How is this combination different from taking separate injections?

This medicine pairs a basal insulin with a GLP-1 agent in one daily injection. That approach can support both fasting and after-meal control while limiting the number of injections compared with using two separate products. Your prescriber decides whether a single combined device or individual components better suit your needs, based on your glucose profile, tolerance, and goals.

Can I use it with mealtime insulin or another GLP-1 therapy?

It is not used with another GLP-1 receptor agonist. Some people may require mealtime insulin, but combining therapies requires careful evaluation to reduce hypoglycemia risk. Your clinician will review your current regimen and determine if additional insulin is appropriate or if adjustments are needed. Always follow the official label and your prescriber’s plan.

Where on the body should I inject?

Inject subcutaneously into the abdomen, thigh, or upper arm. Rotate injection sites within the same region to lower the chance of irritation. Use a new needle for each injection, prime a new pen as instructed, and avoid injecting through clothing. If you have questions about technique, review the Instructions for Use or ask a healthcare professional to demonstrate.

What should I do if I feel nauseated after starting?

Mild nausea can occur when beginning therapy, often easing with time. Eating smaller, more frequent meals and avoiding heavy or greasy foods may help. If symptoms become severe or persistent, contact your prescriber. Seek urgent care if you have severe abdominal pain, which could indicate something more serious such as pancreatitis.

How should I store the pen after the first use?

Follow the label for in-use storage guidance. Generally, unopened pens are refrigerated. Do not freeze. Protect from heat and light, and keep caps on when not in use. Store out of reach of children and pets. If traveling, use an insulated case and carry your medicine and supplies in your hand luggage.

Can it cause low blood sugar?

Yes, low blood sugar can occur, especially when combined with other medicines that increase insulin action or secretion. Learn the signs such as shakiness, sweating, and confusion. Keep a fast-acting carbohydrate available. Your clinician may adjust other therapies to reduce risk. Monitor glucose more often during changes in diet, activity, or dose.

Will this help with weight?

The GLP-1 component can reduce appetite in some people, which may support weight management. Individual results vary. Discuss goals and expectations with your prescriber. Focus on a balanced diet, regular activity, and adherence to your treatment plan for the best chance at sustained improvements in health markers.

Promotion

Xultophy Prefilled Pen

Xultophy® Prefilled Pen for Type 2 Diabetes

Type 2 Diabetes

Stock up and Save - Get 20% off when you buy 3 or more of any one product. Use code SAVE20 at checkout.

Coupon code cannot be combined with other offers. Sale applies to all products originating from Canada. Maximum allowable quantity equal to a 90 day supply per single order.

Price:

$341.99

Secure Encrypted Payments

Xultophy Prefilled Pen is a prescription combination for adults with type 2 diabetes. It pairs basal insulin with a GLP-1 agonist to help manage blood sugar alongside diet and activity. You can access Canadian pricing with US delivery from Canada, even without insurance.

What Xultophy® Is and How It Works

Xultophy® combines insulin degludec and liraglutide in one once-daily injection device. The basal insulin supports steady glucose control, while the GLP-1 component helps reduce glucose after meals and may curb appetite. Together, this medicine works on fasting and post-meal levels. The class aims to lower A1C when used with lifestyle measures.

YouDrugstore is a licensed Canadian pharmacy in Manitoba. Pharmacists review prescriptions before dispensing.

Xultophy insulin degludec liraglutide pen is designed for subcutaneous use in the abdomen, thigh, or upper arm. The combination allows a single daily injection on a regular schedule. Dose adjustments are directed by a prescriber based on blood glucose goals and tolerability.

Who It’s For

This treatment is indicated for adults with type 2 diabetes who need improved glycemic control with adjunct diet and exercise. It is not for type 1 diabetes or for diabetic ketoacidosis. People with a history of medullary thyroid carcinoma or MEN2 should avoid this therapy. Those with a history of pancreatitis should discuss risks with a clinician before starting. Xultophy 100/3.6 injection pen is not approved for pediatric use.

Learn more about the condition at Type 2 Diabetes. For broader supplies and devices, see Diabetes Care.

Dosage and Usage

This medicine is injected once daily, at the same time each day, with or without food. Use the pen as instructed in the official label and by your healthcare professional. Rotate injection sites within the same region to reduce local reactions. Do not share pens or needles.

Prime the device before the first dose of a new pen as directed in the Instructions for Use. Check the solution visually; it should be clear and colorless. Xultophy injection pen 3 mL contains multiple doses; the total number depends on your prescribed dose steps.

