Myrbetriq® (mirabegron) Extended-Release Tablets for Overactive Bladder

What Myrbetriq® Is and How It Works

Myrbetriq® (mirabegron) is a beta-3 adrenergic agonist used for overactive bladder (OAB). It treats urge urinary incontinence, urgency, and urinary frequency. The once-daily, extended-release tablets come in 25 mg and 50 mg strengths. Many people look for Myrbetriq without insurance options to manage out-of-pocket costs. At YouDrugstore, a licensed Canadian pharmacy in Manitoba, prescriptions are reviewed by licensed pharmacists before dispensing, and you can order online with friendly support.

Mirabegron relaxes the detrusor muscle during the storage phase. This increases bladder capacity and helps reduce sudden urges and leaks. It can be used alone or with an antimuscarinic agent in suitable patients. We offer brand and, when available, generic alternatives at Canadian prices, and our team can help with questions about your medication.

We source medicines from licensed, vetted partner pharmacies worldwide to supply authentic brands with a broad selection at affordable rates. YouDrugstore also carries over-the-counter health products for bladder care and general wellness.

Dosage and Usage

Typical adult dosing starts low, then increases if needed. Tablets are extended-release and should be swallowed whole.

• Start: 25 mg once daily, with or without food.
• Titrate: Increase to 50 mg once daily based on response and tolerability, usually after 4–8 weeks.
• Special populations: Dose limits may apply in severe renal impairment or moderate hepatic impairment. Not recommended in end-stage renal disease or severe hepatic impairment.
• Swallow whole: Do not crush, chew, or split.

Missed dose guidance:

• If a dose is missed, take it the same day when remembered.
• If it is almost time for the next dose, skip the missed dose.
• Do not take two doses on the same day.

Storage and travel tips:

• Store at 20–25°C (68–77°F). Short excursions 15–30°C are acceptable.
• Keep tablets in the original bottle, tightly closed, away from moisture.
• For travel, carry in a hand bag with a copy of the prescription.
• Do not store in a car glovebox or near heat sources.

Benefits and Savings

Myrbetriq® reduces urge episodes and bathroom trips and helps improve continence. Many patients see fewer accidents and better sleep due to fewer nightly awakenings. The once-daily dosing is simple, and the tablet has no anticholinergic dry mouth burden at usual doses. Savings can be significant through Canadian pricing.

Ordering from YouDrugstore can offer 60–80% savings compared with typical US retail prices. If paying without insurance, multi-month supplies may lower the per-month cost. Our team can send reorder reminders so therapy stays on track.

Side Effects and Safety

Most people tolerate mirabegron well, but side effects can occur. These are not complete lists.

• Common: increased blood pressure, nasopharyngitis, urinary tract infection, headache, constipation, diarrhea, dizziness, dry mouth.
• Cardiovascular: elevated blood pressure, palpitations, tachycardia.
• Genitourinary: urinary retention risk, especially with bladder outlet obstruction or when combined with antimuscarinics.
• Allergic: rash, pruritus; rare angioedema has been reported.
• Gastrointestinal: abdominal pain, nausea.

Precautions and interactions:

• Blood pressure: Avoid in severe uncontrolled hypertension. Check blood pressure regularly.
• Drug interactions: Mirabegron is a moderate CYP2D6 inhibitor. Levels of CYP2D6 substrates (for example metoprolol, desipramine) can increase. Monitor for dose adjustments of those agents.
• Renal/hepatic impairment: Follow dose limits as directed by the prescriber.
• Urinary retention: Use caution in patients with bladder outlet obstruction or with antimuscarinics.

Seek urgent care for signs of a severe allergic reaction, chest pain, or inability to urinate.

Onset Time

Some improvement may appear within 1–2 weeks. Full benefit often builds over 4–8 weeks as the dose is optimized. Prescribers often reassess after several weeks to gauge response and tolerability.

Compare With Alternatives

Antimuscarinics are established alternatives for OAB. These include solifenacin and tolterodine. Dry mouth and constipation are more common with antimuscarinics, but they work well for many patients. Choice depends on symptom profile, side effect history, and other medicines.

Solifenacin is available as Vesicare®. It is taken once daily. Tolterodine is another option, in immediate-release and long-acting forms. You can compare dosing on Tolterodine and extended dosing on Tolterodine La.

Some patients respond best to a beta-3 agonist like mirabegron. Others do better with an antimuscarinic. Intolerable side effects or limited response often guide switches or combinations.

Combination Therapy

Myrbetriq® may be combined with an antimuscarinic (such as solifenacin) in selected patients. Combination therapy can improve urgency and incontinence episodes more than either agent alone. The risk of urinary retention can rise, so prescribers monitor for voiding difficulty, especially in those with outlet obstruction.

Patient Suitability and Cost-Saving Tips

Myrbetriq® suits adults with OAB who prefer to avoid anticholinergic side effects. It may not suit patients with severe uncontrolled hypertension, end-stage renal disease, or severe hepatic impairment. Discuss a history of urinary retention, glaucoma, and current heart medicines with the prescriber.

Cost-saving ideas:

• Ask your prescriber if 50 mg once daily could replace two lower tablets.
• Choose a multi-month supply when appropriate to lower per-month cost.
• Set reorder reminders to avoid gaps that lead to urgent local fills.

For current promotions, bulk options, and any available Myrbetriq coupon, see our promotions page. If you are comparing Myrbetriq without insurance costs, our team can provide transparent pricing before you place an order.

Learn more about OAB symptoms in our condition guides for Overactive Bladder and Urinary Urgency. You may also find these articles helpful: Effective Myrbetriq Alternatives Options For Bladder Health and Myrbetriq Side Effects You Should Know About.

Authoritative Sources

See the manufacturer’s patient resource on the Myrbetriq Patient Site (Astellas). Review Canadian approval details in the Health Canada Drug Product Database listing. For US labeling, consult the FDA Drugs@FDA entry for mirabegron.

YouDrugstore offers brand and generic medicines at Canadian prices with careful pharmacist review before shipping. Order online or by phone during posted hours, and reach our customer-service chat for support. We ship to the US with prompt, express, cold-chain shipping when needed.

This information is not a substitute for professional medical advice. Always follow your prescriber’s directions and the product monograph. Product availability, appearance, and packaging may vary by manufacturer and country of origin.