include new or worsening heart failure; significant liver injury (watch for dark urine, yellowing of eyes/skin); lung inflammation; marked QT prolongation or torsades de pointes; severe bradycardia or conduction block; and increased risk of stroke or death in permanent AF. Multaq is contraindicated in permanent AF; in NYHA class IV or recently decompensated heart failure; with strong CYP3A inhibitors; with other QT-prolonging antiarrhythmics; and in severe hepatic impairment. Pregnancy and breastfeeding are generally not recommended due to potential fetal and infant risk. Regular follow-up and lab/ECG oversight help reduce these risks.

Onset Time

Steady-state dronedarone levels are reached within about a week. Clinicians often assess rhythm and symptoms over the first 1–2 weeks. Reduction in AF recurrences and hospitalizations is typically evaluated over several weeks to months. If symptoms change, repeat ECG monitoring helps confirm rhythm and guide ongoing therapy.

Compare With Alternatives

Sotalol is another rhythm-control option that combines beta-blockade with class III activity. It can help maintain sinus rhythm in selected patients, but requires QT and renal monitoring. See our pricing for Sotalol if your prescriber has discussed this alternative.

Amiodarone is often more effective for maintaining sinus rhythm but carries higher risks of thyroid, lung, liver, eye, and skin effects with long-term use. Dronedarone avoids iodine-related toxicity, though it may be less potent in some cases.

Stroke prevention is a separate need in many AF patients. An oral anticoagulant such as Pradaxa® may be prescribed alongside rhythm or rate control. This does not treat rhythm but helps reduce clot-related risk as directed by a prescriber.

Combination Therapy

• With rate-control agents (beta-blockers or non-dihydropyridine calcium channel blockers): prescribers may adjust doses to limit bradycardia.
• With an anticoagulant (e.g., dabigatran, apixaban, warfarin): used for stroke risk reduction when indicated.
• With digoxin: dose reductions are often considered due to increased digoxin levels.
• With statins: lower allowable doses of simvastatin may be advised; alternatives may be preferred.
• Electrolyte management (potassium, magnesium) is often optimized to reduce proarrhythmic risk.

Patient Suitability and Cost-Saving Tips

Good candidates are adults with paroxysmal or persistent AF/AFL who are in sinus rhythm (or planned for cardioversion) and need maintenance of rhythm. Less suitable candidates include those with permanent AF, significant conduction disease without a pacemaker, unstable or advanced heart failure, severe hepatic impairment, or marked QT prolongation. Clinicians also review drug interactions and kidney function changes.

Cost-conscious buyers compare multaq cost and multaq 400mg tablets offers across pharmacies. Multi-month fills can lower the multaq price per month. Reorder reminders help prevent gaps in therapy. If available in your region, generic dronedarone may offer a lower multaq generic price. Some customers compare our pricing with multaq cost medicare copays to decide the best route for their budget. Periodic multaq discount events can also help reduce spend when timing your refill.

Authoritative Sources

Sanofi Multaq Product Information

FDA Prescribing Information and Medication Guide

Health Canada Drug Product Database: Multaq (dronedarone)

Order Multaq® from YouDrugstore.com: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This page is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and the package insert.