If you receive other diabetes medicines, your prescriber may adjust them when starting this therapy. Never change your dose on your own. Refer to the patient information and speak with a clinician if unsure.

Strengths and Forms

This product is supplied as a prefilled, multi-dose pen containing insulin degludec and liraglutide. Insulin degludec/liraglutide 100/3.6 pen reflects 100 units/mL of insulin degludec with 3.6 mg/mL of liraglutide in a 3 mL cartridge. Availability of specific presentations may vary. Always check the label and carton for the exact strength you receive.

Missed Dose and Timing

If a dose is missed, take the next dose at the regular time. Do not double dose to make up for a missed injection. Monitor blood glucose more frequently after a missed dose. If multiple doses are missed, consult the prescribing information or your clinician for guidance on restarting.

Storage and Travel Basics

Unopened pens should be stored in a refrigerator as directed on the label. Do not freeze. Keep away from heat and light. After first use, follow the label for in-use storage duration and temperature. Keep caps on when not in use. Store out of reach of children and pets.

When traveling, keep your pen and spare needles in your carry-on. Use a protective case. Bring your prescription or a copy of the label for security checks. Pack an extra glucose meter, test strips, and a hypoglycemia source. Dispose of used needles in an approved sharps container.

For practical step-by-step device tips, see Ozempic Pen Tips. Lifestyle support resources are available in Weight Management and this guide: Reverse Prediabetes Tips.

Pen Handling and Sharps Disposal

Before each injection, attach a new needle and remove both caps. Prime the pen as instructed when starting a new device. Confirm the dose in the window. Insert the needle into the skin, press and hold the injection button to deliver, and keep the needle in the skin for the recommended count before removing. Recap the needle carefully and remove it after use.

Discard used needles in a puncture-resistant sharps container. Do not dispose of needles or pens in household trash. Follow local regulations for sharps disposal or ask your pharmacy about take-back options.

Benefits

This combination can simplify therapy by providing basal insulin and a GLP-1 agent together. It may help lower fasting and after-meal glucose and reduce A1C when used as directed. Once-daily dosing supports routine. Some people may experience less need for multiple injections compared with separate agents.

Side Effects and Safety

Common: nausea, diarrhea, vomiting, decreased appetite
Injection site reactions: redness, itching, or discomfort
Headache or nasopharyngitis
Indigestion or constipation

Serious but less common risks include pancreatitis, gallbladder problems, kidney issues, dehydration, or severe allergic reactions. There is a boxed warning related to thyroid C-cell tumors with GLP-1 receptor agonists; avoid use with a personal or family history of medullary thyroid carcinoma or MEN2. This therapy can increase hypoglycemia risk, especially when used with insulin secretagogues. Seek urgent help for severe abdominal pain, symptoms of low blood sugar, or signs of an allergic reaction.

Drug Interactions and Cautions

Medicines that lower glucose, such as sulfonylureas, can raise the risk of hypoglycemia when combined with this treatment. Corticosteroids, certain diuretics, and some atypical antipsychotics can raise blood sugar and may reduce effect. Beta-blockers can mask symptoms of low blood sugar. Do not use with another GLP-1 receptor agonist. If on warfarin, monitoring may be prudent when therapy changes. Alcohol can affect glucose control and increase hypoglycemia risk.

Tell your prescriber about all medicines, supplements, and herbal products you use. Review your full medical history, including pancreas, kidney, liver, and gallbladder conditions.

What to Expect Over Time

Glucose readings may improve with consistent daily use, diet, and physical activity. Gastrointestinal effects can occur when starting and may lessen over time. Regular monitoring and follow-up with your healthcare professional help guide any adjustments. Keeping injections at the same time each day supports stability.

Compare With Alternatives

Some adults may be managed with basal insulin alone. Others may use an oral agent or a different combination product. For a basal-only option, your prescriber may consider Levemir Penfill Cartridges. As an oral alternative from another class, Sitagliptin may be used in appropriate patients.Suitability depends on medical history, treatment goals, and tolerability. Your clinician will recommend an option that aligns with your needs.

Pricing and Access

We offer transparent listings so you can review the Xultophy Prefilled Pen price before placing an order. Many patients compare options to understand Xultophy Prefilled Pen Canadian pricing and typical cash-pay savings. US shipping from Canada is available with prescription verification. You can also check current offers on our Promotions page. Checkout is protected with encrypted processing.

