Salofalk® Rectal Suppositories for Ulcerative Proctitis

What Salofalk® Is and How It Works

Salofalk is a brand of mesalamine (5-aminosalicylic acid) rectal suppositories used to treat mild to moderate ulcerative proctitis. If you are comparing options for Salofalk Suppositories price and Salofalk Suppositories buy online, you can review strengths and package sizes here. Many people also look for salofalk suppositories without insurance to manage out-of-pocket costs. YouDrugstore is a licensed Canadian pharmacy headquartered in Manitoba; prescriptions are reviewed by licensed pharmacists before dispensing.

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Each suppository delivers mesalamine directly to the rectal mucosa, where it works topically to reduce inflammation. Mesalamine inhibits cyclooxygenase and lipoxygenase pathways and lowers inflammatory mediators in the colonic lining. This local action can improve rectal bleeding, urgency, and tenesmus. Salofalk suppositories are typically used for disease limited to the rectum; if inflammation extends higher, a rectal enema or oral therapy may be added.

Available strengths commonly include salofalk suppositories 500mg and salofalk 1g suppositories (also written as salofalk 1000mg suppositories or salofalk supp 1g). Dosing is usually once nightly for 1 g or one 500 mg suppository two to three times daily, depending on the treatment plan. Many patients continue for several weeks, then taper or switch to maintenance as directed by their prescriber.

Dosage and Usage

• Typical regimens: 1 g at bedtime once daily for induction, or 500 mg two to three times daily. Some plans use 1 g twice daily short term for active flares, then reduce.
• Before insertion, try to empty your bowels. Wash and dry hands.
• Carefully unwrap the suppository. If it is soft, chill it in the refrigerator for 15–30 minutes before use.
• Moisten the pointed end with cool water or a small amount of water-based lubricant.
• Lie on your left side with the right knee bent. Gently insert the suppository pointed end first about 2.5–4 cm into the rectum.
• Remain lying for 10–15 minutes to help prevent slippage. Bedtime dosing helps retention.
• If you miss a dose and it is close to the next one, skip the missed dose. Do not insert two at once.
• Continue as prescribed even if symptoms improve. Ask your prescriber before making changes.

• Store at 15–25°C (59–77°F) in the original foil. Protect from heat and humidity.
• Do not freeze. Avoid leaving in hot cars or near heaters to prevent melting.
• For travel, keep in a small insulated pouch if ambient temperatures exceed 25–30°C (77–86°F).
• Brief room-temperature excursions are usually acceptable. Return to recommended storage as soon as possible.
• Keep out of reach of children and pets.

Benefits and Savings

Rectal mesalamine targets inflammation at the site of disease with minimal systemic absorption. This local delivery can reduce rectal bleeding and urgency and support mucosal healing. Many patients find once-daily 1 g dosing convenient during induction. Both salofalk suppositories 500mg and salofalk 1g suppositories are options providers use depending on symptoms and goals.

Buying from a Canadian pharmacy can offer 60–80% savings versus typical US prices. Many customers seek options when paying without insurance, and multi-month supplies or bulk promotions can lower the per-month cost. You can also set simple reorder reminders so you do not run short during maintenance.

See current offers here: salofalk suppositories coupon.

Side Effects and Safety

• Common: rectal discomfort or burning, mild cramping, gas, or urgency after insertion.
• Gastrointestinal: nausea, abdominal pain, diarrhea, constipation.
• Headache or dizziness.
• Rectal leakage or small amount of residue on underwear.
• Rash or itching.
• Fatigue.

Serious but uncommon risks include allergic reactions to mesalamine or salicylates; kidney issues such as interstitial nephritis; pancreatitis; liver test changes; blood disorders; and rare myocarditis or pericarditis. Stop the medication and contact a clinician if you develop chest pain, shortness of breath, severe abdominal pain, dark urine, persistent vomiting, worsening diarrhea, or a widespread rash. Use caution with known salicylate allergy, severe renal or hepatic impairment, or a history of mesalamine-induced reactions.

Onset Time

Some people notice symptom relief, such as less bleeding and urgency, within a few days. More consistent improvement often appears over 1–2 weeks as dosing stabilizes. Mucosal healing may take several weeks of continued therapy. Providers commonly reassess the response after 2–4 weeks and adjust the plan as needed.

Compare With Alternatives

For disease that extends above the rectum, a rectal enema delivers medicine higher into the distal colon. An option is Salofalk® Suspension, a mesalamine enema often used for proctosigmoiditis or left-sided colitis. Enemas cover a larger area but can be less convenient for some patients.

Another brand of mesalamine suppositories is Pentasa® Suppositories. Both deliver topical mesalamine locally; your prescriber may choose based on availability, strength, tolerance, and previous response.

Oral mesalamine tablets (for example, Salofalk tablets) may be used when inflammation is more extensive. Oral therapy provides colonic coverage, and many plans combine oral and rectal mesalamine to improve outcomes during flares.

Combination Therapy

• Rectal suppository plus oral mesalamine for proctosigmoiditis or left-sided disease.
• Suppository in the morning and mesalamine enema at night during active flares.
• Short courses of rectal corticosteroid foam or suppository if additional anti-inflammatory effect is needed.
• Avoid duplicating products unintentionally; confirm active ingredients and total daily mesalamine exposure with your prescriber.

Patient Suitability and Cost-Saving Tips

Salofalk suppositories are intended for adults and suitable adolescents with mild to moderate ulcerative proctitis. They are not designed for Crohn’s disease isolated to the small bowel. People with hypersensitivity to salicylates or aminosalicylates should not use mesalamine products. Those with significant kidney or liver disease need careful monitoring. Discuss use during pregnancy or breastfeeding with your healthcare provider.

Consider whether 500 mg twice daily or 1 g nightly best fits your schedule and goals. If retention is difficult, inserting at bedtime and remaining on your side can help. Contact your clinician if bleeding worsens or new severe symptoms appear.

To save on therapy, compare pack sizes and strengths. Multi-month supplies can reduce per-month costs, and occasional bulk offers may apply. Set a reminder to reorder before your current box runs low. If you are paying no insurance or out of pocket, reviewing the Salofalk Suppositories price per dose can help you plan monthly expenses.

Authoritative Sources

Health Canada Drug Product Database (DPD) search

Paladin Labs Salofalk product information

FDA Canasa (mesalamine suppository) Prescribing Information

Order Salofalk® from YouDrugstore: add to cart, upload your prescription, and we ship with prompt, express, cold-chain handling.

This material is educational and does not replace advice from your healthcare professional. Always follow your prescriber’s directions and the product labeling.