Vagifem® Vaginal Tablets for Postmenopausal Vaginal Symptoms

What Vagifem Is and How It Works

Vagifem® is a low-dose estradiol vaginal tablet used to treat genitourinary symptoms of menopause, including vaginal dryness, irritation, and pain with intercourse. Each Vagifem 10 mcg tablet delivers localized estrogen to the vaginal tissue. This helps restore the vaginal lining, increase lubrication, and reduce discomfort. Many people search for Vagifem price and Vagifem online to manage ongoing therapy affordably.

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Vagifem tablets contain estradiol, the same estrogen your ovaries made before menopause. The tablet dissolves in the vagina and acts locally with minimal systemic absorption. Typical use begins with daily dosing for two weeks, then twice weekly for maintenance. The product is supplied with disposable applicators for clean placement.

Vagifem is made by Novo Nordisk. You may see it described as Vagifem estradiol, Vagifem 10 micrograms, or estradiol Vagifem tablets. It is sometimes called a Vagifem pill, but it is a vaginal tablet, not an oral pill.

Dosage and Usage

• Start with 10 mcg once daily for 2 weeks, or as directed by your prescriber.
• Then continue with 10 mcg twice weekly (for example, Monday and Thursday).
• Wash hands. Remove one preloaded applicator from the blister just before use.
• While standing with one foot raised or lying down, gently insert the applicator into the vagina.
• Press the plunger to release the tablet. Withdraw the applicator and discard it.
• Use at bedtime to reduce leakage and improve comfort.
• If you miss a dose, insert it when remembered unless it is almost time for the next scheduled dose. Do not use two doses on the same day.
• Do not use during pregnancy or while breastfeeding.
• Keep using maintenance doses long term if symptoms return when therapy stops, as advised by your prescriber.

Storage and travel

• Store at room temperature 20–25 °C (68–77 °F); excursions 15–30 °C (59–86 °F).
• Keep tablets in the original blisters until use to protect from moisture.
• Do not freeze. Avoid excessive heat and direct sunlight.
• Pack in carry-on luggage when flying. Keep in original packaging with your prescription label.
• If crossing time zones, keep the twice-weekly schedule roughly spaced 3–4 days apart.
• Do not store in the bathroom. Keep out of reach of children and pets.

Benefits and Savings

Vagifem 10 mcg focuses treatment where it is needed. Local therapy can relieve dryness and pain with intercourse, often within weeks. The simple twice-weekly maintenance schedule is convenient, and the disposable applicators help with hygienic placement.

Buying from Canada can lower your Vagifem cost. Many patients see 60–80% savings compared with typical US pharmacy prices. You can compare the current Vagifem tablets price by pack size on our product page. Multi-month supplies and occasional bulk promotions may reduce your per-month cost.

For deals and offers, see our promotions page for a vagifem coupon.

Side Effects and Safety

• Common: vaginal discharge, irritation or itching, mild burning, abdominal discomfort.
• Headache, breast tenderness, or spotting, especially when starting therapy.
• Urinary symptoms such as frequency or discomfort may change as tissues heal.
• Yeast infection can occur; contact your prescriber if symptoms persist.
• Application-site discomfort usually improves with continued use.

Serious risks are uncommon with low-dose vaginal estrogen but can include blood clots (deep vein thrombosis or pulmonary embolism), stroke, or heart attack. Estrogen can stimulate the uterine lining. Report any unexpected vaginal bleeding. Do not use if you have known or suspected breast cancer or estrogen-dependent cancer, undiagnosed vaginal bleeding, active or past clotting disorders, severe liver disease, or if you are pregnant. Discuss personal and family history with your clinician, especially if you have risk factors for cardiovascular disease or clotting.

Onset Time

You may notice improved comfort and moisture within 1–2 weeks as the loading phase completes. Pain with intercourse often improves over 2–8 weeks. Tissue changes continue with ongoing maintenance. Urinary symptoms linked to genitourinary syndrome of menopause may take up to 12 weeks to improve. Continue regular doses to maintain relief.

Compare With Alternatives

Some adults prefer a cream for flexible dosing. Premarin® Vaginal Cream contains conjugated estrogens and is applied with a reusable applicator. It can treat similar symptoms but is messier and may have more variable systemic absorption than a low-dose tablet.

Others prefer an oral option for pain with intercourse. Osphena® (ospemifene) is a selective estrogen receptor modulator taken by mouth. It is systemic, so monitoring for hot flashes, clot risk, and drug interactions is needed. It may be an option when local estrogen is not suitable.

Systemic patches such as Climara® can help whole-body menopausal symptoms. They are not first-line for isolated vaginal dryness and often require a progestin if you have a uterus. Local therapy like Vagifem 10 micrograms vaginal tablets typically gives targeted relief with less systemic exposure.

Combination Therapy

• Use with vaginal moisturizers (several times weekly) and lubricants during intercourse.
• Combine with systemic hormone therapy when broader menopausal symptom control is needed; estrogen doses may be adjusted.
• Pelvic floor therapy and regular sexual activity or dilator use can help maintain tissue health.
• Treat urinary tract infections and vaginal infections promptly to avoid worsening irritation.

Patient Suitability and Cost-Saving Tips

Vagifem used for genitourinary symptoms of menopause includes dryness, irritation, itching, and dyspareunia. Candidates are postmenopausal adults seeking local therapy without daily cream application. It is not for use in pregnancy or while breastfeeding. People with breast cancer, estrogen-dependent tumors, unexplained bleeding, active or past blood clots, or severe liver disease should avoid estrogen therapy unless their specialist advises otherwise.

If you have a uterus, your clinician will decide whether a progestin is needed. With low-dose vaginal estradiol, a progestin is often not required, but medical oversight is important. Tell your prescriber about all medicines and supplements you use.

To manage Vagifem cost, consider larger packs when available. Multi-month supplies can reduce shipping fees over time and lower the per-month price. You can set gentle email reminders to reorder before you run out. We offer brand and, where available, generic estradiol options at Canadian prices.

We provide prompt, express shipping across the US. Your order ships discreetly in secure packaging. Temperature control is not required for Vagifem, and standard handling protects the blisters.

Authoritative Sources

FDA Application Overview: Vagifem (estradiol vaginal tablets)

Health Canada Drug Product Database: Estradiol Vaginal Products

Novo Nordisk Company Information

Order Vagifem® from YouDrugstore.com: add to cart, upload your prescription, and we ship with prompt, express handling.

This content is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare professional for guidance specific to your health.