Questions on coverage or budgets can be discussed with your prescriber or our pharmacy team. We can provide receipts for reimbursement if your plan allows out-of-network claims.

Availability and Substitutions

Supply can vary. If this item is unavailable, your prescriber may recommend a suitable alternative in the same class or a different approach. We cannot provide restock dates. Your clinician will determine if switching is appropriate based on your history and current regimen.

Patient Suitability and Cost-Saving Tips

Candidates include adults with type 2 diabetes who need additional control after lifestyle measures and possibly other medicines. It should not be used in type 1 diabetes or during episodes of diabetic ketoacidosis. People with a history of medullary thyroid carcinoma or MEN2 should avoid it. Those with pancreatitis, severe gastrointestinal disease, or significant kidney concerns should review risks first.

To help manage costs, ask your prescriber about multi-month quantities if appropriate. Setting refill reminders can prevent gaps in therapy. Review your plan’s policies, or use cash pay if preferred. Compare options within Diabetes Care to coordinate supplies like needles and sharps containers.

Questions to Ask Your Clinician

Starting dose and titration plan: how will adjustments be made
How to monitor glucose and recognize low blood sugar
What to do when sick or eating less than usual
Which other medicines should be reduced to lower hypoglycemia risk
How long to try this therapy before assessing response
Signs of pancreatitis or thyroid issues to watch for
Travel, storage, and pen handling instructions for your routine

Authoritative Sources

FDA Prescribing Information (DailyMed/Label)

Health Canada Drug Product Database

Manufacturer Information

Ready to proceed? Add to cart and checkout when ready for prompt, express, cold-chain shipping. This information is not a substitute for professional medical advice; always follow your prescriber and the official label.

Express Shipping - from $25.00

Shipping with this method takes 3-5 days

Prices:

Dry-Packed Products $25.00
Cold-Packed Products $35.00

Shipping Countries:

United States (all contiguous states**)
Worldwide (excludes some countries***)

Standard Shipping - $15.00

Shipping with this method takes 5-10 days

Prices:

Dry-Packed Products $15.00
Not available for Cold-Packed products

Shipping Countries:

United States (all contiguous states**)
Worldwide (excludes some countries***)

View All FAQs

How is this combination different from taking separate injections?
This medicine pairs a basal insulin with a GLP-1 agent in one daily injection. That approach can support both fasting and after-meal control while limiting the number of injections compared with using two separate products. Your prescriber decides whether a single combined device or individual components better suit your needs, based on your glucose profile, tolerance, and goals.
Can I use it with mealtime insulin or another GLP-1 therapy?
It is not used with another GLP-1 receptor agonist. Some people may require mealtime insulin, but combining therapies requires careful evaluation to reduce hypoglycemia risk. Your clinician will review your current regimen and determine if additional insulin is appropriate or if adjustments are needed. Always follow the official label and your prescriber’s plan.
Where on the body should I inject?
Inject subcutaneously into the abdomen, thigh, or upper arm. Rotate injection sites within the same region to lower the chance of irritation. Use a new needle for each injection, prime a new pen as instructed, and avoid injecting through clothing. If you have questions about technique, review the Instructions for Use or ask a healthcare professional to demonstrate.
What should I do if I feel nauseated after starting?
Mild nausea can occur when beginning therapy, often easing with time. Eating smaller, more frequent meals and avoiding heavy or greasy foods may help. If symptoms become severe or persistent, contact your prescriber. Seek urgent care if you have severe abdominal pain, which could indicate something more serious such as pancreatitis.
How should I store the pen after the first use?
Follow the label for in-use storage guidance. Generally, unopened pens are refrigerated. Do not freeze. Protect from heat and light, and keep caps on when not in use. Store out of reach of children and pets. If traveling, use an insulated case and carry your medicine and supplies in your hand luggage.
Can it cause low blood sugar?
Yes, low blood sugar can occur, especially when combined with other medicines that increase insulin action or secretion. Learn the signs such as shakiness, sweating, and confusion. Keep a fast-acting carbohydrate available. Your clinician may adjust other therapies to reduce risk. Monitor glucose more often during changes in diet, activity, or dose.
Will this help with weight?
The GLP-1 component can reduce appetite in some people, which may support weight management. Individual results vary. Discuss goals and expectations with your prescriber. Focus on a balanced diet, regular activity, and adherence to your treatment plan for the best chance at sustained improvements in health markers.