Salofalk® for Ulcerative Colitis: Tablets, Granules, and Rectal Forms

What Salofalk® Is and How It Works

Salofalk is a brand of mesalamine (5-aminosalicylic acid). It treats mild to moderate ulcerative colitis and related distal disease, such as proctitis and proctosigmoiditis. The medicine acts topically in the gut. It reduces inflammatory mediators like prostaglandins and leukotrienes. Many people compare salofalk 500 mg price when choosing between oral and rectal options.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba, and licensed pharmacists review prescriptions before dispensing. We work with licensed, vetted international partner pharmacies to source authentic brand medicines, offering a broad selection at affordable pricing.

Salofalk works in the colonic and rectal mucosa. It is not a systemic steroid and does not suppress the whole immune system. Oral forms deliver mesalamine to the colon using pH-dependent coatings or granule matrices. Rectal forms place the drug directly on inflamed tissue in the rectum and sigmoid colon. This targeted approach helps induce remission and maintain control of symptoms.

Formulations are flexible. Options include salofalk tablets (often 500 mg), salofalk 1g tablets in some markets, salofalk granules (Granu-Stix) at 1 g, 2 g, or 3 g doses, and several rectal forms. Rectal therapies include salofalk suppositories, salofalk rectal foam, and a salofalk rectal suspension 4g 60ml enema. Choice depends on disease extent and patient preference.

Typical use is once or twice daily, depending on formulation. Oral mesalamine may be taken in divided doses during induction. Rectal products are often used at bedtime. Maintenance therapy usually follows remission, at a lower daily dose, as advised by a prescriber.

Dosage and Usage

• Induction, oral: Adults with mild to moderate ulcerative colitis often receive 2–4 g per day in divided doses. Common strengths include salofalk 500 mg or granule sachets such as salofalk 2g or salofalk 3g granu stix once daily.
• Maintenance, oral: Many patients continue at 1.5–2 g per day. Some use once-daily granules. Specific dosing depends on the product and medical advice.
• Suppositories: For proctitis, typical dosing is 500 mg to 1 g once nightly or twice daily. Both salofalk suppositories 500mg and 1 g strengths are used in practice.
• Rectal foam: Salofalk foam or salofalk rectal foam is often used once daily at bedtime, or twice daily during active flares, depending on prescriber guidance.
• Rectal suspension: The enema delivers 4 g mesalamine in 60 mL. Many use one salofalk rectal suspension 4g 60ml enema nightly for induction.
• Administration, oral: Swallow tablets or granules whole. Do not crush or chew. Take with water. Follow any specific timing with meals per product instructions.
• Administration, rectal: Empty bowels if possible before dosing. Shake enemas well. Insert suppositories or apply foam as directed for full rectal coverage.
• Missed dose: If a dose is missed, take it when remembered unless it is close to the next dose. Do not double up doses.
• Do not exceed prescribed daily amounts. Seek medical advice before changing dose or frequency.

• Store most products at room temperature, 15–25°C (59–77°F).
• Keep containers dry and tightly closed. Protect tablets and granules from moisture.
• Do not freeze rectal foam. Store upright when possible.
• Keep enemas at room temperature; do not expose to excessive heat.
• When you travel, carry medicines in original packaging with your prescription.
• During flights, keep medicines in your carry-on to avoid extreme temperatures.
• Keep all forms out of reach of children and pets.

Benefits and Savings

Mesalamine is a first-line treatment for mild to moderate ulcerative colitis. Salofalk helps reduce rectal bleeding, urgency, and stool frequency. Rectal options deliver concentrated therapy to the distal colon. Oral options support more extensive disease. Using both routes together can increase rates of remission in left-sided colitis.

Different strengths fit different needs. Choices range from salofalk 500mg tablets to sachets like salofalk granü stix 1000 mg. Rectal choices include suppositories, foam, and enema. This helps tailor therapy for proctitis or broader colitis. Many patients and caregivers also compare salofalk suppositories price when choosing a rectal option.

Buying from Canada can reduce costs. Expect typical savings of 60–80% versus US pharmacy prices. Multi-month supplies can lower the per-month cost. You may set a reorder reminder in your account so you do not run short. You can compare salofalk price across tablets, granules, and rectal therapies to match your prescription and budget.

