Xiidra® Ophthalmic Solution for Signs and Symptoms of Dry Eye

What Xiidra® Is and How It Works

Xiidra® (lifitegrast ophthalmic solution 5%) is a prescription eye drop for the signs and symptoms of dry eye disease. It is a targeted anti-inflammatory treatment used twice daily. Many people look for Xiidra Ophthalmic Solution without insurance to manage ongoing dry eye costs, and you can buy Xiidra Ophthalmic Solution online through our pharmacy.

YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing, and you can order at Canadian prices with chat support during posted hours.

Dry eye disease involves inflammation on the ocular surface. Xiidra blocks the LFA-1/ICAM-1 interaction on T-cells. This helps reduce inflammatory signaling and improves tear film stability. Xiidra 5% Ophthalmic Solution comes in sterile, single-use containers for clean dosing.

The usual regimen is one drop in each eye twice daily, about 12 hours apart. If you wear soft contact lenses, remove them before use and wait at least 15 minutes before reinserting. If you use other eye medications, separate administration to reduce washout.

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Dosage and Usage

• Wash and dry your hands.
• If you wear contact lenses, remove them before instilling drops.
• Open one single-use container by twisting off the tab. Do not touch the tip.
• Tilt your head back, gently pull down the lower lid, and instill one drop into each affected eye.
• Avoid touching the eye or eyelids with the container tip. Blink gently.
• Discard the single-use container immediately after dosing. Do not save any leftover solution.
• Use Xiidra twice daily, roughly 12 hours apart, or as directed by your prescriber.
• If using other eye drops, wait at least 5–10 minutes between products. Use gels/ointments last.
• Missed dose: instill when remembered unless near the next dose. Do not double up.

• Storage temperature: keep at 20–25 °C (68–77 °F); brief excursions 15–30 °C (59–86 °F) are acceptable.
• Keep single-use vials in the original foil pouch to protect from light.
• After opening a vial, use it right away and discard. Do not reuse.
• Do not freeze. Avoid excessive heat.
• For travel, carry vials in your hand luggage. Keep pouches sealed and protected from crushing.
• Do not share eye drops with anyone.

Benefits and Savings

Xiidra dry eye treatment can reduce eye irritation, burning, and foreign body sensation, and improve corneal staining. Many people notice symptom improvements within a few weeks, with continued gains by three months. Single-use packaging supports sterility and simple dosing twice per day.

Ordering Xiidra Ophthalmic Solution online from Canada may lower your out-of-pocket costs. Typical savings range from 60–80% versus common US prices. If you pay cash, the Xiidra Ophthalmic Solution cash price at Canadian pharmacies can be competitive, and multi-month supplies may reduce the per-month cost even further.

If you are comparing the Xiidra Ophthalmic Solution price across pharmacies, consider total value: product cost, shipping, and support. You can order Xiidra Ophthalmic Solution confidently and receive prompt, express shipping to the US. For those purchasing Xiidra Ophthalmic Solution without insurance, our bulk promotions can help lower the effective monthly spend.

Looking for promotions? See our Xiidra Ophthalmic Solution coupon details for current offers.

Side Effects and Safety

• Eye irritation or discomfort when instilling drops
• Unusual taste in the mouth (dysgeusia)
• Blurred vision temporarily after dosing
• Eye redness (conjunctival hyperemia)
• Watery eyes or discharge
• Headache
• Dryness or itching

Serious reactions are uncommon. Stop use and seek care for signs of allergy (swelling, rash, severe redness), persistent vision changes, or eye pain. Remove contact lenses before use and wait at least 15 minutes before reinserting. If you develop an eye infection or significant trauma, consult your prescriber before continuing therapy.

Onset Time

Some patients experience symptom relief with Xiidra within 2–6 weeks. Optimal benefits often emerge by 8–12 weeks of steady use. Individual response varies based on disease severity, adherence, and concurrent measures such as lid hygiene or artificial tears. Continue as directed so your prescriber can assess progress over time.

Compare With Alternatives

Restasis® (cyclosporine ophthalmic emulsion 0.05%) treats dry eye disease by increasing tear production while lowering ocular surface inflammation. It is dosed twice daily and may take longer to show full effect, often several months.

Cequa (cyclosporine 0.09% solution) is another calcineurin-inhibitor option. It offers a higher cyclosporine concentration with a similar twice-daily regimen. Some patients respond better to lifitegrast, others to cyclosporine; your prescriber can help choose.

Non-prescription artificial tears and nighttime gels provide symptomatic moisture but do not address underlying inflammation. They are often used with prescription therapy for comfort. For a broader view of dry eye causes and care, see our condition page on Dry Eye Syndrome.

Combination Therapy

• Xiidra with preservative-free artificial tears during the day (separate dosing by at least 5–10 minutes).
• Nighttime lubricating ointment for nocturnal dryness; apply after all other eye medications.
• Eyelid hygiene and warm compresses for meibomian gland support.
• Punctal plugs or environmental changes (humidifier, screen breaks) as guided by your eye care professional.
• Antihistamine or mast-cell stabilizer drops if allergic conjunctivitis coexists; separate dosing to avoid washout.

Patient Suitability and Cost-Saving Tips

Xiidra is intended for adults with signs and symptoms of dry eye disease. It may not be suitable for those with known hypersensitivity to lifitegrast or formulation components. People with active eye infections or significant ocular trauma should be clinically evaluated before use. Safety in children has not been established. Discuss use during pregnancy or breastfeeding with your prescriber.

If you wear contact lenses, remove them prior to dosing and wait at least 15 minutes before reinsertion. Temporary blurred vision can occur after instillation, so use caution with activities that require clear vision until it resolves. If you use multiple ophthalmic products, space them several minutes apart and apply gels or ointments last.

To manage the Xiidra Ophthalmic Solution cost, consider a multi-month supply when you and your prescriber are comfortable with the regimen. Reorder reminders can help prevent gaps in therapy. Watch for discount Xiidra Ophthalmic Solution promotions that lower your effective monthly price. If you pay out of pocket, comparing the Xiidra eye drops price across Canadian pharmacies can help you find value. This approach can support those seeking Xiidra Ophthalmic Solution no insurance options.

Authoritative Sources

Official Xiidra Consumer Site

FDA Medication Guide for Xiidra (lifitegrast)

For general eye wellness tips, you can also read our article on Healthy Vision Month Protect Your Eyes Today.

Order Xiidra® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express shipping.

This page is for educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment.