Xiidra® (lifitegrast) Ophthalmic Solution for Dry Eye Disease

What Xiidra® Is and How It Works

Xiidra® (lifitegrast ophthalmic solution 5%) is a prescription eye drop for the signs and symptoms of dry eye disease. It is preservative free and supplied in single-use containers. Dosing is twice daily in each eye. YouDrugstore is a licensed Canadian pharmacy in Manitoba. Our pharmacists review prescriptions before dispensing, and we ship across the US. Many patients search for Xiidra Ophthalmic Solution without insurance, so we make pricing clear and support easy ordering. For search clarity, this page covers Xiidra® and the term “Xiidra Ophthalmic Solution” as used by many patients.

Lifitegrast blocks LFA-1/ICAM-1 interaction on immune cells. This helps reduce ocular surface inflammation linked to dry eye symptoms like burning, stinging, and irritation. Some people notice relief within weeks, and benefit can build over time. We work with licensed, vetted partner pharmacies to source authentic brand medicines at fair prices and with a broad selection.

Dosage and Usage

Use Xiidra® exactly as prescribed. Typical dosing is one drop in each eye twice a day, about 12 hours apart. Read the enclosed instructions before first use. The product is single use, so discard each opened vial after dosing both eyes.

• Wash and dry your hands.
• Open one single-use container. Do not touch the tip.
• Tilt your head back and pull down the lower eyelid.
• Instill one drop into the eye. Avoid touching the eye or lashes.
• Repeat in the other eye.
• Discard the opened container. Do not save leftovers.
• Remove contact lenses before dosing. Wait 15 minutes before reinserting.
• If using other eye drops, space them by at least 15 minutes.

Missed a dose?

• Use it when remembered unless it is close to the next dose.
• Do not double the next dose.

Storage and travel tips:

• Store at room temperature, about 15–25°C (59–77°F).
• Keep vials in the original foil pouch until use.
• Protect from light. Do not freeze.
• When traveling, keep vials in carry-on luggage.
• Avoid heat above 30°C (86°F) and direct sun in cars.
• Carry extra vials and your prescription with you.

Benefits and Savings

Xiidra® targets the inflammatory component of dry eye disease. Patients often report less burning, stinging, and foreign body sensation. Many also see improved tear film stability. Dosing is simple at twice daily, and vials are preservative free.

US customers can often save 60–80% compared with typical US retail prices. We offer transparent pricing and helpful support for patients paying without insurance. You can order online or by phone during posted hours. Customer-service chat is available for ordering help, and pharmacists can address medication questions.

Side Effects and Safety

Most side effects are mild to moderate and resolve with continued use. Not everyone experiences side effects. This list is not complete.

• Eye irritation, discomfort, or redness.
• Temporary blurred vision after instillation.
• Unusual taste in the mouth (dysgeusia).
• Watery eyes or increased tearing.
• Headache.

Serious effects are less common but need prompt care:

• Signs of eye infection (worsening redness, pain, discharge, sensitivity to light).
• Severe allergic reaction, swelling, or rash around the eyes.
• Vision changes that do not clear after dosing.

Do not use if allergic to lifitegrast or any ingredients. The product is single use and preservative free. Remove contact lenses before dosing and wait 15 minutes before reinsertion. Tell a healthcare professional about all eye products in use. Safety data in pregnancy and breastfeeding are limited.

Onset Time

Some patients notice symptom relief in about 2 weeks. Benefits can increase over 6 to 12 weeks. Individual responses vary. Keep using as prescribed to maintain effect.

Compare With Alternatives

Restasis (cyclosporine ophthalmic emulsion) is another prescription option for dry eye disease. It also modulates ocular surface inflammation but uses cyclosporine rather than lifitegrast. It is typically dosed twice daily, and onset may take several weeks to months. You can review Restasis® if your prescriber has recommended it.

Over-the-counter artificial tears can help with lubrication. They do not target inflammation but can ease mild symptoms and support comfort with prescription therapy. Preservative-free tears may be preferable for frequent use.

Other prescription options include cyclosporine 0.09% (Cequa) and varenicline nasal spray (Tyrvaya). These may suit different patient needs based on tolerability and coverage. Always follow your prescriber’s guidance when switching therapies.

Some patients also use glaucoma medicines. Those are not for dry eye. For example, Vyzulta® Ophthalmic Solution lowers intraocular pressure in open-angle glaucoma or ocular hypertension. It is not a substitute for Xiidra® in treating dry eye disease.

Combination Therapy

Xiidra® can be used with lubricating eye drops. Separate administration by at least 15 minutes. Ointments should be used last. Some patients benefit from eyelid hygiene, warm compresses, and environmental changes, such as humidifiers and screen breaks. Discuss any combination plan with a healthcare professional.

Patient Suitability and Cost-Saving Tips

Xiidra® is considered for patients with signs and symptoms of dry eye disease. It may help when inflammation contributes to discomfort and reduced tear quality. It is not for active eye infections. Patients with contact lenses can use it with the timing guidance above. Children, pregnant patients, or those breastfeeding should consult a clinician due to limited data.

There is no approved generic lifitegrast in the US or Canada at this time. For background on how brand and generic products compare, see Generics Vs Brand Name Medications.

To manage costs, consider multi-month supplies when appropriate, which can lower the per-month price. You can turn on gentle reorder reminders in your account so you never run short. For seasonal eye care tips, read Healthy Vision Month Protect Your Eyes Today. For condition details, our resource on Dry Eye Syndrome explains common symptoms and triggers.

Looking for a deal? See our Xiidra Ophthalmic Solution coupon page for current offers and bulk options.

Authoritative Sources

Learn more from the manufacturer’s site at the official Xiidra patient website. The FDA Drug Database provides prescribing information. For Canadian product listings, consult the Health Canada Drug Product Database.

You can order from YouDrugstore with confidence. We meet Canadian pharmacy standards, and prescriptions are checked by licensed pharmacists. We offer prompt, express shipping to the US, with caring support during posted office hours.

This information is not a substitute for professional medical advice. Always follow your prescriber’s directions and the patient leaflet in the box. Report unexpected symptoms promptly to a healthcare professional.