How does this combination differ from taking metformin alone?

The tablet pairs metformin extended-release with an SGLT2 inhibitor (dapagliflozin). Metformin helps reduce liver glucose production and improve insulin sensitivity. The SGLT2 inhibitor increases urinary glucose excretion. Using both may enhance glucose control when diet and activity are not enough with metformin alone. Your clinician will decide if a dual-mechanism approach suits your A1C goals, kidney function, and tolerability profile.

Will I lose weight on this medicine?

Some people may experience modest weight changes due to glucose loss in urine and lifestyle measures. Results vary. Metformin is weight-neutral for many, while SGLT2 inhibitors can contribute to slight reductions for some. Focus on a balanced meal plan, activity, and regular monitoring. Your healthcare professional can review expectations and adjust your plan if weight is a key goal.

Can I drink alcohol while taking it?

Alcohol can increase the risk of lactic acidosis with metformin, especially with heavy use or dehydration. If you drink, do so in moderation, avoid binge drinking, and maintain hydration. Discuss your typical intake with your prescriber before starting. They may provide specific limits or advise against alcohol depending on your health status and lab results.

What if I have kidney issues?

Kidney function is important for both components. Your prescriber will assess your estimated glomerular filtration rate (eGFR) before starting and periodically after. Dose selection and continued use depend on those results and on how you respond. If your kidney function declines, the therapy may need to be adjusted or stopped. Follow the official label and your clinician’s advice.

Do I need to check blood sugar more often at the start?

Your clinician may ask you to monitor more closely when beginning or changing diabetes therapy, especially if you also use insulin or a sulfonylurea. This helps watch for low blood sugar and guides follow-up visits. Keep a log of readings, meals, and any symptoms. Share these records at appointments so your care plan can be adjusted safely.

Should I stop metformin before a contrast scan?

Many people need to hold metformin around the time of iodinated contrast imaging, depending on kidney function and the type of study. Your healthcare professional will provide instructions on timing and when to restart. Always tell the radiology team and your prescriber about your medicines before a scan. Do not stop or restart without guidance.

Can I cut or crush the tablets?

No. These are extended-release tablets and should be swallowed whole. Cutting, crushing, or chewing can alter the release profile, potentially changing exposure and increasing side effects. If you have trouble swallowing tablets, talk to your clinician or pharmacist about alternatives or different strengths. They can suggest practical strategies that maintain safety and effectiveness.

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Xigduo® XR is a prescription tablet that combines dapagliflozin and metformin extended-release to help manage blood sugar in adults with type 2 diabetes. This page explains what it is, how it works, and how to use it safely. We support US delivery from Canada so you can manage refills conveniently, even if you pay without insurance.

What Xigduo Is and How It Works

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Xigduo® XR contains two proven diabetes medicines. Dapagliflozin is an SGLT2 inhibitor that helps your kidneys remove excess glucose in urine. Metformin XR reduces glucose production in the liver and improves insulin sensitivity. Together, this combination can lower A1C as part of a broader care plan that includes diet and activity. Your prescriber decides if this therapy fits your needs based on your medical history and current treatment.

Because it combines two mechanisms, the treatment may offer convenient, once-daily dosing for many adults. People sometimes compare dapagliflozin-based options with metformin-only therapy; your clinician will weigh benefits and risks for you. If you want to review the SGLT2 component by itself, see our Dapagliflozin listing for background on this class.

Who It’s For

This medicine is indicated for adults with type 2 diabetes to improve glycemic control, alongside diet and exercise. It is not for type 1 diabetes or for treating diabetic ketoacidosis. People with significant kidney problems, severe liver disease, or a history of lactic acidosis should generally avoid metformin-containing therapies. Those with recurrent genital infections or frequent urinary tract infections may need extra monitoring when using an SGLT2 inhibitor.

Tell your healthcare professional about all conditions, including heart failure, dehydration risk, or planned surgery. Discuss pregnancy and breastfeeding plans. Your prescriber may order lab tests to ensure it is appropriate before starting.

Dosage and Usage

Follow your prescription exactly. The usual approach is once daily with the evening meal. Swallow tablets whole. Do not split, crush, or chew extended-release tablets. Your prescriber may adjust the strength based on blood glucose targets, kidney function, and tolerability. Maximum approved daily doses are set by the official label; when uncertain, defer to that guidance.

If you are switching from metformin or an SGLT2 inhibitor alone, your clinician may select a starting strength that matches your current regimen. Take the tablet at the same time each day to build a routine. If gastrointestinal upset occurs, taking it with food may help. Your clinician may also recommend hydration strategies, especially during hot weather or illness.

Strengths and Forms

This therapy is available as extended-release tablets in several combinations. Common options include 5/500 mg, with others available depending on market and manufacturer supply. Availability may vary.

Missed Dose and Timing

If you miss a dose, take it when you remember on the same day. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at once. If vomiting or diarrhea occurs, contact your prescriber for guidance, especially if you cannot keep fluids down.

Storage and Travel Basics

Store tablets at room temperature and protect from moisture. Keep the bottle tightly closed and out of reach of children and pets. Do not store in the bathroom. When traveling, keep your medicine in your carry-on bag with the original label. Bring a copy of your prescription and a medication list. If you cross time zones, set reminders to take it at a consistent local time. Avoid excessive heat in cars or direct sunlight on pill organizers.

Benefits

This combination targets glucose from two angles, which may help many adults meet their A1C goals when used with lifestyle measures. Once-daily extended-release dosing can simplify your schedule. You can Buy Xigduo XR online through YouDrugstore after we receive your valid prescription. For many, having one tablet instead of two separate agents can support adherence.

Side Effects and Safety

Digestive upset: nausea, diarrhea, gas, or stomach discomfort
Increased urination and thirst
Genital yeast infections or irritation
Headache or mild dizziness

Serious but uncommon risks include lactic acidosis with metformin, diabetic ketoacidosis with SGLT2 inhibitors even if glucose is not very high, severe urinary infections, dehydration, and kidney problems. Seek urgent care for symptoms like rapid breathing, severe abdominal pain, confusion, or chest discomfort. Low blood sugar can occur when this medicine is combined with insulin or a sulfonylurea; your clinician may discuss monitoring and signs of hypoglycemia.

Drug Interactions and Cautions

Tell your prescriber about all medicines you take. Diuretics may increase dehydration risk. Insulin and sulfonylureas can increase hypoglycemia risk when used together with this therapy. Excess alcohol raises the risk of lactic acidosis with metformin. Iodinated contrast for imaging may require temporarily stopping metformin; follow your clinician’s instructions. Report any history of pancreatitis, frequent urinary infections, or foot ulcers. Keep up with kidney and liver function tests as advised.

What to Expect Over Time

Many people notice more frequent urination at the start due to glucose excretion. Gastrointestinal effects often improve after your body adapts. Your prescriber may check A1C and kidney function over time and adjust therapy if needed. Adherence, meals, and activity remain important for long-term control. Questions about Dapagliflozin metformin extended-release price often arise, but selection should focus on clinical fit first.

Compare With Alternatives

Other SGLT2 options include Jardiance and combination therapies like Invokamet. Your prescriber may consider cardiovascular or kidney protection data, tolerability, and dosing preferences. When comparing Dapagliflozin metformin XR price to single-agent approaches, remember that tablet burden and convenience also matter in day-to-day use.

Pricing and Access

We offer transparent Canadian pricing with Xigduo XR price from Canada clearly listed on the product page. You can also view per-fill options and compare strengths. If you’re looking for coupons, see our Promotions page. Enjoy US shipping from Canada with efficient fulfilment and secure checkout. For broader diabetes options, browse Type 2 Diabetes and Diabetes Care categories. Our prescription required and verified process helps keep your therapy safe.

Availability and Substitutions

Stock can vary by strength and manufacturer. If a particular option is temporarily unavailable, your prescriber may recommend a therapeutic alternative. Questions about Xigduo XR coupon price come up often; discounts can change, so check the product page for current details or speak with our team. Do not substitute on your own. Any change should be directed by your clinician.

Patient Suitability and Cost-Saving Tips

Good candidates are adults with type 2 diabetes who need additional glycemic control and can tolerate metformin and an SGLT2 inhibitor. Those with advanced kidney disease, active metabolic acidosis, or severe liver impairment may not be suitable. If weight considerations or cardiovascular risk influence therapy, your clinician can review the latest guidance.

To manage costs, consider larger fills if appropriate, set refill reminders, and compare generic or alternative classes when clinically acceptable. People sometimes ask about Dapagliflozin metformin XR 10/1000 price; multi-month refills can lower per-tablet costs in some cases. Discuss options with your prescriber and pharmacist to balance clinical goals with budget.

Questions to Ask Your Clinician

Is this combination right for my A1C target and kidney function?
Should I adjust other diabetes medicines when starting this therapy?
What signs of low or high blood sugar should I watch for?
How should I handle sick days, travel, or surgery?
When will we recheck labs and review progress?
What lifestyle steps best complement this treatment?

Authoritative Sources

AstraZeneca Prescribing Information FDA DailyMed: Xigduo XR Health Canada Drug Product Database

Storage, Safety, and Learning More

For deeper reading on metformin, see Metformin Role and common tolerability tips in Metformin Diarrhea. If your prescriber changes your plan, we can coordinate the next fill efficiently.

Ready to proceed? Place your order with YouDrugstore for prompt shipping that Ships from Canada to US, then upload your prescription. This information is not a substitute for professional medical advice; always follow your clinician’s instructions and the official label.

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View All FAQs

How does this combination differ from taking metformin alone?
The tablet pairs metformin extended-release with an SGLT2 inhibitor (dapagliflozin). Metformin helps reduce liver glucose production and improve insulin sensitivity. The SGLT2 inhibitor increases urinary glucose excretion. Using both may enhance glucose control when diet and activity are not enough with metformin alone. Your clinician will decide if a dual-mechanism approach suits your A1C goals, kidney function, and tolerability profile.
Will I lose weight on this medicine?
Some people may experience modest weight changes due to glucose loss in urine and lifestyle measures. Results vary. Metformin is weight-neutral for many, while SGLT2 inhibitors can contribute to slight reductions for some. Focus on a balanced meal plan, activity, and regular monitoring. Your healthcare professional can review expectations and adjust your plan if weight is a key goal.
Can I drink alcohol while taking it?
Alcohol can increase the risk of lactic acidosis with metformin, especially with heavy use or dehydration. If you drink, do so in moderation, avoid binge drinking, and maintain hydration. Discuss your typical intake with your prescriber before starting. They may provide specific limits or advise against alcohol depending on your health status and lab results.
What if I have kidney issues?
Kidney function is important for both components. Your prescriber will assess your estimated glomerular filtration rate (eGFR) before starting and periodically after. Dose selection and continued use depend on those results and on how you respond. If your kidney function declines, the therapy may need to be adjusted or stopped. Follow the official label and your clinician’s advice.
Do I need to check blood sugar more often at the start?
Your clinician may ask you to monitor more closely when beginning or changing diabetes therapy, especially if you also use insulin or a sulfonylurea. This helps watch for low blood sugar and guides follow-up visits. Keep a log of readings, meals, and any symptoms. Share these records at appointments so your care plan can be adjusted safely.
Should I stop metformin before a contrast scan?
Many people need to hold metformin around the time of iodinated contrast imaging, depending on kidney function and the type of study. Your healthcare professional will provide instructions on timing and when to restart. Always tell the radiology team and your prescriber about your medicines before a scan. Do not stop or restart without guidance.
Can I cut or crush the tablets?
No. These are extended-release tablets and should be swallowed whole. Cutting, crushing, or chewing can alter the release profile, potentially changing exposure and increasing side effects. If you have trouble swallowing tablets, talk to your clinician or pharmacist about alternatives or different strengths. They can suggest practical strategies that maintain safety and effectiveness.