Resotran® for Chronic Constipation in Adults

What Resotran® Is and How It Works

Resotran is the brand name for prucalopride, a selective 5‑HT4 receptor agonist. It is used for chronic idiopathic constipation in adults who did not respond to laxatives. Tablets are taken once daily. Many people check the Resotran price before starting therapy, especially if buying without insurance.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

Prucalopride stimulates colonic peristalsis by activating 5‑HT4 receptors in the gut. This helps move stool through the colon and increases spontaneous bowel movements. It may also reduce straining and improve stool consistency. Resotran 2 mg is the usual adult dose. A 1 mg strength is available for some patients.

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Resotran is taken by mouth, with or without food. It is not a stimulant laxative. It acts on motility and is often tried after fiber, osmotic laxatives, or stool softeners have not helped enough. Discuss your history and other medicines with your prescriber before starting.

Dosage and Usage

• Adults: take 2 mg once daily at the same time each day.
• Older adults may start at 1 mg daily and increase to 2 mg if needed.
• Severe renal impairment (creatinine clearance <30 mL/min): 1 mg once daily.
• End‑stage renal disease on dialysis: use is generally not recommended.
• Take with or without food. Swallow tablets with water.
• If you miss a dose, take it when you remember. If it is near the next dose, skip the missed dose. Do not double up.
• If symptoms do not improve after four weeks, speak with your prescriber about whether to continue.
• Keep taking it daily for sustained benefit unless told to stop.

• Store tablets at room temperature, 15–30 °C (59–86 °F).
• Keep in the original blister or bottle to protect from moisture.
• Do not store in a bathroom. Avoid heat and direct sunlight.
• When traveling, carry your medicine in your hand luggage.
• Bring enough for your trip plus extra days.
• Keep out of reach of children and pets.

Benefits and Savings

Many patients have more frequent, predictable bowel movements within the first week. Resotran can lessen straining, abdominal discomfort, and bloating. Quality of life can improve as routines normalize. Once‑daily dosing is simple and fits most schedules.

Buying from Canada can lower your Resotran cost by 60–80% compared with typical U.S. prices. Savings may be helpful if you are paying without insurance. Choosing a multi‑month supply can reduce your per‑month price. You can also set simple reorder reminders so you do not run out.

For current offers, see our resotran coupon page. You may also find a periodic Resotran discount or other promotion there.

Side Effects and Safety

• Headache
• Nausea or vomiting
• Diarrhea
• Abdominal pain or cramps
• Dizziness or fatigue
• Gas or bloating
• Dry mouth

Serious effects are uncommon. Seek urgent care for signs of allergy (rash, swelling, trouble breathing), severe or persistent diarrhea with dehydration, severe abdominal pain, blood in stool, or new or worsening depression, anxiety, or suicidal thoughts. Do not use if you have intestinal perforation or obstruction, severe inflammatory bowel disease (such as active Crohn’s disease or ulcerative colitis), or toxic megacolon/megarectum. Dose adjustments are needed in severe kidney impairment. Discuss pregnancy or breastfeeding with your prescriber.

Onset Time

Some people notice a bowel movement within 1–3 days of starting. Others need a full week or more as the daily dose stabilizes. Clinical studies often assess response at four weeks. If you have not improved by then, your prescriber may reassess treatment. Ongoing daily dosing is usually needed to maintain benefit.

Compare With Alternatives

Linaclotide (brand Constella) is a guanylate cyclase‑C agonist used for chronic idiopathic constipation. It increases intestinal fluid and transit. It is taken once daily on an empty stomach. Diarrhea can occur. For more details, read Constella Medication Uses Side Effects And Dosage Guide.

Lubiprostone (brand Amitiza) activates chloride channels to increase intestinal fluid. It is taken twice daily with food and water. Nausea is common in some patients.

Over‑the‑counter options include polyethylene glycol powder, fiber supplements, and stool softeners. These are often tried first. If laxatives fail, a prescription option like Resotran may be considered. Explore condition information in our Chronic Constipation section.

Combination Therapy

• Your prescriber may allow occasional rescue laxatives while starting Resotran.
• Dietary fiber and adequate fluids can support regularity.
• Osmotic laxatives (for example, polyethylene glycol) may be used short term if needed.
• Avoid combining with other prescription prokinetics unless your clinician directs it.
• Report persistent diarrhea; dose changes or therapy review may be needed.

Patient Suitability and Cost-Saving Tips

Resotran may suit adults with chronic idiopathic constipation who did not respond to laxatives. It is not for bowel obstruction, perforation, severe active inflammatory bowel disease, or toxic megacolon/megarectum. Use caution with severe kidney impairment; the typical dose is 1 mg daily in that setting. People with a history of depression or suicidal ideation should be monitored for mood changes.

Resotran generic name is prucalopride. Where available, a prucalopride generic may lower costs. If you compare Resotran 2 mg and resotran 1mg prices, the per‑tablet cost can differ by strength and pack size. You can often lower your monthly spend by choosing a larger supply. This is helpful if you are managing the resotran cash price.

Use reorder reminders, and consider a two‑ or three‑month supply to reduce shipping fees. Check our promotions page for current site deals. If you have questions about brands or availability, contact our customer service during office hours via chat or phone.

Authoritative Sources

Health Canada Drug Product Database (Resotran/prucalopride)

FDA Prescribing Information for prucalopride (Motegrity)

Manufacturer information for prucalopride (HCP site)

Order Resotran® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This material is educational and does not replace advice from your own health professional. Always follow your prescriber’s directions for your specific situation.