Vimovo® (Naproxen/Esomeprazole) Delayed-Release Tablets for Arthritis

What Vimovo® Is and How It Works

Vimovo® combines naproxen, a nonsteroidal anti-inflammatory drug (NSAID), with esomeprazole, a proton pump inhibitor (PPI). It is for adults who need NSAID therapy for arthritis and also need stomach protection. Typical use is twice daily. You take the delayed-release tablet before meals.

Naproxen reduces pain, swelling, and stiffness by blocking cyclooxygenase enzymes. Esomeprazole lowers stomach acid to help reduce the risk of NSAID-related ulcers. Vimovo® is used for osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is not for immediate pain relief or for children.

YouDrugstore is a licensed Canadian pharmacy in Manitoba that meets Canadian pharmacy standards. Our pharmacists review each prescription before we dispense, and we offer Canadian prices online with friendly support during posted office hours.

We source through licensed, vetted partner pharmacies and suppliers, offering authentic brand medicines and broad selection at affordable prices. You can order Vimovo® online or by phone where available, with US shipping.

Dosage and Usage

Follow your prescriber’s directions. Do not change your dose without guidance. Common strengths are 375 mg/20 mg and 500 mg/20 mg. Most adults take one tablet twice daily.

• Take each dose at least 30 minutes before meals.
• Swallow tablets whole with water. Do not split, crush, or chew.
• Use the lowest effective dose for the shortest time needed.
• If you miss a dose, take it when remembered unless it is close to your next dose. Skip the missed dose if needed. Do not double up.
• Avoid taking other NSAIDs at the same time unless your prescriber agrees.

Storage and travel tips:

• Store at 15–30°C (59–86°F) in a dry place, in the original bottle.
• Keep the container tightly closed and away from moisture and heat.
• For travel, keep tablets in your carry-on with the labeled pharmacy bottle.
• Do not store in a hot car or in the bathroom.
• Keep out of reach of children and pets.

Benefits and Savings

Naproxen helps reduce joint pain, swelling, and morning stiffness. Esomeprazole helps lower the chance of developing stomach or duodenal ulcers compared with naproxen alone. The fixed-dose tablet supports adherence because you do not need two separate medicines.

Buying through YouDrugstore can offer 60–80% savings versus typical US prices. We carry brand and, when available, generic options at Canadian prices. We also offer US shipping and helpful customer-service chat during office hours if you have ordering questions.

For people managing Osteoarthritis or Rheumatoid Arthritis, predictable dosing and built-in stomach protection can be an advantage. You can also read about back pain care in our article Lower Back Pain Common Causes And Treatment.

Side Effects and Safety

Most people tolerate Vimovo® well, but side effects can occur. This is not a complete list. Seek medical help for severe or worrying symptoms.

• Common: stomach pain, nausea, constipation, diarrhea, gas, headache, dizziness, indigestion.
• Fluid retention or increased blood pressure.
• Upper respiratory symptoms.
• Less common: rash, itching, tiredness.
• Serious: chest pain, sudden weakness or slurred speech, shortness of breath, black or bloody stools, vomiting blood, severe stomach pain, yellowing skin or eyes, dark urine, little or no urine, severe skin blistering.

Important warnings:

NSAIDs can increase the risk of heart attack and stroke. Do not use right before or after coronary artery bypass graft (CABG) surgery. NSAIDs can also cause stomach and intestinal bleeding or ulcers, which may occur without warning.

Do not use if you had asthma, hives, or an allergic reaction after aspirin or any NSAID. Do not use in the third trimester of pregnancy. Talk to your prescriber if you are breastfeeding or planning pregnancy.

Tell your prescriber about all medicines and supplements. Interactions can occur with blood thinners, antiplatelets, SSRIs/SNRIs, other NSAIDs, corticosteroids, lithium, methotrexate, cyclosporine, ACE inhibitors, ARBs, and diuretics. Esomeprazole can interact with clopidogrel and some antifungals, HIV medicines, and drugs that depend on stomach acid for absorption. Avoid heavy alcohol use.

Onset Time

Naproxen may start to ease pain within one to two hours, but Vimovo® is not an acute pain medicine. Arthritis symptoms may keep improving over several days of regular dosing. Esomeprazole’s acid suppression begins within hours and stabilizes over a few days.

Compare With Alternatives

Some patients use a single NSAID without a built-in PPI. Celecoxib is a COX-2 selective NSAID that may have a lower ulcer risk than nonselective NSAIDs, but GI risk still exists, especially with aspirin. Meloxicam is a once-daily NSAID option for chronic arthritis pain.

Others pair an NSAID with a separate PPI like omeprazole. This offers flexibility to adjust components. Topical NSAIDs can help with localized joint pain and have lower systemic exposure; see Voltaren® Emulgel Extra Strength for targeted relief on superficial joints.

Your choice depends on your medical history, risk factors, and treatment goals. Your prescriber can help compare options.

Combination Therapy

Vimovo® may be used alongside physical therapy, exercise, and weight management. It is often part of a broader plan for arthritis. In rheumatoid arthritis, it may be used with disease-modifying drugs if your clinician advises. Do not combine it with other oral NSAIDs. Low-dose aspirin for heart protection may be continued only if your prescriber agrees, as bleeding risk increases.

Patient Suitability and Cost-Saving Tips

Vimovo® suits adults who need steady NSAID therapy and have a risk of ulcers or past stomach issues. It may be useful if you had GI side effects on NSAIDs alone. It is not right for people with active GI bleeding, severe kidney disease, or a history of serious NSAID reactions. It is not for late pregnancy.

To lower costs, ask your prescriber if a lower strength meets your needs. Choosing a multi-month supply can reduce the per-month price. We can send gentle reorder reminders so you do not run out. Bulk promotions may be available when allowed.

You can check current deals and bulk options on our promotions page; see the vimovo coupon entry for any active offers.

If back pain limits your activity, lifestyle steps may help alongside medicine. Our article Upper Mid Back Pain Cervical Pain Treatment outlines simple changes you can discuss with your clinician.

Authoritative Sources

Review the manufacturer information on the FDA Prescribing Information for Vimovo. The Health Canada listing is available in the Drug Product Database Vimovo entry. You may also visit the Horizon product page for corporate details.

Ready to get started? Order from YouDrugstore, a licensed Canadian pharmacy. Our team reviews your prescription and supports safe dispensing at Canadian prices. We offer prompt, express shipping to the US.

This information is not a substitute for professional medical advice. Always follow your prescriber’s directions and read the patient leaflet. If you have severe symptoms or an emergency, seek urgent medical care.