Vyzulta® Ophthalmic Solution for Lowering Eye Pressure

What Vyzulta® Is and How It Works

Vyzulta (latanoprostene bunod ophthalmic solution 0.024%) is a once-daily eye drop used to lower intraocular pressure in open-angle glaucoma or ocular hypertension. Many patients compare Vyzulta Ophthalmic Solution online to understand options and costs, including Vyzulta Ophthalmic Solution without insurance. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

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Vyzulta is a prostaglandin analog that also donates nitric oxide. After instillation, it converts to latanoprost acid, which increases uveoscleral outflow. The nitric oxide moiety relaxes the trabecular meshwork and Schlemm’s canal, improving aqueous humor outflow through the conventional pathway. The dual action helps lower eye pressure over 24 hours with one evening dose.

Indications include reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. The route is topical ophthalmic use.

Dosage and Usage

• Usual dose: one drop in the affected eye(s) once daily in the evening.
• Do not use more than once daily; extra doses may reduce effectiveness.
• Wash hands before use. Avoid touching the dropper tip to any surface.
• Remove soft contact lenses before instillation. Wait at least 15 minutes to reinsert.
• If using other eye medicines, separate products by at least 5 minutes.
• Apply gentle pressure to the inner corner of the eye (punctal occlusion) for 1 minute.
• If a dose is missed, skip the missed dose and resume the next evening.
• Stop and consult a healthcare professional if severe eye pain, vision changes, or swelling occur.

• Before opening, store refrigerated at 2–8°C (36–46°F). Do not freeze.
• After first opening, store at room temperature up to 25°C (77°F) for up to 8 weeks.
• Keep the bottle tightly closed and protect from light.
• Write the date you open the bottle on the label to track the 8-week window.
• For travel, carry the bottle in your hand luggage with a small insulated pouch.
• Do not leave drops in a hot car or in direct sun.
• If flying, keep the cap secure to prevent leaks and keep the box or a photo of the label with you.

Benefits and Savings

Vyzulta eye drops offer once-daily evening dosing, which supports routine use. The dual mechanism targets both uveoscleral and trabecular outflow, providing effective pressure reduction across the day and night. Patients appreciate simple dosing, especially when other eye drops are also prescribed.

Ordering from Canada can reduce Vyzulta Ophthalmic Solution cost. Typical savings are 60–80% compared with many US retail prices. These savings may help those paying Vyzulta Ophthalmic Solution without insurance or with high deductibles.

For current offers, see our Vyzulta Ophthalmic Solution coupons page.

Side Effects and Safety

• Eye redness (conjunctival hyperemia)
• Eye irritation, burning, or stinging after instillation
• Eyelash growth and thickening
• Increased pigmentation of the iris, eyelid skin, or eyelashes
• Dry eye, itching, foreign body sensation
• Blurred vision shortly after use
• Headache or light sensitivity
• Punctate keratitis

Iris color change may be permanent and more noticeable in mixed-color irides. Serious but less common risks include macular edema (higher risk in aphakia or a torn posterior lens capsule), uveitis, or herpetic keratitis recurrence. The product contains benzalkonium chloride, which can discolor soft lenses and may irritate the ocular surface. Avoid use in patients with known hypersensitivity to any component.

Onset Time

Pressure lowering begins within hours of the first dose. Many patients see meaningful intraocular pressure reductions within 1–2 weeks as dosing remains consistent. The full effect may stabilize by 4 weeks. Prescribers often assess response at a follow-up visit after several weeks of steady use.

Compare With Alternatives

Latanoprost is a widely used first-line prostaglandin analog. A preservative-free option, Monoprost®, may suit patients with sensitive ocular surfaces or contact lens intolerance. It is typically dosed once daily in the evening.

Bimatoprost is another prostaglandin analog with proven pressure-lowering activity. In Canada, Lumigan Rc® is a common brand and is also used once nightly. Choice among these agents can depend on tolerability, ocular surface health, and target pressure.

Fixed combinations, such as brimonidine/timolol (for example, Combigan), are often added when one agent alone does not meet target pressure. These products reduce drop burden but carry each component’s profile.

Combination Therapy

• Often combined with a topical beta-blocker (timolol) when additional IOP lowering is needed.
• Alpha-2 agonists (brimonidine) or carbonic anhydrase inhibitors (dorzolamide, brinzolamide) are common add-ons.
• Separate each product by at least 5 minutes to reduce washout.
• Assess ocular surface tolerance; consider preservative load when multiple drops are required.
• If irritation increases, clinicians may adjust products or switch to preservative-free options.

Patient Suitability and Cost-Saving Tips

Vyzulta Ophthalmic Solution usage is intended for adults with open-angle glaucoma or ocular hypertension who need pressure reduction. It is not for acute angle-closure glaucoma. Use caution in eyes with active intraocular inflammation, a history of uveitis, herpetic keratitis, or risk factors for macular edema. Safety in pediatric patients has not been established.

Contact lens wearers should remove lenses before use and wait 15 minutes to reinsert. Patients with hypersensitivity to latanoprostene bunod or benzalkonium chloride should not use it. Discuss use during pregnancy or breastfeeding with a qualified professional.

To manage Vyzulta Ophthalmic Solution price, consider multi-month supplies when permitted. Larger fills can lower the per-month cost, and reorder reminders help you avoid gaps. Those paying the Vyzulta Ophthalmic Solution cash price may also discuss alternatives, such as latanoprost, with their prescriber if appropriate.

Authoritative Sources

Bausch + Lomb Vyzulta professional information

Health Canada Drug Product Database: Vyzulta

US FDA Prescribing Information: Vyzulta

Order Vyzulta® from Youdrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This page is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and the product label.