Salofalk® (mesalamine) tablets, granules, foam, and suppositories for ulcerative colitis

What Salofalk® Is and How It Works

Salofalk® is mesalamine (5-aminosalicylic acid, 5-ASA). It treats mild to moderate ulcerative colitis and distal disease such as proctitis and proctosigmoiditis. It is available as oral gastro-resistant tablets, granules, rectal foam, rectal suspension, and suppositories. Common strengths include salofalk 500 mg tablets, salofalk 500 mg suppositories, and salofalk 1g suppositories.

Mesalamine acts locally in the gut. It reduces mucosal inflammation by inhibiting cyclooxygenase and lipoxygenase pathways, lowering prostaglandins and leukotrienes in the intestinal lining. The topical action helps induce remission during flares and maintain remission afterward.

YouDrugstore is a licensed Canadian pharmacy based in Manitoba. Prescriptions are reviewed by licensed pharmacists before dispensing, and you can order online with support from our friendly customer-service chat during posted office hours. We offer brand and generic medicines at Canadian prices and ship to the US.

We source from licensed, vetted international partner pharmacies so you receive authentic brand medications, a broad selection, and fair pricing. Formulations include salofalk 500mg gastro resistant tablets, salofalk granule (1 g GranuStix), salofalk rectal foam, salofalk rectal suspension 4g 60ml, and salofalk tablets for ongoing maintenance. Some patients use salofalk 1000 mg products where higher-dose rectal therapy is needed.

Dosage and Usage

Follow the regimen prescribed by your clinician. Typical use depends on disease location and severity. Oral and rectal 5-ASA may be used together to increase mucosal delivery in left-sided disease.

• Initiation: Treatment often starts during a flare to induce remission. Oral mesalamine may be given once daily or in divided doses, while rectal products (foam, suspension, or suppositories) target distal inflammation.
• Titration: The dose and frequency can change based on response and tolerance. Once controlled, a lower maintenance dose is usually continued to prevent relapse.
• Rectal forms: Suppositories are placed rectally, usually at bedtime for proctitis; foam or suspension enemas cover higher segments for proctosigmoiditis or left-sided colitis.
• Missed dose: If a dose is missed, follow prescriber guidance. General advice is to take it when remembered unless it is close to the next dose; do not double up.

• Storage: Store tablets, granules, and rectal products at room temperature away from moisture. Keep in the original package. Do not freeze rectal foam or suspension.
• Travel: Pack enough medicine for your trip. Keep your prescription label with you. Use a travel case to protect suppositories and keep rectal foam upright.
• Ordering: You can upload your prescription and place your order online. Use your account to track shipments and set gentle reorder reminders.

Benefits and Savings

Salofalk® delivers mesalamine directly to the inflamed mucosa. It helps reduce rectal bleeding, urgency, and stool frequency. Rectal formulations can provide fast, targeted relief for distal disease, while oral tablets and granules maintain remission across the colon.

Convenient options include once-daily oral dosing in many regimens, and a range of rectal forms for tailored coverage. Low systemic absorption supports a favorable safety profile for long-term maintenance compared to systemic steroids.

Ordering from YouDrugstore gives you access to Canadian pricing on brand and generic mesalamine. Many customers save 60–80% versus typical US prices. Multi-month supplies can further lower per-month costs, and our team can help you review strengths such as salofalk 1g, salofalk 1000 mg, or salofalk 500mg tablets to match your prescription.

Side Effects and Safety

Mesalamine is generally well tolerated. Side effects may occur, especially at the start of therapy.

• Common: headache, nausea, abdominal pain, diarrhea, gas, constipation, mild rectal discomfort (with rectal products), and rash.
• Less common: fever, fatigue, joint pain, dizziness, and hair thinning.
• Serious (seek urgent care): signs of allergic reaction; severe abdominal pain or cramping; chest pain; shortness of breath; severe rash; unusual bruising or bleeding; yellowing of the skin or eyes; severe persistent diarrhea; or signs of pancreatitis (severe upper abdominal pain, vomiting).
• Kidney concerns: Interstitial nephritis is rare but possible. Periodic kidney function tests are often recommended during treatment.
• Contraindications: Known hypersensitivity to salicylates or mesalamine; severe renal or hepatic impairment. Use caution with azathioprine or 6-mercaptopurine due to bone marrow suppression risk.

Always discuss new or worsening symptoms with a healthcare professional and follow the product directions provided with your prescribed form.

Onset Time

Symptom relief can begin within several days for distal disease treated with rectal products. Many patients see meaningful improvement within 1–2 weeks, with full induction of remission often taking 4–8 weeks. Maintenance therapy is then continued to help prevent flares.

Compare With Alternatives

Other mesalamine brands have different release profiles. Pentasa releases mesalamine throughout the small intestine and colon via microgranules, while some gastro-resistant tablets focus delivery to the colon. For left-sided disease, rectal therapy is often preferred for faster local action.

Patients who need a liquid rectal option may consider Salofalk® Suspension, which provides a 4 g mesalamine dose per enema to cover the distal colon. Those comparing brands might look at Pentasa® Enema as another 5-ASA rectal alternative.

When 5-ASA is insufficient, prescribers may choose topical or oral corticosteroids (for example, budesonide) for short-term control. Moderate to severe cases may require immunomodulators or biologics under specialist care.

Combination Therapy

Combining oral mesalamine with rectal 5-ASA often improves outcomes for proctitis or proctosigmoiditis. Rectal suppositories or foam can provide rapid symptom control, while oral tablets or granules maintain broader colonic coverage. During a flare, a short course of corticosteroids may be added, then tapered once remission is achieved. Long-term steroid use is generally avoided due to systemic risks.

Patient Suitability and Cost-Saving Tips

Salofalk® suits many adults with mild to moderate ulcerative colitis, including distal disease. It can also be used for maintenance of remission. It may be considered for inflammatory Crohn’s colitis in select cases under clinician guidance. It is not appropriate for patients with salicylate allergy or severe kidney or liver impairment.

Cost-saving ideas:

• Ask your prescriber about the most efficient form for disease location. Rectal 5-ASA may reduce the amount of oral medicine needed for distal disease.
• Compare strengths and pack sizes. Salofalk 1g suppositories and salofalk 1000mg suppositories can be convenient for once-daily dosing in proctitis.
• Consider multi-month orders. Larger supplies often reduce the per-month price and cut repeat shipping costs.
• Check whether a generic mesalamine alternative suits your prescription to lower spend.
• Use your account to set gentle reorder reminders so you do not run short during travel or holidays.

Explore condition guides such as Ulcerative Colitis and Proctitis for more background. Many people compare inflammatory bowel disease with irritable bowel syndrome; our article Ibs What Is Ibs Causes Symptoms Treatment explains the differences.

Common searches include salofalk for ulcerative colitis, salofalk rectal foam, salofalk suspension, salofalk 1g tablets, salofalk 1000 mg granu stix, and salofalk tab. If you are unsure which form your prescription specifies, our customer-service team can help interpret product names before you place your order.

Authoritative Sources

Health Canada Drug Product Database: Mesalamine/Salofalk

FDA Medication Guide and Labeling for Mesalamine Products

Dr. Falk Pharma: Salofalk (mesalazine) product information

You can order from YouDrugstore online. Our licensed team supports your needs from prescription review to delivery. We offer prompt, express shipping to the US, careful packaging for rectal products, and clear communication at each step.

This content is for general information only. It does not replace advice from your healthcare professional. Always follow your prescriber’s directions and the instructions that come with your specific product.