Sitagliptin Malate (Generic for Januvia®) Tablets Information

What Sitagliptin Malate Is and How It Works

Sitagliptin Malate is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It is used with diet and exercise to improve blood sugar in adults with type 2 diabetes. Many people compare the Sitagliptin Malate price, including Sitagliptin Malate without insurance, before they buy Sitagliptin Malate online.

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Sitagliptin Malate increases active incretin hormones (GLP-1 and GIP). This boosts insulin release and reduces glucagon in a glucose-dependent way. That means it helps when blood glucose is high. It has a low risk of hypoglycemia when used alone. Sitagliptin comes as oral tablets taken once daily.

Typical use includes monotherapy or combination therapy with metformin, SGLT2 inhibitors, thiazolidinediones, sulfonylureas, or basal insulin. It is not for type 1 diabetes or diabetic ketoacidosis. You can order Sitagliptin Malate tablets online and have them dispensed at Canadian prices.

Dosage and Usage

• Standard dose: 100 mg by mouth once daily.
• Renal adjustment: 50 mg once daily for moderate impairment (eGFR 30 to <45 mL/min/1.73 m²).
• Renal adjustment: 25 mg once daily for severe impairment or end-stage renal disease (eGFR <30), including dialysis.
• No routine hepatic adjustment is usually required.
• Take with or without food, at the same time each day.
• Swallow tablets whole. Do not crush or split unless your prescriber directs otherwise.
• When adding to a sulfonylurea or insulin, a dose reduction of the other drug may help reduce hypoglycemia.
• Missed dose: take it when remembered on the same day. Skip if it is near the next dose. Do not double.

• Store tablets at 15–30°C (59–86°F) in a dry place.
• Keep in the original bottle with the cap closed to protect from moisture.
• Do not store in a bathroom or above a stove or dishwasher.
• When you travel, pack tablets in your carry‑on bag.
• Bring extra doses and your prescription details.
• Use a daily reminder or pill organizer to help you stay on schedule.
• Do not leave medicine in a hot car or near windows.
• Keep out of reach of children and pets.

Benefits and Savings

Sitagliptin Malate lowers fasting and post‑meal glucose and helps reduce A1C by about 0.5% to 0.8% in studies. It is weight‑neutral and has a low risk of hypoglycemia when used without insulin or a sulfonylurea. Once‑daily dosing adds convenience. Renal‑based dosing supports use across kidney function ranges.

Buying through YouDrugstore can offer 60–80% savings compared with typical US prices. Multi‑month supplies and bulk promotions may reduce your per‑month Sitagliptin Malate cost. You can set simple reorder reminders in your account so you never run short. These options may help if you need Sitagliptin Malate without insurance.

To see current deals, visit our Sitagliptin Malate coupon page for active promotions.

Side Effects and Safety

• Common: stuffy or runny nose, sore throat, upper respiratory infection.
• Headache or dizziness.
• Stomach discomfort, nausea, or diarrhea.
• Joint pain or back pain.
• Rash or mild itching.

Serious but less common reactions include pancreatitis (severe abdominal pain that may radiate to the back), severe joint pain, bullous pemphigoid (blistering skin), significant hypersensitivity reactions (anaphylaxis or angioedema), and worsening kidney function in susceptible patients. Discuss any history of pancreatitis, serious skin disorders, or allergies before use. Hypoglycemia risk rises when sitagliptin is combined with insulin or a sulfonylurea.

Onset Time

Blood glucose may start to improve within the first week as dosing is established. Post‑meal glucose often improves early as incretin activity increases. A1C reductions are usually measurable by 8 to 12 weeks. Full response is generally assessed at about three months and may continue to refine by six months when used steadily.

Compare With Alternatives

Metformin remains the foundation for most adults with type 2 diabetes due to strong A1C reduction, weight neutrality or modest loss, and cardiovascular data. Sitagliptin Malate pairs well with metformin when A1C remains above goal.

SGLT2 inhibitors such as empagliflozin or dapagliflozin lower A1C and support weight loss and blood pressure benefits. They also provide proven heart and kidney protection in many patients. They can be combined with sitagliptin when more control is needed.

GLP‑1 receptor agonists (for example, semaglutide) offer larger A1C drops and meaningful weight loss. They are injections and may have higher gastrointestinal side effects. DPP‑4 inhibitors like sitagliptin are oral and weight‑neutral, which some people prefer.

Combination Therapy

• Metformin plus sitagliptin: common and complementary for glucose control.
• SGLT2 inhibitor plus sitagliptin: targets fasting and post‑meal glucose.
• Basal insulin plus sitagliptin: may improve post‑meal control; consider insulin dose adjustments to limit hypoglycemia.
• Sulfonylurea plus sitagliptin: may require sulfonylurea dose reduction to reduce hypoglycemia risk.
• Thiazolidinedione plus sitagliptin: combination is possible; monitor for edema with TZDs.

Patient Suitability and Cost-Saving Tips

Sitagliptin Malate is for adults with type 2 diabetes who need better glucose control with diet and exercise. It is not for type 1 diabetes or diabetic ketoacidosis. Dose selection should consider kidney function. Most patients with mild hepatic impairment do not need adjustment.

Those with a history of pancreatitis, serious hypersensitivity to sitagliptin, or bullous pemphigoid may not be candidates. Report unexplained severe abdominal pain, blisters, or allergic symptoms. Older adults and patients with chronic kidney disease may use sitagliptin with dosing based on eGFR. Pregnancy and breastfeeding require individualized discussion.

To lower your Sitagliptin Malate cost, choose the generic, compare package sizes, and consider a multi‑month supply. Bulk purchase options can reduce your monthly spend. You can set reorder reminders in your account so you refill on time. These steps can help if you are paying without insurance.

Authoritative Sources

Januvia (sitagliptin) US Prescribing Information

Health Canada Drug Product Database: JANUVIA Product Information

FDA Label: Sitagliptin Tablets (Medication Guide/PI)

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This content is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.