Vyzulta Ophthalmic Solution for Glaucoma and Ocular Hypertension

What Vyzulta Is and How It Works

Vyzulta Ophthalmic Solution (lantanoprostene bunod 0.024%) is a prescription eye drop used to lower intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. It is a nitric oxide-donating prostaglandin analog. You apply it topically to the eye once each evening. YouDrugstore is a licensed Canadian pharmacy based in Manitoba that serves US patients online. We coordinate sourcing and shipment through licensed partner pharmacies, and their pharmacists review prescriptions before release. Our team also carries OTC health products to support eye care.

Vyzulta lowers IOP by increasing the outflow of aqueous humor through two pathways. After instillation, it releases latanoprost acid, which increases uveoscleral outflow. It also donates nitric oxide, which relaxes the trabecular meshwork and Schlemm’s canal to increase trabecular outflow. Using both routes can produce robust, sustained pressure reductions in many patients with glaucoma.

We source through vetted international partner pharmacies that supply authentic brand medications at competitive Canadian prices, giving you a broad selection and good value.

Dosage and Usage

Use Vyzulta exactly as your prescriber directs. The usual dose is one drop in each affected eye once daily in the evening. Do not use it more than once per day, since extra doses can reduce its effect.

• Wash your hands. Check the dropper tip to make sure it is clean.
• Remove contact lenses before use. Wait at least 15 minutes before reinserting them.
• Tilt your head back. Pull down the lower eyelid to form a pocket.
• Hold the bottle above the eye. Instill one drop without touching the eye or lashes.
• Close the eye gently. Press a finger on the inner corner of the eye for 1 minute to reduce systemic absorption.
• If you use other eye drops, wait at least 5 minutes between products.

Missed dose: If you miss a dose, skip it and use the next dose at the usual time the next evening. Do not double up.

• Storage before first opening: Keep refrigerated at 2–8 C (36–46 F). Do not freeze.
• After opening: You may store at 2–25 C (36–77 F). Keep the bottle tightly closed and away from light. Follow your product’s discard date.
• Travel: Use an insulated pouch with cold packs for unopened bottles. Keep out of direct sun and do not leave in a hot car.

Benefits and Savings

Vyzulta reduces IOP in patients with open-angle glaucoma or ocular hypertension. Lower pressure helps slow optic nerve damage and reduces the risk of vision loss over time. Once-daily dosing supports adherence, and evening use may reduce the impact of temporary redness.

Patients who respond to prostaglandin-class therapy often see clinically meaningful IOP reductions across the 24-hour curve. Vyzulta’s dual mechanism helps increase outflow through both the uveoscleral and trabecular pathways.

Ordering through YouDrugstore lets many US patients pay 60–80% less than typical US retail prices. We offer brand medications at Canadian pricing, online ordering, and customer-service chat during posted hours to help with account or order questions.

Side Effects and Safety

Most side effects are mild and improve with continued use. Call your prescriber if symptoms are severe, persistent, or concerning.

• Common: Mild eye redness, irritation, burning or stinging, itching, dry eye, blurred vision, eye pain, foreign body sensation, increased tearing, light sensitivity.
• Appearance changes: Long lashes, darker lashes, increased iris pigmentation (brown color change), eyelid or periorbital skin darkening, and deepening of the eyelid sulcus. Iris color changes may be permanent.
• Less common but important: Inflammation inside the eye (uveitis), macular edema (especially in aphakic or certain pseudophakic patients), corneal edema, and reactivation of herpetic keratitis.
• Allergy or severe reaction: Swelling, severe redness, eye discharge, or vision changes. Stop use and seek medical care.

Precautions: Tell your prescriber if you have had eye surgery, have risk for macular edema, active ocular inflammation, a history of herpes simplex keratitis, or severe dry eye. Discuss use in pregnancy or nursing. Do not touch the dropper tip to any surface. This helps prevent contamination.

Onset Time

Vyzulta begins to lower IOP within hours of the first dose. Many patients see meaningful reductions within the first week. Maximum effect often develops over 2 to 4 weeks of consistent evening use. Your eye care professional will set follow-up visits to measure your pressure and assess response.

Compare With Alternatives

Glaucoma therapy is individualized. Your prescriber may choose a prostaglandin analog first, then adjust based on IOP targets and tolerability.

Bimatoprost and travoprost are other once-daily prostaglandin options. Some patients respond differently across agents. Vyzulta’s nitric oxide donation can add trabecular outflow benefits compared with traditional prostaglandins.

If a non-prostaglandin is needed, alpha-2 agonists and carbonic anhydrase inhibitors are common. Brimonidine is widely used; you can review alphagan ophthalmic solution or the newer formulation alphagan p ophthalmic solution. Carbonic anhydrase inhibitors like brinzolamide are dosed two to three times daily; see azopt for details. Your provider may also consider timolol or fixed-combination drops when suitable.

There is no approved generic for Vyzulta in the US or Canada at this time. If cost is a concern, talk with your prescriber about alternatives that meet your pressure goals, then compare pricing.

Combination Therapy

Many patients reach target IOP with a single agent. If not, Vyzulta can be combined with other classes such as beta blockers, carbonic anhydrase inhibitors, or alpha-2 agonists. Do not use two prostaglandin analogs together, as this can blunt efficacy.

When using multiple eye drops, separate each product by at least 5 minutes. If using gel-forming drops or ointments, apply those last to avoid diluting other medications.

Patient Suitability and Cost-Saving Tips

Vyzulta may suit adults with open-angle glaucoma or ocular hypertension who need once-daily therapy with strong outflow-enhancing effects. It is less suitable for patients with a history of uveitis, macular edema risk after complicated lens surgery, or active herpetic eye disease. Discuss these factors with your eye care professional.

Eye redness or eyelash growth is common across the class. Iris color change is more likely if your eyes are mixed-color or light brown. These changes can be permanent. If you are sensitive to redness or have cosmetic concerns, bring them up before you start.

To manage cost, consider ordering a multi-month supply when your prescription allows. This can lower your per-month cost and reduce shipping fees. You can also turn on gentle reorder reminders in your account so you do not run out. If your prescriber recommends a different agent, compare prices across options in our glaucoma category and discuss whether the expected IOP reduction meets your target.

If you are comparing brands and generics, our article generics vs brand name medications explains how regulators assess equivalence. For general eye wellness, see tips in healthy vision month protect your eyes today. If you have symptoms of dry eye syndrome, ask your provider how to integrate artificial tears without washing out medicated drops.

Authoritative Sources

For complete prescribing details, review the US FDA Prescribing Information for Vyzulta, the Health Canada Product Monograph, and the manufacturer’s Vyzulta patient and HCP site.

You can order Vyzulta Ophthalmic Solution from YouDrugstore online or by phone during office hours. We act as your referral partner, coordinating with licensed pharmacies for fulfillment and prompt, express, cold-chain shipping to the US.

Disclaimer: This content is educational and does not replace your prescriber’s advice. Always follow your eye care professional’s directions and read the patient leaflet that comes with your medication.