Side Effects and Safety

• Common: Headache, nausea, abdominal pain, diarrhea, gas, or bloating.
• Rectal products: Mild rectal irritation, cramping, or urgency can occur.
• Other: Dizziness, rash, or fatigue in some patients.
• Lab changes: Rare increases in liver enzymes or changes in blood counts.

Serious reactions are uncommon but possible. These include acute intolerance syndrome (worsening cramps, pain, bloody diarrhea, fever), pancreatitis, interstitial nephritis, hepatitis, pericarditis, or blood disorders. Stop therapy and seek care if severe symptoms occur. Use caution with kidney or liver impairment. Avoid if allergic to salicylates or aminosalicylates. Discuss interactions with azathioprine, 6-mercaptopurine, and warfarin.

Onset Time

Many patients notice symptom relief within 1–2 weeks as inflammation settles. Rectal forms, such as salofalk suppositories or foam, can ease rectal bleeding and urgency within days. Oral therapy may take 2–4 weeks to show clear benefit in stool frequency and bleeding.

Mucosal healing often requires longer. Clinical trials suggest continued improvement through weeks 4–8. Maintenance dosing helps sustain remission and reduce relapse risk.

Compare With Alternatives

Other mesalamine brands offer different release profiles. Preparations like multi-matrix tablets or beads aim for once-daily dosing. Generic Mesalamine can be an effective, lower-cost alternative when the same delivery characteristics are appropriate.

Rectal therapy choices vary. Suppositories target the rectum. Enemas reach higher into the sigmoid and descending colon. If proctitis is the focus, consider Salofalk® Suppositories for localized coverage.

Topical steroids are another option for flares. Budesonide foam is used in some regions. Some providers alternate budenofalk and salofalk in short courses for distal disease. Steroids can help induce remission but are not used for long-term maintenance.

Combination Therapy

• Oral plus rectal mesalamine: Often used for left-sided ulcerative colitis to increase remission rates.
• Rectal mesalamine plus budesonide foam: Short-term addition during flares of proctitis or proctosigmoiditis.
• Systemic corticosteroids: For more severe flares when mesalamine alone is not enough.
• Immunomodulators or biologics: Added in moderate to severe disease per specialist guidance.
• Monitor for additive gastrointestinal effects. Coordinate dosing to avoid duplication across products.

Patient Suitability and Cost-Saving Tips

Salofalk for ulcerative colitis is suitable for many adults with mild to moderate disease. Rectal forms fit proctitis or proctosigmoiditis. Oral therapy supports more extensive inflammation. Patients with known salicylate or aminosalicylate allergy should avoid this medicine. Caution is advised in renal or hepatic impairment. Monitoring of kidney function is often recommended with ongoing use.

Pregnancy and breastfeeding require individualized assessment. Mesalamine has been used in pregnancy when the benefits outweigh the risks. Discuss any therapy changes with a healthcare professional. Children and adolescents may use mesalamine under specialist guidance.

To reduce costs, compare formulations that meet the same clinical goal. For distal disease, rectal products may allow lower total daily doses. For broader disease, once-daily granules can support adherence. You may find value in salofalk 500mg tablets for maintenance or salofalk 1g tablets where available. Granules such as salofalk 2g and sachets like salofalk granü stix 1000 mg may suit once-daily routines. Those requiring higher induction doses might use salofalk 3g granu stix under prescriber direction.

Set a reminder before you run low. Ordering a multi-month supply can reduce monthly spend and shipping frequency. You can compare salofalk price across salofalk oral options and rectal products, including salofalk foam and enemas like salofalk 4g 60 ml equivalents in some markets. If rectal therapy is needed, consider total cost differences between salofalk suppositories and enema products.

Authoritative Sources

Dr. Falk Pharma: Salofalk (mesalamine) product information

Health Canada Drug Product Database: Salofalk and mesalamine listings

FDA prescribing information: Mesalamine rectal suspension (reference label)

Order Salofalk® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This page is for educational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider about diagnosis, treatment, and dosing choices.